Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study.

PubWeight™: 1.34‹?› | Rank: Top 10%

🔗 View Article (PMC 2780352)

Published in PLoS Genet on December 04, 2009

Authors

Sara Hägg1, Josefin Skogsberg, Jesper Lundström, Peri Noori, Roland Nilsson, Hua Zhong, Shohreh Maleki, Ming-Mei Shang, Björn Brinne, Maria Bradshaw, Vladimir B Bajic, Ann Samnegård, Angela Silveira, Lee M Kaplan, Bruna Gigante, Karin Leander, Ulf de Faire, Stefan Rosfors, Ulf Lockowandt, Jan Liska, Peter Konrad, Rabbe Takolander, Anders Franco-Cereceda, Eric E Schadt, Torbjörn Ivert, Anders Hamsten, Jesper Tegnér, Johan Björkegren

Author Affiliations

1: The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Articles citing this

Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. Lancet (2012) 5.16

Gene scanning and heart attack risk. Trends Cardiovasc Med (2015) 1.40

Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. J Am Coll Cardiol (2015) 1.19

Systems-based approaches to cardiovascular disease. Nat Rev Cardiol (2012) 1.04

Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Med (2014) 1.02

Reverse-engineering human regulatory networks. Wiley Interdiscip Rev Syst Biol Med (2012) 0.98

Genetics of atherosclerosis. Trends Genet (2012) 0.97

STAT1-dependent signal integration between IFNγ and TLR4 in vascular cells reflect pro-atherogenic responses in human atherosclerosis. PLoS One (2014) 0.92

MicroRNAs act complementarily to regulate disease-related mRNA modules in human diseases. RNA (2013) 0.92

A multi-platform draft de novo genome assembly and comparative analysis for the Scarlet Macaw (Ara macao). PLoS One (2013) 0.92

Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. PLoS Genet (2014) 0.89

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability. J Transl Med (2014) 0.87

A draft de novo genome assembly for the northern bobwhite (Colinus virginianus) reveals evidence for a rapid decline in effective population size beginning in the Late Pleistocene. PLoS One (2014) 0.87

Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulin. PLoS One (2011) 0.83

Cardiovascular genomics: a biomarker identification pipeline. IEEE Trans Inf Technol Biomed (2012) 0.81

kruX: matrix-based non-parametric eQTL discovery. BMC Bioinformatics (2014) 0.81

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease. Cell Syst (2016) 0.81

Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients. Mol Metab (2016) 0.79

Systematic analysis of chromatin interactions at disease associated loci links novel candidate genes to inflammatory bowel disease. Genome Biol (2016) 0.79

Effects of statin on circulating microRNAome and predicted function regulatory network in patients with unstable angina. BMC Med Genomics (2015) 0.78

Mutation in ST6GALNAC5 identified in family with coronary artery disease. Sci Rep (2014) 0.78

Data mining of atherosclerotic plaque transcriptomes predicts STAT1-dependent inflammatory signal integration in vascular disease. Int J Mol Sci (2014) 0.78

Identification of candidate genes involved in coronary artery calcification by transcriptome sequencing of cell lines. BMC Genomics (2014) 0.77

Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus. Circulation (2017) 0.76

Protease inhibitor 15, a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. Physiol Genomics (2014) 0.76

From hairballs to an understanding of transendothelial migration of monocytes in atherosclerosis. Arterioscler Thromb Vasc Biol (2014) 0.76

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci. Nat Commun (2016) 0.76

Systems biology: An emerging strategy for discovering novel pathogenetic mechanisms that promote cardiovascular disease. Glob Cardiol Sci Pract (2016) 0.75

Articles cited by this

Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A (1998) 192.97

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95

DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol (2003) 84.79

The Pfam protein families database. Nucleic Acids Res (2004) 56.46

Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res (2003) 52.74

Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med (2005) 28.21

TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res (2006) 22.20

Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44

Atherosclerosis. Nature (2000) 15.95

A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. Circulation (1975) 10.97

STRING: known and predicted protein-protein associations, integrated and transferred across organisms. Nucleic Acids Res (2005) 10.44

Adipose tissue, inflammation, and cardiovascular disease. Circ Res (2005) 8.72

Human epicardial adipose tissue is a source of inflammatory mediators. Circulation (2003) 6.31

Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med (2001) 5.97

Coupled two-way clustering analysis of gene microarray data. Proc Natl Acad Sci U S A (2000) 5.55

TNF-mediated inflammatory disease. J Pathol (2008) 5.00

Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements. Nucleic Acids Res (2004) 4.43

Superparamagnetic clustering of data. Phys Rev Lett (1996) 3.56

The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc Natl Acad Sci U S A (1998) 2.64

Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature (1996) 2.57

The environmental contribution to gene expression profiles. Nat Rev Genet (2008) 2.54

Functional analysis of the nuclear LIM domain interactor NLI. Mol Cell Biol (1997) 2.04

Multistep control of pituitary organogenesis. Science (1997) 1.82

Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation (2003) 1.68

The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice. Proc Natl Acad Sci U S A (2000) 1.65

Growth factors induce monocyte binding to vascular smooth muscle cells: implications for monocyte retention in atherosclerosis. Am J Physiol Cell Physiol (2004) 1.62

Embracing complexity, inching closer to reality. Sci STKE (2005) 1.62

A new automated computerized analyzing system simplifies readings and reduces the variability in ultrasound measurement of intima-media thickness. Stroke (1997) 1.59

Transesophageal echocardiographically detected atherosclerotic aortic plaque is a marker for coronary artery disease. J Am Coll Cardiol (1993) 1.53

Brca1 required for T cell lineage development but not TCR loci rearrangement. Nat Immunol (2000) 1.48

LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc Natl Acad Sci U S A (1993) 1.36

Intima media thickness as a surrogate marker for generalised atherosclerosis. Cardiovasc Drugs Ther (2002) 1.30

Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet (2008) 1.25

The LIM-only protein, LMO4, and the LIM domain-binding protein, LDB1, expression in squamous cell carcinomas of the oral cavity. Br J Cancer (2003) 1.18

Prospects for personalized cardiovascular medicine: the impact of genomics. J Am Coll Cardiol (2005) 1.11

Spiral computed tomography evidence of close correlation between coronary and thoracic aorta calcifications. Atherosclerosis (2004) 1.11

A comparison of coronary and internal mammary arteries and implications of the results in the etiology of arteriosclerosis. Am Heart J (1983) 1.09

PECAM-1 is a critical mediator of atherosclerosis. Dis Model Mech (2008) 1.09

Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Diabetes (2002) 1.08

Perturbations to uncover gene networks. Trends Genet (2006) 1.03

Interaction of monocytes with vascular smooth muscle cells regulates monocyte survival and differentiation through distinct pathways. Arterioscler Thromb Vasc Biol (2004) 1.03

Leukocyte recruitment in atherosclerosis: potential targets for therapeutic approaches? Cell Mol Life Sci (2006) 1.02

Super paramagnetic clustering of protein sequences. BMC Bioinformatics (2005) 1.02

Central adipose distribution is related to coronary atherosclerosis. Arterioscler Thromb (1991) 1.01

Signal transduction mechanisms for leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils. J Immunol (1994) 0.99

Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. Oncogene (1996) 0.97

The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration. Mol Biol Cell (2009) 0.94

Importance of junctional adhesion molecule-A for neointimal lesion formation and infiltration in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol (2005) 0.93

Carotid atherosclerosis is correlated with extent and severity of coronary artery disease evaluated by myocardial perfusion scintigraphy. Angiology (2004) 0.92

Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Multi-organ whole-genome measurements and reverse engineering to uncover gene networks underlying complex traits. J Lipid Res (2006) 0.91

Inhibition of LPL expression in human monocyte-derived macrophages is dependent on LDL oxidation state: a key role for lysophosphatidylcholine. Arterioscler Thromb Vasc Biol (1998) 0.89

Defect of tumour necrosis factor-alpha (TNF-alpha) production and TNF-alpha-induced ICAM-1-expression in BRCA1 mutations carriers. Breast Cancer Res Treat (2003) 0.89

Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis. Arterioscler Thromb Vasc Biol (2007) 0.86

Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells. J Virol (2007) 0.84

Hepatocyte nuclear factor 4 alpha ligand binding and F domains mediate interaction and transcriptional synergy with the pancreatic islet LIM HD transcription factor Isl1. J Mol Biol (2006) 0.84

Vaccination against TIE2 reduces atherosclerosis. Atherosclerosis (2008) 0.83

Clinical and angiographic correlates and prognostic significance of the coronary extent score. Am J Cardiol (1988) 0.80

Articles by these authors

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet (2002) 23.18

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Genetics of gene expression and its effect on disease. Nature (2008) 21.35

Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science (2003) 16.80

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13

Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med (2013) 13.92

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07

Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09

The origin of the Haitian cholera outbreak strain. N Engl J Med (2010) 9.85

EuroSCORE II. Eur J Cardiothorac Surg (2012) 9.52

Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med (2011) 9.37

The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37

Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med (2009) 8.73

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59

EGASP: the human ENCODE Genome Annotation Assessment Project. Genome Biol (2006) 7.06

Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97

Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet (2002) 6.87

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science (2012) 6.79

Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66

Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45

A promoter-level mammalian expression atlas. Nature (2014) 6.25

An atlas of combinatorial transcriptional regulation in mouse and man. Cell (2010) 6.24

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02

Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81

Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet (2008) 5.80

Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study. Lancet (2002) 5.77

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32

Reverse engineering gene networks using singular value decomposition and robust regression. Proc Natl Acad Sci U S A (2002) 5.29

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73

Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet (2009) 4.71

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62

Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments. Trends Genet (2005) 4.56

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37

Guideline on antiplatelet and anticoagulation management in cardiac surgery. Eur J Cardiothorac Surg (2008) 4.36

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33

Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med (2013) 4.15

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13

Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum Mol Genet (2007) 4.09

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA (2007) 4.03

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet (2011) 3.92

Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet (2005) 3.86