Published in Curr Biol on June 05, 2001
Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell (2003) 4.28
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev (2005) 3.88
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol (2004) 3.49
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. J Cell Biol (2003) 3.12
Chromosomal passengers: the four-dimensional regulation of mitotic events. Chromosoma (2004) 2.94
The 3Ms of central spindle assembly: microtubules, motors and MAPs. Nat Rev Mol Cell Biol (2009) 2.88
Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis. Genes Dev (2002) 2.77
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J (2003) 2.70
Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol (2009) 2.61
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. J Clin Invest (2004) 2.59
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56
Molecular requirements for kinetochore-associated microtubule formation in mammalian cells. Curr Biol (2006) 2.48
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. J Cell Biol (2004) 2.44
Cytokinesis in eukaryotes. Microbiol Mol Biol Rev (2002) 2.43
Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep (2006) 1.82
Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property. Mol Cell Biol (2005) 1.67
Survivin modulates microtubule dynamics and nucleation throughout the cell cycle. Mol Biol Cell (2006) 1.57
CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1. J Cell Biol (2003) 1.52
Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro. Cell Cycle (2011) 1.48
Expression of different survivin variants in gastric carcinomas: first clues to a role of survivin-2B in tumour progression. Br J Cancer (2002) 1.45
Differential requirements for survivin in hematopoietic cell development. Proc Natl Acad Sci U S A (2005) 1.43
Aurora B kinase activation requires survivin priming phosphorylation by PLK1. J Mol Cell Biol (2010) 1.43
The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis. Mol Biol Cell (2002) 1.33
Features of cardiomyocyte proliferation and its potential for cardiac regeneration. J Cell Mol Med (2008) 1.27
The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions. Mol Biol Cell (2007) 1.23
Aurora-B regulates RNA methyltransferase NSUN2. Mol Biol Cell (2007) 1.22
Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J Exp Med (2004) 1.22
Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells. Biochem J (2005) 1.20
The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol Biol Cell (2009) 1.15
Yes-associated protein regulates the hepatic response after bile duct ligation. Hepatology (2012) 1.15
Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Nucleic Acids Res (2002) 1.15
Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival. Am J Pathol (2004) 1.13
Heterochromatin protein 1alpha: a hallmark of cell proliferation relevant to clinical oncology. EMBO Mol Med (2009) 1.12
Phosphorylation at serine 331 is required for Aurora B activation. J Cell Biol (2011) 1.10
A small C-terminal sequence of Aurora B is responsible for localization and function. Mol Biol Cell (2004) 1.07
A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc Natl Acad Sci U S A (2009) 1.06
PRC1 cooperates with CLASP1 to organize central spindle plasticity in mitosis. J Biol Chem (2009) 1.06
Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs. Br J Cancer (2010) 1.03
Targeting survivin and p53 in pediatric acute lymphoblastic leukemia. Leukemia (2011) 1.03
Schizosaccharomyces pombe Bir1p, a nuclear protein that localizes to kinetochores and the spindle midzone, is essential for chromosome condensation and spindle elongation during mitosis. Genetics (2002) 1.03
Localization, dynamics, and function of survivin revealed by expression of functional survivinDsRed fusion proteins in the living cell. Mol Biol Cell (2003) 1.02
RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo. Neuro Oncol (2011) 0.99
The localization of inner centromeric protein (INCENP) at the cleavage furrow is dependent on Kif12 and involves interactions of the N terminus of INCENP with the actin cytoskeleton. Mol Biol Cell (2007) 0.99
Knockdown of cyclin-dependent kinase inhibitors induces cardiomyocyte re-entry in the cell cycle. J Biol Chem (2011) 0.99
A Bir1p Sli15p kinetochore passenger complex regulates septin organization during anaphase. Mol Biol Cell (2007) 0.97
3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin. Cancer Prev Res (Phila) (2009) 0.95
Perturbation of Incenp function impedes anaphase chromatid movements and chromosomal passenger protein flux at centromeres. Chromosoma (2008) 0.94
Breast tumor subgroups reveal diverse clinical prognostic power. Sci Rep (2014) 0.92
A novel role for the CBF3 kinetochore-scaffold complex in regulating septin dynamics and cytokinesis. J Cell Biol (2005) 0.92
A single amino acid change (Asp 53 --> Ala53) converts Survivin from anti-apoptotic to pro-apoptotic. Mol Biol Cell (2003) 0.90
Enhanced tumor suppression in vitro and in vivo by co-expression of survivin-specific siRNA and wild-type p53 protein. Cancer Gene Ther (2010) 0.90
EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B. J Cell Biol (2014) 0.89
Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development. Am J Pathol (2010) 0.88
Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers. J Interferon Cytokine Res (2009) 0.86
Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome. J Autoimmune Dis (2007) 0.86
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen. J Cancer Res Clin Oncol (2010) 0.86
Terameprocol (tetra-O-methyl nordihydroguaiaretic acid), an inhibitor of Sp1-mediated survivin transcription, induces radiosensitization in non-small cell lung carcinoma. J Thorac Oncol (2011) 0.84
Survivin antisense compound inhibits proliferation and promotes apoptosis in liver cancer cells. World J Gastroenterol (2005) 0.83
Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone. Semin Cell Dev Biol (2010) 0.83
Kaposi's sarcoma-associated herpesvirus-encoded LANA contributes to viral latent replication by activating phosphorylation of survivin. J Virol (2014) 0.82
Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis. Blood (2006) 0.82
Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex. Biochemistry (2009) 0.79
Bifunctional roles of survivin-ΔEx3 and survivin-2B for susceptibility to apoptosis in endometrial carcinomas. J Cancer Res Clin Oncol (2014) 0.79
Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53. Mol Cancer (2014) 0.79
TAT-IL-24-KDEL-induced apoptosis is inhibited by survivin but restored by the small molecular survivin inhibitor, YM155, in cancer cells. Oncotarget (2016) 0.78
Inhibition of caspase-3 by Survivin prevents Wee1 Kinase degradation and promotes cell survival by maintaining phosphorylation of p34Cdc2. Gene Ther Mol Biol (2009) 0.78
The functional repertoire of survivin's tails. Cell Cycle (2015) 0.78
Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo. Open Biol (2014) 0.78
Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis. BMC Genomics (2015) 0.78
The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic. Front Cell Dev Biol (2015) 0.77
Aurora B but not rho/MLCK signaling is required for localization of diphosphorylated myosin II regulatory light chain to the midzone in cytokinesis. PLoS One (2013) 0.76
High chromosome number in hematological cancer cell lines is a negative predictor of response to the inhibition of Aurora B and C by GSK1070916. J Transl Med (2011) 0.75
Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis. Neural Regen Res (2012) 0.75
An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes. Front Microbiol (2014) 0.75
Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. PLoS One (2017) 0.75
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (1994) 10.22
Structure and function in the nucleus. Science (1998) 6.26
Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma (1985) 6.17
Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol (2001) 5.09
Topoisomerase II is a structural component of mitotic chromosome scaffolds. J Cell Biol (1985) 5.00
Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J Cell Biol (1987) 4.50
Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J Cell Biol (2001) 4.38
CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J (1991) 4.22
The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis. J Cell Biol (1987) 4.05
DNA arrangement in isometric phage heads. Nature (1977) 3.98
DNA packaging by the double-stranded DNA bacteriophages. Cell (1980) 3.92
CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. Cell (1992) 3.70
The centromere: hub of chromosomal activities. Science (1995) 3.64
Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres. Curr Biol (1997) 3.62
INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow. Curr Biol (2000) 3.55
Induction of apoptosis by cancer chemotherapy. Exp Cell Res (2000) 3.51
Localization of topoisomerase II in mitotic chromosomes. J Cell Biol (1985) 3.35
Formation of spindle poles by dynein/dynactin-dependent transport of NuMA. J Cell Biol (2000) 3.23
ScII: an abundant chromosome scaffold protein is a member of a family of putative ATPases with an unusual predicted tertiary structure. J Cell Biol (1994) 2.98
Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci U S A (1995) 2.89
CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase. J Cell Biol (1994) 2.86
Two distinct pathways leading to nuclear apoptosis. J Exp Med (2000) 2.84
Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. J Cell Sci (2001) 2.82
Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110. EMBO J (1999) 2.79
Architecture of metaphase chromosomes and chromosome scaffolds. J Cell Biol (1983) 2.61
A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis. J Cell Biol (1998) 2.55
CENP-B: a major human centromere protein located beneath the kinetochore. J Cell Biol (1990) 2.55
Chromatin-associated protein phosphatase 1 regulates aurora-B and histone H3 phosphorylation. J Biol Chem (2001) 2.54
The kinetochore is part of the metaphase chromosome scaffold. J Cell Biol (1984) 2.51
Chromosomal proteins and cytokinesis: patterns of cleavage furrow formation and inner centromere protein positioning in mitotic heterokaryons and mid-anaphase cells. J Cell Biol (1997) 2.50
High titers of autoantibodies to topoisomerase I (Scl-70) in sera from scleroderma patients. Science (1986) 2.50
Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis. J Cell Biol (1993) 2.48
Injection of anticentromere antibodies in interphase disrupts events required for chromosome movement at mitosis. J Cell Biol (1990) 2.46
Modulation of cell death by Bcl-XL through caspase interaction. Proc Natl Acad Sci U S A (1998) 2.42
cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment. Proc Natl Acad Sci U S A (1988) 2.38
Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle. Proc Natl Acad Sci U S A (1988) 2.34
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci U S A (1996) 2.31
Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells. Dev Cell (2001) 2.30
INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. J Cell Biol (1998) 2.23
Topoisomerase II: A specific marker for cell proliferation. J Cell Biol (1986) 2.22
The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. Chromosoma (1998) 2.18
Caspases and caspase inhibitors. Trends Biochem Sci (1997) 2.17
Assembly of nucleosomes: the reaction involving X. laevis nucleoplasmin. Cell (1980) 2.12
Clinical associations of anticentromere antibodies and antibodies to topoisomerase I. A study of 355 patients. Arthritis Rheum (1988) 2.06
Three related centromere proteins are absent from the inactive centromere of a stable isodicentric chromosome. Chromosoma (1985) 2.04
Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase. Chromosoma (1997) 2.03
Identification of overlapping DNA-binding and centromere-targeting domains in the human kinetochore protein CENP-C. Mol Cell Biol (1996) 1.99
The structural organization of DNA packaged within the heads of T4 wild-type, isometric and giant bacteriophages. Cell (1978) 1.99
Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity. J Cell Sci (1993) 1.90
Mitotic chromatin condensation in vitro using somatic cell extracts and nuclei with variable levels of endogenous topoisomerase II. J Cell Biol (1990) 1.88
Disruption of centromere assembly during interphase inhibits kinetochore morphogenesis and function in mitosis. Cell (1991) 1.85
Identification of a subdomain of CENP-B that is necessary and sufficient for localization to the human centromere. J Cell Biol (1992) 1.81
Antiperinuclear factor and keratin antibodies in rheumatoid arthritis. Ann Rheum Dis (1981) 1.79
Structure of the human centromere at metaphase. Trends Biochem Sci (1990) 1.74
Down-regulation of HP1Hsalpha expression is associated with the metastatic phenotype in breast cancer. Cancer Res (2000) 1.66
The SMC proteins and the coming of age of the chromosome scaffold hypothesis. Bioessays (1995) 1.64
Molecular analysis of the INCENPs (inner centromere proteins): separate domains are required for association with microtubules during interphase and with the central spindle during anaphase. J Cell Biol (1993) 1.63
Characterization of neo-centromeres in marker chromosomes lacking detectable alpha-satellite DNA. Hum Mol Genet (1997) 1.60
Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. J Cell Sci (1998) 1.59
INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow. Exp Cell Res (2001) 1.59
Nucleosome assembly. Nature (1980) 1.56
Cleavage furrows formed between centrosomes lacking an intervening spindle and chromosomes contain microtubule bundles, INCENP, and CHO1 but not CENP-E. Mol Biol Cell (1999) 1.51
Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. Chromosoma (2001) 1.50
Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes. Hum Mol Genet (2000) 1.50
ICE-related proteases in apoptosis. Curr Opin Genet Dev (1996) 1.48
Activation of multiple interleukin-1beta converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis. J Biol Chem (1997) 1.46
Transmission of a fully functional human neocentromere through three generations. Am J Hum Genet (1999) 1.38
Compartmentalization within the nucleus: discovery of a novel subnuclear region. J Cell Biol (1991) 1.37
The structure and dynamics of ring chromosomes in human neoplastic and non-neoplastic cells. Hum Genet (1999) 1.31
Anti-topoisomerase II recognizes meiotic chromosome cores. Chromosoma (1989) 1.28
Functional complementation of a genetic deficiency with human artificial chromosomes. Am J Hum Genet (2001) 1.26
Further evidence that CENP-C is a necessary component of active centromeres: studies of a dic(X; 15) with simultaneous immunofluorescence and FISH. Hum Mol Genet (1995) 1.26
Direct and indirect association of the small GTPase ran with nuclear pore proteins and soluble transport factors: studies in Xenopus laevis egg extracts. Mol Biol Cell (1996) 1.25
Untangling the role of DNA topoisomerase II in mitotic chromosome structure and function. Bioessays (1997) 1.24
Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B. Proc Natl Acad Sci U S A (1987) 1.20
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions. Blood (1997) 1.20
Hereditary antithrombin III deficiency. Effect of antithrombin III deficiency on platelet function. Am J Med (1976) 1.20
Improving tuberculosis contact tracing: the role of evaluations in the home and workplace. Int J Tuberc Lung Dis (2012) 1.19
Molecular mechanism in the formation of a human ring chromosome 21. Proc Natl Acad Sci U S A (1989) 1.19
The distal half of the tail fibre of bacteriophage T4. Rigidly linked domains and cross-beta structure. J Mol Biol (1979) 1.19
In vivo phosphorylation of the 170-kDa form of eukaryotic DNA topoisomerase II. Cell cycle analysis. J Biol Chem (1989) 1.14
Partial deletion of alpha satellite DNA associated with reduced amounts of the centromere protein CENP-B in a mitotically stable human chromosome rearrangement. Mol Cell Biol (1990) 1.14
Surprising deficiency of CENP-B binding sites in African green monkey alpha-satellite DNA: implications for CENP-B function at centromeres. Mol Cell Biol (1996) 1.13
Neutralization of low molecular weight heparin by polybrene prevents thromboxane release and severe pulmonary hypertension in awake sheep. Circulation (1990) 1.12
The size of the bacteriophage T4 head in solution with comments about the dimension of virus particles as visualized by electron microscopy. J Mol Biol (1978) 1.11
Apparent caspase independence of programmed cell death in Dictyostelium. Curr Biol (1998) 1.09
Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis. J Biol Chem (1999) 1.09
DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution. Curr Biol (2000) 1.08
Comparison of paclitaxel-, 5-fluoro-2'-deoxyuridine-, and epidermal growth factor (EGF)-induced apoptosis. Evidence for EGF-induced anoikis. J Biol Chem (1999) 1.08
A dynamic connection between centromeres and ND10 proteins. J Cell Sci (1999) 1.07
Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression. Exp Cell Res (1999) 1.06
CAD/DFF40 nuclease is dispensable for high molecular weight DNA cleavage and stage I chromatin condensation in apoptosis. J Biol Chem (2001) 1.05
Mapping DNA within the mammalian kinetochore. J Cell Biol (1993) 1.03
Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution. J Cell Biol (1998) 1.03
Centromeres: old tales and new tools. FEBS Lett (2008) 1.03
Intranasally delivered siRNA targeting PI3K/Akt/mTOR inflammatory pathways protects from aspergillosis. Mucosal Immunol (2009) 1.03
Predictors of delayed sputum smear and culture conversion among a Portuguese population with pulmonary tuberculosis. Rev Port Pneumol (2012) 1.02