Nutrient-sensing nuclear receptors coordinate autophagy.

PubWeight™: 1.57‹?› | Rank: Top 4%

🔗 View Article (PMC 4267857)

Published in Nature on November 12, 2014

Authors

Jae Man Lee1, Martin Wagner1, Rui Xiao1, Kang Ho Kim1, Dan Feng2, Mitchell A Lazar2, David D Moore1

Author Affiliations

1: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
2: Division of Endocrinology, Diabetes, and Metabolism and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19014, USA.

Articles citing this

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab (2016) 2.15

Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Nat Commun (2016) 1.05

Transcriptional and epigenetic regulation of autophagy in aging. Autophagy (2015) 0.97

Cellular and Molecular Connections between Autophagy and Inflammation. Mediators Inflamm (2015) 0.96

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut (2016) 0.94

Regulation of Liver Metabolism by Autophagy. Gastroenterology (2015) 0.89

Role of Autophagy in the Maintenance of Intestinal Homeostasis. Gastroenterology (2015) 0.87

Autophagy-mediated longevity is modulated by lipoprotein biogenesis. Autophagy (2016) 0.86

Transcriptional and Chromatin Regulation during Fasting - The Genomic Era. Trends Endocrinol Metab (2015) 0.83

Regulation of Hepatic Drug-Metabolizing Enzymes in Germ-Free Mice by Conventionalization and Probiotics. Drug Metab Dispos (2015) 0.82

Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals. Sci Rep (2016) 0.82

Cell metabolism: autophagy transcribed. Nature (2014) 0.82

The lysosome as a command-and-control center for cellular metabolism. J Cell Biol (2016) 0.81

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells. Autophagy (2015) 0.81

Role of bile acids in the regulation of the metabolic pathways. World J Diabetes (2016) 0.81

Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. Autophagy (2015) 0.81

Functions of autophagy in pathological cardiac hypertrophy. Int J Biol Sci (2015) 0.81

G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice. Hepatology (2016) 0.81

Cross-talk between bile acids and intestinal microbiota in host metabolism and health. J Zhejiang Univ Sci B (2015) 0.79

Autophagy-A free meal in sickness-associated anorexia. Autophagy (2016) 0.78

Role of farnesoid X receptor and bile acids in alcoholic liver disease. Acta Pharm Sin B (2015) 0.78

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism. Mol Metab (2015) 0.77

In search for novel strategies towards neuroprotection and neuroregeneration: is PPARα a promising therapeutic target? Neural Regen Res (2015) 0.76

Autophagy and modular restructuring of metabolism control germline tumor differentiation and proliferation in C. elegans. Autophagy (2016) 0.76

The mysterious relationship between reproduction and longevity. Worm (2015) 0.76

Emerging roles of autophagy in metabolism and metabolic disorders. Front Biol (Beijing) (2015) 0.76

Evolutionary trends and functional anatomy of the human expanded autophagy network. Autophagy (2015) 0.76

Suppressed translation and ULK1 degradation as potential mechanisms of autophagy limitation under prolonged starvation. Autophagy (2016) 0.76

Editor's Highlight: Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPARα-Signaling in Mouse Liver. Toxicol Sci (2016) 0.76

The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling. J Biol Chem (2016) 0.76

Thermogenic activation represses autophagy in brown adipose tissue. Int J Obes (Lond) (2016) 0.76

Expanding perspectives on the significance of mitophagy in cancer. Semin Cancer Biol (2017) 0.76

It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin. Am J Physiol Cell Physiol (2016) 0.75

Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia. PLoS Genet (2017) 0.75

Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1-AKT-mTOR Axis in Mice. Cell Mol Gastroenterol Hepatol (2016) 0.75

Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis. FASEB J (2016) 0.75

Store-Operated Ca(2+) Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism. Cell Metab (2017) 0.75

Naoxintong/PPARγ Signaling Inhibits Cardiac Hypertrophy via Activation of Autophagy. Evid Based Complement Alternat Med (2017) 0.75

Transcriptional coordination of hepatic autophagy by nutrient-sensing nuclear receptor PPARα and FXR. Ann Pediatr Endocrinol Metab (2016) 0.75

Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21. PLoS One (2017) 0.75

Preferential PPAR-α activation reduces neuroinflammation, and blocks neurodegeneration in vivo. Hum Mol Genet (2015) 0.75

Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy. Nucleic Acids Res (2017) 0.75

BILE DUCT LIGATION INDUCES ATZ GLOBULE CLEARANCE IN A MOUSE MODEL OF ALPHA-1 ANTITRYPSIN DEFICIENCY. Gene Expr (2016) 0.75

Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance. J Clin Invest (2017) 0.75

Bile Acids: The Hidden Gateway Behind Autophagy Modulation in the Liver. Cell Mol Gastroenterol Hepatol (2017) 0.75

O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity. Oncotarget (2016) 0.75

NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson's disease. Sci Rep (2016) 0.75

ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism. Cell Rep (2017) 0.75

Short-term starvation attenuates liver ischemia-reperfusion injury (IRI) by Sirt1-autophagy signaling in mice. Am J Transl Res (2016) 0.75

Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance. Cell Rep (2017) 0.75

Breaking fat: The regulation and mechanisms of lipophagy. Biochim Biophys Acta (2017) 0.75

Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions. Cell Rep (2017) 0.75

A Novel Role of Astrocyte Elevated Gene-1 (AEG-1) in Regulating Non-alcoholic Steatohepatitis (NASH). Hepatology (2017) 0.75

The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis. Cell Death Discov (2017) 0.75

A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J (2017) 0.75

RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network. Nat Commun (2017) 0.75

The mucolipin-1 (TRPML1) ion channel, transmembrane-163 (TMEM163) protein, and lysosomal zinc handling. Front Biosci (Landmark Ed) (2017) 0.75

High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. Cell Death Differ (2017) 0.75

Articles cited by this

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12

The human genome browser at UCSC. Genome Res (2002) 168.23

Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

mTOR signaling in growth control and disease. Cell (2012) 29.21

MEME SUITE: tools for motif discovery and searching. Nucleic Acids Res (2009) 23.27

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Methods in mammalian autophagy research. Cell (2010) 20.08

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem (2009) 12.73

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy (2007) 11.74

AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 10.42

TFEB links autophagy to lysosomal biogenesis. Science (2011) 8.87

The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol (2011) 8.18

Autophagy and metabolism. Science (2010) 8.10

PPARs and the complex journey to obesity. Nat Med (2004) 7.44

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol (1995) 7.12

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell (2000) 6.71

A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science (2011) 5.91

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc Natl Acad Sci U S A (1993) 4.56

The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell (2012) 4.40

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc Natl Acad Sci U S A (1992) 4.38

Identification of a candidate therapeutic autophagy-inducing peptide. Nature (2013) 3.76

Autophagy: basic principles and relevance to disease. Annu Rev Pathol (2008) 3.52

Redundant pathways for negative feedback regulation of bile acid production. Dev Cell (2002) 3.51

Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest (2006) 3.44

AMPK and mTOR in cellular energy homeostasis and drug targets. Annu Rev Pharmacol Toxicol (2011) 2.78

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell (2002) 2.68

Identification of a chemical tool for the orphan nuclear receptor FXR. J Med Chem (2000) 2.67

FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature (2013) 2.62

Regulation of glucose production by the liver. Annu Rev Nutr (1999) 2.23

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine. Hepatology (2010) 2.10

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. Gastroenterology (2003) 1.54

Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. Mol Cell (2013) 1.44

Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. EMBO J (2012) 1.31

Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. Bioorg Med Chem Lett (2001) 1.28

"Don't know much bile-ology". Cell (2000) 1.15

SnapShot: Selective autophagy. Cell (2013) 0.99

Lysosome: regulator of lipid degradation pathways. Trends Cell Biol (2014) 0.99

Farnesoid X receptor represses hepatic human APOA gene expression. J Clin Invest (2011) 0.94