Published in Birth Defects Res B Dev Reprod Toxicol on September 17, 2014
Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway. J Biol Chem (2015) 0.84
Ketamine exposure during embryogenesis inhibits cellular proliferation in rat fetal cortical neurogenic regions. Acta Anaesthesiol Scand (2016) 0.75
PACAP Protects Adult Neural Stem Cells from the Neurotoxic Effect of Ketamine Associated with Decreased Apoptosis, ER Stress and mTOR Pathway Activation. PLoS One (2017) 0.75
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature (1996) 26.30
CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev (1999) 24.83
Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (1997) 11.48
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature (2000) 8.35
Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science (1999) 6.37
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med (2002) 5.79
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev (1997) 5.58
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med (2002) 5.25
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem (1998) 5.09
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med (2002) 4.69
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol Cell Biol (2000) 3.93
Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem (2004) 2.82
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A (2008) 2.48
Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene (2006) 2.42
Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J Neurosci (1998) 2.05
Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinology (2001) 2.00
Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses. J Neurosci (2010) 1.86
14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J (2004) 1.75
Ketamine. Handb Exp Pharmacol (2008) 1.72
The role of the N-methyl-D-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture. Neuroscience (2005) 1.50
Ketamine alters the neurogenesis of rat cortical neural stem progenitor cells. Crit Care Med (2012) 1.50
Akt-1 expression level regulates CNS precursors. J Neurosci (2004) 1.48
Potential neurotoxicity of ketamine in the developing rat brain. Toxicol Sci (2009) 1.33
Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in culture. Toxicol Sci (2006) 1.24
Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner. J Neurochem (2005) 1.20
NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor, LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3beta-induced apoptosis. J Neurochem (2005) 1.17
Activity-dependent NMDA receptor-mediated activation of protein kinase B/Akt in cortical neuronal cultures. J Neurochem (2002) 1.13
Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways. Neurochem Res (2008) 1.10
Phosphorylation-dependent interaction of the N-methyl-D-aspartate receptor epsilon 2 subunit with phosphatidylinositol 3-kinase. Genes Cells (1999) 1.03
Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus. PLoS One (2009) 1.02
The role of Akt-GSK-3beta signaling and synaptic strength in phencyclidine-induced neurodegeneration. Neuropsychopharmacology (2007) 0.98
Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neurons. J Biol Chem (2008) 0.95
Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockade. J Neurochem (2008) 0.94
Transforming growth factor-beta1 regulates the fate of cultured spinal cord-derived neural progenitor cells. Cell Prolif (2008) 0.86
Lithium protection of phencyclidine-induced neurotoxicity in developing brain: the role of phosphatidylinositol-3 kinase/Akt and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways. J Pharmacol Exp Ther (2008) 0.85
Phosphatidylinositol 3-kinase is essential for the proliferation of lymphoblastoid cells. Oncogene (2002) 0.83
Insulin rescues ES cell-derived neural progenitor cells from apoptosis by differential regulation of Akt and ERK pathways. Neurosci Lett (2007) 0.82
Functional Status Scale: new pediatric outcome measure. Pediatrics (2009) 2.42
A comparison of critical care research funding and the financial burden of critical illness in the United States. Crit Care Med (2012) 2.07
Weaning and extubation readiness in pediatric patients. Pediatr Crit Care Med (2009) 2.00
Morphine administration and short-term pulmonary outcomes among ventilated preterm infants. Pediatrics (2005) 1.57
A framework for conducting follow-up meetings with parents after a child's death in the pediatric intensive care unit. Pediatr Crit Care Med (2011) 1.57
Ketamine alters the neurogenesis of rat cortical neural stem progenitor cells. Crit Care Med (2012) 1.50
Oral sucrose and "facilitated tucking" for repeated pain relief in preterms: a randomized controlled trial. Pediatrics (2012) 1.50
Anesthetic neurotoxicity in newborns: should we change clinical practice? Anesthesiology (2007) 1.50
Is "rescue" therapy ethical in randomized controlled trials? Pediatr Crit Care Med (2009) 1.46
Research as a Standard of Care in the PICU. Pediatr Crit Care Med (2016) 1.44
Of mice and men: should we extrapolate rodent experimental data to the care of human neonates? Anesthesiology (2005) 1.43
Collaborative pediatric critical care research network: looking back and moving forward. Pediatr Crit Care Med (2010) 1.35
Morphine does not provide adequate analgesia for acute procedural pain among preterm neonates. Pediatrics (2005) 1.29
Ketamine reduces the cell death following inflammatory pain in newborn rat brain. Pediatr Res (2007) 1.22
Interpretation of cortisol concentrations and reference intervals from the CALIPER database. Clin Chem (2013) 1.15
More information, less understanding: a randomized study on consent issues in neonatal research. Pediatrics (2009) 1.06
Use of analgesic and sedative drugs in the NICU: integrating clinical trials and laboratory data. Pediatr Res (2010) 0.99
Double-blind, placebo-controlled pilot randomized trial of methylprednisolone infusion in pediatric acute respiratory distress syndrome. Pediatr Crit Care Med (2015) 0.95
Does neonatal morphine use affect neuropsychological outcomes at 8 to 9 years of age? Pain (2012) 0.94
Taking up the challenge of measuring prolonged pain in (premature) neonates: the COMFORTneo scale seems promising. Clin J Pain (2009) 0.94
Eight years later, are we still hurting newborn infants? Neonatology (2014) 0.92
Early adversity, socioemotional development, and stress in urban 1-year-old children. J Pediatr (2013) 0.91
Real-time free cortisol quantification among critically ill children. Pediatr Crit Care Med (2011) 0.89
Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: a pilot randomized, double-blind, placebo-controlled trial. Pediatr Crit Care Med (2012) 0.87
Evaluation and development of potentially better practices to improve pain management of neonates. Pediatrics (2006) 0.85
A single nucleotide polymorphism in the corticotropin receptor gene is associated with a blunted cortisol response during pediatric critical illness. Pediatr Crit Care Med (2014) 0.82
Pain panacea for opiophobia in infants? JAMA (2013) 0.78
Severe acute asthma exacerbation in children: a stepwise approach for escalating therapy in a pediatric intensive care unit. J Pediatr Pharmacol Ther (2013) 0.78
Opioid receptor desensitization contributes to thermal hyperalgesia in infant rats. Eur J Pharmacol (2004) 0.77
Chronic pain in the newborn: toward a definition. Clin J Pain (2014) 0.76
Anaesthetic neurotoxicity in rodents: is the ketamine controversy real? Acta Paediatr (2007) 0.76
Methodological Considerations for Hair Cortisol Measurements in Children. Ther Drug Monit (2015) 0.75
Inherent Risk Factors for Nosocomial Infection in the Long Stay Critically Ill Child Without Known Baseline Immunocompromise: A Post Hoc Analysis of the CRISIS Trial. Pediatr Infect Dis J (2016) 0.75
Cognitive Development 1 Year After Infantile Critical Pertussis. Pediatr Crit Care Med (2017) 0.75