Published in Proc Natl Acad Sci U S A on November 03, 2014
Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. Elife (2015) 0.96
What do you mean, "epigenetic"? Genetics (2015) 0.93
Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation. Biol Open (2016) 0.92
Acute loss of TET function results in aggressive myeloid cancer in mice. Nat Commun (2015) 0.88
Evidence that DNA methylation engenders dynamic gene regulation. Proc Natl Acad Sci U S A (2015) 0.87
Epigenetic Therapeutics: A New Weapon in the War Against Cancer. Annu Rev Med (2016) 0.87
DNA methylation and hydroxymethylation in hematologic differentiation and transformation. Curr Opin Cell Biol (2015) 0.86
Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility. Elife (2016) 0.80
Tissue-specific DNA demethylation is required for proper B-cell differentiation and function. Proc Natl Acad Sci U S A (2016) 0.80
Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms. Transl Psychiatry (2017) 0.80
Promoter methylation of the immune checkpoint receptor PD-1 (PDCD1) is an independent prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients following radical prostatectomy. Oncoimmunology (2016) 0.79
Dynamic Changes in the Transcriptome and Methylome of Chlamydomonas reinhardtii throughout Its Life Cycle. Plant Physiol (2015) 0.78
HMPL: A Pipeline for Identifying Hemimethylation Patterns by Comparing Two Samples. Cancer Inform (2015) 0.77
CpG methylation differences between neurons and glia are highly conserved from mouse to human. Hum Mol Genet (2015) 0.77
Reply to Wilkinson: Minor role of programmed methylation and demethylation in mammalian development. Proc Natl Acad Sci U S A (2015) 0.76
Effect of CpG dinucleotides within IgH switch region repeats on immunoglobulin class switch recombination. Mol Immunol (2015) 0.76
Epigenetic changes in the developing brain: Effects on behavior. Proc Natl Acad Sci U S A (2015) 0.76
Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis. Biomed Res Int (2017) 0.75
Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation. J Biol Chem (2015) 0.75
Epigenetics: An elusive DNA base in mammals. Nature (2016) 0.75
Queen pheromones modulate DNA methyltransferase activity in bee and ant workers. Biol Lett (2016) 0.75
TET Methylcytosine Oxidases in T Cell and B Cell Development and Function. Front Immunol (2017) 0.75
DNA methylation and DNA methyltransferases. Epigenetics Chromatin (2017) 0.75
DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation. Hum Mol Genet (2017) 0.75
Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation. PLoS Pathog (2017) 0.75
Zebrafish Discoveries in Cancer Epigenetics. Adv Exp Med Biol (2016) 0.75
Connecting the Dots Between Fatty Acids, Mitochondrial Function, and DNA Methylation in Atherosclerosis. Curr Atheroscler Rep (2017) 0.75
Targeted DNA methylation in human cells using engineered dCas9-methyltransferases. Sci Rep (2017) 0.75
Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function. Epigenetics Chromatin (2017) 0.75
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell (1992) 27.80
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86
DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature (2011) 8.75
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature (2004) 7.57
Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat Genet (1998) 7.49
High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell (1990) 7.45
Dnmt3L and the establishment of maternal genomic imprints. Science (2001) 7.42
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet (2001) 6.92
DNA methylation and the regulation of globin gene expression. Cell (1983) 6.49
Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature (1999) 6.42
Global epigenomic reconfiguration during mammalian brain development. Science (2013) 6.14
Sp1 elements protect a CpG island from de novo methylation. Nature (1994) 5.60
Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev (1994) 4.95
DNA methylation at a CCGG sequence in the large intron of the rabbit beta-globin gene: tissue-specific variations. Nucleic Acids Res (1978) 4.77
Cytosine methylation and mammalian development. Genes Dev (1999) 3.82
Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res (2011) 3.36
Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts. Cell (1986) 3.34
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell (2013) 3.31
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet (2011) 3.16
In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells. Proc Natl Acad Sci U S A (1982) 2.92
Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks. PLoS Genet (2012) 2.89
DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci (2001) 2.75
DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev (1996) 2.51
Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity (2002) 2.47
Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment. Nature (1977) 2.44
De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines. Proc Natl Acad Sci U S A (1990) 2.42
Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns. Genome Res (2010) 2.25
Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol (2007) 2.15
An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA. EMBO J (1998) 1.74
Nucleotide frequency variation across human genes. Genome Res (2003) 1.68
Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes. Mol Cell (2012) 1.36
Effects of cytosine methylation on transcription factor binding sites. BMC Genomics (2014) 1.31
The primary function of a redundant Sp1 binding site in the mouse aprt gene promoter is to block epigenetic gene inactivation. Nucleic Acids Res (1998) 1.26
Protein binding protects sites on stable episomes and in the chromosome from de novo methylation. Mol Cell Biol (2001) 1.25
Cytosine methylation mediates sexual conflict. Trends Genet (2003) 1.10
Effects of 5-azacytidine on methylation and expression of specific DNA sequences in C3H 10T1/2 cells. Mol Cell Biol (1984) 1.02
DNA hypomethylation and activation of germline-specific genes in cancer. Adv Exp Med Biol (2013) 0.91
Reply to Wilkinson: Minor role of programmed methylation and demethylation in mammalian development. Proc Natl Acad Sci U S A (2015) 0.76