HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.

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🔗 View Article (PMID 25217962)

Published in Nat Genet on September 14, 2014

Authors

Graham A Heap¹, Michael N Weedon², Claire M Bewshea³, Abhey Singh⁴, Mian Chen⁵, Jack B Satchwell⁵, Julian P Vivian⁶, Kenji So⁴, Patrick C Dubois⁷, Jane M Andrews⁸, Vito Annese⁹, Peter Bampton¹⁰, Martin Barnardo⁵, Sally Bell¹¹, Andy Cole¹², Susan J Connor¹³, Tom Creed¹⁴, Fraser R Cummings¹⁵, Mauro D'Amato¹⁶, Tawfique K Daneshmend⁴, Richard N Fedorak¹⁷, Timothy H Florin¹⁸, Daniel R Gaya¹⁹, Emma Greig²⁰, Jonas Halfvarson²¹, Alisa Hart²², Peter M Irving²³, Gareth Jones²⁴, Amir Karban²⁵, Ian C Lawrance²⁶, James C Lee²⁷, Charlie Lees²⁴, Raffi Lev-Tzion²⁸, James O Lindsay²⁹, John Mansfield³⁰, Joel Mawdsley³¹, Zia Mazhar³², Miles Parkes²⁷, Kirstie Parnell³³, Timothy R Orchard³⁴, Graham Radford-Smith³⁵, Richard K Russell³⁶, David Reffitt³⁷, Jack Satsangi²⁴, Mark S Silverberg³⁸, Giacomo C Sturniolo³⁹, Mark Tremelling⁴⁰, Epameinondas V Tsianos⁴¹, David A van Heel⁴², Alissa Walsh⁴³, Gill Watermeyer⁴⁴, Rinse K Weersma⁴⁵, Sebastian Zeissig⁴⁶, Jamie Rossjohn⁶, Arthur L Holden⁴⁷, International Serious Adverse Events Consortium, IBD Pharmacogenetics Study Group, Tariq Ahmad³

Author Affiliations

1: 1] IBD Pharmacogenetics, Royal Devon and Exeter Hospital, Exeter, UK. [2] Precision Medicine Exeter, University of Exeter, Exeter, UK. [3].
2: 1] Precision Medicine Exeter, University of Exeter, Exeter, UK. [2].
3: 1] IBD Pharmacogenetics, Royal Devon and Exeter Hospital, Exeter, UK. [2] Precision Medicine Exeter, University of Exeter, Exeter, UK.
4: IBD Pharmacogenetics, Royal Devon and Exeter Hospital, Exeter, UK.
5: Oxford Transplant Centre, Oxford University Hospital National Health Service (NHS) Trust, Oxford, UK.
6: Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia.
7: Department of Gastroenterology, King's College Hospital, London, UK.
8: IBD Service, Department of Gastroenterology and University of Adelaide at Royal Adelaide Hospital, Adelaide, South Australia, Australia.
9: Division of Gastroenterology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
10: Flinders Medical Centre, Flinders University of South Australia, Adelaide, South Australia, Australia.
11: Department of Gastroenterology, St. Vincent's Hospital, Fitzroy, Victoria, Australia.
12: Gastroenterology and Hepatology, Royal Derby Hospital, Derby, UK.
13: Department of Gastroenterology and Hepatology, Liverpool Hospital, Sydney, New South Wales, Australia.
14: Joint Clinical Research Unit, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
15: Department of Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
16: Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
17: Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.
18: The University of Queensland School of Medicine, South Brisbane, Queensland, Australia.
19: Gastroenterology Unit, Glasgow Royal Infirmary, Glasgow, UK.
20: Department of Gastroenterology, Taunton and Somerset NHS Foundation Trust, Taunton, UK.
21: Division of Gastroenterology, Örebro University Hospital and School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
22: Department of Medicine, St. Mark's Hospital and Academic Institute, North West London Hospitals NHS Trust, London, UK.
23: Department of Gastroenterology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
24: Department of Gastroenterology, Western General Hospital, Edinburgh, UK.
25: Department of Gastroenterology, Rambam Medical Center, Haifa, Israel.
26: Centre for Inflammatory Bowel Diseases, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia.
27: Department of Gastroenterology, Cambridge University Hospitals NHS Trust, Cambridge, UK.
28: Paediatric Gastroenterology and Nutrition Unit, Shaare Zedek Medical Centre, Jerusalem, Israel.
29: Department of Gastroenterology, Barts and The London NHS Trust, London, UK.
30: Department of Gastroenterology, Newcastle University Hospitals NHS Trust, Newcastle, UK.
31: Department of Gastroenterology, West Middlesex University Hospital NHS Trust, Isleworth, UK.
32: Department of Gastroenterology, Basildon and Thurrock Hospital NHS Trust, Basildon, UK.
33: Precision Medicine Exeter, University of Exeter, Exeter, UK.
34: Department of Medicine, Imperial College Healthcare NHS, London, UK.
35: 1] Department of Gastroenterology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. [2] IBD Group, Queensland Institute of Medical Research and University of Queensland School of Medicine, Herston Campus, Brisbane, Queensland, Australia.
36: Department of Paediatric Gastroenterology, Yorkhill Hospital, Glasgow, UK.
37: Department of Gastroenterology, Lewisham and Greenwich NHS Trust, London, UK.
38: Inflammatory Bowel Disease Group, Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
39: Gastroenterologia, Univerita di Padova, Padova, Italy.
40: Department of Gastroenterology, Norfolk and Norwich Hospital NHS Trust, Norwich, UK.
41: 1st Division of Internal Medicine and Division of Gastroenterology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
42: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
43: Department of Gastroenterology, St. Vincent's Hospital, Sydney, New South Wales, Australia.
44: Gastrointestinal Clinic, Groote Schuur Hospital, Cape Town, South Africa.
45: Department of Gastroenterology and Hepatology, University Medical Center Groningen and the University of Groningen, Groningen, the Netherlands.
46: Department of Internal Medicine, University Medical Center Schleswig-Holstein, Kiel, Germany.
47: The International Serious Adverse Events Consortium, Chicago, Illinois, USA.