Published in Open Biol on November 01, 2014
Aurora-A Kinase as a Promising Therapeutic Target in Cancer. Front Oncol (2016) 0.86
Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. Elife (2016) 0.78
New Auroras on the Roles of the Chromosomal Passenger Complex in Cytokinesis: Implications for Cancer Therapies. Front Oncol (2015) 0.78
Minimal model for collective kinetochore-microtubule dynamics. Proc Natl Acad Sci U S A (2015) 0.78
The selectivity of protein kinase inhibitors: a further update. Biochem J (2007) 15.73
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol (2003) 9.27
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol (2003) 8.32
Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma (1985) 6.17
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell (1995) 5.56
Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J Cell Biol (2001) 4.38
Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell (2003) 4.28
The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis. J Cell Biol (1987) 4.05
Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell (2007) 3.98
Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer (2010) 3.74
The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell (2004) 3.68
INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow. Curr Biol (2000) 3.55
Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Curr Biol (2000) 3.50
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol (2004) 3.49
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol Cell (2005) 3.14
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol (2001) 2.62
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56
Production of cyclic peptides and proteins in vivo. Proc Natl Acad Sci U S A (1999) 2.42
Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. J Biol Chem (2002) 2.40
Validating Aurora B as an anti-cancer drug target. J Cell Sci (2006) 2.30
INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. J Cell Biol (1998) 2.23
Protein trans-splicing by a split intein encoded in a split DnaE gene of Synechocystis sp. PCC6803. Proc Natl Acad Sci U S A (1998) 2.16
Molecular basis of drug resistance in aurora kinases. Chem Biol (2008) 2.03
Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J Biol Chem (2004) 1.97
Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase. J Med Chem (2007) 1.81
Modulation of intein activity by its neighboring extein substrates. Proc Natl Acad Sci U S A (2009) 1.39
Split-intein mediated circular ligation used in the synthesis of cyclic peptide libraries in E. coli. Nat Protoc (2007) 1.31
Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis. Mol Endocrinol (2006) 1.30
INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol (2009) 1.23
Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nat Chem Biol (2009) 1.19
Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development (2011) 1.15
Mitotic drivers--inhibitors of the Aurora B Kinase. Cancer Metastasis Rev (2009) 1.14
Structural requirements for the biosynthesis of backbone cyclic peptide libraries. Chem Biol (2001) 1.07
A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development. Hum Reprod (2011) 1.05
Zinc inhibition of protein trans-splicing and identification of regions essential for splicing and association of a split intein*. J Biol Chem (2001) 1.02
Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis. J Biol Chem (2010) 0.96
Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes. PLoS Genet (2014) 0.95
Use of inteins for the in vivo production of stable cyclic peptide libraries in E. coli. Methods Mol Biol (2003) 0.91
Crystal structure of human aurora B in complex with INCENP and VX-680. J Med Chem (2012) 0.87
Evolution of resistance to Aurora kinase B inhibitors in leukaemia cells. PLoS One (2012) 0.84