Published in Intensive Care Med on October 01, 2014
A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators. Intensive Care Med (2015) 4.95
The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care (2016) 1.43
Identification of Gram-Negative Bacteria and Genetic Resistance Determinants from Positive Blood Culture Broths by Use of the Verigene Gram-Negative Blood Culture Multiplex Microarray-Based Molecular Assay. J Clin Microbiol (2015) 1.12
Year in review in Intensive Care Medicine 2014: III. Severe infections, septic shock, healthcare-associated infections, highly resistant bacteria, invasive fungal infections, severe viral infections, Ebola virus disease and paediatrics. Intensive Care Med (2015) 1.12
Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Crit Care (2016) 1.04
Early goal-directed resuscitation of patients with septic shock: current evidence and future directions. Crit Care (2015) 0.95
Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival. Crit Care (2016) 0.93
Perforated peptic ulcer. Lancet (2015) 0.92
The new sepsis consensus definitions (Sepsis-3): the good, the not-so-bad, and the actually-quite-pretty. Intensive Care Med (2016) 0.85
Early goal-directed therapy: what do we do now? Crit Care (2014) 0.83
Evolving trends in the epidemiology, resource utilization, and outcomes of pregnancy-associated severe sepsis: a population-based cohort study. J Clin Med Res (2015) 0.83
Early goal-directed therapy: do we have a definitive answer? Intensive Care Med (2016) 0.78
A two-stage clinical decision support system for early recognition and stratification of patients with sepsis: an observational cohort study. JRSM Open (2015) 0.77
The Effect of Early Goal-Directed Therapy on Outcome in Adult Severe Sepsis and Septic Shock Patients: A Meta-Analysis of Randomized Clinical Trials. Anesth Analg (2016) 0.77
Acute Kidney Injury in Burn Patients: Clinically Significant Over the Initial Hospitalization and 1 Year After Injury: An Original Retrospective Cohort Study. Ann Surg (2016) 0.75
A Multidisciplinary Sepsis Program Enabled by a Two-Stage Clinical Decision Support System: Factors That Influence Patient Outcomes. Am J Med Qual (2015) 0.75
Sepsis Prevalence and Outcome on the General Wards and Emergency Departments in Wales: Results of a Multi-Centre, Observational, Point Prevalence Study. PLoS One (2016) 0.75
A prospective observational study assessing the outcome of Sepsis in intensive care unit of a tertiary care hospital, Peshawar. Pak J Med Sci (2016) 0.75
Early management of sepsis with emphasis on early goal directed therapy: AME evidence series 002. J Thorac Dis (2017) 0.75
Alert cell strategy in SIRS-induced vasculitis: sepsis and endothelial cells. J Intensive Care (2016) 0.75
High-fidelity medical simulation training improves medical students' knowledge and confidence levels in septic shock resuscitation. Open Access Emerg Med (2016) 0.75
A Comparison of Residents' Knowledge Regarding the Surviving Sepsis Campaign 2012 Guideline. Indian J Crit Care Med (2017) 0.75
Association Between Hospital Case Volume of Sepsis, Adherence to Evidence-Based Processes of Care and Patient Outcomes. Crit Care Med (2017) 0.75
Getting a consensus: advantages and disadvantages of Sepsis 3 in the context of middle-income settings. Rev Bras Ter Intensiva (2017) 0.75
Scoring System for Multiple Organ Dysfunction in Adult Horses with Acute Surgical Gastrointestinal Disease. J Vet Intern Med (2016) 0.75
Focus on acute circulatory failure. Intensive Care Med (2016) 0.75
Fixed minimum volume resuscitation: Pro. Intensive Care Med (2016) 0.75
In sepsis, everything old is new again. Intensive Care Med (2016) 0.75
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37
Mortality after surgery in Europe: a 7 day cohort study. Lancet (2012) 9.96
Association between critical care physician management and patient mortality in the intensive care unit. Ann Intern Med (2008) 9.21
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
Trial of the route of early nutritional support in critically ill adults. N Engl J Med (2014) 7.06
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA (2008) 6.29
Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med (2014) 5.70
Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial. Anesthesiology (2015) 5.52
Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department. Chest (2006) 5.31
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit. Crit Care Med (2007) 4.54
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA (2003) 4.54
A systematic review and meta-analysis on the use of preemptive hemodynamic intervention to improve postoperative outcomes in moderate and high-risk surgical patients. Anesth Analg (2010) 4.29
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med (2008) 4.21
Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]. Crit Care (2005) 4.14
Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis. Crit Care Med (2014) 4.11
Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis (2012) 4.07
DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients? Clin Infect Dis (2014) 3.99
Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med (2001) 3.95
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit Care Med (2005) 3.85
Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med (2004) 3.61
Acquired weakness, handgrip strength, and mortality in critically ill patients. Am J Respir Crit Care Med (2008) 3.59
High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest (2005) 3.58
Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med (2015) 3.55
Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology. Eur Heart J (2005) 3.50
Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients. Intensive Care Med (2012) 3.39
Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Crit Care Med (2006) 3.38
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med (2014) 3.37
Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med (2006) 3.36
Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). Am J Respir Crit Care Med (2007) 3.34
Identification and characterisation of the high-risk surgical population in the United Kingdom. Crit Care (2006) 3.30
Fluid challenges in intensive care: the FENICE study: A global inception cohort study. Intensive Care Med (2015) 3.27
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18
The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17
Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA (2004) 3.07
Glucose variability and mortality in patients with sepsis. Crit Care Med (2008) 3.00
Hostile marital interactions, proinflammatory cytokine production, and wound healing. Arch Gen Psychiatry (2005) 2.94
Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J Natl Cancer Inst (2003) 2.87
Positive-end expiratory pressure reduces incidence of ventilator-associated pneumonia in nonhypoxemic patients. Crit Care Med (2008) 2.87
Efficacy of single-dose antibiotic against early-onset pneumonia in comatose patients who are ventilated. Chest (2013) 2.85
Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Crit Care Med (2015) 2.81
Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest (2006) 2.69
Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67
Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65
An outbreak in an intensive care unit of a strain of methicillin-resistant Staphylococcus aureus sequence type 239 associated with an increased rate of vascular access device-related bacteremia. Clin Infect Dis (2007) 2.64
Assessing and grading congestion in acute heart failure: a scientific statement from the acute heart failure committee of the heart failure association of the European Society of Cardiology and endorsed by the European Society of Intensive Care Medicine. Eur J Heart Fail (2010) 2.64
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Point: Are the best patient outcomes achieved when ICU bundles are rigorously adhered to? Yes. Chest (2013) 2.59
Influence of overweight on ICU mortality: a prospective study. Chest (2004) 2.54
The Eldicus prospective, observational study of triage decision making in European intensive care units. Part II: intensive care benefit for the elderly. Crit Care Med (2012) 2.46
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med (2003) 2.44
Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Crit Care Med (2007) 2.42
An international survey: Public awareness and perception of sepsis. Crit Care Med (2009) 2.40
Activated protein C and septic shock: a propensity-matched cohort study*. Crit Care Med (2012) 2.39
Logistic regression analysis: applications to ophthalmic research. Am J Ophthalmol (2009) 2.33
Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res (2006) 2.32
Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest. J Am Coll Cardiol (2002) 2.27
Obesity is associated with increased morbidity but not mortality in critically ill patients. Intensive Care Med (2008) 2.27
Open randomized phase II trial of an extracorporeal endotoxin adsorber in suspected Gram-negative sepsis. Crit Care Med (2004) 2.18
Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis (2004) 2.17