Published in JAMA on May 21, 2008
Effects of External Inspection on Sepsis Detection and Treatment | NCT02747121
Lotta Alla Sepsi Ospedaliera - Fighting Hospital Sepsis | NCT01804764
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
The effect of multidisciplinary care teams on intensive care unit mortality. Arch Intern Med (2010) 4.41
Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis*. Crit Care Med (2014) 3.82
Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcome. Am J Respir Crit Care Med (2012) 3.36
Factors associated with nonadherence to early goal-directed therapy in the ED. Chest (2010) 3.23
Population burden of long-term survivorship after severe sepsis in older Americans. J Am Geriatr Soc (2012) 2.78
Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Crit Care (2008) 2.65
Bundled care for septic shock: an analysis of clinical trials. Crit Care Med (2010) 2.57
Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med (2013) 2.52
The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study*. Crit Care Med (2012) 2.29
The importance of the first complication: understanding failure to rescue after emergent surgery in the elderly. J Am Coll Surg (2014) 2.11
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07
Recommendations for sepsis management in resource-limited settings. Intensive Care Med (2012) 2.03
New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev (2012) 2.01
Assessment of pancreatic cancer care in the United States based on formally developed quality indicators. J Natl Cancer Inst (2009) 1.92
Randomized trial of automated, electronic monitoring to facilitate early detection of sepsis in the intensive care unit*. Crit Care Med (2012) 1.69
Availability of critical care resources to treat patients with severe sepsis or septic shock in Africa: a self-reported, continent-wide survey of anaesthesia providers. Crit Care (2011) 1.67
Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study. BMJ (2011) 1.64
An Electronic Tool for the Evaluation and Treatment of Sepsis in the ICU: A Randomized Controlled Trial. Crit Care Med (2015) 1.58
The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study. Crit Care (2013) 1.46
Temporal Changes in the Influence of Hospitals and Regional Healthcare Networks on Severe Sepsis Mortality. Crit Care Med (2015) 1.45
An updated meta-analysis to understand the variable efficacy of drotrecogin alfa (activated) in severe sepsis and septic shock. Minerva Anestesiol (2012) 1.44
Variation in the Contents of Sepsis Bundles and Quality Measures. A Systematic Review. Ann Am Thorac Soc (2015) 1.40
Differences in compliance with Surviving Sepsis Campaign recommendations according to hospital entrance time: day versus night. Crit Care (2013) 1.36
Decreasing mortality in severe sepsis and septic shock patients by implementing a sepsis bundle in a hospital setting. PLoS One (2011) 1.35
Utilization patterns and outcomes associated with central venous catheter in septic shock: a population-based study. Crit Care Med (2013) 1.34
Performance of health workers in the management of seriously sick children at a Kenyan tertiary hospital: before and after a training intervention. PLoS One (2012) 1.29
Reducing mortality in severe sepsis with the implementation of a core 6-hour bundle: results from the Portuguese community-acquired sepsis study (SACiUCI study). Crit Care (2010) 1.27
Genotypic profile of Streptococcus suis serotype 2 and clinical features of infection in humans, Thailand. Emerg Infect Dis (2011) 1.23
The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes. Crit Care (2009) 1.22
Advances in the management of sepsis and the understanding of key immunologic defects. Anesthesiology (2011) 1.21
Outcome effectiveness of the severe sepsis resuscitation bundle with addition of lactate clearance as a bundle item: a multi-national evaluation. Crit Care (2011) 1.20
Quality of blood culture testing - a survey in intensive care units and microbiological laboratories across four European countries. Crit Care (2013) 1.19
Out-of-hospital fluid in severe sepsis: effect on early resuscitation in the emergency department. Prehosp Emerg Care (2010) 1.16
Toward an integrated research agenda for critical illness in aging. Am J Respir Crit Care Med (2010) 1.10
Rapid diagnosis of sepsis. Virulence (2013) 1.06
The research agenda in ICU telemedicine: a statement from the Critical Care Societies Collaborative. Chest (2011) 1.06
Antibiotic prescription patterns in the empiric therapy of severe sepsis: combination of antimicrobials with different mechanisms of action reduces mortality. Crit Care (2012) 1.05
Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Crit Care (2016) 1.04
Effect of performance improvement programs on compliance with sepsis bundles and mortality: a systematic review and meta-analysis of observational studies. PLoS One (2015) 1.02
Effects on management and outcome of severe sepsis and septic shock patients admitted to the intensive care unit after implementation of a sepsis program: a pilot study. Crit Care (2009) 1.01
Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study. Crit Care (2014) 1.00
Nationwide survey on resource availability for implementing current sepsis guidelines in Mongolia. Bull World Health Organ (2010) 0.99
Serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis. PLoS One (2009) 0.98
The accuracy of presepsin (sCD14-ST) for the diagnosis of sepsis in adults: a meta-analysis. Crit Care (2015) 0.98
Temporal trends in the systemic inflammatory response syndrome, sepsis, and medical coding of sepsis. BMC Anesthesiol (2015) 0.96
The impact of nationwide education program on clinical practice in sepsis care and mortality of severe sepsis: a population-based study in Taiwan. PLoS One (2013) 0.95
Long-term effect of computer-assisted decision support for antibiotic treatment in critically ill patients: a prospective 'before/after' cohort study. BMJ Open (2014) 0.95
Feasibility of modified surviving sepsis campaign guidelines in a resource-restricted setting based on a cohort study of severe S. aureus sepsis [corrected]. PLoS One (2012) 0.95
Early goal-directed resuscitation of patients with septic shock: current evidence and future directions. Crit Care (2015) 0.95
Implementation challenges in the intensive care unit: the why, who, and how of daily interruption of sedation. J Crit Care (2012) 0.95
Initial emergency department diagnosis and management of adult patients with severe sepsis and septic shock. Scand J Trauma Resusc Emerg Med (2012) 0.94
Fluid management and risk factors for renal dysfunction in patients with severe sepsis and/or septic shock. Crit Care (2012) 0.93
Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study. Intensive Care Med (2013) 0.91
Extending international sepsis epidemiology: the impact of organ dysfunction. Crit Care (2009) 0.91
Diagnostic accuracy and effectiveness of automated electronic sepsis alert systems: A systematic review. J Hosp Med (2015) 0.91
Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria. Crit Care Med (2016) 0.91
Epidemiology and recent trends of severe sepsis in Spain: a nationwide population-based analysis (2006-2011). BMC Infect Dis (2014) 0.90
Prognostic Value of Procalcitonin in Adult Patients with Sepsis: A Systematic Review and Meta-Analysis. PLoS One (2015) 0.90
Surviving sepsis: a guide to the guidelines. Crit Care (2008) 0.88
Implementing a collaborative protocol in a sepsis intervention program: lessons learned. Lung (2010) 0.88
Multicenter Implementation of a Treatment Bundle for Patients with Sepsis and Intermediate Lactate Values. Am J Respir Crit Care Med (2016) 0.87
Improving data quality control in quality improvement projects. Int J Qual Health Care (2009) 0.87
Year in review 2008: Critical Care--sepsis. Crit Care (2009) 0.86
Survival and mitochondrial function in septic patients according to mitochondrial DNA haplogroup. Crit Care (2012) 0.86
Immunomodulation in sepsis: the role of endotoxin removal by polymyxin B-immobilized cartridge. Mediators Inflamm (2013) 0.86
Febrile neutropenia in French emergency departments: results of a prospective multicentre survey. Crit Care (2010) 0.85
Impact of 6-hour sepsis resuscitation bundle compliance on hospital mortality in a saudi hospital. Crit Care Res Pract (2012) 0.85
Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85
Strategies of initiation and streamlining of antibiotic therapy in 41 French intensive care units. Crit Care (2011) 0.84
Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO). Ann Hematol (2014) 0.84
Management of severe sepsis: advances, challenges, and current status. Drug Des Devel Ther (2015) 0.84
An automated dispensing system for improving medication timing in the emergency department. World J Emerg Med (2012) 0.83
Association between hospital volume and network membership and an analgesia, sedation and delirium order set quality score: a cohort study. Crit Care (2012) 0.82
Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates. Crit Care (2016) 0.82
Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial. Intensive Care Med (2017) 0.81
Late recognition and illness severity are determinants of early death in severe septic patients. Clinics (Sao Paulo) (2013) 0.81
The burden of sepsis: a call to action in support of World Sepsis Day 2013. Rev Bras Ter Intensiva (2013) 0.81
Compliance with severe sepsis bundles and its effect on patient outcomes of severe community-acquired pneumonia in a limited resources country. Arch Med Sci (2014) 0.81
Acute respiratory distress syndrome: prevention and early recognition. Ann Intensive Care (2013) 0.81
How much fluid resuscitation is optimal in septic shock? Crit Care (2012) 0.80
Effects of increasing compliance with minimal sedation on duration of mechanical ventilation: a quality improvement intervention. Crit Care (2012) 0.80
Systematic screening is essential for early diagnosis of severe sepsis and septic shock. Rev Bras Ter Intensiva (2015) 0.80
Early goal-directed resuscitation for patients with severe sepsis and septic shock: a meta-analysis and trial sequential analysis. Scand J Trauma Resusc Emerg Med (2016) 0.79
Lack of clinically evident signs of organ failure affects ED treatment of patients with severe sepsis. Int J Emerg Med (2013) 0.79
Conservative fluid therapy in septic shock: an example of targeted therapeutic minimization. Crit Care (2014) 0.79
Multifaceted interventions to decrease mortality in patients with severe sepsis/septic shock-a quality improvement project. PeerJ (2015) 0.78
The effect of hospital volume on mortality in patients admitted with severe sepsis. PLoS One (2014) 0.77
Clinical impact of stress dose steroids in patients with septic shock: insights from the PROWESS-Shock trial. Crit Care (2015) 0.77
Protocol-Based Resuscitation for Septic Shock: A Meta-Analysis of Randomized Trials and Observational Studies. Yonsei Med J (2016) 0.77
Hospital staff education on severe sepsis/septic shock and hospital mortality: an original hypothesis. BMC Anesthesiol (2012) 0.76
What are effective strategies for the implementation of care bundles on ICUs: a systematic review. Implement Sci (2015) 0.76
Improving sepsis care: the road ahead. JAMA (2008) 0.76
Why activated protein C was not successful in severe sepsis and septic shock: are we still tilting at windmills? Curr Infect Dis Rep (2013) 0.76
Self-reported use of personal protective equipment among Chinese critical care clinicians during 2009 H1N1 influenza pandemic. PLoS One (2012) 0.76
Can emergency physicians perform common carotid Doppler flow measurements to assess volume responsiveness? West J Emerg Med (2015) 0.76
Could a protocol based on early goal-directed therapy improve outcomes in patients with severe sepsis and septic shock in the Intensive Care Unit setting? Indian J Crit Care Med (2015) 0.76
Patient safety: Needs and initiatives. Indian J Crit Care Med (2008) 0.76
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med (2014) 5.70
The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. Crit Care Med (2004) 5.23
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA (2003) 4.54
Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA (2002) 4.09
Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis (2012) 4.07
Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med (2001) 3.95
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit Care Med (2005) 3.85
High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest (2005) 3.58
Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med (2015) 3.55
Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). Am J Respir Crit Care Med (2007) 3.34
Fluid challenges in intensive care: the FENICE study: A global inception cohort study. Intensive Care Med (2015) 3.27
A bedside scoring system ("Candida score") for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med (2006) 3.12
The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med (2011) 3.03
Impact of therapeutic strategies on the prognosis of candidemia in the ICU. Crit Care Med (2014) 2.95
Positive-end expiratory pressure reduces incidence of ventilator-associated pneumonia in nonhypoxemic patients. Crit Care Med (2008) 2.87
Rationing critical care beds: a systematic review. Crit Care Med (2004) 2.86
Efficacy of single-dose antibiotic against early-onset pneumonia in comatose patients who are ventilated. Chest (2013) 2.85
Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Crit Care Med (2015) 2.81
A clinical classification of the acute respiratory distress syndrome for predicting outcome and guiding medical therapy*. Crit Care Med (2015) 2.78
An early PEEP/FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med (2007) 2.69
End-of-life care for the critically ill: A national intensive care unit survey. Crit Care Med (2006) 2.61
The Eldicus prospective, observational study of triage decision making in European intensive care units. Part II: intensive care benefit for the elderly. Crit Care Med (2012) 2.46
Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock. Crit Care Med (2007) 2.44
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med (2003) 2.44
An international survey: Public awareness and perception of sepsis. Crit Care Med (2009) 2.40
Obesity is associated with increased morbidity but not mortality in critically ill patients. Intensive Care Med (2008) 2.27
Primary angioplasty vs. early routine post-fibrinolysis angioplasty for acute myocardial infarction with ST-segment elevation: the GRACIA-2 non-inferiority, randomized, controlled trial. Eur Heart J (2007) 2.21
Effects of admission hyperglycemia on stroke outcome in reperfused tissue plasminogen activator--treated patients. Stroke (2003) 2.20
Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive. BMJ (2008) 2.15
Influence of systemic inflammatory response syndrome and sepsis on outcome of critically ill infected patients. Am J Respir Crit Care Med (2003) 2.10
Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial. Intensive Care Med (2003) 2.05
Nosocomial outbreak of infection with pan-drug-resistant Acinetobacter baumannii in a tertiary care university hospital. Infect Control Hosp Epidemiol (2009) 2.02
Higher risk of further vascular events among transient ischemic attack patients with diffusion-weighted imaging acute ischemic lesions. Stroke (2004) 1.91
A universal definition of ARDS: the PaO2/FiO2 ratio under a standard ventilatory setting--a prospective, multicenter validation study. Intensive Care Med (2013) 1.89
Statin therapy prior to ICU admission: protection against infection or a severity marker? Intensive Care Med (2005) 1.86
Comparing clinician ratings of the quality of palliative care in the intensive care unit. Crit Care Med (2011) 1.81
Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study. Am J Respir Crit Care Med (2009) 1.80
C-reactive protein predicts further ischemic events in first-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease. Stroke (2003) 1.78
A risk tertiles model for predicting mortality in patients with acute respiratory distress syndrome: age, plateau pressure, and P(aO(2))/F(IO(2)) at ARDS onset can predict mortality. Respir Care (2011) 1.72
Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. Crit Care Med (2004) 1.72
Open Lung Approach for the Acute Respiratory Distress Syndrome: A Pilot, Randomized Controlled Trial. Crit Care Med (2016) 1.66
Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: a randomized trial. Am J Respir Crit Care Med (2011) 1.65
Host adaptive immunity deficiency in severe pandemic influenza. Crit Care (2010) 1.64
Successful determination of lower inflection point and maximal compliance in a population of patients with acute respiratory distress syndrome. Crit Care Med (2002) 1.60
The Eldicus prospective, observational study of triage decision making in European intensive care units: part I--European Intensive Care Admission Triage Scores. Crit Care Med (2012) 1.59
Acute community-acquired bacterial meningitis in adults admitted to the intensive care unit: clinical manifestations, management and prognostic factors. Intensive Care Med (2003) 1.57
Biomarkers: diagnosis and risk assessment in sepsis. Clin Chest Med (2008) 1.57
A common haplotype of the LBP gene predisposes to severe sepsis. Crit Care Med (2009) 1.55
Noninvasive positive pressure ventilation in critical and palliative care settings: understanding the goals of therapy. Crit Care Med (2007) 1.55
A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis. Crit Care Med (2007) 1.54
Evaluating the use of recombinant human activated protein C in adult severe sepsis: results of the Surviving Sepsis Campaign. Crit Care Med (2012) 1.51
PEEP in ARDS--how much is enough? N Engl J Med (2004) 1.50
Evolution over a 15-year period of clinical characteristics and outcomes of critically ill patients with community-acquired bacteremia. Crit Care Med (2013) 1.50
Trends in AIDS and mortality in HIV-infected subjects with hemophilia from 1985 to 2003: the competing risks for death between AIDS and liver disease. J Acquir Immune Defic Syndr (2006) 1.50
A multifaceted intervention to improve compliance with process measures for ICU clinician communication with ICU patients and families. Crit Care Med (2013) 1.48
Proposed quality measures for palliative care in the critically ill: a consensus from the Robert Wood Johnson Foundation Critical Care Workgroup. Crit Care Med (2006) 1.48
Prognostic value of the pulmonary dead-space fraction during the early and intermediate phases of acute respiratory distress syndrome. Respir Care (2010) 1.47
Sepsis severity score: an internationally derived scoring system from the surviving sepsis campaign database*. Crit Care Med (2014) 1.46
Rationing in the intensive care unit. Crit Care Med (2006) 1.45
Low reticulocyte hemoglobin content is associated with a higher blood transfusion rate in critically ill patients: a cohort study. Anesthesiology (2010) 1.43
The world's major religions' points of view on end-of-life decisions in the intensive care unit. Intensive Care Med (2007) 1.43
Hypercapnic respiratory failure in obesity-hypoventilation syndrome: CO₂ response and acetazolamide treatment effects. Respir Care (2010) 1.42
Triage decision making for the elderly: doing the right thing. Crit Care Med (2012) 1.40
[Clinical benefit following the implementation of a specialized urgent stroke care system]. Med Clin (Barc) (2004) 1.40
Hypercapnia test as a predictor of success in spontaneous breathing trials and extubation. Respir Care (2008) 1.39
[Cost-effectiveness of drotrecogin alpha [activated] in the treatment of severe sepsis in Spain]. Gac Sanit (2004) 1.39
Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Intensive Care Med (2014) 1.38
[Profile of neurovascular emergencies in a tertiary care hospital: evolution over the period 2001-2008]. Rev Neurol (2011) 1.38
Dying in America. Crit Care Med (2004) 1.38
Combined multilocus sequence typing and O serogrouping distinguishes Escherichia coli subtypes associated with infant urosepsis and/or meningitis. J Infect Dis (2007) 1.38
[Recurrent Transient Global Amnesia, a manifestation of ischemic cerebrovascular disease]. Med Clin (Barc) (2005) 1.37
The ethical conduct of clinical research involving critically ill patients in the United States and Canada: principles and recommendations. Am J Respir Crit Care Med (2004) 1.36
Use of the sequential organ failure assessment score as a severity score. Intensive Care Med (2005) 1.34
Intensivists at night: putting resources in the right place. Crit Care (2013) 1.33
Perceptions of cost constraints, resource limitations, and rationing in United States intensive care units: results of a national survey. Crit Care Med (2008) 1.23
International differences in end-of-life attitudes in the intensive care unit: results of a survey. Arch Intern Med (2005) 1.22
Mechanical ventilation in sepsis-induced acute lung injury/acute respiratory distress syndrome: an evidence-based review. Crit Care Med (2004) 1.20
Patterns of colonization by Pseudomonas aeruginosa in intubated patients: a 3-year prospective study of 1,607 isolates using pulsed-field gel electrophoresis with implications for prevention of ventilator-associated pneumonia. Intensive Care Med (2004) 1.19
Reasons for refusal of admission to intensive care and impact on mortality. Intensive Care Med (2010) 1.17
Safety and efficacy of intravenous tissue plasminogen activator stroke treatment in the 3- to 6-hour window using multimodal transcranial Doppler/MRI selection protocol. Stroke (2005) 1.16
Current incidence and outcome of the acute respiratory distress syndrome. Curr Opin Crit Care (2016) 1.16
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Crit Care Med (2017) 1.15