The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.

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Published in PLoS One on November 20, 2014

Authors

Nanda Kumar Sasi1, Kanchan Tiwari2, Fen-Fen Soon3, Dorine Bonte2, Tong Wang4, Karsten Melcher5, H Eric Xu3, Michael Weinreich2

Author Affiliations

1: Laboratory of Genome Integrity and Tumorigenesis, Van Andel Research Institute (VARI), Grand Rapids, MI, United States of America; Graduate Program in Genetics, Michigan State University, East Lansing, MI, United States of America.
2: Laboratory of Genome Integrity and Tumorigenesis, Van Andel Research Institute (VARI), Grand Rapids, MI, United States of America.
3: Laboratory of Structural Sciences, VARI, Grand Rapids, MI, United States of America.
4: Translational Drug Development, Inc. (TD2), Scottsdale, AZ, United States of America.
5: Laboratory of Structural Biology and Biochemistry, VARI, Grand Rapids, MI, United States of America.

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