Published in Nature on August 18, 2004
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Small RNAs as guardians of the genome. Cell (2009) 8.88
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature (2007) 8.33
The impact of retrotransposons on human genome evolution. Nat Rev Genet (2009) 8.08
The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10
DNA methylation: roles in mammalian development. Nat Rev Genet (2013) 6.65
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev (2008) 5.58
Natural mutagenesis of human genomes by endogenous retrotransposons. Cell (2010) 5.50
L1 retrotransposition in human neural progenitor cells. Nature (2009) 4.78
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature (2007) 4.49
Landscape of somatic retrotransposition in human cancers. Science (2012) 4.37
Large-scale structure of genomic methylation patterns. Genome Res (2005) 4.11
Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes. PLoS Genet (2008) 3.89
Active human retrotransposons: variation and disease. Curr Opin Genet Dev (2012) 3.60
Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET. Nature (2010) 3.55
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates. Cell (2011) 3.39
Genomic imprinting: the emergence of an epigenetic paradigm. Nat Rev Genet (2011) 3.10
Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line. PLoS Genet (2006) 3.07
Mighty Piwis defend the germline against genome intruders. Cell (2007) 3.06
Epigenetic modifications in pluripotent and differentiated cells. Nat Biotechnol (2010) 3.02
Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science (2010) 2.98
Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks. PLoS Genet (2012) 2.89
MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS One (2008) 2.82
The human LINE-1 retrotransposon creates DNA double-strand breaks. J Mol Biol (2006) 2.77
Mammalian DNA methyltransferases: a structural perspective. Structure (2008) 2.72
In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. PLoS Genet (2012) 2.70
L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism. Genes Dev (2009) 2.68
Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol (2008) 2.67
Dynamic interactions between transposable elements and their hosts. Nat Rev Genet (2011) 2.61
Mammalian genomic imprinting. Cold Spring Harb Perspect Biol (2011) 2.59
Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev Cell (2008) 2.58
Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A (2005) 2.56
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Res (2012) 2.55
Mammalian cytosine methylation at a glance. J Cell Sci (2009) 2.43
Regulation and function of DNA methylation in plants and animals. Cell Res (2011) 2.41
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet (2012) 2.35
Extensive somatic L1 retrotransposition in colorectal tumors. Genome Res (2012) 2.29
The consequences of asynapsis for mammalian meiosis. Nat Rev Genet (2009) 2.29
Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes. Development (2011) 2.28
Genomic imprinting: employing and avoiding epigenetic processes. Genes Dev (2009) 2.26
Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet (2009) 2.11
High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer. Proc Natl Acad Sci U S A (2007) 2.10
Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution. PLoS Genet (2009) 2.07
Inviting instability: Transposable elements, double-strand breaks, and the maintenance of genome integrity. Mutat Res (2006) 2.00
Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet (2006) 1.99
MORC family ATPases required for heterochromatin condensation and gene silencing. Science (2012) 1.97
Functional dynamics of H3K9 methylation during meiotic prophase progression. EMBO J (2007) 1.96
Zili is required for germ cell differentiation and meiosis in zebrafish. EMBO J (2008) 1.87
The take and give between retrotransposable elements and their hosts. Annu Rev Genet (2008) 1.86
DNA methylation dynamics during the mammalian life cycle. Philos Trans R Soc Lond B Biol Sci (2013) 1.85
Natural history of S-adenosylmethionine-binding proteins. BMC Struct Biol (2005) 1.85
A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Res (2010) 1.83
GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet (2009) 1.83
Epigenetic mechanisms in mammals. Cell Mol Life Sci (2009) 1.82
Human transposon tectonics. Cell (2012) 1.81
Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet (2007) 1.79
Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation. J Cell Biol (2008) 1.77
DNA methylation and its basic function. Neuropsychopharmacology (2012) 1.76
Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry (2010) 1.74
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes. Science (2014) 1.74
Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers. Philos Trans R Soc Lond B Biol Sci (2013) 1.70
Transposable elements re-wire and fine-tune the transcriptome. PLoS Genet (2013) 1.70
Small RNA guides for de novo DNA methylation in mammalian germ cells. Genes Dev (2008) 1.68
A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation. PLoS Genet (2006) 1.66
Epigenetic disruption of the PIWI pathway in human spermatogenic disorders. PLoS One (2012) 1.64
L1 mobile element expression causes multiple types of toxicity. Gene (2008) 1.60
A role for retrotransposon LINE-1 in fetal oocyte attrition in mice. Dev Cell (2014) 1.59
Lsh is involved in de novo methylation of DNA. EMBO J (2006) 1.57
Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline. Development (2012) 1.55
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos. Genes Dev (2014) 1.55
Nanos2 suppresses meiosis and promotes male germ cell differentiation. Genes Dev (2008) 1.55
Death by transposition - the enemy within? Bioessays (2013) 1.53
Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses. Nucleic Acids Res (2006) 1.53
Meiotic silencing and the epigenetics of sex. Chromosome Res (2007) 1.52
All y'all need to know 'bout retroelements in cancer. Semin Cancer Biol (2010) 1.52
Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A (2010) 1.52
Hypermutation of an ancient human retrovirus by APOBEC3G. J Virol (2008) 1.50
L1 integration in a transgenic mouse model. Genome Res (2005) 1.50
HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse. PLoS Genet (2015) 1.49
New insights into establishment and maintenance of DNA methylation imprints in mammals. Philos Trans R Soc Lond B Biol Sci (2013) 1.49
Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men. Eur J Hum Genet (2010) 1.48
Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells. Nature (2010) 1.47
A unique configuration of genome-wide DNA methylation patterns in the testis. Proc Natl Acad Sci U S A (2006) 1.46
Sex in fungi. Annu Rev Genet (2011) 1.45
The parental non-equivalence of imprinting control regions during mammalian development and evolution. PLoS Genet (2010) 1.41
DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo. PLoS Genet (2010) 1.41
Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair. Nucleic Acids Res (2006) 1.40
Notes on the role of dynamic DNA methylation in mammalian development. Proc Natl Acad Sci U S A (2014) 1.36
Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome. PLoS Genet (2012) 1.35
Transcriptional regulation of early transposon elements, an active family of mouse long terminal repeat retrotransposons. J Virol (2005) 1.35
L1 retrotransposons in human cancers. J Biomed Biotechnol (2006) 1.34
A mobile threat to genome stability: The impact of non-LTR retrotransposons upon the human genome. Semin Cancer Biol (2010) 1.34
Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote. Chromosoma (2007) 1.33
LINE dancing in the human genome: transposable elements and disease. Genome Med (2009) 1.33
Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogramming. Cell Res (2011) 1.33
Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility. Hum Mol Genet (2011) 1.31
Meiotically stable natural epialleles of Sadhu, a novel Arabidopsis retroposon. PLoS Genet (2006) 1.28
DNA methylation patterns in lung carcinomas. Semin Cancer Biol (2009) 1.25
DNA transposons: nature and applications in genomics. Curr Genomics (2010) 1.25
Eukaryotic cytosine methyltransferases. Annu Rev Biochem (2005) 15.45
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
The colorful history of active DNA demethylation. Cell (2008) 8.50
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell (2007) 7.66
Large-scale structure of genomic methylation patterns. Genome Res (2005) 4.11
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science (2006) 3.87
Methylation dynamics of imprinted genes in mouse germ cells. Genomics (2002) 3.19
Altered methylation patterns in cancer cell genomes: cause or consequence? Cancer Cell (2002) 3.09
Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science (2010) 2.98
Mammalian cytosine methylation at a glance. J Cell Sci (2009) 2.43
Hyperconserved CpG domains underlie Polycomb-binding sites. Proc Natl Acad Sci U S A (2007) 2.41
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet (2012) 2.35
Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome. Hum Mol Genet (2002) 2.33
Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns. Genome Res (2010) 2.25
Epigenetic decisions in mammalian germ cells. Science (2007) 1.88
Computational prediction of methylation status in human genomic sequences. Proc Natl Acad Sci U S A (2006) 1.83
Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation. J Cell Biol (2008) 1.77
Dynamics of Dnmt1 methyltransferase expression and intracellular localization during oogenesis and preimplantation development. Dev Biol (2002) 1.44
Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit. Proc Natl Acad Sci U S A (2005) 1.43
Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells. Dev Biol (2004) 1.41
The parental non-equivalence of imprinting control regions during mammalian development and evolution. PLoS Genet (2010) 1.41
Histone modification and replacement in chromatin activation. Genes Dev (2002) 1.38
Decatenation checkpoint deficiency in stem and progenitor cells. Cancer Cell (2005) 1.34
Biological functions of DNA methyltransferase 1 require its methyltransferase activity. Mol Cell Biol (2007) 1.27
Cytosine methylation: remaining faithful. Curr Biol (2008) 1.18
BRCA1 promoter methylation is associated with increased mortality among women with breast cancer. Breast Cancer Res Treat (2008) 1.16
Dynamic instability of genomic methylation patterns in pluripotent stem cells. Epigenetics Chromatin (2010) 1.15
Coordinate regulation of DNA methyltransferase expression during oogenesis. BMC Dev Biol (2007) 1.12
Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L. BMC Dev Biol (2007) 0.97
Allele-specific demethylation at an imprinted mammalian promoter. Nucleic Acids Res (2007) 0.96
Helicase homologues maintain cytosine methylation in plants and mammals. Bioessays (2002) 0.96
Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation. Mol Cancer (2002) 0.93
Decatenation checkpoint deficiency destabilizes the stem cell genome. Cell Cycle (2006) 0.82
Genetics and epigenetics of hydatidiform moles. Nat Genet (2006) 0.77
Combing over heritable gene silencing. Nat Struct Mol Biol (2006) 0.75