Mechanisms of integral membrane protein insertion and folding.

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Energy coupling mechanisms of MFS transporters. Protein Sci (2015) 0.96

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors. Elife (2015) 0.96

Channel crossing: how are proteins shipped across the bacterial plasma membrane? Philos Trans R Soc Lond B Biol Sci (2015) 0.92

Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins. Nat Struct Mol Biol (2015) 0.90

Regulation of multispanning membrane protein topology via post-translational annealing. Elife (2015) 0.88

Mapping the energy landscape for second-stage folding of a single membrane protein. Nat Chem Biol (2015) 0.82

ATP-dependent Conformational Changes Trigger Substrate Capture and Release by an ECF-type Biotin Transporter. J Biol Chem (2015) 0.82

Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane. Elife (2016) 0.81

Structure formation during translocon-unassisted co-translational membrane protein folding. Sci Rep (2017) 0.81

Implications of aromatic-aromatic interactions: From protein structures to peptide models. Protein Sci (2015) 0.80

Anomalous behavior of water inside the SecY translocon. Proc Natl Acad Sci U S A (2015) 0.80

Refining the treatment of membrane proteins by coarse-grained models. Proteins (2015) 0.79

From Nanodiscs to Isotropic Bicelles: A Procedure for Solution Nuclear Magnetic Resonance Studies of Detergent-Sensitive Integral Membrane Proteins. Structure (2016) 0.79

Biological insertion of computationally designed short transmembrane segments. Sci Rep (2016) 0.78

Hydrophobic blocks facilitate lipid compatibility and translocon recognition of transmembrane protein sequences. Biochemistry (2015) 0.78

Membrane insertion of a Tc toxin in near-atomic detail. Nat Struct Mol Biol (2016) 0.78

Documentation of an Imperative To Improve Methods for Predicting Membrane Protein Stability. Biochemistry (2016) 0.77

YidC assists the stepwise and stochastic folding of membrane proteins. Nat Chem Biol (2016) 0.76

Energetics of side-chain snorkeling in transmembrane helices probed by nonproteinogenic amino acids. Proc Natl Acad Sci U S A (2016) 0.76

The messy process of guiding proteins into membranes. Elife (2015) 0.76

How does a β-barrel integral membrane protein insert into the membrane? Protein Cell (2016) 0.76

Identification and reconstitution of the rubber biosynthetic machinery on rubber particles from Hevea brasiliensis. Elife (2016) 0.76

From membrane tension to channel gating: A principal energy transfer mechanism for mechanosensitive channels. Protein Sci (2016) 0.76

Marginally hydrophobic transmembrane α-helices shaping membrane protein folding. Protein Sci (2015) 0.75

Evidence for Amino Acid Snorkeling from a High-Resolution, In Vivo Analysis of Fis1 Tail Anchor Insertion at the Mitochondrial Outer Membrane. Genetics (2016) 0.75

Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide. Nat Commun (2016) 0.75

Structurally detailed coarse-grained model for Sec-facilitated co-translational protein translocation and membrane integration. PLoS Comput Biol (2017) 0.75

Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins. Proc Natl Acad Sci U S A (2017) 0.75

Transmural gradients in ion channel and auxiliary subunit expression. Prog Biophys Mol Biol (2016) 0.75

Sec61: A static framework for membrane-protein insertion. Channels (Austin) (2015) 0.75

Folding of newly translated membrane protein CCR5 is assisted by the chaperonin GroEL-GroES. Sci Rep (2015) 0.75

Stability and flexibility of marginally hydrophobic-segment stalling at the endoplasmic reticulum translocon. Mol Biol Cell (2016) 0.75

Comprehensive study of liposome-assisted synthesis of membrane proteins using a reconstituted cell-free translation system. Sci Rep (2015) 0.75

Type 3 Secretion Translocators Spontaneously Assemble a Hexadecameric Transmembrane Complex. J Biol Chem (2016) 0.75

Submillisecond Dynamics of Mastoparan X Insertion into Lipid Membranes. J Phys Chem Lett (2016) 0.75

Transmembrane helices containing a charged arginine are thermodynamically stable. Eur Biophys J (2017) 0.75

Stable membrane orientations of small dual-topology membrane proteins. Proc Natl Acad Sci U S A (2017) 0.75

Artificial cell mimics as simplified models for the study of cell biology. Exp Biol Med (Maywood) (2017) 0.75

Charged residues next to transmembrane regions revisited: "Positive-inside rule" is complemented by the "negative inside depletion/outside enrichment rule". BMC Biol (2017) 0.75

Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates. Mol Biol Cell (2017) 0.75

Plant-specific 4/1 polypeptide interacts with an endoplasmic reticulum protein related to human BAP31. Planta (2016) 0.75

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Structure of bacteriorhodopsin at 1.55 A resolution. J Mol Biol (1999) 8.17

Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature (2005) 7.72

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The structure of the eukaryotic ribosome at 3.0 Å resolution. Science (2011) 6.09

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Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes. Nature (2007) 4.99

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Molecular code for transmembrane-helix recognition by the Sec61 translocon. Nature (2007) 4.60

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Helical membrane protein folding, stability, and evolution. Annu Rev Biochem (2000) 3.63

Membrane protein assembly into Nanodiscs. FEBS Lett (2009) 3.58

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Solving the membrane protein folding problem. Nature (2005) 2.96

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Conformational transition of Sec machinery inferred from bacterial SecYE structures. Nature (2008) 2.48

Polar residues drive association of polyleucine transmembrane helices. Proc Natl Acad Sci U S A (2001) 2.47

The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain. Cell (2000) 2.46

Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein. Nat Struct Mol Biol (2005) 2.33

Control of membrane protein topology by a single C-terminal residue. Science (2010) 2.28

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A putative molecular-activation switch in the transmembrane domain of erbB2. Proc Natl Acad Sci U S A (2002) 1.86

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Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution. Cell (2014) 1.80

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Structural basis of Sec-independent membrane protein insertion by YidC. Nature (2014) 1.79

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Recognition of a signal peptide by the signal recognition particle. Nature (2010) 1.77

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Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens. J Biol Chem (2003) 1.71

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Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion. Nature (2014) 1.68

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Membrane partitioning: distinguishing bilayer effects from the hydrophobic effect. Biochemistry (1993) 1.65

Secondary structure formation of a transmembrane segment in Kv channels. Biochemistry (2005) 1.62

Elucidating the native architecture of the YidC: ribosome complex. J Mol Biol (2013) 1.61

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Topological "frustration" in multispanning E. coli inner membrane proteins. Cell (1994) 1.59

Arginine in membranes: the connection between molecular dynamics simulations and translocon-mediated insertion experiments. J Membr Biol (2010) 1.58

Divergent stalling sequences sense and control cellular physiology. Biochem Biophys Res Commun (2010) 1.57

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes. Proc Natl Acad Sci U S A (2010) 1.57

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Programmed drug-dependent ribosome stalling. Mol Microbiol (2008) 1.54

Structure of the SecY channel during initiation of protein translocation. Nature (2013) 1.53

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The crystal structure of the signal recognition particle in complex with its receptor. Science (2011) 1.41

Translocon "pulling" of nascent SecM controls the duration of its translational pause and secretion-responsive secA regulation. J Bacteriol (2003) 1.38

YidC and Oxa1 form dimeric insertion pores on the translating ribosome. Mol Cell (2009) 1.36

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Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions. J Mol Biol (2004) 1.32

Methods for measuring the thermodynamic stability of membrane proteins. Methods Enzymol (2009) 1.29

The hydrophobic core of the Sec61 translocon defines the hydrophobicity threshold for membrane integration. Mol Biol Cell (2010) 1.29

Transmembrane helix dimerization: beyond the search for sequence motifs. Biochim Biophys Acta (2011) 1.26

A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration. Nat Struct Mol Biol (2012) 1.24

Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor domain. Proc Natl Acad Sci U S A (2007) 1.24

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In silico partitioning and transmembrane insertion of hydrophobic peptides under equilibrium conditions. J Am Chem Soc (2011) 1.20

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Dramatic destabilization of transmembrane helix interactions by features of natural membrane environments. J Am Chem Soc (2011) 1.17

Escherichia coli signal recognition particle receptor FtsY contains an essential and autonomous membrane-binding amphipathic helix. J Biol Chem (2007) 1.17

The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication. J Biol Chem (2004) 1.16