Published in Cell Cycle on September 17, 2012
Iron and cancer: more ore to be mined. Nat Rev Cancer (2013) 2.40
Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention. Oncotarget (2014) 1.34
A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination. Mol Cell (2015) 1.27
DNA2 drives processing and restart of reversed replication forks in human cells. J Cell Biol (2015) 1.27
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J (2013) 1.25
End resection at double-strand breaks: mechanism and regulation. Cold Spring Harb Perspect Biol (2014) 1.21
DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells. J Biol Chem (2014) 1.14
The Fanconi anaemia pathway: new players and new functions. Nat Rev Mol Cell Biol (2016) 1.07
What is the DNA repair defect underlying Fanconi anemia? Curr Opin Cell Biol (2015) 1.03
DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining. PLoS Genet (2015) 1.02
The BLM dissolvasome in DNA replication and repair. Cell Mol Life Sci (2013) 0.97
Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells. Cell Cycle (2014) 0.95
G-quadruplexes and helicases. Nucleic Acids Res (2016) 0.90
Mechanism and regulation of DNA end resection in eukaryotes. Crit Rev Biochem Mol Biol (2016) 0.88
A hidden role of the inactivated FANCD2: upregulating ΔNp63. Oncotarget (2013) 0.87
Sumoylation regulates EXO1 stability and processing of DNA damage. Cell Cycle (2015) 0.86
Advances in the understanding of the Fanconi anemia tumor suppressor pathway. Cancer Biol Ther (2013) 0.85
Regulation of Single-Strand Annealing and its Role in Genome Maintenance. Trends Genet (2016) 0.85
ZNF365 promotes stalled replication forks recovery to maintain genome stability. Cell Cycle (2013) 0.82
Borrowing nuclear DNA helicases to protect mitochondrial DNA. Int J Mol Sci (2015) 0.82
To trim or not to trim: progression and control of DSB end resection. Cell Cycle (2013) 0.82
Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response. Nucleic Acids Res (2014) 0.81
A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy. EBioMedicine (2016) 0.80
The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers. Oncotarget (2014) 0.80
Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response. G3 (Bethesda) (2014) 0.79
DNA double-strand breaks with 5' adducts are efficiently channeled to the DNA2-mediated resection pathway. Nucleic Acids Res (2015) 0.78
EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele. Nucleic Acids Res (2015) 0.76
More tasks for Dna2 in S-phase. Cell Cycle (2012) 0.76
Influence of PJ34 on the genotoxicity induced by melphalan in human multiple myeloma cells. Arch Med Sci (2015) 0.76
Examining the roles of DNA2 during mammalian end resection. Cell Cycle (2012) 0.75
Metnase Mediates Loading of Exonuclease 1 onto Single-strand Overhang DNA for End Resection at Stalled Replication Forks. J Biol Chem (2016) 0.75
Rapid and Sensitive Detection of Breast Cancer Cells in Patient Blood with Nuclease-Activated Probe Technology. Mol Ther Nucleic Acids (2017) 0.75
DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein? Int J Mol Sci (2017) 0.75
Human CtIP promotes DNA end resection. Nature (2007) 10.63
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev (1999) 9.50
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell (2008) 7.63
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature (2005) 7.45
Double-strand break end resection and repair pathway choice. Annu Rev Genet (2011) 7.31
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev (2001) 5.60
DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev (2008) 5.07
How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (2009) 4.85
Mechanism of replication-coupled DNA interstrand crosslink repair. Cell (2008) 4.53
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell (2011) 4.41
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood (2002) 4.27
Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nat Genet (1999) 4.18
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A (2005) 3.93
Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A (2003) 3.88
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature (2009) 3.88
The structural determinants of checkpoint activation. Genes Dev (2007) 3.53
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev (2011) 3.47
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell (2012) 3.26
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol (2004) 3.20
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol Cell (2009) 3.12
Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat Res (1990) 2.94
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol Cell (2010) 2.91
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair. Proc Natl Acad Sci U S A (2008) 2.70
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol (2010) 2.40
Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase delta. Mol Cell Biol (2006) 2.35
The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum Mol Genet (2005) 2.23
Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. Mol Cell (2008) 2.12
The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing. Cell (2012) 2.07
Mechanism of RAD51-dependent DNA interstrand cross-link repair. Science (2011) 2.04
Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair. J Biol Chem (2007) 1.94
Checkpoint signaling from a single DNA interstrand crosslink. Mol Cell (2009) 1.92
Human Dna2 is a nuclear and mitochondrial DNA maintenance protein. Mol Cell Biol (2009) 1.83
Common fragile sites: mechanisms of instability revisited. Trends Genet (2011) 1.80
Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription. Mol Cell (2012) 1.59
Flap endonuclease 1 contributes to telomere stability. Curr Biol (2008) 1.56
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Mol Cell (2012) 1.50
A novel role for Fanconi anemia (FA) pathway effector protein FANCD2 in cell cycle progression of untransformed primary human cells. Cell Cycle (2010) 1.50
A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell (2010) 1.50
Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress. J Cell Sci (2009) 1.44
Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response. Genes Dev (2007) 1.41
RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks. Nat Struct Mol Biol (2011) 1.36
DNA end resection by CtIP and exonuclease 1 prevents genomic instability. EMBO Rep (2010) 1.33
Dna2 helicase/nuclease causes replicative fork stalling and double-strand breaks in the ribosomal DNA of Saccharomyces cerevisiae. J Biol Chem (2003) 1.29
Evidence that yeast SGS1, DNA2, SRS2, and FOB1 interact to maintain rDNA stability. Mutat Res (2003) 1.24
Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context. J Biol Chem (2011) 1.23
The role of RPA2 phosphorylation in homologous recombination in response to replication arrest. Carcinogenesis (2010) 1.14
Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection. Cancer Res (2012) 1.10
Rescue of replication failure by Fanconi anaemia proteins. Chromosoma (2011) 1.02
Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate. DNA Repair (Amst) (2010) 1.01
DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci. J Biol Chem (2005) 1.01
DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange. PLoS One (2011) 1.00
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem (2012) 0.98
The MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing. J Biol Chem (2009) 0.97
Homologous recombination assay for interstrand cross-link repair. Methods Mol Biol (2011) 0.95
Function of the ATR N-terminal domain revealed by an ATM/ATR chimera. Exp Cell Res (2007) 0.92
Activation of fanconi anemia pathway in cells with re-replicated DNA. Cell Cycle (2006) 0.82
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell (2006) 18.81
Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene (2002) 3.80
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev (2011) 3.47
Telomerase maintains telomere structure in normal human cells. Cell (2003) 3.29
DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2. Nature (2010) 3.04
High-efficiency RNA interference in human embryonic stem cells. Stem Cells (2005) 2.76
Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint. Mol Cell (2008) 2.63
Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase delta. Mol Cell Biol (2006) 2.35
Inviability of a DNA2 deletion mutant is due to the DNA damage checkpoint. Cell Cycle (2011) 2.25
Human Dna2 is a nuclear and mitochondrial DNA maintenance protein. Mol Cell Biol (2009) 1.83
On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing. J Biol Chem (2004) 1.72
Biochemical analysis of human Dna2. Nucleic Acids Res (2006) 1.61
A network of multi-tasking proteins at the DNA replication fork preserves genome stability. PLoS Genet (2005) 1.61
Flap endonuclease 1 contributes to telomere stability. Curr Biol (2008) 1.56
The transcriptome of prematurely aging yeast cells is similar to that of telomerase-deficient cells. Mol Biol Cell (2004) 1.44
Saccharomyces cerevisiae DNA polymerase epsilon and polymerase sigma interact physically and functionally, suggesting a role for polymerase epsilon in sister chromatid cohesion. Mol Cell Biol (2003) 1.44
Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal. J Biol Chem (2008) 1.43
The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants. Proc Natl Acad Sci U S A (2003) 1.42
Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair. PLoS One (2009) 1.40
Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res (2009) 1.38
Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation. J Biol Chem (2004) 1.34
Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication. Mol Cell Biol (2002) 1.30
Contribution of Trf4/5 and the nuclear exosome to genome stability through regulation of histone mRNA levels in Saccharomyces cerevisiae. Genetics (2006) 1.30
Dna2 helicase/nuclease causes replicative fork stalling and double-strand breaks in the ribosomal DNA of Saccharomyces cerevisiae. J Biol Chem (2003) 1.29
Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition. J Biol Chem (2008) 1.28
Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway. J Biol Chem (2009) 1.27
Dynamic removal of replication protein A by Dna2 facilitates primer cleavage during Okazaki fragment processing in Saccharomyces cerevisiae. J Biol Chem (2008) 1.24
Evidence that yeast SGS1, DNA2, SRS2, and FOB1 interact to maintain rDNA stability. Mutat Res (2003) 1.24
Revealing novel telomere proteins using in vivo cross-linking, tandem affinity purification, and label-free quantitative LC-FTICR-MS. Mol Cell Proteomics (2010) 1.22
Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates. J Biol Chem (2009) 1.18
Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res (2012) 1.17
FEN1 ensures telomere stability by facilitating replication fork re-initiation. J Biol Chem (2010) 1.14
Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM. Cell Cycle (2010) 1.11
SCKs as nanoparticle carriers of doxorubicin: investigation of core composition on the loading, release and cytotoxicity profiles. Chem Commun (Camb) (2008) 1.07
Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation. J Biol Chem (2006) 1.01
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem (2012) 0.98
Mutations in DNA replication genes reduce yeast life span. Mol Cell Biol (2002) 0.98
Flap endonuclease disengages Dna2 helicase/nuclease from Okazaki fragment flaps. J Biol Chem (2006) 0.98
Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates. Nucleic Acids Res (2009) 0.97
In vivo reconstitution of Saccharomyces cerevisiae DNA polymerase epsilon in insect cells. Purification and characterization. J Biol Chem (2001) 0.97
An alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicase. J Biol Chem (2010) 0.97
Significance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae. J Biol Chem (2009) 0.96
Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway. Mol Cancer Res (2011) 0.94
Dpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae. Genetics (2008) 0.91
Cross talk between the nuclease and helicase activities of Dna2: role of an essential iron-sulfur cluster domain. Nucleic Acids Res (2012) 0.91
Dna2 exhibits a unique strand end-dependent helicase function. J Biol Chem (2010) 0.89
Senescence: the good the bad and the dysfunctional. Curr Opin Genet Dev (2008) 0.88
Linking mitosis with S-phase: Cdc6 at play. Cell Cycle (2008) 0.87
Regulation of the localization and stability of Cdc6 in living yeast cells. Biochem Biophys Res Commun (2003) 0.86
Alternative lengthening of telomeres (ALT) and chromatin: is there a connection? Biochimie (2007) 0.86
Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1. Nucleic Acids Res (2012) 0.86
Components of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processing. J Biol Chem (2010) 0.83
Mitotic Cdc6 stabilizes anaphase-promoting complex substrates by a partially Cdc28-independent mechanism, and this stabilization is suppressed by deletion of Cdc55. Mol Cell Biol (2006) 0.83
Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2. J Biol Chem (2011) 0.83
Defective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiae. Mutat Res (2009) 0.81
CORRIGENDUM: Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity. Genet Med (2015) 0.79
Notes from the field: atypical pneumonia in three members of an extended family - South Carolina and north Carolina, july-august 2013. MMWR Morb Mortal Wkly Rep (2014) 0.78
Dna2 is involved in CA strand resection and nascent lagging strand completion at native yeast telomeres. J Biol Chem (2013) 0.77
DNA replication: changing faces, trading places. Nat Chem Biol (2010) 0.75