Published in Am J Pathol on December 04, 2014
Hematopoietic Stem Cell Regulation by Type I and II Interferons in the Pathogenesis of Acquired Aplastic Anemia. Front Immunol (2016) 0.79
Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation. Arthritis Res Ther (2015) 0.77
The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. PLoS Pathog (2016) 0.76
Rickettsia australis Activates Inflammasome in Human and Murine Macrophages. PLoS One (2016) 0.76
Interferon-Alpha Promotes Th1 Response and Epithelial Apoptosis via Inflammasome Activation in Human Intestinal Mucosa. Cell Mol Gastroenterol Hepatol (2016) 0.75
For Whom the Bell Tolls (and Nods): Spit-acular Saliva. Curr Trop Med Rep (2016) 0.75
NK Cell-Mediated Regulation of Protective Memory Responses against Intracellular Ehrlichial Pathogens. PLoS One (2016) 0.75
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev (2017) 0.75
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods (1999) 17.06
A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science (1995) 11.38
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol (2009) 7.80
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature (2005) 7.72
Pathogen recognition by the innate immune system. Int Rev Immunol (2011) 5.76
The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol (2011) 5.73
Activation and regulation of the inflammasomes. Nat Rev Immunol (2013) 5.71
Sensing and reacting to microbes through the inflammasomes. Nat Immunol (2012) 5.24
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell (2012) 4.44
Type I interferon: friend or foe? J Exp Med (2010) 4.40
Regulation of inflammasome signaling. Nat Immunol (2012) 4.10
Caspase-11 protects against bacteria that escape the vacuole. Science (2013) 4.01
Regulation of type I interferon responses. Nat Rev Immunol (2014) 3.60
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. Nature (2012) 3.40
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol (2013) 3.08
Ehrlichiosis presenting as a life-threatening illness with features of the toxic shock syndrome. Am J Med (1993) 2.67
Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma. J Exp Med (2010) 2.66
Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta (2008) 2.60
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature (2012) 2.41
Human monocytic and granulocytic ehrlichioses. Discovery and diagnosis of emerging tick-borne infections and the critical role of the pathologist. Arch Pathol Lab Med (1997) 1.58
Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages. J Cell Sci (2012) 1.57
Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proc Natl Acad Sci U S A (2014) 1.54
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature (2014) 1.50
Cytosolic LC3 ratio as a sensitive index of macroautophagy in isolated rat hepatocytes and H4-II-E cells. Autophagy (2007) 1.38
Caspase-11 activation in response to bacterial secretion systems that access the host cytosol. PLoS Pathog (2013) 1.38
Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production. J Immunol (2013) 1.32
An intradermal environment promotes a protective type-1 response against lethal systemic monocytotropic ehrlichial infection. Infect Immun (2006) 1.31
Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection. Proc Natl Acad Sci U S A (2012) 1.28
Ehrlichia subversion of host innate responses. Curr Opin Microbiol (2006) 1.20
Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection. Curr Opin Microbiol (2013) 1.19
NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature (2012) 1.16
Role of the inflammasome, IL-1β, and IL-18 in bacterial infections. ScientificWorldJournal (2011) 1.15
Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis. Autophagy (2008) 1.14
Inflammasomes and host defenses against bacterial infections. Curr Opin Microbiol (2013) 1.11
New insight into immunity and immunopathology of Rickettsial diseases. Clin Dev Immunol (2011) 1.10
Current status of immune mechanisms of killing of intracellular microorganisms. FEMS Microbiol Lett (2002) 1.09
Human ehrlichioses. Med Clin North Am (2002) 1.08
Control of NKT cell differentiation by tissue-specific microenvironments. J Immunol (2003) 1.05
Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants. Expert Rev Vaccines (2012) 1.01
Immunology. Orchestrating inflammasomes. Science (2012) 1.01
Detection of pyroptosis by measuring released lactate dehydrogenase activity. Methods Mol Biol (2013) 1.00
Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress. J Biol Chem (2013) 1.00
Licensing Adaptive Immunity by NOD-Like Receptors. Front Immunol (2013) 0.99
Differential interaction of dendritic cells with Rickettsia conorii: impact on host susceptibility to murine spotted fever rickettsiosis. Infect Immun (2007) 0.99
Recognition of bacterial infection by innate immune sensors. Crit Rev Microbiol (2012) 0.97
Regulatory roles of CD1d-restricted NKT cells in the induction of toxic shock-like syndrome in an animal model of fatal ehrlichiosis. Infect Immun (2008) 0.97
Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis. Infect Immun (2007) 0.97
Autophagy regulation in macrophages and neutrophils. Exp Cell Res (2012) 0.96
Protective heterologous immunity against fatal ehrlichiosis and lack of protection following homologous challenge. Infect Immun (2008) 0.95
Autophagic elimination of intracellular parasites: convergent induction by IFN-gamma and CD40 ligation? Autophagy (2007) 0.94
Persistent infection contributes to heterologous protective immunity against fatal ehrlichiosis. Infect Immun (2009) 0.93
Natural killer cells promote tissue injury and systemic inflammatory responses during fatal Ehrlichia-induced toxic shock-like syndrome. Am J Pathol (2010) 0.92
Neutrophils mediate immunopathology and negatively regulate protective immune responses during fatal bacterial infection-induced toxic shock. Infect Immun (2013) 0.90
A subset of NKT cells that lacks the NK1.1 marker, expresses CD1d molecules, and autopresents the alpha-galactosylceramide antigen. J Immunol (2000) 0.90
Ehrlichia chaffeensis tandem repeat proteins and Ank200 are type 1 secretion system substrates related to the repeats-in-toxin exoprotein family. Front Cell Infect Microbiol (2011) 0.89
The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria. J Immunol (2011) 0.87
Autophagy inhibition induces podocyte apoptosis by activating the pro-apoptotic pathway of endoplasmic reticulum stress. Exp Cell Res (2014) 0.86
TLR2 and Nod2 mediate resistance or susceptibility to fatal intracellular Ehrlichia infection in murine models of ehrlichiosis. PLoS One (2013) 0.85
Autophagy activation by interferon-γ via the p38 mitogen-activated protein kinase signalling pathway is involved in macrophage bactericidal activity. Immunology (2014) 0.85
Immune mediators of protective and pathogenic immune responses in patients with mild and fatal human monocytotropic ehrlichiosis. BMC Immunol (2012) 0.84
Detection of cytosolic bacteria by inflammatory caspases. Curr Opin Microbiol (2013) 0.84
Cleaving Beclin 1 to suppress autophagy in chemotherapy-induced apoptosis. Autophagy (2011) 0.83
Type I interferons promote severe disease in a mouse model of lethal ehrlichiosis. Infect Immun (2014) 0.81
Balancing protective immunity and immunopathology: a unifying model of monocytotropic ehrlichiosis. Ann N Y Acad Sci (2005) 0.79
Induction of HGF and VEGF in hepatic regeneration after hepatotoxin-induced cirrhosis in mice. Hepatogastroenterology (2011) 0.78
Autophagy and immune response in kidneys. Semin Nephrol (2013) 0.78