N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases.

PubWeight™: 4.27‹?› | Rank: Top 1%

🔗 View Article (PMC 317867)

Published in Nucleic Acids Res on May 25, 1989

Authors

A E Gorbalenya1, A P Donchenko, E V Koonin, V M Blinov

Author Affiliations

1: Institute of Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences, Moscow region.

Articles citing this

The alphaviruses: gene expression, replication, and evolution. Microbiol Rev (1994) 16.68

Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci U S A (1991) 14.05

Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc Natl Acad Sci U S A (1990) 8.92

Structure and organization of the hepatitis C virus genome isolated from human carriers. J Virol (1991) 8.33

Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J Virol (1993) 6.36

Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins. J Virol (1991) 4.63

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Virol (1993) 4.57

trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication. J Virol (1997) 4.17

Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein. Proc Natl Acad Sci U S A (1990) 4.12

In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3. J Virol (1990) 3.50

Processing of the yellow fever virus nonstructural polyprotein: a catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sites. J Virol (1991) 3.41

Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. J Virol (1993) 3.37

Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily. J Virol (1991) 3.35

Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates. Proc Natl Acad Sci U S A (1991) 3.34

Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes. Microbiol Rev (1993) 3.33

Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses. Proc Natl Acad Sci U S A (1992) 3.24

Molecular evolution of dengue viruses: contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease. Infect Genet Evol (2009) 3.19

Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics. J Virol (1994) 2.64

Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site. J Virol (1993) 2.56

Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection. J Virol (2002) 2.55

Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function. J Virol (1999) 2.44

Completion of Kunjin virus RNA sequence and recovery of an infectious RNA transcribed from stably cloned full-length cDNA. J Virol (1994) 2.43

Genomic organization of GB viruses A and B: two new members of the Flaviviridae associated with GB agent hepatitis. J Virol (1995) 2.38

Insertion of a sequence encoding light chain 3 of microtubule-associated proteins 1A and 1B in a pestivirus genome: connection with virus cytopathogenicity and induction of lethal disease in cattle. J Virol (1998) 2.36

The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids. J Virol (1999) 2.34

Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease. J Virol (1992) 2.33

Molecular targets for flavivirus drug discovery. Antiviral Res (2008) 2.32

The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3). J Virol (1996) 2.30

Mutagenesis of the yellow fever virus NS2B protein: effects on proteolytic processing, NS2B-NS3 complex formation, and viral replication. J Virol (1993) 2.25

RNA-protein interactions: involvement of NS3, NS5, and 3' noncoding regions of Japanese encephalitis virus genomic RNA. J Virol (1997) 2.12

Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease. J Virol (1990) 2.11

Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity. J Virol (1993) 2.06

Pestivirus NS3 (p80) protein possesses RNA helicase activity. J Virol (1995) 2.06

Pestivirus gene expression: the first protein product of the bovine viral diarrhea virus large open reading frame, p20, possesses proteolytic activity. J Virol (1991) 2.04

Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication. J Virol (1997) 2.00

cis- and trans-acting elements in flavivirus RNA replication. J Virol (2000) 1.91

Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res (2009) 1.87

Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5. J Virol (1992) 1.59

Multiple origins of viral capsid proteins from cellular ancestors. Proc Natl Acad Sci U S A (2017) 1.53

Dengue virus-specific, human CD4+ CD8- cytotoxic T-cell clones: multiple patterns of virus cross-reactivity recognized by NS3-specific T-cell clones. J Virol (1991) 1.52

Cytopathogenicity of a pestivirus correlates with a 27-nucleotide insertion. J Virol (1996) 1.44

Dual mechanisms of pestiviral superinfection exclusion at entry and RNA replication. J Virol (2005) 1.35

Mutagenesis of the yellow fever virus NS2B/3 cleavage site: determinants of cleavage site specificity and effects on polyprotein processing and viral replication. J Virol (1995) 1.33

Mutational analysis of the octapeptide sequence motif at the NS1-NS2A cleavage junction of dengue type 4 virus. J Virol (1992) 1.31

De novo synthesis of negative-strand RNA by Dengue virus RNA-dependent RNA polymerase in vitro: nucleotide, primer, and template parameters. J Virol (2003) 1.28

Flavivirus enzyme-substrate interactions studied with chimeric proteinases: identification of an intragenic locus important for substrate recognition. J Virol (1991) 1.27

Purification and characterization of West Nile virus nucleoside triphosphatase (NTPase)/helicase: evidence for dissociation of the NTPase and helicase activities of the enzyme. J Virol (2001) 1.25

Identification of residues in the dengue virus type 2 NS2B cofactor that are critical for NS3 protease activation. J Virol (2004) 1.19

Bovine viral diarrhea virus strain Oregon: a novel mechanism for processing of NS2-3 based on point mutations. J Virol (1998) 1.13

Translation of the flavivirus kunjin NS3 gene in cis but not its RNA sequence or secondary structure is essential for efficient RNA packaging. J Virol (2006) 1.10

Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay. Antimicrob Agents Chemother (2010) 1.09

Identification of the amino acid sequence in Sindbis virus nsP4 that binds to the promoter for the synthesis of the subgenomic RNA. Proc Natl Acad Sci U S A (2004) 1.08

Upregulation of signalase processing and induction of prM-E secretion by the flavivirus NS2B-NS3 protease: roles of protease components. J Virol (1997) 1.06

Genetic and phenotypic characterization of sylvatic dengue virus type 2 strains. Virology (2008) 1.04

Characterisation of divergent flavivirus NS3 and NS5 protein sequences detected in Rhipicephalus microplus ticks from Brazil. Mem Inst Oswaldo Cruz (2013) 1.04

Replication cycle and molecular biology of the West Nile virus. Viruses (2013) 1.03

The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme. J Virol (1997) 0.99

A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice. J Virol (2006) 0.99

Mutagenesis of the NS3 protease of dengue virus type 2. J Virol (1998) 0.99

Molecular links between the E2 envelope glycoprotein and nucleocapsid core in Sindbis virus. J Mol Biol (2011) 0.98

The NS5A protein of bovine viral diarrhea virus contains an essential zinc-binding site similar to that of the hepatitis C virus NS5A protein. J Virol (2006) 0.94

Langat flavivirus protease NS3 binds caspase-8 and induces apoptosis. J Virol (2002) 0.92

Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides. Biochem J (2006) 0.92

Neuroblastoma cell-adapted yellow fever 17D virus: characterization of a viral variant associated with persistent infection and decreased virus spread. J Virol (2002) 0.89

Effects of detergents on the West Nile virus protease activity. Bioorg Med Chem (2009) 0.88

Functional analysis of potential carboxy-terminal cleavage sites of tick-borne encephalitis virus capsid protein. J Virol (2007) 0.85

High affinity human antibody fragments to dengue virus non-structural protein 3. PLoS Negl Trop Dis (2010) 0.85

Ecuador Paraiso Escondido Virus, a New Flavivirus Isolated from New World Sand Flies in Ecuador, Is the First Representative of a Novel Clade in the Genus Flavivirus. J Virol (2015) 0.84

West Nile virus drug discovery. Viruses (2013) 0.82

Phenotypic characterization of patient dengue virus isolates in BALB/c mice differentiates dengue fever and dengue hemorrhagic fever from dengue shock syndrome. Virol J (2011) 0.81

Quantitative proteomic analysis of host-virus interactions reveals a role for Golgi brefeldin A resistance factor 1 (GBF1) in dengue infection. Mol Cell Proteomics (2014) 0.79

A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease. Antimicrob Agents Chemother (2013) 0.77

Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells. Acta Pharmacol Sin (2015) 0.77

Flavivirus RNA synthesis in vitro. Methods (2015) 0.75

Articles cited by this

Establishing homologies in protein sequences. Methods Enzymol (1983) 15.70

Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science (1985) 8.54

Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses. Nucleic Acids Res (1984) 8.36

Viral proteinases. Annu Rev Biochem (1988) 6.76

A new superfamily of replicative proteins. Nature (1988) 6.20

Nucleotide sequence of the 26S mRNA of Sindbis virus and deduced sequence of the encoded virus structural proteins. Proc Natl Acad Sci U S A (1981) 6.08

Molecular cloning and nucleotide sequence of the pestivirus bovine viral diarrhea virus. Virology (1988) 5.92

Serine proteases: structure and mechanism of catalysis. Annu Rev Biochem (1977) 5.37

Nucleotide sequence of dengue 2 RNA and comparison of the encoded proteins with those of other flaviviruses. Virology (1988) 4.78

Cysteine proteases of positive strand RNA viruses and chymotrypsin-like serine proteases. A distinct protein superfamily with a common structural fold. FEBS Lett (1989) 4.29

Nucleotide and complete amino acid sequences of Kunjin virus: definitive gene order and characteristics of the virus-specified proteins. J Gen Virol (1988) 4.09

Complete nucleotide sequence of the Japanese encephalitis virus genome RNA. Virology (1987) 3.96

Redesigning trypsin: alteration of substrate specificity. Science (1985) 3.70

Evolution of proteolytic enzymes. Science (1984) 3.57

The nucleotide sequence of dengue type 4 virus: analysis of genes coding for nonstructural proteins. Virology (1987) 3.51

Comparisons of the pestivirus bovine viral diarrhoea virus with members of the flaviviridae. J Gen Virol (1988) 3.31

The capsid protein of Semliki Forest virus has clusters of basic amino acids and prolines in its amino-terminal region. Proc Natl Acad Sci U S A (1980) 3.26

Proteins encoded by bovine viral diarrhea virus: the genomic organization of a pestivirus. Virology (1988) 3.21

Sequence of the lon gene in Escherichia coli. A heat-shock gene which encodes the ATP-dependent protease La. J Biol Chem (1988) 3.21

Western equine encephalitis virus is a recombinant virus. Proc Natl Acad Sci U S A (1988) 3.19

A novel superfamily of nucleoside triphosphate-binding motif containing proteins which are probably involved in duplex unwinding in DNA and RNA replication and recombination. FEBS Lett (1988) 3.09

An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication. J Mol Evol (1989) 3.00

Primary structure of the West Nile flavivirus genome region coding for all nonstructural proteins. Virology (1986) 2.75

Splice junctions: association with variation in protein structure. Science (1983) 2.54

Primary structure of human neutrophil elastase. Proc Natl Acad Sci U S A (1987) 2.45

Ross River virus 26 s RNA: complete nucleotide sequence and deduced sequence of the encoded structural proteins. Virology (1983) 2.38

Partial nucleotide sequence of the Murray Valley encephalitis virus genome. Comparison of the encoded polypeptides with yellow fever virus structural and non-structural proteins. J Mol Biol (1986) 1.96

Nucleotide sequence of the 26 S mRNA of the virulent Trinidad donkey strain of Venezuelan equine encephalitis virus and deduced sequence of the encoded structural proteins. Virology (1986) 1.84

Nucleotide sequence of the genome region encoding the 26S mRNA of eastern equine encephalomyelitis virus and the deduced amino acid sequence of the viral structural proteins. J Gen Virol (1987) 1.65

Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin. Biochemistry (1987) 1.48

Is Sindbis a simple picornavirus with an envelope? EMBO J (1987) 1.21

[Cloning, expression and structure of the functionally active shortened lon gene in Escherichia coli]. Bioorg Khim (1988) 1.10

Accelerated method for comparing amino acid sequences with allowance for possible gaps. Plotting optimum correspondence paths. Int J Pept Protein Res (1981) 1.10

DNA stimulates ATP-dependent proteolysis and protein-dependent ATPase activity of protease La from Escherichia coli. Proc Natl Acad Sci U S A (1982) 1.09

[Evolution of RNA-dependent RNA polymerases of positive riboviruses]. Mol Gen Mikrobiol Virusol (1987) 1.02

Articles by these authors

Initial sequencing and analysis of the human genome. Nature (2001) 212.86

A genomic perspective on protein families. Science (1997) 50.51

The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res (2000) 49.22

The COG database: new developments in phylogenetic classification of proteins from complete genomes. Nucleic Acids Res (2001) 43.17

Protein sequence similarity searches using patterns as seeds. Nucleic Acids Res (1998) 23.87

Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements. Nucleic Acids Res (2001) 22.33

Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks. Proc Natl Acad Sci U S A (1994) 18.46

A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J (1997) 15.10

Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science (1998) 13.64

BRCA1 protein products ... Functional motifs... Nat Genet (1996) 11.50

AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res (1999) 11.30

Bacterial rhodopsin: evidence for a new type of phototrophy in the sea. Science (2000) 10.82

Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res (1989) 10.03

Novel domains of the prokaryotic two-component signal transduction systems. FEMS Microbiol Lett (2001) 8.45

Iterated profile searches with PSI-BLAST--a tool for discovery in protein databases. Trends Biochem Sci (1998) 8.01

Microbial culturomics: paradigm shift in the human gut microbiome study. Clin Microbiol Infect (2012) 7.97

IMPALA: matching a protein sequence against a collection of PSI-BLAST-constructed position-specific score matrices. Bioinformatics (1999) 6.91

Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs). Genome Biol (2000) 6.50

Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum. J Bacteriol (2001) 6.46

A minimal gene set for cellular life derived by comparison of complete bacterial genomes. Proc Natl Acad Sci U S A (1996) 6.38

Comparison of the complete protein sets of worm and yeast: orthology and divergence. Science (1998) 6.28

Sources of systematic error in functional annotation of genomes: domain rearrangement, non-orthologous gene displacement and operon disruption. In Silico Biol (1998) 6.22

Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches. J Mol Biol (1999) 5.90

Using the COG database to improve gene recognition in complete genomes. Genetica (2000) 5.80

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast. Cell (2000) 5.69

Metabolism and evolution of Haemophilus influenzae deduced from a whole-genome comparison with Escherichia coli. Curr Biol (1996) 5.50

Genome alignment, evolution of prokaryotic genome organization, and prediction of gene function using genomic context. Genome Res (2001) 5.37

Conserved domains in DNA repair proteins and evolution of repair systems. Nucleic Acids Res (1999) 4.80

Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics. Microbiol Mol Biol Rev (2001) 4.75

Genome trees constructed using five different approaches suggest new major bacterial clades. BMC Evol Biol (2001) 4.59

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs. Proc Natl Acad Sci U S A (1997) 4.40

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biol (2001) 4.39

Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eucaryotes and archaebacteria. Nucleic Acids Res (1992) 4.39

Cysteine proteases of positive strand RNA viruses and chymotrypsin-like serine proteases. A distinct protein superfamily with a common structural fold. FEBS Lett (1989) 4.29

Common origin of four diverse families of large eukaryotic DNA viruses. J Virol (2001) 4.28

Conserved structural domains in the 5'-untranslated region of picornaviral genomes: an analysis of the segment controlling translation and neurovirulence. Virology (1989) 4.22

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell (2000) 4.19

The HD domain defines a new superfamily of metal-dependent phosphohydrolases. Trends Biochem Sci (1998) 4.11

SAP - a putative DNA-binding motif involved in chromosomal organization. Trends Biochem Sci (2000) 4.10

Evidence for massive gene exchange between archaeal and bacterial hyperthermophiles. Trends Genet (1998) 4.10

The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase. Virology (1991) 4.07

Who's your neighbor? New computational approaches for functional genomics. Nat Biotechnol (2000) 4.04

Construction and analysis of bacterial artificial chromosome libraries from a marine microbial assemblage. Environ Microbiol (2000) 3.99

Viral proteins containing the purine NTP-binding sequence pattern. Nucleic Acids Res (1989) 3.96

Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science (1998) 3.83

Conservation of the secondary structure elements of the 5'-untranslated region of cardio- and aphthovirus RNAs. Nucleic Acids Res (1989) 3.81

Comparative genomics of the Archaea (Euryarchaeota): evolution of conserved protein families, the stable core, and the variable shell. Genome Res (1999) 3.62

SURVEY AND SUMMARY: holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectories. Nucleic Acids Res (2000) 3.56

Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. Genome Res (1999) 3.44

Coronavirus genome: prediction of putative functional domains in the non-structural polyprotein by comparative amino acid sequence analysis. Nucleic Acids Res (1989) 3.38

Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses. FEBS Lett (1991) 3.35

DNA polymerase beta-like nucleotidyltransferase superfamily: identification of three new families, classification and evolutionary history. Nucleic Acids Res (1999) 3.32

Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis. RNA (1999) 3.30

A new superfamily of putative NTP-binding domains encoded by genomes of small DNA and RNA viruses. FEBS Lett (1990) 3.30

Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. J Mol Biol (1999) 3.28

Lineage-specific loss and divergence of functionally linked genes in eukaryotes. Proc Natl Acad Sci U S A (2000) 3.27

Non-orthologous gene displacement. Trends Genet (1996) 3.12

Lineage-specific gene expansions in bacterial and archaeal genomes. Genome Res (2001) 3.10

A novel superfamily of nucleoside triphosphate-binding motif containing proteins which are probably involved in duplex unwinding in DNA and RNA replication and recombination. FEBS Lett (1988) 3.09

An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication. J Mol Evol (1989) 3.00

A conserved NTP-motif in putative helicases. Nature (1988) 2.94

Novel families of putative protein kinases in bacteria and archaea: evolution of the "eukaryotic" protein kinase superfamily. Genome Res (1998) 2.91

Detection of new genes in a bacterial genome using Markov models for three gene classes. Nucleic Acids Res (1995) 2.89

Rickettsiae and Chlamydiae: evidence of horizontal gene transfer and gene exchange. Trends Genet (1999) 2.87

Predicting functions from protein sequences--where are the bottlenecks? Nat Genet (1998) 2.86

Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins. Nucleic Acids Res (1998) 2.82

SEALS: a system for easy analysis of lots of sequences. Proc Int Conf Intell Syst Mol Biol (1997) 2.80

Prediction of transcription regulatory sites in Archaea by a comparative genomic approach. Nucleic Acids Res (2000) 2.80

RNA sequence of astrovirus: distinctive genomic organization and a putative retrovirus-like ribosomal frameshifting signal that directs the viral replicase synthesis. Proc Natl Acad Sci U S A (1993) 2.77

Role of CED-4 in the activation of CED-3. Nature (1997) 2.76

The U box is a modified RING finger - a common domain in ubiquitination. Curr Biol (2000) 2.73

Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. J Mol Biol (2001) 2.68

Adaptations of the helix-grip fold for ligand binding and catalysis in the START domain superfamily. Proteins (2001) 2.65

Phosphoesterase domains associated with DNA polymerases of diverse origins. Nucleic Acids Res (1998) 2.61

The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation. Trends Biochem Sci (2000) 2.58

The genome of molluscum contagiosum virus: analysis and comparison with other poxviruses. Virology (1997) 2.58

The domains of death: evolution of the apoptosis machinery. Trends Biochem Sci (1999) 2.56

DNA-binding proteins and evolution of transcription regulation in the archaea. Nucleic Acids Res (1999) 2.53

A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity. Protein Sci (1997) 2.47

Gene order is not conserved in bacterial evolution. Trends Genet (1996) 2.44

Did DNA replication evolve twice independently? Nucleic Acids Res (1999) 2.44

Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell (1996) 2.39

The bacterial replicative helicase DnaB evolved from a RecA duplication. Genome Res (2000) 2.39

The catalytic domain of the P-type ATPase has the haloacid dehalogenase fold. Trends Biochem Sci (1998) 2.39

Fold prediction and evolutionary analysis of the POZ domain: structural and evolutionary relationship with the potassium channel tetramerization domain. J Mol Biol (1999) 2.37

Superfamily of UvrA-related NTP-binding proteins. Implications for rational classification of recombination/repair systems. J Mol Biol (1990) 2.34

A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease. Trends Biochem Sci (1998) 2.33

Genome sequence comparison and scenarios for gene rearrangements: a test case. Genomics (1995) 2.32