Published in Cell on September 30, 2011
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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
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Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell (2010) 6.79
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STAT1-dependent innate immunity to a Norwalk-like virus. Science (2003) 6.35
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Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet (2011) 6.20
Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proc Natl Acad Sci U S A (2010) 6.10
Viruses in the faecal microbiota of monozygotic twins and their mothers. Nature (2010) 5.92
Peripheral education of the immune system by colonic commensal microbiota. Nature (2011) 5.80
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Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A (2011) 5.44
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Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2010) 5.10
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Unravelling the effects of the environment and host genotype on the gut microbiome. Nat Rev Microbiol (2011) 4.57
Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe (2010) 4.54
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Metagenomic analysis of human diarrhea: viral detection and discovery. PLoS Pathog (2008) 4.29
Herpesvirus latency confers symbiotic protection from bacterial infection. Nature (2007) 4.27
Control of TH17 cells occurs in the small intestine. Nature (2011) 4.03
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest (2010) 3.91
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet (2011) 3.65
Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet (2009) 3.64
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe (2011) 3.46
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Toward defining the autoimmune microbiome for type 1 diabetes. ISME J (2010) 3.03
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Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. J Exp Med (2010) 2.54
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. Hum Mol Genet (2010) 2.51
An antibiotic-responsive mouse model of fulminant ulcerative colitis. PLoS Med (2008) 2.50
Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J Immunol (2009) 2.21
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Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia (2010) 2.04
Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies. Diabetologia (2008) 2.01
The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe (2011) 1.97
Pan-genome of the dominant human gut-associated archaeon, Methanobrevibacter smithii, studied in twins. Proc Natl Acad Sci U S A (2011) 1.96
Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. Science (2011) 1.88
Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Cell Host Microbe (2011) 1.86
Latent herpesvirus infection arms NK cells. Blood (2010) 1.80
Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes (2011) 1.78
Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model. ISME J (2009) 1.74
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FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection. Diabetes (2011) 1.22
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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature (2007) 6.67
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet (2007) 6.11
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 5.68
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94
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Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
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Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
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A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
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PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes. Diabetes (2008) 2.74
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A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes (2008) 2.51
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet (2009) 2.38
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Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes. Genome Res (2002) 1.68
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Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. J Immunol (2004) 1.59
Seven newly identified loci for autoimmune thyroid disease. Hum Mol Genet (2012) 1.57
Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet (2004) 1.48
Regression mapping of association between the human leukocyte antigen region and Graves disease. Am J Hum Genet (2004) 1.47
Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. PLoS Genet (2013) 1.47
T1DBase, a community web-based resource for type 1 diabetes research. Nucleic Acids Res (2005) 1.44
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A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Hum Mol Genet (2007) 1.35
Type 1 diabetes genes and pathways shared by humans and NOD mice. J Autoimmun (2005) 1.34
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. J Immunol (2012) 1.31
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet (2011) 1.30
Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. Hum Mol Genet (2011) 1.29
Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain. J Immunol (2004) 1.29
T1DBase: update 2011, organization and presentation of large-scale data sets for type 1 diabetes research. Nucleic Acids Res (2010) 1.23
Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species. Biochem Soc Trans (2008) 1.23
Genetic analysis of adult-onset autoimmune diabetes. Diabetes (2011) 1.22
FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection. Diabetes (2011) 1.22
Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes. Hum Mol Genet (2012) 1.20
Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct. Diabetes (2011) 1.20
The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome. Diabetes (2003) 1.18
Reduced expression of IFIH1 is protective for type 1 diabetes. PLoS One (2010) 1.18
Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. BMC Genet (2005) 1.14
Proteome-wide analysis of disease-associated SNPs that show allele-specific transcription factor binding. PLoS Genet (2012) 1.13
An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes. Diabetes (2011) 1.13
Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping. BMC Biotechnol (2004) 1.11
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations. Nat Genet (2008) 1.10
The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes. BMC Med Genet (2007) 1.10
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat Genet (2005) 1.09
Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics. Hum Genomics (2004) 1.08
Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes. J Immunol (2007) 1.08
Prevalence of abnormal lipid profiles and the relationship with the development of microalbuminuria in adolescents with type 1 diabetes. Diabetes Care (2009) 1.08
Fluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis. Adv Bioinformatics (2009) 1.07
Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci. Genet Epidemiol (2005) 1.05
The usefulness of different density SNP maps for disease association studies of common variants. Hum Mol Genet (2003) 1.05
Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes. J Autoimmun (2005) 1.04
Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis. Hum Genet (2006) 1.03
Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes. Diabetes (2004) 1.01
Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis. BMC Med Genet (2009) 1.01
Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene. Genome Res (2003) 1.01
Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes. Diabetes (2012) 1.00
Association of human endogenous retrovirus K-18 polymorphisms with type 1 diabetes. Diabetes (2004) 0.99
Next generation sequencing reveals the association of DRB3*02:02 with type 1 diabetes. Diabetes (2013) 0.98
Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes. Diabetes (2004) 0.98
Multiplexed immunophenotyping of human antigen-presenting cells in whole blood by polychromatic flow cytometry. Nat Protoc (2010) 0.97
A multimarker regression-based test of linkage for affected sib-pairs at two linked loci. Genet Epidemiol (2006) 0.96
No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes. Am J Hum Genet (2005) 0.96
Limitations of stratifying sib-pair data in common disease linkage studies: an example using chromosome 10p14-10q11 in type 1 diabetes. Am J Med Genet (2002) 0.96