Screening of phosphatidylinositol kinase inhibitors from Streptomyces.

PubWeight™: 0.85‹?›

🔗 View Article (PMID 2542210)

Published in J Antibiot (Tokyo) on May 01, 1989

Authors

H Nishioka1, M Imoto, T Sawa, M Hamada, H Naganawa, T Takeuchi, K Umezawa

Author Affiliations

1: Institute of Microbial Chemistry, Tokyo, Japan.

Articles by these authors

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release (2000) 14.89

Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci (1995) 6.36

Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene. EMBO J (1985) 5.47

ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury. Mol Microbiol (1997) 4.94

Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections. J Infect Dis (2001) 4.06

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest (1999) 3.86

Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities. Eur J Biochem (1985) 3.76

New antibiotics, bleomycin A and B. J Antibiot (Tokyo) (1966) 3.58

Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S. Infect Immun (1997) 3.49

Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis. Cancer Res (2000) 3.32

Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene (2007) 3.11

Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. J Clin Invest (1999) 2.67

Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo) (2000) 2.64

Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo) (1970) 2.52

Ludloff's medial approach for open reduction of congenital dislocation of the hip. A 20-year follow-up. J Bone Joint Surg Br (1996) 2.45

Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. J Control Release (2001) 2.44

Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease. Arthritis Rheum (2001) 2.28

Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan Thoracic Oncology Group trial (WJTOG0403). Br J Cancer (2008) 2.19

Letter: Two beta-lactamase inhibitors produced by a streptomyces. J Antibiot (Tokyo) (1973) 2.16

Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice. Nucleic Acids Res (1990) 2.13

Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis (2008) 2.11

Fetal Minamata disease. A neuropathological study of two cases of intrauterine intoxication by a methyl mercury compound. J Neuropathol Exp Neurol (1965) 2.05

Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis: RRR (remission induction by Remicade in RA) study. Ann Rheum Dis (2010) 2.04

Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin. Aliment Pharmacol Ther (2014) 2.03

The effect of coronary vasospasm on the direction of ST-segment deviation in patients with both hypertrophic cardiomyopathy and vasospastic angina. Chest (2000) 2.01

Role of alveolar macrophages in initiation and regulation of inflammation in Pseudomonas aeruginosa pneumonia. Infect Immun (1998) 1.92

Analyis of met-form haemoglobins in human erythrocytes of normal adults and of a patient with hereditary methaemoglobinaemia due to deficiency of NADH-cytochrome b5 reductase. Biochem J (1979) 1.88

Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus. Mol Cell Biol (1986) 1.87

Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation. J Biol Chem (2001) 1.80

Effect of pepstatin on acid proteases. J Antibiot (Tokyo) (1971) 1.75

Appendiceal mucocele with concomitant colonic cancer. Report of two cases. Dis Colon Rectum (1996) 1.69

Targeting mechanisms of Pseudomonas aeruginosa pathogenesis. Med Mal Infect (2006) 1.68

Interleukin-6 is a useful marker for early prediction of the severity of acute pancreatitis. Pancreas (1997) 1.68

SINEs and LINEs share common 3' sequences: a review. Gene (1997) 1.67

Pathological changes observed in the finger biopsy of patients with vibration-induced white finger. Scand J Work Environ Health (1986) 1.67

Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. J Clin Invest (1997) 1.67

Nestin expression in the kidney with an obstructed ureter. Kidney Int (2007) 1.66

Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J Antibiot (Tokyo) (1976) 1.66

Treatment of peritoneal dissemination from gastric cancer by peritonectomy and chemohyperthermic peritoneal perfusion. Br J Surg (2005) 1.65

Melanin production in cultured albino melanocytes transfected with mouse tyrosinase cDNA. Jpn J Genet (1989) 1.61

A clinical study of lectin-reactive alpha-fetoprotein as an early indicator of hepatocellular carcinoma in the follow-up of cirrhotic patients. Hepatology (1995) 1.57

Nodal cytotoxic lymphoma spectrum: a clinicopathologic study of 66 patients. Am J Surg Pathol (1999) 1.55

Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene. Development (1990) 1.55

Biopsy of labial salivary glands and lacrimal glands in the diagnosis of Sjögren's syndrome. J Rheumatol (1996) 1.55

Isolation of a cDNA clone encoding pancreatic polypeptide. Proc Natl Acad Sci U S A (1985) 1.54

Left ventricular hypertrophy precedes other target-organ damage in primary aldosteronism. Hypertension (1997) 1.51

A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation. Nat Cell Biol (2001) 1.51

Letter: A thermolysin inhibitor produced by Actinomycetes: phospholamidon. J Antibiot (Tokyo) (1973) 1.50

Gastrointestinal stromal tumors of the small intestine that expressed c-kit protein. Intern Med (2000) 1.49

Studies on bleomycin. Cancer (1967) 1.49

Characteristic sequences in the upstream region of the human tyrosinase gene. Biochim Biophys Acta (1989) 1.47

The 3' ends of tRNA-derived short interspersed repetitive elements are derived from the 3' ends of long interspersed repetitive elements. Mol Cell Biol (1996) 1.47

Pigmented squamous cell carcinoma of the scrotum associated with a lentigo. Br J Dermatol (1999) 1.46

Induction of suppression following autologous mixed lymphocyte reaction; role of a novel 2H4 antigen. Eur J Immunol (1987) 1.46

A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody. J Clin Invest (1987) 1.46

Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase. J Med Chem (1997) 1.45

Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells. J Biol Chem (1999) 1.45

The progression of retinopathy of prematurity and fluctuation in blood gas tension. Graefes Arch Clin Exp Ophthalmol (1993) 1.44

Letter: Kanamycin phosphotransferase. I. Mechanism of cross resistance between kanamycin and lividomycin. J Antibiot (Tokyo) (1973) 1.44

The effect of small amounts of alcohol on the clinical course of chronic pancreatitis. Mayo Clin Proc (2001) 1.43

Differences in genomic DNA sequences between pathogenic and nonpathogenic isolates of Entamoeba histolytica identified by polymerase chain reaction. J Clin Microbiol (1991) 1.40

Nosocomial pneumonia likely caused by Stenotrophomonas maltophilia in two patients with polymyositis. Intern Med (1999) 1.39

Anomalous aortic origin of the left anterior descending coronary artery with dilated cardiomyopathy. Cathet Cardiovasc Diagn (1990) 1.39

Nitrosothiol formation catalyzed by ceruloplasmin. Implication for cytoprotective mechanism in vivo. J Biol Chem (1999) 1.39

Intraperitoneal free cancer cells and their viability in gastric cancer. Cancer (1979) 1.39

Analysis of loss of heterozygosity in small adenocarcinomas of the lung. Jpn J Clin Oncol (1998) 1.38

Multinucleated giant cells in submucosal layer of human urinary bladder: an immunohistochemical and electron microscopic study. Pathol Res Pract (2000) 1.38

Isolated congenital left ventricular diverticulum in an adult. A case report. Angiology (1994) 1.37

Biological activities of analogues of lipid A based chemically on the revised structural model. Comparison of mediator-inducing, immunomodulating and endotoxic activities. Eur J Biochem (1984) 1.37

A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine----serine substitution at position 85. Eur J Biochem (1990) 1.37

Etiologic factors of myelopathy. A radiographic evaluation of the aging changes in the cervical spine. Clin Orthop Relat Res (1987) 1.37

Breast cancer risk factors according to combined estrogen and progesterone receptor status: a case-control analysis. Am J Epidemiol (1997) 1.37

Activity and toxicity of bleomycin. J Antibiot (Tokyo) (1967) 1.35

Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage. J Cereb Blood Flow Metab (1999) 1.35

Therapeutic administration of anti-PcrV F(ab')(2) in sepsis associated with Pseudomonas aeruginosa. J Immunol (2001) 1.35

Inhibition of tumorigenesis in mouse skin by leupeptin, a protease inhibitor from Actinomycetes. Cancer Res (1972) 1.34

Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice. Gut (2004) 1.34

Orientation of erythrocytes in a strong static magnetic field. Blood (1993) 1.34

Sarcomatoid carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical analysis of 14 patients. Hum Pathol (2000) 1.34

Migrastatin, a novel 14-membered lactone from Streptomyces sp. MK929-43F1. J Antibiot (Tokyo) (2000) 1.33

Mapping soil-transmitted helminths in Southeast Asia and implications for parasite control. Southeast Asian J Trop Med Public Health (2003) 1.30

Leupeptins, new protease inhibitors from Actinomycetes. J Antibiot (Tokyo) (1969) 1.29

Serum levels of ifn-inducible PROTEIN-10 relating to the activity of systemic lupus erythematosus. Cytokine (2000) 1.29

Frameshift mutation, A263fsinsGG, in the hepatocyte nuclear factor-1beta gene associated with diabetes and renal dysfunction. Diabetes (1998) 1.29

Light harvesting in photosystems I and II. Biochem Soc Trans (1993) 1.29

Non-Alzheimer non-Pick dementia with Fahr's syndrome. Clin Neuropathol (1992) 1.28

A novel monoclonal antibody (OPD4) recognizing a helper/inducer T cell subset. Its application to paraffin-embedded tissues. Am J Pathol (1989) 1.28

KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1. J Clin Invest (1998) 1.27

Biological activity of pepstatins, pepstanone A and partial peptides on pepsin, cathepsin D and renin. J Antibiot (Tokyo) (1972) 1.26

Involvement of heterotrimeric GTP-binding protein and rho protein, but not protein kinase C, in agonist-induced Ca2+ sensitization of skinned muscle of guinea pig vas deferens. J Pharmacol Exp Ther (1995) 1.26

Effect of beta-blockers on circulating levels of inflammatory and anti-inflammatory cytokines in patients with dilated cardiomyopathy. J Am Coll Cardiol (2001) 1.26

Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod (1990) 1.26