Published in Diabetes on August 01, 1998
Mutations in hepatocyte nuclear factor-1beta and their related phenotypes. J Med Genet (2005) 2.24
A transcriptional network in polycystic kidney disease. EMBO J (2004) 2.21
The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. J Clin Invest (2005) 1.78
Lack of TCF2/vHNF1 in mice leads to pancreas agenesis. Proc Natl Acad Sci U S A (2005) 1.74
Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice. J Clin Invest (2004) 1.67
Mutations in the hepatocyte nuclear factor-1beta gene are associated with familial hypoplastic glomerulocystic kidney disease. Am J Hum Genet (2000) 1.64
Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. Proc Natl Acad Sci U S A (2001) 1.46
vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain. Genes Dev (2001) 1.45
Learning from molecular genetics: novel insights arising from the definition of genes for monogenic and type 2 diabetes. Diabetes (2008) 1.31
HNF1B mutations associate with hypomagnesemia and renal magnesium wasting. J Am Soc Nephrol (2009) 1.29
Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line. Nucleic Acids Res (2004) 1.22
The mutated human gene encoding hepatocyte nuclear factor 1beta inhibits kidney formation in developing Xenopus embryos. Proc Natl Acad Sci U S A (2000) 1.16
HNF1B-associated renal and extra-renal disease-an expanding clinical spectrum. Nat Rev Nephrol (2014) 1.09
Hepatic phenotypes of HNF1B gene mutations: a case of neonatal cholestasis requiring portoenterostomy and literature review. World J Gastroenterol (2015) 0.93
Hepatocyte Nuclear Factor 1β-Associated Kidney Disease: More than Renal Cysts and Diabetes. J Am Soc Nephrol (2015) 0.90
Retroviral-mediated Insertional Mutagenesis in Zebrafish. Methods Cell Biol (2011) 0.83
Clinical translation of genetic predictors for type 2 diabetes. Curr Opin Endocrinol Diabetes Obes (2009) 0.81
Genetic Counseling for Diabetes Mellitus. Curr Genet Med Rep (2014) 0.79
HNF1B-associated clinical phenotypes: the kidney and beyond. Pediatr Nephrol (2015) 0.79
Identification and Functional Characterization of P159L Mutation in HNF1B in a Family with Maturity-Onset Diabetes of the Young 5 (MODY5). Genomics Inform (2014) 0.78
Heat-shock mediated overexpression of HNF1β mutations has differential effects on gene expression in the Xenopus pronephric kidney. PLoS One (2012) 0.77
Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology. F1000Res (2016) 0.75
Hepatocyte nuclear factor-1β: A regulator of kidney development and cystogenesis. Indian J Nephrol (2015) 0.75
Models for the specific adhesion of cells to cells. Science (1978) 28.03
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83
Polymorphic DNA region adjacent to the 5' end of the human insulin gene. Proc Natl Acad Sci U S A (1981) 12.86
A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes (1984) 10.09
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet (2000) 8.33
The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences. Nature (1982) 7.47
Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein. Proc Natl Acad Sci U S A (1988) 7.26
Phenanthrenequinone as an analytical reagent for arginine and other monosubstituted guanidines. Biochim Biophys Acta (1966) 7.11
Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med (2001) 6.79
Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1) Nature (1996) 6.72
A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet (1996) 6.58
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell (1999) 6.40
Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci (1995) 6.36
Sequence of the human insulin gene. Nature (1980) 5.76
Cell adhesion. Competition between nonspecific repulsion and specific bonding. Biophys J (1984) 5.72
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3) Nature (1996) 5.32
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest (2000) 5.07
Ribosomal RNA genes of Saccharomyces cerevisiae. I. Physical map of the repeating unit and location of the regions coding for 5 S, 5.8 S, 18 S, and 25 S ribosomal RNAs. J Biol Chem (1977) 4.76
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol (1998) 4.74
Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill (2013) 4.44
Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY. Nat Genet (1997) 4.19
Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate. Am J Hum Genet (1989) 4.13
Ribosomal RNA genes of Saccharomyces cerevisiae. II. Physical map and nucleotide sequence of the 5 S ribosomal RNA gene and adjacent intergenic regions. J Biol Chem (1977) 4.03
A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination. FEBS Lett (2000) 4.03
Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. N Engl J Med (1993) 3.96
Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet (1999) 3.95
A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest (1999) 3.86
RFLPs for transforming growth factor alpha (TGFA) gene at 2p13. Nucleic Acids Res (1986) 3.72
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J Biol Chem (2000) 3.71
New antibiotics, bleomycin A and B. J Antibiot (Tokyo) (1966) 3.58
Analysis of the regions flanking the human insulin gene and sequence of an Alu family member. Nucleic Acids Res (1980) 3.55
Molecular biology of mammalian glucose transporters. Diabetes Care (1990) 3.33
Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med (1992) 3.31
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J (1999) 3.19
Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. J Biol Chem (1988) 3.18
Disease associations. Chance, artifact, or susceptibility genes? Diabetes (1989) 3.12
Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene (2007) 3.11
Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization. Nucleic Acids Res (1986) 3.11
Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins. Science (1983) 2.97
The LiMB database. Science (1988) 2.89
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol (1999) 2.87
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature (1992) 2.86
Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. J Biol Chem (1989) 2.81
The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science (1993) 2.77
Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res (1999) 2.74
Polymorphic human glucose transporter gene (GLUT) is on chromosome 1p31.3----p35. Diabetes (1987) 2.72
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol (1994) 2.70
Requirement of CD9 on the egg plasma membrane for fertilization. Science (2000) 2.65
Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo) (2000) 2.64
Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation. Proc Natl Acad Sci U S A (1988) 2.62
Cell growth and division. IV. Determination of volume growth rate and division probability. Biophys J (1969) 2.57
Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol (1999) 2.56
Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro. Microbiol Immunol (2001) 2.52
Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice. Proc Natl Acad Sci U S A (2001) 2.51
Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1. Science (1992) 2.50
Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues. Nature (1985) 2.49
Ludloff's medial approach for open reduction of congenital dislocation of the hip. A 20-year follow-up. J Bone Joint Surg Br (1996) 2.45
Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature (1983) 2.44
Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med (1996) 2.42
Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues. J Biol Chem (1993) 2.42
Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor. Nature (1983) 2.41
Cell growth and division. I. A mathematical model with applications to cell volume distributions in mammalian suspension cultures. Biophys J (1967) 2.41
Exon duplication and divergence in the human preproglucagon gene. Nature (1983) 2.37
Fructose transporter in human spermatozoa and small intestine is GLUT5. J Biol Chem (1992) 2.35
The inhomogeneous structure of water at ambient conditions. Proc Natl Acad Sci U S A (2009) 2.31
Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues. Nature (1985) 2.29
Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease. Arthritis Rheum (2001) 2.28
Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med (1994) 2.27
Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev (2001) 2.26
Facilitative glucose transporters: an expanding family. Trends Biochem Sci (1990) 2.22
Extracellular accumulation of a new amino acid, O-2-hydroxypropylhomoserine, from 1,2-propanediol by flavobacterium rigense. Appl Environ Microbiol (1978) 2.21
Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int J Radiat Oncol Biol Phys (1999) 2.19
Pathophysiology of "tethered cord syndrome". J Neurosurg (1981) 2.17
Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science (2001) 2.17
Nucleotide sequence of the yeast 5S ribosomal RNA gene and adjacent putative control regions. Nature (1977) 2.15
Structure and function of mammalian facilitative sugar transporters. J Biol Chem (1993) 2.14
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol (1999) 2.14
Sequence of a cDNA clone encoding human preproinsulin-like growth factor II. Nature (1984) 2.13
Induction of transforming growth factor-alpha in activated human alveolar macrophages. Cell (1988) 2.13
Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice. Nucleic Acids Res (1990) 2.13
Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase). Proc Natl Acad Sci U S A (1998) 2.12
Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis (2008) 2.11
The results, indications, and physiology of posteroventral pallidotomy for patients with Parkinson's disease. Neurosurgery (1995) 2.09
Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A (1992) 2.07
Genetic dissection of nodal function in patterning the mouse embryo. Development (2001) 2.07
Developmental abnormalities of glycosylphosphatidylinositol-anchor-deficient embryos revealed by Cre/loxP system. Lab Invest (1999) 2.06
Expression of insulin-like growth factor-II transcripts in Wilms' tumour. Nature (1985) 2.06
Fetal Minamata disease. A neuropathological study of two cases of intrauterine intoxication by a methyl mercury compound. J Neuropathol Exp Neurol (1965) 2.05
Mammalian facilitative glucose transporter family: structure and molecular regulation. Annu Rev Physiol (1992) 2.05
Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis: RRR (remission induction by Remicade in RA) study. Ann Rheum Dis (2010) 2.04
Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin. Aliment Pharmacol Ther (2014) 2.03
The insulin gene is located on chromosome 11 in humans. Nature (1980) 2.03