The initial response to the Boston marathon bombing: lessons learned to prepare for the next disaster.

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🔗 View Article (PMID 25386862)

Published in Ann Surg on December 01, 2014

Authors

Jonathan D Gates1, Sandra Arabian, Paul Biddinger, Joe Blansfield, Peter Burke, Sarita Chung, Jonathan Fischer, Franklin Friedman, Alice Gervasini, Eric Goralnick, Alok Gupta, Andreas Larentzakis, Maria McMahon, Juan Mella, Yvonne Michaud, David Mooney, Reuven Rabinovici, Darlene Sweet, Andrew Ulrich, George Velmahos, Cheryl Weber, Michael B Yaffe

Author Affiliations

1: *Brigham and Women's Hospital †Tufts Medical Center ‡Massachusetts General Hospital §Boston Medical Center ¶Boston's Children's Hospital, and ‖Beth Israel Deaconess Medical Center, Boston, MA.

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Characterization of a murine model of endotoxin-induced acute lung injury. Shock (2002) 1.37

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