SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.

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Intracellular Mono-ADP-Ribosylation in Signaling and Disease. Cells (2015) 0.85

Cyclic AMP signaling reduces sirtuin 6 expression in non-small cell lung cancer cells by promoting ubiquitin-proteasomal degradation via inhibition of the Raf-MEK-ERK (Raf/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase) pathway. J Biol Chem (2015) 0.85

SIRTain regulators of premature senescence and accelerated aging. Protein Cell (2015) 0.82

SIRT6: Novel Mechanisms and Links to Aging and Disease. Trends Endocrinol Metab (2016) 0.79

Sirtuins in glucose and lipid metabolism. Oncotarget (2017) 0.78

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity. Cell Rep (2017) 0.76

Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer. Molecules (2017) 0.75

Sirtuins in metabolism, DNA repair and cancer. J Exp Clin Cancer Res (2016) 0.75

Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch Dermatol (2010) 8.55

Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell (2009) 6.09

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11

Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11

The sirtuin SIRT6 regulates lifespan in male mice. Nature (2012) 4.07

Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. J Clin Invest (2001) 3.01

SIRT6 promotes DNA repair under stress by activating PARP1. Science (2011) 2.99

Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab (2010) 2.89

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell (2012) 2.78

Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science (2010) 2.74

Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat Rev Cancer (2005) 2.69

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature (2013) 2.52

SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY) (2009) 2.50

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab (2006) 2.43

Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling. Nat Rev Cancer (2004) 2.31

COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. Carcinogenesis (1998) 2.30

Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res (2002) 2.20

AMP-activated kinase regulates cytoplasmic HuR. Mol Cell Biol (2002) 2.14

FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci U S A (2007) 2.08

From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest (2012) 2.01

SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem (2010) 1.86

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nat Cell Biol (2012) 1.81

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med (2012) 1.69

SIRT6 in DNA repair, metabolism and ageing. J Intern Med (2008) 1.61

From sirtuin biology to human diseases: an update. J Biol Chem (2012) 1.60

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A (2010) 1.49

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling. Mol Cell (2013) 1.47

Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin. Exp Dermatol (2014) 1.47

AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. J Biol Chem (2004) 1.46

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol Cell (2012) 1.39

UV radiation and the skin. Int J Mol Sci (2013) 1.37

Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett (2008) 1.36

Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci U S A (2010) 1.30

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev (2013) 1.29

Chromatin regulation and genome maintenance by mammalian SIRT6. Trends Biochem Sci (2010) 1.28

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle (2011) 1.24

Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis. Mol Carcinog (2007) 1.24

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A (2012) 1.20

A miR-34a-SIRT6 axis in the squamous cell differentiation network. EMBO J (2013) 1.18

A role for cyclooxygenase-2 in ultraviolet light-induced skin carcinogenesis. Mol Carcinog (2007) 1.15

TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway. J Immunol (2000) 1.13

UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes. Mol Carcinog (2008) 1.10

The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J Biol Chem (2013) 1.09

Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance. Oncogene (2006) 1.09

PTEN positively regulates UVB-induced DNA damage repair. Cancer Res (2011) 1.09

Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4. Cancer Res (2007) 1.08

SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency. Oncogene (2012) 1.05

UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes. Oncogene (2009) 1.03

Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients. Hepatology (2013) 1.02

The role of PI 3-kinase in the UVB-induced expression of c-fos. Oncogene (2002) 0.96

Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. J Biol Chem (2011) 0.94

Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics. Protein Cell (2013) 0.91

Dual role of SIRT1 in UVB-induced skin tumorigenesis. Oncogene (2014) 0.89

Effects of SIRT6 silencing on collagen metabolism in human dermal fibroblasts. Cell Biol Int (2012) 0.77

Cell-type-specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis (2014) 0.76