Published in PLoS One on December 08, 2014
PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL. Cell Death Dis (2016) 0.75
The Slavic NBN Founder Mutation: A Role for Reproductive Fitness? PLoS One (2016) 0.75
A case of contralateral breast cancer and skin cancer associated with NBN heterozygous pathogenic variant c.698_701delAACA. Fam Cancer (2017) 0.75
Nijmegen Breakage Syndrome fibroblasts and iPSCs: cellular models for uncovering disease-associated signaling pathways and establishing a screening platform for anti-oxidants. Sci Rep (2017) 0.75
Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem (1996) 45.70
STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res (2012) 18.26
Human CtIP promotes DNA end resection. Nature (2007) 10.63
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J (1999) 9.00
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science (2005) 8.77
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature (2005) 7.45
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell (1998) 6.58
The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol (2002) 6.44
Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol Cell (2007) 5.31
ATM activation by oxidative stress. Science (2010) 5.22
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell (2004) 4.99
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res (2008) 4.79
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell (1998) 4.72
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell (1995) 4.64
Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal. Genes Dev (2005) 4.61
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science (2004) 4.58
Ribosomopathies: human disorders of ribosome dysfunction. Blood (2010) 4.43
Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res (1999) 4.24
RNA helicase A mediates association of CBP with RNA polymerase II. Cell (1997) 4.00
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature (2000) 3.96
Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. J Biol Chem (2008) 3.52
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science (1999) 3.47
gammaH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia (2010) 3.46
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol (2005) 3.25
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J (2004) 3.20
PARP goes transcription. Cell (2003) 3.16
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell (2009) 2.90
Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol (2001) 2.85
Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr Biol (2001) 2.72
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem (2007) 2.62
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat Genet (1998) 2.55
Assembly and function of DNA double-strand break repair foci in mammalian cells. DNA Repair (Amst) (2010) 2.51
XRCC1 protein interacts with one of two distinct forms of DNA ligase III. Biochemistry (1997) 2.46
Cell and tissue responses to oxidative damage. Lab Invest (1993) 2.45
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain. Curr Biol (2002) 2.44
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep (2008) 2.35
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J (2012) 2.34
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol Cell (2004) 2.31
ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage. DNA Repair (Amst) (2002) 2.30
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J (2010) 2.27
A novel MALDI LIFT-TOF/TOF mass spectrometer for proteomics. Anal Bioanal Chem (2003) 2.27
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. J Cell Biol (2008) 2.21
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin. J Cell Biol (2008) 2.18
Mitochondria, oxidative stress and neurodegeneration. J Neurol Sci (2012) 2.15
CtIP links DNA double-strand break sensing to resection. Mol Cell (2009) 2.11
Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail. J Biol Chem (2005) 2.10
An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele. Nat Genet (2001) 2.09
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell (2009) 2.07
Human RNA helicase A is homologous to the maleless protein of Drosophila. J Biol Chem (1993) 1.97
A murine model of Nijmegen breakage syndrome. Curr Biol (2002) 1.96
53BP1: function and mechanisms of focal recruitment. Biochem Soc Trans (2009) 1.90
Chk2 activation dependence on Nbs1 after DNA damage. Mol Cell Biol (2001) 1.85
The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol (2010) 1.80
Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Res (2000) 1.76
Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization. Mol Cell Biol (2001) 1.73
Tip60: connecting chromatin to DNA damage signaling. Cell Cycle (2010) 1.73
Inhibition of hsp90 compromises the DNA damage response to radiation. Cancer Res (2006) 1.68
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J (2002) 1.64
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A (2008) 1.63
Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications. J Am Chem Soc (2009) 1.59
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene (2004) 1.58
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature (2007) 1.58
DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'. Cell Cycle (2007) 1.57
Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining. Int J Radiat Oncol Biol Phys (2013) 1.57
The role of DNA dependent protein kinase in synapsis of DNA ends. Nucleic Acids Res (2003) 1.51
The clinical manifestation of a defective response to DNA double-strand breaks as exemplified by Nijmegen breakage syndrome. Oncogene (2007) 1.46
Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis. Cancer Res (2003) 1.45
Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair. J Mol Cell Biol (2013) 1.37
Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage. Mol Cell Biol (2003) 1.37
Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks. DNA Repair (Amst) (2004) 1.33
Protein identification by mass spectrometry: issues to be considered. Mol Cell Proteomics (2003) 1.30
ALT-associated PML bodies are present in viable cells and are enriched in cells in the G(2)/M phase of the cell cycle. J Cell Sci (2000) 1.30
NBS1 and its functional role in the DNA damage response. DNA Repair (Amst) (2004) 1.30
Solving the RIDDLE of 53BP1 recruitment to sites of damage. Cell Cycle (2009) 1.27
Nijmegen breakage syndrome (NBS). Orphanet J Rare Dis (2012) 1.27
Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation. J Biol Chem (2003) 1.25
Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response. Bioinformatics (2006) 1.18
An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. Hum Mol Genet (2004) 1.16
N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair. J Biol Chem (2009) 1.15
Nijmegen Breakage Syndrome mutations and risk of breast cancer. Int J Cancer (2008) 1.14
Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta. Genes Dev (2004) 1.14
Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling. Nat Struct Mol Biol (2012) 1.14
Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene (2004) 1.12
BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation. Proc Natl Acad Sci U S A (2012) 1.11
BRCT domain interactions in the heterodimeric DNA repair protein XRCC1-DNA ligase III. Biochemistry (2001) 1.10
Impaired elimination of DNA double-strand break-containing lymphocytes in ataxia telangiectasia and Nijmegen breakage syndrome. DNA Repair (Amst) (2006) 1.08
MRN and the race to the break. Chromosoma (2009) 1.04
Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation. Cell Cycle (2008) 1.03
Specificity of protein interactions mediated by BRCT domains of the XRCC1 DNA repair protein. J Biol Chem (2005) 1.03
NBS1 Heterozygosity and Cancer Risk. Curr Genomics (2008) 1.03
Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation. Mutagenesis (2000) 0.99
The R215W mutation in NBS1 impairs gamma-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients. Biochem Biophys Res Commun (2008) 0.98
Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response. Chromosoma (2013) 0.98
Dancing on damaged chromatin: functions of ATM and the RAD50/MRE11/NBS1 complex in cellular responses to DNA damage. J Radiat Res (2008) 0.96
Role of poly(ADP-ribosyl)ation in DNA-PKcs- independent V(D)J recombination. Proc Natl Acad Sci U S A (2002) 0.94
Nijmegen breakage syndrome (NBS) with neurological abnormalities and without chromosomal instability. J Med Genet (2005) 0.93
Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview. Blood Transfus (2014) 0.93
Red blood cell subpopulations in freshly drawn blood: application of proteomics and metabolomics to a decades-long biological issue. Blood Transfus (2012) 0.88
Clinical metabolomics: the next stage of clinical biochemistry. Blood Transfus (2012) 0.87
Shaking hands with the future through omics application in transfusion medicine and clinical biochemistry. Blood Transfus (2012) 0.87
Classic and alternative red blood cell storage strategies: seven years of "-omics" investigations. Blood Transfus (2014) 0.81
Deoxygenation of leucofiltered erythrocyte concentrates preserves proteome stability during storage in the blood bank. Blood Transfus (2013) 0.80
Supplementation of anti-oxidants in leucofiltered erythrocyte concentrates: assessment of morphological changes through scanning electron microscopy. Blood Transfus (2014) 0.79
Erectile dysfunction and diabetes: Association with the impairment of lipid metabolism and oxidative stress. Clin Biochem (2015) 0.76
Proteomic profiling and post-translational modifications in human keratinocytes treated with Mucuna pruriens leaf extract. J Ethnopharmacol (2013) 0.76
Red blood cell storage affects the stability of cytosolic native protein complexes. Transfusion (2015) 0.76
Expression and oxidative modifications of plasma proteins in autism spectrum disorders: Interplay between inflammatory response and lipid peroxidation. Proteomics Clin Appl (2016) 0.76
Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome. Neurosci Res (2015) 0.76
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism. Mol Autism (2016) 0.75
In reply to: "Further comments on platelet proteomics in Transfusion Medicine". Blood Transfus (2013) 0.75
Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways. J Proteomics (2016) 0.75
Proteomic analysis of the Rett syndrome experimental model mecp2(Q63X) mutant zebrafish. J Proteomics (2017) 0.75
Proteomic analysis of 4-hydroxynonenal and nitrotyrosine modified proteins in RTT fibroblasts. Int J Biochem Cell Biol (2016) 0.75