Published in Science on March 24, 1989
Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci U S A (1990) 7.39
Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul (1991) 5.80
The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J (1990) 4.28
A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine. Mol Cell Biol (1991) 3.20
Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol Biol Cell (1993) 3.17
Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein. EMBO J (1991) 2.87
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma. EMBO J (1992) 2.82
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J (1992) 2.79
Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol Biol Cell (1994) 2.78
Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase. EMBO J (1990) 2.76
Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C. Proc Natl Acad Sci U S A (1989) 2.75
High-order fluorescence fluctuation analysis of model protein clusters. Proc Natl Acad Sci U S A (1989) 2.64
Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J Cell Biol (1993) 2.59
Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J (1993) 2.44
PDGF ligand and receptor gene expression during repair of arterial injury. J Cell Biol (1990) 2.26
Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells. Proc Natl Acad Sci U S A (1990) 2.26
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit. Mol Cell Biol (1992) 2.11
Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity. Proc Natl Acad Sci U S A (1990) 2.08
Image correlation spectroscopy. II. Optimization for ultrasensitive detection of preexisting platelet-derived growth factor-beta receptor oligomers on intact cells. Biophys J (1999) 1.99
K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes. Proc Natl Acad Sci U S A (1990) 1.99
Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region. Mol Cell Biol (1993) 1.98
Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells. Proc Natl Acad Sci U S A (1992) 1.89
Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively. Mol Cell Biol (1993) 1.88
Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1. EMBO J (1989) 1.81
Induction of NF-kappa B DNA-binding activity during the G0-to-G1 transition in mouse fibroblasts. Mol Cell Biol (1991) 1.78
Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase. Mol Biol Cell (2000) 1.62
A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein. EMBO J (1997) 1.60
Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit. Cell Regul (1991) 1.55
Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene. Proc Natl Acad Sci U S A (1991) 1.53
Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1. Proc Natl Acad Sci U S A (1992) 1.51
Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors. J Cell Biol (1996) 1.47
Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction. Mol Cell Biol (1991) 1.42
Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways. Proc Natl Acad Sci U S A (1989) 1.39
Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling. Mol Cell Biol (1995) 1.38
Ligand-induced transphosphorylation between different FGF receptors. EMBO J (1991) 1.37
Obliterative bronchiolitis after lung transplantation: a fibroproliferative disorder associated with platelet-derived growth factor. Proc Natl Acad Sci U S A (1992) 1.36
Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells. Mol Cell Biol (1993) 1.36
Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement. EMBO J (1992) 1.35
Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts. J Exp Med (1992) 1.33
Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. J Clin Invest (1993) 1.33
Platelet-derived growth factor indirectly stimulates angiogenesis in vitro. Am J Pathol (1993) 1.30
Regulation of expression of growth arrest-specific genes in mouse fibroblasts. Mol Cell Biol (1990) 1.28
Induction of macrophage colony-stimulating factor-dependent growth and differentiation after introduction of the murine c-fms gene into FDC-P1 cells. Mol Cell Biol (1989) 1.26
Cellular transformation by a transmembrane peptide: structural requirements for the bovine papillomavirus E5 oncoprotein. Proc Natl Acad Sci U S A (1994) 1.22
Decreased level of PDGF-stimulated receptor autophosphorylation by fibroblasts in mechanically relaxed collagen matrices. J Cell Biol (1993) 1.21
Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells. Proc Natl Acad Sci U S A (1991) 1.20
Cell-specific cyclic AMP-mediated induction of the PDGF receptor. EMBO J (1990) 1.13
Platelet-derived growth factor (PDGF)-induced disulfide-linked dimerization of PDGF receptor in living cells. Mol Cell Biol (1991) 1.10
PDGF and intracellular signaling in the timing of oligodendrocyte differentiation. J Cell Biol (1989) 1.10
Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types. Mol Cell Biol (1993) 1.09
Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines. Proc Natl Acad Sci U S A (1992) 1.08
Transmembrane signaling by a chimera of the Escherichia coli aspartate receptor and the human insulin receptor. Proc Natl Acad Sci U S A (1989) 1.08
Platelet-derived growth factor (PDGF) BB acts as a chemoattractant for human malignant mesothelioma cells via PDGF receptor beta-integrin alpha3beta1 interaction. Clin Exp Metastasis (1998) 1.08
Angiotensin II induces delayed mitogenesis and cellular proliferation in rat aortic smooth muscle cells. Correlation with the expression of specific endogenous growth factors and reversal by suramin. J Clin Invest (1994) 1.08
Development and postnatal regulation of adult myoblasts. Microsc Res Tech (1995) 1.07
Testicular development involves the spatiotemporal control of PDGFs and PDGF receptors gene expression and action. J Cell Biol (1995) 1.07
Isolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epithelium. Mol Cell Biol (1990) 1.02
Repression of platelet-derived growth factor beta-receptor expression by mitogenic growth factors and transforming oncogenes in murine 3T3 fibroblasts. Mol Cell Biol (1995) 1.01
Expressions of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes are stimulated by recombinant platelet-derived growth factor isomers. Proc Natl Acad Sci U S A (1991) 1.01
Oncostatin M is a mitogen for rabbit vascular smooth muscle cells. Proc Natl Acad Sci U S A (1993) 0.98
The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction. Mol Cell Biol (1991) 0.98
Expression of two different forms of fibroblast growth factor receptor 1 in different mouse tissues and cell lines. Proc Natl Acad Sci U S A (1991) 0.98
Lymphoid cells transformed by Abelson virus require the v-abl protein-tyrosine kinase only during early G1. Proc Natl Acad Sci U S A (1992) 0.97
Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein. EMBO J (1992) 0.96
Protein kinase C regulates the stimulated accumulation of 3-phosphorylated phosphoinositides in platelets. Biochem J (1991) 0.94
Differential effects of carboxy-terminal sequence deletions on platelet-derived growth factor receptor signaling activities and interactions with cellular substrates. Mol Cell Biol (1992) 0.93
The N-terminal 34 residues of the 55 kDa regulatory subunits of phosphoinositide 3-kinase interact with tubulin. Biochem J (2000) 0.92
Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with phosphatidylinositol 3-kinase in rat heart. Biochem J (1995) 0.91
Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells. World J Gastroenterol (2005) 0.91
PDGF upregulates Mcl-1 through activation of β-catenin and HIF-1α-dependent signaling in human prostate cancer cells. PLoS One (2012) 0.89
Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation. Mol Cell Biol (1992) 0.88
Enhancement of dedifferentiation and myoid differentiation of retinal pigment epithelial cells by platelet derived growth factor. Br J Ophthalmol (2000) 0.88
Interrupting autocrine ligand-receptor binding: comparison between receptor blockers and ligand decoys. Biophys J (1992) 0.87
Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling. J Clin Invest (1993) 0.87
Putting together structures of epidermal growth factor receptors. Curr Opin Struct Biol (2014) 0.86
Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src. Mol Cell Biol (1990) 0.86
Platelet-derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects. J Clin Invest (1993) 0.85
Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling. J Cell Biol (1994) 0.85
Acute electrophysiological responses of bradykinin-stimulated human fibroblasts. J Physiol (1991) 0.84
Chimeras of the native form or achondroplasia mutant (G375C) of human fibroblast growth factor receptor 3 induce ligand-dependent differentiation of PC12 cells. Mol Cell Biol (1997) 0.84
Role of tyrosine kinase and protein kinase C in the steroidogenic actions of angiotensin II, alpha-melanocyte-stimulating hormone and corticotropin in the rat adrenal cortex. Biochem J (1995) 0.84
Molecular genetics of neurological tumours. J Med Genet (1992) 0.84
Green tea polyphenol epigallocatechin-3-gallate blocks PDGF-induced proliferation and migration of rat pancreatic stellate cells. World J Gastroenterol (2005) 0.84
Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo. Onco Targets Ther (2014) 0.83
Membrane-anchored form of v-sis/PDGF-B induces mitogenesis without detectable PDGF receptor autophosphorylation. J Cell Biol (1991) 0.83
Evaluation of enrichment techniques for mass spectrometry: identification of tyrosine phosphoproteins in cancer cells. J Mol Diagn (2007) 0.81
Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets. Proc Natl Acad Sci U S A (1990) 0.81
Ligand stimulation of transfected and endogenous growth factor receptors enhances cytokine production by mast cells. EMBO J (1991) 0.81
Mechanism of kinase activation in the receptor for colony-stimulating factor 1. Proc Natl Acad Sci U S A (1990) 0.81
Ca(2+)-channel blockers modulate expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and low density lipoprotein receptor genes stimulated by platelet-derived growth factor. Proc Natl Acad Sci U S A (1991) 0.81
Ligand regulation of a constitutively dimeric EGF receptor. Nat Commun (2015) 0.81
The v-sis oncoprotein loses transforming activity when targeted to the early Golgi complex. J Cell Biol (1994) 0.80
Retinoic acid suppresses the response to platelet-derived growth factor in human hepatic Ito-cell-like myofibroblasts: a post-receptor mechanism independent of raf/fos/jun/egr activation. Biochem J (1993) 0.80
Safety and efficacy of sunitinib in patients with unresectable pancreatic neuroendocrine tumors. Clin Med Insights Oncol (2012) 0.79
Changes in inositol lipids and phosphates after stimulation of the MAS-transfected NG115-401L-C3 cell line by mitogenic and non-mitogenic stimuli. Biochem J (1990) 0.78
Dual gene transfer of bFGF and PDGF in a single plasmid for the treatment of myocardial infarction. Exp Ther Med (2014) 0.78
Tyrosine phosphorylation in the human duodenum. Gut (1995) 0.77
Protein tyrosine phosphorylation and regulation of the receptor for platelet-activating factor in rat Kupffer cells. Effect of sodium vanadate. Biochem J (1992) 0.77
Receptor tyrosine kinase signaling: regulating neural crest development one phosphate at a time. Curr Top Dev Biol (2015) 0.77
Interactions of growth factor receptors with cytoplasmic signaling molecules. Cold Spring Harb Symp Quant Biol (1991) 0.75