Published in Genes Dev on June 15, 2010
Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell (2011) 2.54
Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases. Cell (2011) 2.40
ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37
Regulated eukaryotic DNA replication origin firing with purified proteins. Nature (2015) 2.07
Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast. EMBO J (2011) 1.94
Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature (2010) 1.86
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Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res (2011) 1.78
Temporospatial coordination of meiotic DNA replication and recombination via DDK recruitment to replisomes. Cell (2014) 1.74
Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication. Science (2014) 1.69
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A (2012) 1.55
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DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome. Elife (2014) 1.40
Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J Cell Biol (2011) 1.37
Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation. EMBO J (2012) 1.37
Helicase activation and establishment of replication forks at chromosomal origins of replication. Cold Spring Harb Perspect Biol (2013) 1.32
Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast. Genes Dev (2012) 1.29
Mechanisms for initiating cellular DNA replication. Annu Rev Biochem (2013) 1.28
Helicase loading at chromosomal origins of replication. Cold Spring Harb Perspect Biol (2013) 1.26
Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases. EMBO J (2011) 1.25
Genomic instability in cancer. Cold Spring Harb Perspect Biol (2013) 1.23
Location, location, location: it's all in the timing for replication origins. Genes Dev (2013) 1.23
Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function. Genes Dev (2014) 1.22
Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev (2012) 1.17
Cdc45 is a critical effector of myc-dependent DNA replication stress. Cell Rep (2013) 1.16
A conserved MCM single-stranded DNA binding element is essential for replication initiation. Elife (2014) 1.15
Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. EMBO J (2012) 1.15
Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment. Mol Cell (2013) 1.14
Replication timing and its emergence from stochastic processes. Trends Genet (2012) 1.12
A role for H2B ubiquitylation in DNA replication. Mol Cell (2012) 1.11
Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity. Cell Rep (2014) 1.11
Highly organized DnaA-oriC complexes recruit the single-stranded DNA for replication initiation. Nucleic Acids Res (2011) 1.10
Origin plasticity during budding yeast DNA replication in vitro. EMBO J (2014) 1.08
Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase. Mol Cell (2015) 1.08
Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate. Nat Commun (2016) 1.04
Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase. Cell Rep (2015) 1.03
Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated. Chromosoma (2014) 1.03
Impediments to replication fork movement: stabilisation, reactivation and genome instability. Chromosoma (2013) 1.02
Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat Struct Mol Biol (2013) 1.01
The Cdc45·Mcm2-7·GINS protein complex in trypanosomes regulates DNA replication and interacts with two Orc1-like proteins in the origin recognition complex. J Biol Chem (2011) 1.00
Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast. EMBO J (2011) 1.00
The level of origin firing inversely affects the rate of replication fork progression. J Cell Biol (2013) 1.00
ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress. Genes Dev (2013) 0.98
Analysis of the crystal structure of an active MCM hexamer. Elife (2014) 0.98
New insights into replisome fluidity during chromosome replication. Trends Biochem Sci (2012) 0.98
Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation. EMBO J (2016) 0.97
Retracted The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly. J Biol Chem (2014) 0.96
Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress. J Biol Chem (2013) 0.96
Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex. J Biol Chem (2011) 0.95
Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA. J Biol Chem (2011) 0.95
Quantitative proteomic analysis of chromatin reveals that Ctf18 acts in the DNA replication checkpoint. Mol Cell Proteomics (2011) 0.94
Regulation of the cell division cycle in Trypanosoma brucei. Eukaryot Cell (2012) 0.94
The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Mol Biol Cell (2013) 0.94
Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex. Proc Natl Acad Sci U S A (2012) 0.93
Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. J Biol Chem (2011) 0.93
High-resolution replication profiles define the stochastic nature of genome replication initiation and termination. Cell Rep (2013) 0.93
Regulation and roles of Cdc7 kinase under replication stress. Cell Cycle (2014) 0.92
DNA replication and homologous recombination factors: acting together to maintain genome stability. Chromosoma (2013) 0.92
DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast. Mol Biol Cell (2012) 0.92
DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding. Nucleic Acids Res (2013) 0.92
Rif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome. PLoS One (2014) 0.91
The CRL2LRR-1 ubiquitin ligase regulates cell cycle progression during C. elegans development. Development (2010) 0.91
Crystal structure of human CDC7 kinase in complex with its activator DBF4. Nat Struct Mol Biol (2012) 0.91
Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase. Proc Natl Acad Sci U S A (2015) 0.91
Defining the replication program through the chromatin landscape. Crit Rev Biochem Mol Biol (2011) 0.89
RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans. G3 (Bethesda) (2016) 0.89
RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells. Cell Cycle (2015) 0.89
Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob. J Biol Chem (2012) 0.89
Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. Mol Cell (2014) 0.89
Mcm10 coordinates the timely assembly and activation of the replication fork helicase. Nucleic Acids Res (2015) 0.88
"The Octet": Eight Protein Kinases that Control Mammalian DNA Replication. Front Physiol (2012) 0.88
Comparison of luminescence ADP production assay and radiometric scintillation proximity assay for Cdc7 kinase. Comb Chem High Throughput Screen (2011) 0.88
Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase. J Biol Chem (2015) 0.86
Analysis of model replication origins in Drosophila reveals new aspects of the chromatin landscape and its relationship to origin activity and the prereplicative complex. Mol Biol Cell (2011) 0.86
Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance. PLoS Genet (2011) 0.86
Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA. Cell Cycle (2016) 0.85
Novel insights into maintaining genomic integrity: Wee1 regulating Mus81/Eme1. Cell Div (2011) 0.85
Different nucleosomal architectures at early and late replicating origins in Saccharomyces cerevisiae. BMC Genomics (2014) 0.85
DNA replication origin function is promoted by H3K4 di-methylation in Saccharomyces cerevisiae. Genetics (2012) 0.85
Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage. J Biol Chem (2014) 0.85
p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress. Cell Cycle (2016) 0.85
Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1. Open Biol (2014) 0.85
DNA replication: mammalian Treslin-TopBP1 interaction mirrors yeast Sld3-Dpb11. Curr Biol (2011) 0.84
DNA replication checkpoint signaling depends on a Rad53-Dbf4 N-terminal interaction in Saccharomyces cerevisiae. Genetics (2013) 0.84
Efficient initiation of DNA replication in eukaryotes requires Dpb11/TopBP1-GINS interaction. Mol Cell Biol (2013) 0.84
Interaction between human Ctf4 and the Cdc45/Mcm2-7/GINS (CMG) replicative helicase. Proc Natl Acad Sci U S A (2013) 0.83
Mechanism of cancer cell death induced by depletion of an essential replication regulator. PLoS One (2012) 0.83
CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans. J Cell Biol (2014) 0.83
Retracted The Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase. J Biol Chem (2015) 0.82
The chromatin backdrop of DNA replication: lessons from genetics and genome-scale analyses. Biochim Biophys Acta (2012) 0.82
Do replication forks control late origin firing in Saccharomyces cerevisiae? Nucleic Acids Res (2011) 0.82
Quantitative BrdU immunoprecipitation method demonstrates that Fkh1 and Fkh2 are rate-limiting activators of replication origins that reprogram replication timing in G1 phase. Genome Res (2016) 0.82
Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells. Nat Commun (2016) 0.82
The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One (2014) 0.81
DNA replication and spindle checkpoints cooperate during S phase to delay mitosis and preserve genome integrity. J Cell Biol (2014) 0.81
Three wise centromere functions: see no error, hear no break, speak no delay. EMBO Rep (2013) 0.81
Building a double hexamer of DNA helicase at eukaryotic replication origins. EMBO J (2011) 0.80
CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat Commun (2015) 0.80
The Role of the Transcriptional Response to DNA Replication Stress. Genes (Basel) (2017) 0.79
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GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol (2006) 6.36
Uninterrupted MCM2-7 function required for DNA replication fork progression. Science (2000) 6.27
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