Published in Nucleic Acids Res on September 23, 2014
Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation. J Clin Med (2015) 0.79
A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma. Q Rev Biophys (2015) 0.77
Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide. PLoS One (2015) 0.77
Interactions of two large antiviral polyamides with the long control region of HPV16. Biochimie (2016) 0.76
An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors. Mol Cancer Ther (2015) 0.76
Improved Antiviral Activity of a Polyamide Against High-Risk Human Papillomavirus Via N-Terminal Guanidinium Substitution. Medchemcomm (2016) 0.75
The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res (2004) 9.70
Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc (2006) 8.42
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol (2008) 5.10
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev (2002) 4.58
Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands. Nature (1998) 3.77
Causes and consequences of replication stress. Nat Cell Biol (2014) 3.70
The structural determinants of checkpoint activation. Genes Dev (2007) 3.53
ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev (2004) 3.44
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell (2012) 3.26
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat Struct Mol Biol (2008) 3.22
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature (2001) 2.50
Analysis of protein dynamics at active, stalled, and collapsed replication forks. Genes Dev (2011) 2.47
Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins. Cancer Res (2006) 2.46
Nuclear dynamics of PCNA in DNA replication and repair. Mol Cell Biol (2005) 2.44
Recognition of DNA by designed ligands at subnanomolar concentrations. Nature (1996) 2.32
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J Biol Chem (2007) 2.31
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci U S A (2007) 2.04
Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates. Nucleic Acids Res (2004) 1.84
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest (2007) 1.80
RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. J Biol Chem (2006) 1.79
Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. J Biol Chem (2004) 1.76
Plx1 is required for chromosomal DNA replication under stressful conditions. EMBO J (2008) 1.73
ATR autophosphorylation as a molecular switch for checkpoint activation. Mol Cell (2011) 1.70
Specific interactions of distamycin A and its analogs with (A-T) rich and (G-C) rich duplex regions of DNA and deoxypolynucleotides. Nucleic Acids Res (1977) 1.63
DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation. FEBS Lett (2006) 1.62
A consensus DNA-binding site for the androgen receptor. Mol Endocrinol (1992) 1.59
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol (2009) 1.55
Influence of netropsin and distamycin A on the secondary structure and template activity of DNA. Eur J Biochem (1971) 1.53
Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress. Nucleic Acids Res (2012) 1.47
Solid-phase synthesis of DNA binding polyamides on oxime resin. Bioorg Med Chem (2002) 1.45
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress. Proc Natl Acad Sci U S A (2011) 1.45
Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress. J Cell Sci (2009) 1.44
Identification of proteins at active, stalled, and collapsed replication forks using isolation of proteins on nascent DNA (iPOND) coupled with mass spectrometry. J Biol Chem (2013) 1.43
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. Br J Cancer (2011) 1.39
H2AX is required for cell cycle arrest via the p53/p21 pathway. Mol Cell Biol (2009) 1.36
FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling. Mol Cell (2013) 1.34
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. J Biol Chem (2001) 1.33
Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival. Mol Pharmacol (2009) 1.33
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs. Nucleic Acids Res (2000) 1.26
DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network. Cell Cycle (2012) 1.23
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. J Am Chem Soc (2009) 1.21
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. J Biol Chem (2011) 1.16
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding. J Am Chem Soc (2010) 1.15
Antitumor activity of a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A (2013) 1.13
Effects of analogs of the DNA minor groove binder Hoechst 33258 on topoisomerase II and I mediated activities. Biochim Biophys Acta (1992) 1.09
Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem (2010) 1.07
ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway. Cancer Res (2012) 1.03
Stepwise activation of the ATR signaling pathway upon increasing replication stress impacts fragile site integrity. PLoS Genet (2013) 0.96
A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair. Nucleic Acids Res (2013) 0.92
DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism. FEBS Lett (2012) 0.90
Synthesis and growth inhibition activity of alpha-bromoacrylic heterocyclic and benzoheterocyclic derivatives of distamycin A modified on the amidino moiety. Bioorg Med Chem (2003) 0.88
Coupling dTTP hydrolysis with DNA unwinding by the DNA helicase of bacteriophage T7. J Biol Chem (2011) 0.86
Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2. J Biol Chem (2011) 0.83
Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence. Exp Dermatol (2011) 0.79