Published in Science on January 01, 1999
PANDA (Pediatric Anesthesia & NeuroDevelopment Assessment) Study | NCT00881764
Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology (2009) 9.51
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat Rev Neurosci (2010) 5.27
Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology (2010) 4.44
Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci U S A (2002) 4.18
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci (2008) 4.04
The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J (2001) 3.85
Cognitive and behavioral outcomes after early exposure to anesthesia and surgery. Pediatrics (2011) 3.76
Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain. Br J Pharmacol (2005) 2.61
Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys. Neurotoxicol Teratol (2011) 2.41
Neuraxial labor analgesia for vaginal delivery and its effects on childhood learning disabilities. Anesth Analg (2010) 2.31
Surgery and neurodevelopmental outcome of very low-birth-weight infants. JAMA Pediatr (2014) 2.18
Isoflurane causes greater neurodegeneration than an equivalent exposure of sevoflurane in the developing brain of neonatal mice. Anesthesiology (2010) 2.08
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Clinical anesthesia causes permanent damage to the fetal guinea pig brain. Brain Pathol (2008) 1.71
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Early childhood general anaesthesia exposure and neurocognitive development. Br J Anaesth (2010) 1.67
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Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain. Anesthesiology (2012) 1.59
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Early alterations of AMPA receptors mediate synaptic potentiation induced by neonatal seizures. J Neurosci (2008) 1.51
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Ketamine alters the neurogenesis of rat cortical neural stem progenitor cells. Crit Care Med (2012) 1.50
Coupling of the NMDA receptor to neuroprotective and neurodestructive events. Biochem Soc Trans (2009) 1.50
Anesthesia for cesarean delivery and learning disabilities in a population-based birth cohort. Anesthesiology (2009) 1.47
Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain. Br J Anaesth (2013) 1.47
High dose magnesium sulfate exposure induces apoptotic cell death in the developing neonatal mouse brain. Neonatology (2009) 1.46
Acute neonatal glucocorticoid exposure produces selective and rapid cerebellar neural progenitor cell apoptotic death. Cell Death Differ (2008) 1.44
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Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci (2010) 1.40
Brain maturation in neonatal rodents is impeded by sevoflurane anesthesia. Anesthesiology (2015) 1.38
Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain. Ann N Y Acad Sci (2010) 1.37
General anesthesia causes long-lasting disturbances in the ultrastructural properties of developing synapses in young rats. Neurotox Res (2009) 1.37
Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology. Schizophr Bull (2008) 1.37
General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain. Anesthesiology (2011) 1.36
Hypothermic neuroprotection. NeuroRx (2006) 1.36
Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy. J Pharmacol Exp Ther (2007) 1.35
Hypoxic-ischemic encephalopathy in the term infant. Clin Perinatol (2009) 1.35
Potential neurotoxicity of ketamine in the developing rat brain. Toxicol Sci (2009) 1.33
Lithium protects against anesthesia-induced developmental neuroapoptosis. Anesthesiology (2009) 1.33
Identification of a fluorescent general anesthetic, 1-aminoanthracene. Proc Natl Acad Sci U S A (2009) 1.29
NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation in the barrel cortex. Mol Cell Neurosci (2002) 1.26
Are anaesthetics toxic to the brain? Br J Anaesth (2011) 1.26
Ethanol causes and lithium prevents neuroapoptosis and suppression of pERK in the infant mouse brain. Neurobiol Dis (2008) 1.24
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Compartmentalized NMDA receptor signalling to survival and death. J Physiol (2007) 1.21
Neuronal death enhanced by N-methyl-D-aspartate antagonists. Proc Natl Acad Sci U S A (2000) 1.21
Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system. Neurobiol Dis (2008) 1.20
Neonatal seizures: an update on mechanisms and management. Clin Perinatol (2009) 1.19
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A rice glutamate receptor-like gene is critical for the division and survival of individual cells in the root apical meristem. Plant Cell (2005) 1.18
Cognitive dysfunction in schizophrenia: unifying basic research and clinical aspects. Eur Arch Psychiatry Clin Neurosci (1999) 1.18
Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat. Anesthesiology (2010) 1.17
Nitrous oxide plus isoflurane induces apoptosis and increases beta-amyloid protein levels. Anesthesiology (2009) 1.17
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Influence of the NR3A subunit on NMDA receptor functions. Prog Neurobiol (2010) 1.14
GABAergic mechanism of propofol toxicity in immature neurons. J Neurosurg Anesthesiol (2008) 1.13
Neurotoxicity of general anesthetics: cause for concern? Anesthesiology (2009) 1.13
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From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development. Proc Natl Acad Sci U S A (2006) 1.13
Alcohol-induced neuroapoptosis in the fetal macaque brain. Neurobiol Dis (2010) 1.13
Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons. J Neurosci (2009) 1.11
N-methyl-D-aspartate receptor subunit changes after traumatic injury to the developing brain. J Neurotrauma (2006) 1.10
Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex. Cereb Cortex (2008) 1.09
Response to neonatal anesthesia: effect of sex on anatomical and behavioral outcome. Neuroscience (2008) 1.08
Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain. Nat Commun (2014) 1.08
Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunit. Proc Natl Acad Sci U S A (2005) 1.06
Postnatal binge-like alcohol exposure decreases dendritic complexity while increasing the density of mature spines in mPFC Layer II/III pyramidal neurons. Synapse (2010) 1.06
Potential mechanism of cell death in the developing rat brain induced by propofol anesthesia. Int J Dev Neurosci (2008) 1.05
Isoflurane does not affect brain cell death, hippocampal neurogenesis, or long-term neurocognitive outcome in aged rats. Anesthesiology (2010) 1.04
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Neonatal exposure to phenobarbital potentiates schizophrenia-like behavioral outcomes in the rat. Neuropharmacology (2012) 1.04
NMDA receptors and metaplasticity: mechanisms and possible roles in neuropsychiatric disorders. Neurosci Biobehav Rev (2012) 1.03
Isoflurane impairs immature astroglia development in vitro: the role of actin cytoskeleton. J Neuropathol Exp Neurol (2011) 1.03
NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice. J Clin Invest (2010) 1.03
Abnormal angular gyrus asymmetry in schizophrenia. Am J Psychiatry (2000) 1.02
Experimental intracerebral hemorrhage: avoiding pitfalls in translational research. J Cereb Blood Flow Metab (2011) 1.02
Environmental agents that have the potential to trigger massive apoptotic neurodegeneration in the developing brain. Environ Health Perspect (2000) 1.01
Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits. Psychopharmacology (Berl) (2004) 1.00
Cell age-specific vulnerability of neurons to anesthetic toxicity. Ann Neurol (2013) 1.00
Brevetoxin activation of voltage-gated sodium channels regulates Ca dynamics and ERK1/2 phosphorylation in murine neocortical neurons. J Neurochem (2004) 0.99
Electroacupuncture enhances cell proliferation and neuronal differentiation in young rat brains. Neurol Sci (2010) 0.99
Molecular approaches to improving general anesthetics. Anesthesiol Clin (2010) 0.98
Ketamine and phencyclidine: the good, the bad and the unexpected. Br J Pharmacol (2015) 0.97
Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology (2009) 0.97
Genetic deletion of CD36 enhances injury after acute neonatal stroke. Ann Neurol (2012) 0.97
Cell biology in neuroscience: Death of developing neurons: new insights and implications for connectivity. J Cell Biol (2013) 0.97
Dizocilpine (MK-801) induces distinct changes of N-methyl-D-aspartic acid receptor subunits in parvalbumin-containing interneurons in young adult rat prefrontal cortex. Int J Neuropsychopharmacol (2009) 0.97
General anesthetics in pediatric anesthesia: influences on the developing brain. Curr Drug Targets (2012) 0.96
Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches. PLoS One (2007) 0.96
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