Published in Cell on April 21, 1995
Structure of the E. coli protein-conducting channel bound to a translating ribosome. Nature (2005) 3.10
YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase. EMBO J (2000) 2.70
Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein. EMBO J (1998) 2.23
Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane. J Cell Biol (2003) 2.07
Tail-anchored membrane protein insertion into the endoplasmic reticulum. Nat Rev Mol Cell Biol (2011) 1.95
ATP transport through a single mitochondrial channel, VDAC, studied by current fluctuation analysis. Biophys J (1998) 1.86
Role of the proline knot motif in oleosin endoplasmic reticulum topology and oil body targeting. Plant Cell (1997) 1.76
Membrane topology and insertion of membrane proteins: search for topogenic signals. Microbiol Mol Biol Rev (2000) 1.74
Membrane protein insertion at the endoplasmic reticulum. Annu Rev Cell Dev Biol (2011) 1.74
Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane. J Cell Biol (1996) 1.68
Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion. Nature (2014) 1.68
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes. Proc Natl Acad Sci U S A (2010) 1.57
Topological changes in the transmembrane domains of hepatitis C virus envelope glycoproteins. EMBO J (2002) 1.52
The SecYEG preprotein translocation channel is a conformationally dynamic and dimeric structure. EMBO J (2002) 1.46
Molecular mechanism of signal sequence orientation in the endoplasmic reticulum. EMBO J (2003) 1.46
Cellular mechanisms of membrane protein folding. Nat Struct Mol Biol (2009) 1.45
Probing the environment along the protein import pathways in yeast mitochondria by site-specific photocrosslinking. Proc Natl Acad Sci U S A (1997) 1.43
Mechanisms of integral membrane protein insertion and folding. J Mol Biol (2014) 1.43
Non-bilayer lipids are required for efficient protein transport across the plasma membrane of Escherichia coli. EMBO J (1995) 1.36
Sec61p contributes to signal sequence orientation according to the positive-inside rule. Mol Biol Cell (2003) 1.35
Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin. EMBO J (1997) 1.33
A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer. Proc Natl Acad Sci U S A (1998) 1.30
Molecular dynamics studies of the archaeal translocon. Biophys J (2006) 1.27
Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membrane. EMBO J (2003) 1.27
Signal sequence recognition in cotranslational translocation by protein components of the endoplasmic reticulum membrane. J Cell Biol (1998) 1.27
SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon. EMBO J (2001) 1.25
Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor. EMBO J (2001) 1.24
Free-energy cost for translocon-assisted insertion of membrane proteins. Proc Natl Acad Sci U S A (2011) 1.16
Glycosylation can influence topogenesis of membrane proteins and reveals dynamic reorientation of nascent polypeptides within the translocon. J Cell Biol (1999) 1.16
Sec-dependent membrane protein biogenesis: SecYEG, preprotein hydrophobicity and translocation kinetics control the stop-transfer function. EMBO J (1998) 1.14
Cotranslational integration and initial sorting at the endoplasmic reticulum translocon of proteins destined for the inner nuclear membrane. Proc Natl Acad Sci U S A (2004) 1.14
Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol Biol Cell (2003) 1.12
Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon. Mol Biol Cell (2008) 1.11
Structure of the native Sec61 protein-conducting channel. Nat Commun (2015) 1.05
Role of lipids in the translocation of proteins across membranes. Biochem J (2000) 1.04
A trans-membrane segment inside the ribosome exit tunnel triggers RAMP4 recruitment to the Sec61p translocase. J Cell Biol (2009) 1.03
Membrane protein TM segments are retained at the translocon during integration until the nascent chain cues FRET-detected release into bulk lipid. Mol Cell (2012) 0.99
Biogenesis of CFTR and other polytopic membrane proteins: new roles for the ribosome-translocon complex. J Membr Biol (2004) 0.93
An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate. Elife (2014) 0.92
Structure of the Sec61 channel opened by a signal sequence. Science (2016) 0.92
Membrane topology of the high-affinity L-glutamate transporter (GLAST-1) of the central nervous system. J Cell Biol (1996) 0.90
Role of ribosome and translocon complex during folding of influenza hemagglutinin in the endoplasmic reticulum of living cells. Mol Biol Cell (2000) 0.90
Mechanisms of CFTR Folding at the Endoplasmic Reticulum. Front Pharmacol (2012) 0.90
Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex. Biochem J (1998) 0.89
Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events. Mol Cell (2015) 0.89
Crystal structure of a substrate-engaged SecY protein-translocation channel. Nature (2016) 0.88
TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein. J Biol Chem (2009) 0.87
Sizing the protein translocation pathway of colicin Ia channels. J Gen Physiol (2003) 0.86
Identification of a novel stage of ribosome/nascent chain association with the endoplasmic reticulum membrane. J Cell Biol (1997) 0.85
Regulation of the ribosome-membrane junction at early stages of presecretory protein translocation in the mammalian endoplasmic reticulum. J Cell Biol (1997) 0.84
Positive charges determine the topology and functionality of the transmembrane domain in the chloroplastic outer envelope protein Toc34. J Cell Biol (1998) 0.82
Free energy of nascent-chain folding in the translocon. J Am Chem Soc (2011) 0.82
Environmental transition of signal-anchor sequences during membrane insertion via the endoplasmic reticulum translocon. Mol Biol Cell (2009) 0.82
Secretion of a type II integral membrane protein induced by mutation of the transmembrane segment. Biochem J (1997) 0.81
Role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins. PLoS One (2012) 0.81
The PBN1 gene of Saccharomyces cerevisiae: an essential gene that is required for the post-translational processing of the protease B precursor. Genetics (1998) 0.81
The nascent-polypeptide-associated complex: having a "NAC" for fidelity in translocation. Proc Natl Acad Sci U S A (1995) 0.81
Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone. J Cell Sci (2016) 0.81
Bacterial protein toxins and cell vesicle trafficking. Experientia (1996) 0.80
Membrane translocation of lumenal domains of membrane proteins powered by downstream transmembrane sequences. Mol Biol Cell (2013) 0.76
Stability and flexibility of marginally hydrophobic-segment stalling at the endoplasmic reticulum translocon. Mol Biol Cell (2016) 0.75
Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis. J Cell Sci (2017) 0.75
Viroporins, Examples of the Two-Stage Membrane Protein Folding Model. Viruses (2015) 0.75
The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding. J Biol Chem (2015) 0.75
Passenger protein determines translocation versus retention in the endoplasmic reticulum for aromatase expression. Mol Pharmacol (2013) 0.75
Two-step insertion at the SecY translocon. Nat Struct Mol Biol (2012) 0.75
Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide. Elife (2017) 0.75
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol (1975) 36.95
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol (1975) 15.47
Secretory protein translocation across membranes-the role of the "docking protein'. Nature (1982) 7.23
Common principles of protein translocation across membranes. Science (1996) 7.00
In vitro synthesis and processing of a putative precursor for the small subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A (1977) 5.89
Cell-free synthesis and membrane insertion of mouse H-2Dd histocompatibility antigen and beta 2-microglobulin. Cell (1979) 4.72
A novel in vitro transcription-translation system: accurate and efficient synthesis of single proteins from cloned DNA sequences. EMBO J (1984) 4.50
A T5 promoter-based transcription-translation system for the analysis of proteins in vitro and in vivo. Methods Enzymol (1987) 4.21
Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains. Nature (1989) 4.05
MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell (1990) 3.85
Isolation and characterization of the intracellular MHC class II compartment. Nature (1994) 3.50
Protein transfer across microsomal membranes reassembled from separated membrane components. Nature (1978) 3.39
Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens. Cell (1982) 3.36
Signal sequences: more than just greasy peptides. Trends Cell Biol (1998) 3.18
Assembly of the Semliki Forest virus membrane glycoproteins in the membrane of the endoplasmic reticulum in vitro. J Mol Biol (1978) 3.16
A membrane component essential for vectorial translocation of nascent proteins across the endoplasmic reticulum: requirements for its extraction and reassociation with the membrane. J Cell Biol (1980) 3.09
Mouse histocompatibility genes: structure and organisation of a Kd gene. EMBO J (1983) 3.07
Functional interaction of plant ribosomes with animal microsomal membranes. Biochem Biophys Res Commun (1977) 2.77
YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase. EMBO J (2000) 2.70
Identification and characterization of a membrane component essential for the translocation of nascent proteins across the membrane of the endoplasmic reticulum. J Cell Biol (1980) 2.63
Transfer of proteins across membranes, Biosynthesis in vitro of pretrypsinogen and trypsinogen by cell fractions of canine pancreas. Eur J Biochem (1978) 2.62
Evidence for high-energy extraterrestrial neutrinos at the IceCube detector. Science (2013) 2.56
The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain. Cell (2000) 2.46
Single bilayer vesicles prepared without sonication. Physico-chemical properties. Biochim Biophys Acta (1976) 2.32
E. coli 4.5S RNA is part of a ribonucleoprotein particle that has properties related to signal recognition particle. Cell (1990) 2.22
Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length. Nucleic Acids Res (1986) 2.21
A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site. Nature (1989) 2.18
An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY. EMBO J (1994) 2.13
Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting. Nature (1996) 2.07
The membrane-spanning segment of invariant chain (I gamma) contains a potentially cleavable signal sequence. Cell (1986) 2.04
The organization of the 7SL RNA in the signal recognition particle. Nucleic Acids Res (1983) 2.03
Signal-sequence recognition by an Escherichia coli ribonucleoprotein complex. Nature (1992) 2.02
First observation of PeV-energy neutrinos with IceCube. Phys Rev Lett (2013) 2.00
Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid. EMBO J (1992) 1.97
Hydrophobic binding of the ectodomain of influenza hemagglutinin to membranes occurs through the "fusion peptide". J Biol Chem (1989) 1.96
The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain. J Cell Biol (1990) 1.95
Structure of C-terminal half of two H-2 antigens from cloned mRNA. Nature (1981) 1.90
cDNA clone coding for part of a mouse H-2d major histocompatibility antigen. Proc Natl Acad Sci U S A (1981) 1.90
The methionine-rich domain of the 54 kDa subunit of signal recognition particle is sufficient for the interaction with signal sequences. EMBO J (1992) 1.85
Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence. J Biol Chem (1993) 1.85
Photolabeling identifies a putative fusion domain in the envelope glycoprotein of rabies and vesicular stomatitis viruses. J Biol Chem (1995) 1.80
Isolation and identification of a cDNA clone corresponding to an HLA-DR antigen beta chain. Proc Natl Acad Sci U S A (1982) 1.75
Molecular mechanism of membrane protein integration into the endoplasmic reticulum. Cell (1997) 1.70
The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail. J Cell Sci (1993) 1.69
Discrimination between SRP- and SecA/SecB-dependent substrates involves selective recognition of nascent chains by SRP and trigger factor. EMBO J (2000) 1.68
Membrane interaction of influenza virus M1 protein. Virology (2000) 1.63
A tripartite structure of the signals that determine protein insertion into the endoplasmic reticulum membrane. J Cell Biol (1989) 1.61
Hosts as ecological traps for the vector of Lyme disease. Proc Biol Sci (2009) 1.59
Requirements for the membrane insertion of signal-anchor type proteins. J Cell Biol (1991) 1.59
Evaluation of a PCR assay for identification and differentiation of Campylobacter fetus subspecies. Aust Vet J (1997) 1.58
Characterization of molecules involved in protein translocation using a specific antibody. J Cell Biol (1982) 1.58
Sec-dependent membrane protein insertion: sequential interaction of nascent FtsQ with SecY and YidC. EMBO Rep (2001) 1.57
Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J (1999) 1.56
Signal recognition particle-dependent membrane insertion of mouse invariant chain: a membrane-spanning protein with a cytoplasmically exposed amino terminus. J Cell Biol (1986) 1.54
Lipid interactions of the hemagglutinin HA2 NH2-terminal segment during influenza virus-induced membrane fusion. J Biol Chem (1992) 1.53
Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries. J Neurol Neurosurg Psychiatry (2001) 1.53
H+-induced membrane insertion of influenza virus hemagglutinin involves the HA2 amino-terminal fusion peptide but not the coiled coil region. J Biol Chem (1996) 1.52
Interferon messenger RNA content of human fibroblasts during induction, shutoff, and superinduction of interferon production. Proc Natl Acad Sci U S A (1977) 1.51
The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER. J Cell Biol (1991) 1.51
Structure of the murine Ia-associated invariant (Ii) chain as deduced from a cDNA clone. EMBO J (1984) 1.51
Low-pH induced conformational changes in viral fusion proteins: implications for the fusion mechanism. J Gen Virol (1995) 1.50
The mode of association of the enzyme complex sucrase.isomaltase with the intestinal brush border membrane. J Biol Chem (1979) 1.50
Selective labeling of the hydrophobic core of membranes with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine, a carbene-generating reagent. Biochemistry (1981) 1.49
Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. Nucleic Acids Res (1988) 1.47
Evidence for H(+)-induced insertion of influenza hemagglutinin HA2 N-terminal segment into viral membrane. J Biol Chem (1994) 1.44
YidC, an assembly site for polytopic Escherichia coli membrane proteins located in immediate proximity to the SecYE translocon and lipids. EMBO Rep (2001) 1.41
Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta. Proc Natl Acad Sci U S A (1997) 1.41
Translation efficiency of zein mRNA is reduced by hybrid formation between the 5'- and 3'-untranslated region. EMBO J (1985) 1.39
Assembly of the 68- and 72-kD proteins of signal recognition particle with 7S RNA. J Cell Biol (1993) 1.37
The hydrophobic anchor of small-intestinal sucrase--isomaltase: N-terminal sequence of isomaltase subunit. FEBS Lett (1978) 1.37
Nascent Lep inserts into the Escherichia coli inner membrane in the vicinity of YidC, SecY and SecA. FEBS Lett (2000) 1.36
The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents. J Cell Biol (1990) 1.35
Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion. J Cell Biol (1993) 1.35
Electrostatic and hydrophobic interactions of synapsin I and synapsin I fragments with phospholipid bilayers. J Cell Biol (1989) 1.35
The signal sequence interacts with the methionine-rich domain of the 54-kD protein of signal recognition particle. J Cell Biol (1991) 1.35
Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. Proc Natl Acad Sci U S A (1996) 1.34
Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin. EMBO J (1997) 1.33
Mammalian and Escherichia coli signal recognition particles. Mol Microbiol (1994) 1.32
Signal sequence recognition in cotranslational translocation by protein components of the endoplasmic reticulum membrane. J Cell Biol (1998) 1.27
Signal and membrane anchor functions overlap in the type II membrane protein I gamma CAT. J Cell Biol (1988) 1.26
The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains. J Biol Chem (1999) 1.26
SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon. EMBO J (2001) 1.25
Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4. EMBO J (1999) 1.24
Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum. FEBS Lett (1999) 1.23
The plasma membrane Ca2+ pump contains a site that interacts with its calmodulin-binding domain. J Biol Chem (1991) 1.19
Structure and biosynthesis of the signal-sequence receptor. Eur J Biochem (1990) 1.19
3-Trifluoromethyl-3-phenyldiazirine. A new carbene generating group for photolabeling reagents. J Biol Chem (1980) 1.19
Single bilayer lipid-protein vesicles formed from phosphatidylcholine and small intestinal sucrase.isomaltase. J Biol Chem (1978) 1.17
Signal recognition particle arrests elongation of nascent secretory and membrane proteins at multiple sites in a transient manner. J Biol Chem (1987) 1.17
A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins. EMBO J (1995) 1.14
Analysis of membranes photolabeled with lipid analogues. Reaction of phospholipids containing a disulfide group and a nitrene or carbene precursor with lipids and with gramicidin A. J Biol Chem (1980) 1.14
Mischarging Escherichia coli tRNAPhe with L-4'-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenylalanine, a photoactivatable analogue of phenylalanine. Biochemistry (1988) 1.14
The protease-protected 30 kDa domain of SecA is largely inaccessible to the membrane lipid phase. EMBO J (1997) 1.13
Interactions of ribosome nascent chain complexes of the chloroplast-encoded D1 thylakoid membrane protein with cpSRP54. EMBO J (1999) 1.13
Disassembly and domain structure of the proteins in the signal-recognition particle. Eur J Biochem (1987) 1.12
Hydrophobic photolabeling identifies BHA2 as the subunit mediating the interaction of bromelain-solubilized influenza virus hemagglutinin with liposomes at low pH. Biochemistry (1988) 1.12
Structural requirements for membrane assembly of proteins spanning the membrane several times. J Cell Biol (1989) 1.12
Snapshots of membrane-translocating proteins. Trends Cell Biol (1996) 1.12