Chk2 activation dependence on Nbs1 after DNA damage.

PubWeight™: 1.85‹?› | Rank: Top 3%

🔗 View Article (PMC 87245)

Published in Mol Cell Biol on August 01, 2001

Authors

G Buscemi1, C Savio, L Zannini, F Miccichè, D Masnada, M Nakanishi, H Tauchi, K Komatsu, S Mizutani, K Khanna, P Chen, P Concannon, L Chessa, D Delia

Author Affiliations

1: Department of Experimental Oncology, Istituto Nazionale Tumori, 20133 Milan, Italy.

Articles citing this

Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A (2005) 4.24

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev (2002) 4.12

The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J (2003) 3.91

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev (2002) 3.49

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol (2004) 2.67

The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep (2003) 1.97

Nbs1 is required for ATR-dependent phosphorylation events. EMBO J (2004) 1.95

MRE11/RAD50/NBS1: complex activities. Chromosoma (2004) 1.79

ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres. EMBO J (2012) 1.69

Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proc Natl Acad Sci U S A (2005) 1.69

Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J (2002) 1.64

Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol (2004) 1.57

53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J (2009) 1.47

The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint. Mol Cell Biol (2003) 1.45

Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR. J Cell Biol (2006) 1.43

RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation. J Cell Biol (2009) 1.41

ATM activation in the presence of oxidative stress. Cell Cycle (2010) 1.40

The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A. Mol Cell Biol (2007) 1.38

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J Exp Med (2007) 1.32

Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol (2005) 1.31

The involvement of DNA-damage and -repair defects in neurological dysfunction. Am J Hum Genet (2008) 1.17

NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. J Cell Sci (2007) 1.14

Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance. Mol Cell Biol (2003) 1.09

DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. Mol Cell Biol (2006) 1.07

ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. J Biol Chem (2011) 0.98

Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation. Genetics (2005) 0.96

Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. J Biol Chem (2011) 0.95

Nijmegen breakage syndrome (NBS) with neurological abnormalities and without chromosomal instability. J Med Genet (2005) 0.93

Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Mol Cell Biol (2008) 0.92

ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair. Mol Cell Biol (2013) 0.90

The Nijmegen breakage syndrome gene and its role in genome stability. Chromosoma (2004) 0.89

ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor. Biomolecules (2015) 0.86

Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation. PLoS One (2014) 0.83

Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism. Mol Cell Biol (2012) 0.83

Modification in the expression of Mre11/Rad50/Nbs1 complex in low dose irradiated human lymphocytes. Dose Response (2009) 0.81

Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells. Blood (2007) 0.81

Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex. Cell Cycle (2009) 0.80

Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition. DNA Repair (Amst) (2010) 0.79

The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint. Genetics (2010) 0.79

Recent progress in mouse models for tumor suppressor genes and its implications in human cancer. Clin Med Insights Oncol (2013) 0.78

NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication. DNA Repair (Amst) (2009) 0.78

EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele. Nucleic Acids Res (2015) 0.76

NBS1 and multiple regulations of DNA damage response. J Radiat Res (2016) 0.75

Meiotic localization of Mre11 and Rad50 in wild type, spo11-1, and MRN complex mutants of Coprinus cinereus. Chromosoma (2009) 0.75

Articles cited by this

The DNA damage response: putting checkpoints in perspective. Nature (2000) 19.07

A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20

Cell cycle control and cancer. Science (1994) 10.90

The structural basis for 14-3-3:phosphopeptide binding specificity. Cell (1997) 10.87

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science (1998) 8.74

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science (1997) 8.43

DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (2000) 7.85

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev (2000) 7.29

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell (1998) 6.58

Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem (1999) 6.14

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev (2000) 5.90

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev (2000) 5.72

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A (2000) 5.64

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature (2000) 5.55

The many substrates and functions of ATM. Nat Rev Mol Cell Biol (2000) 5.46

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature (1999) 5.38

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science (1999) 5.09

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell (1998) 4.72

Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J (1999) 4.64

The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J (1996) 4.45

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol Cell Biol (1997) 4.11

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev (1999) 4.08

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature (2000) 3.96

Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell (1998) 3.80

The genetic defect in ataxia-telangiectasia. Annu Rev Immunol (1997) 3.69

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature (2000) 3.65

ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet (2000) 3.49

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature (2000) 3.48

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene (1999) 3.23

The FHA domain is a modular phosphopeptide recognition motif. Mol Cell (1999) 3.16

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. Nat Cell Biol (2000) 2.66

A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.51

DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev (1998) 2.44

A new chromosomal instability disorder: the Nijmegen breakage syndrome. Acta Paediatr Scand (1981) 2.16

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. J Biol Chem (2000) 2.00

The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response. Am J Hum Genet (1999) 1.73

Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase. Oncogene (1999) 1.68

Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation. J Biol Chem (1996) 1.59

Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia. Trends Genet (1998) 1.52

Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53. J Biol Chem (1999) 1.47

Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defect. Hum Genet (1987) 1.47

The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity. J Biol Chem (2001) 1.43

The gene for the ataxia-telangiectasia variant, Nijmegen breakage syndrome, maps to a 1-cM interval on chromosome 8q21. Am J Hum Genet (1997) 1.41

Cell cycle. Checkpoint on the nuclear frontier. Nature (1999) 1.22

Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation. Mol Cell Biol (1997) 1.15

Expression of full-length NBS1 protein restores normal radiation responses in cells from Nijmegen breakage syndrome patients. Biochem Biophys Res Commun (1999) 1.12

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia. Int J Radiat Biol (1999) 1.02

Defective control of apoptosis, radiosensitivity, and spindle checkpoint in ataxia telangiectasia. Cancer Res (1998) 0.99

Fine localization of the Nijmegen breakage syndrome gene to 8q21: evidence for a common founder haplotype. Am J Hum Genet (1998) 0.96

Defective control of apoptosis and mitotic spindle checkpoint in heterozygous carriers of ATM mutations. Cancer Res (1999) 0.92

Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome. Clin Immunol Immunopathol (1997) 0.89

Characterization of cell cycle checkpoint responses after ionizing radiation in Nijmegen breakage syndrome cells. Cancer Res (1998) 0.89

A variant of the Nijmegen breakage syndrome with unusual cytogenetic features and intermediate cellular radiosensitivity. J Med Genet (1997) 0.85

Impaired p53-mediated DNA damage response, cell-cycle disturbance and chromosome aberrations in Nijmegen breakage syndrome lymphoblastoid cell lines. Int J Radiat Biol (1999) 0.83

Radiation induction of p53 in cells from Nijmegen breakage syndrome is defective but not similar to ataxia-telangiectasia. Biochem Biophys Res Commun (1998) 0.82

ATM protein and p53-serine 15 phosphorylation in ataxia-telangiectasia (AT) patients and at heterozygotes. Br J Cancer (2000) 0.80

ATM: the p53 booster. Nat Med (1998) 0.80

Articles by these authors

RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature (1970) 19.89

Antisense transcription in the mammalian transcriptome. Science (2005) 15.69

A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20

Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet (2000) 8.33

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci U S A (2001) 6.70

A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet (1996) 6.58

A restriction map of the bacteriophage T4 genome. Mol Gen Genet (1980) 6.37

Sequence of retrovirus provirus resembles that of bacterial transposable elements. Nature (1980) 5.95

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell (1998) 4.72

Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin. Proc Natl Acad Sci U S A (1981) 4.50

Expression of the CD34 gene in vascular endothelial cells. Blood (1990) 4.41

Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science (1995) 4.41

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev (2000) 4.38

Structure, organization and polymorphism of murine and human T-cell receptor alpha and beta chain gene families. Immunol Rev (1988) 4.23

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci (2000) 4.14

Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet (1999) 3.95

Localization of an ataxia-telangiectasia gene to chromosome 11q22-23. Nature (1988) 3.82

P53 expression in breast cancer. Int J Cancer (1988) 3.51

ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet (2000) 3.49

Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat Cell Biol (1999) 3.45

Initiation of Sendai virus multiplication from transfected cDNA or RNA with negative or positive sense. Genes Cells (1996) 3.41

An international outbreak of Salmonella infections caused by alfalfa sprouts grown from contaminated seeds. J Infect Dis (1997) 3.39

A DNA-depenent DNA polymerase and a DNA endonuclease in virions of Rous sarcoma virus. Nature (1970) 3.31

virG, a plasmid-coded virulence gene of Shigella flexneri: identification of the virG protein and determination of the complete coding sequence. J Bacteriol (1989) 3.31

Evidence for the direct involvement of the rhinovirus canyon in receptor binding. Proc Natl Acad Sci U S A (1988) 3.29

CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev (1996) 3.27

Characterization of oligonucleotide transport into living cells. Proc Natl Acad Sci U S A (1989) 3.27

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J (1999) 3.22

In vitro synthesis of an infectious RNA from cDNA clones of human rhinovirus type 14. J Virol (1985) 3.19

Molecular cloning and complete sequence determination of RNA genome of human rhinovirus type 14. Proc Natl Acad Sci U S A (1985) 3.17

Eight genes in region 5 that form an operon are essential for invasion of epithelial cells by Shigella flexneri 2a. J Bacteriol (1993) 2.82

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control. Proc Natl Acad Sci U S A (1998) 2.81

A dual transcriptional activation system for the 230 kb plasmid genes coding for virulence-associated antigens of Shigella flexneri. Mol Microbiol (1989) 2.81

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol Cell (2001) 2.69

Functional organization and nucleotide sequence of virulence Region-2 on the large virulence plasmid in Shigella flexneri 2a. Mol Microbiol (1989) 2.68

Lack of serological relationship among DNA polymerases of avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and chicken cells. J Virol (1973) 2.46

bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood (1993) 2.45

NAK is an IkappaB kinase-activating kinase. Nature (2000) 2.44

MicroRNA profile analysis of human prostate cancers. Cancer Gene Ther (2008) 2.43

Infectious and noninfectious recombinant clones of the provirus of SNV differ in cellular DNA and are apparently the same in viral DNA. Cell (1980) 2.35

Molecular cloning of engrailed: a gene involved in the development of pattern in Drosophila melanogaster. Cell (1985) 2.26

Splicing defects in the ataxia-telangiectasia gene, ATM: underlying mutations and consequences. Am J Hum Genet (1999) 2.26

Antitumor action of some Basidiomycetes, especially Phllinus linteus. Gan (1968) 2.25

A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome. EMBO J (2001) 2.22

Diversity and structure of human T-cell receptor beta-chain variable region genes. Proc Natl Acad Sci U S A (1986) 2.19

Eukaryotic DNA polymerases: proposal for a revised nomenclature. J Biol Chem (2001) 2.15

Regulated genomic instability and neoplasia in the lymphoid lineage. Blood (1999) 2.13

Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells. J Biol Chem (1998) 2.13

The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV. Appl Environ Microbiol (2001) 2.11

Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium. Am J Hum Genet (1995) 2.07

Predominance of null mutations in ataxia-telangiectasia. Hum Mol Genet (1996) 2.06

Ten-year incidence of dementia in a rural elderly US community population: the MoVIES Project. Neurology (2000) 2.03

A Japanese family of X-linked auto-immune enteropathy with haemolytic anaemia and polyendocrinopathy. Eur J Pediatr (1993) 1.99

Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product. Ophthalmologica (1997) 1.98

Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex. Cell (1986) 1.96

Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes. A hit and run phenomenon. J Biol Chem (1999) 1.90

Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney. J Am Soc Nephrol (2001) 1.88

Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems. Cancer Res (1996) 1.85

Mechanisms of GDF-5 action during skeletal development. Development (1999) 1.83

The absence of a surface protease, OmpT, determines the intercellular spreading ability of Shigella: the relationship between the ompT and kcpA loci. Mol Microbiol (1993) 1.79

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. Br J Cancer (2001) 1.77

A cDNA clone closely associated with non-A, non-B hepatitis. Nucleic Acids Res (1990) 1.76

RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins. Proc Natl Acad Sci U S A (1991) 1.74

Enzymes and nucleotides in virions of Rous sarcoma virus. J Virol (1971) 1.74

A 10-year experience of liver transplantation for hepatitis C: analysis of factors determining outcome in over 500 patients. Ann Surg (2001) 1.73

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization. Mol Cell Biol (2001) 1.73

Transfer RNA modification: influence on translational frameshifting and metabolism. FEBS Lett (1999) 1.73

Positional cloning of the gene for Nijmegen breakage syndrome. Nat Genet (1998) 1.73

Distinct phenotypes distinguish the molecular classes of Angelman syndrome. J Med Genet (2001) 1.71

DNA ligase and exonuclease activities in virions of rous sarcoma virus. Nat New Biol (1971) 1.71

Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation. J Thromb Haemost (2005) 1.70

Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax. J Biol Chem (2001) 1.70

B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene. Proc Natl Acad Sci U S A (1988) 1.70

Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion. Cancer Res (2001) 1.70

Diversity and structure of human T-cell receptor alpha-chain variable region genes. Proc Natl Acad Sci U S A (1987) 1.69

Anatomic correction of transposition of the great arteries. J Thorac Cardiovasc Surg (1981) 1.69

Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase. Oncogene (1999) 1.68

Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes. Appl Environ Microbiol (1999) 1.66

Hepatitis B virus genotype distribution among chronic hepatitis B virus carriers in Shanghai, China. Intervirology (2001) 1.65

Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease. Aliment Pharmacol Ther (2013) 1.64

Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization. Nat Med (1997) 1.62

Development of a digital image database for chest radiographs with and without a lung nodule: receiver operating characteristic analysis of radiologists' detection of pulmonary nodules. AJR Am J Roentgenol (2000) 1.61

Superior outcome of infant acute myeloid leukemia with intensive chemotherapy: results of the Japan Infant Leukemia Study Group. Blood (2001) 1.61

Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival. PLoS One (2007) 1.61

Specific serological relationships among partially purified DNA polymerases of avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and avian cells. J Virol (1974) 1.61

An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair (Amst) (2004) 1.60

Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation. J Biol Chem (1996) 1.59

Nephrotic syndrome after treatment with 5-aminosalicylic acid. Br Med J (Clin Res Ed) (1988) 1.59

Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation. Cancer Res (1995) 1.59

Analysis of complex relationships between age, p53, epidermal growth factor receptor, and survival in glioblastoma patients. Cancer Res (2001) 1.59

Isolation of human haematopoietic progenitor cells using monoclonal antibodies. Nature (1980) 1.57

EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells. Clin Exp Metastasis (1996) 1.57

Functional analyses of the promoters in the lantibiotic mutacin II biosynthetic locus in Streptococcus mutans. Appl Environ Microbiol (1999) 1.55

Genotype-phenotype relationships in ataxia-telangiectasia and variants. Am J Hum Genet (1998) 1.55