Published in Proc Natl Acad Sci U S A on August 04, 2008
The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol (2011) 3.83
The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev Mol Cell Biol (2009) 3.50
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell (2009) 2.90
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell (2009) 2.07
DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol (2013) 1.72
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response. DNA Repair (Amst) (2009) 1.66
Focus on histone variant H2AX: to be or not to be. FEBS Lett (2010) 1.56
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol (2009) 1.55
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Mol Cell (2012) 1.50
Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci (2009) 1.49
Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance. Mol Cell (2014) 1.45
DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints. Trends Cell Biol (2010) 1.44
MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol (2011) 1.40
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem (2009) 1.39
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. Mol Biol Cell (2009) 1.33
The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet (2013) 1.27
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet (2011) 1.23
Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners. PLoS One (2009) 1.21
MDC1: The art of keeping things in focus. Chromosoma (2010) 1.15
The cellular response to DNA damage: a focus on MDC1 and its interacting proteins. Nucleus (2009) 1.13
The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response. Genes Dev (2013) 1.09
hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic Acids Res (2011) 1.08
MRN and the race to the break. Chromosoma (2009) 1.04
Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. J Mol Biol (2008) 1.01
DNA double-strand break signaling and human disorders. Genome Integr (2010) 1.00
MCL-1 localizes to sites of DNA damage and regulates DNA damage response. Cell Cycle (2010) 0.98
CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Res (2009) 0.97
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. Nat Cell Biol (2014) 0.97
Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer. Oncotarget (2012) 0.97
Ancient and recent adaptive evolution of primate non-homologous end joining genes. PLoS Genet (2010) 0.96
Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain. Nucleic Acids Res (2012) 0.93
The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination. J Biol Chem (2012) 0.93
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator. Nucleic Acids Res (2012) 0.93
Epigenetic regulation of genomic integrity. Chromosoma (2012) 0.93
Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks. EMBO J (2014) 0.91
ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair. Mol Cell Biol (2013) 0.90
A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin. EMBO Rep (2010) 0.90
A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinase. J Biol Chem (2012) 0.89
Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks. Cell Cycle (2010) 0.89
Time to bloom. Genome Integr (2010) 0.89
Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses. J Biol Chem (2012) 0.86
Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks. Mutat Res (2013) 0.86
NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53. Mol Cancer Res (2011) 0.85
Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells. J Biomed Res (2010) 0.84
Oligomerization of MDC1 protein is important for proper DNA damage response. J Biol Chem (2011) 0.84
Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation. PLoS One (2014) 0.83
Spatiotemporal dynamics of early DNA damage response proteins on complex DNA lesions. PLoS One (2013) 0.83
The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer. Cancers (Basel) (2015) 0.82
Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure (2013) 0.82
A specific inhibitor of protein kinase CK2 delays gamma-H2Ax foci removal and reduces clonogenic survival of irradiated mammalian cells. Radiat Oncol (2011) 0.82
ATM-mediated KDM2A phosphorylation is required for the DNA damage repair. Oncogene (2015) 0.79
A mutation in the FHA domain of Coprinus cinereus Nbs1 Leads to Spo11-independent meiotic recombination and chromosome segregation. G3 (Bethesda) (2013) 0.79
ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination. J Immunol (2014) 0.79
Structural studies of DNA end detection and resection in homologous recombination. Cold Spring Harb Perspect Biol (2014) 0.78
PHRF1 promotes genome integrity by modulating non-homologous end-joining. Cell Death Dis (2015) 0.77
The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii. Front Microbiol (2016) 0.75
And-1 is required for homologous recombination repair by regulating DNA end resection. Nucleic Acids Res (2016) 0.75
The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression. Cell Rep (2017) 0.75
ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability. Nat Commun (2017) 0.75
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell (2006) 20.92
Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A (2004) 10.78
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science (2005) 8.77
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature (2005) 7.45
One-thousand-and-one substrates of protein kinase CK2? FASEB J (2003) 6.89
MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature (2003) 6.81
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell (1998) 6.58
Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature (2000) 5.55
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell (1999) 5.44
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A (2007) 4.75
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell (1998) 4.72
MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature (2003) 4.56
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev (2002) 4.12
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature (2000) 3.96
The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J (2003) 3.91
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev (2002) 3.49
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature (2000) 3.48
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J (2004) 3.20
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature (2003) 3.00
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain. Curr Biol (2002) 2.44
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep (2008) 2.35
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. J Cell Biol (2008) 2.21
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin. J Cell Biol (2008) 2.18
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2. Biochem Biophys Res Commun (2004) 1.70
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene (2004) 1.58
The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity. J Biol Chem (2001) 1.43
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J (2003) 1.37
Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses. Nucleic Acids Res (2002) 1.27
Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response. Bioinformatics (2006) 1.18
Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. J Biol Chem (2004) 1.17
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
The BRCT domain is a phospho-protein binding domain. Science (2003) 7.42
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science (2007) 5.88
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol (2004) 4.78
DBC1 is a negative regulator of SIRT1. Nature (2008) 4.66
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol (2008) 4.56
Genomic instability in laminopathy-based premature aging. Nat Med (2005) 4.54
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell (2009) 4.48
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol (2003) 4.36
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol (2009) 3.79
53BP1 is required for class switch recombination. J Cell Biol (2004) 3.57
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev (2006) 3.44
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science (2006) 3.41
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem (2003) 3.34
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell (2010) 3.33
USP10 regulates p53 localization and stability by deubiquitinating p53. Cell (2010) 3.17
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature (2011) 3.10
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature (2003) 3.00
PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A (2009) 2.98
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science (2010) 2.80
Histone H3-K56 acetylation is important for genomic stability in mammals. Cell Cycle (2009) 2.77
UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. J Biol Chem (2004) 2.72
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol (2008) 2.68
RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol (2009) 2.67
19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. FASEB J (2007) 2.63
CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol (2007) 2.55
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J Biol Chem (2003) 2.50
MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev (2009) 2.49
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell (2009) 2.41
The annealing helicase HARP protects stalled replication forks. Genes Dev (2009) 2.19
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol (2002) 2.09
Human claspin is required for replication checkpoint control. J Biol Chem (2003) 2.02
Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J Biol Chem (2003) 2.00
WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol (2011) 2.00
Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. Eur J Immunol (2007) 1.98
Chfr is required for tumor suppression and Aurora A regulation. Nat Genet (2005) 1.97
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest (2010) 1.97
Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem (2010) 1.95
Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem (2008) 1.93
RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem (2013) 1.86
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol (2004) 1.82
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure (2004) 1.82
The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J Biol Chem (2001) 1.82
The DNA damage response pathways: at the crossroad of protein modifications. Cell Res (2008) 1.80
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol (2009) 1.79
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol (2009) 1.73
Image-based models of cardiac structure in health and disease. Wiley Interdiscip Rev Syst Biol Med (2010) 1.67
Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation. Mol Cell Biol (2004) 1.66
BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell (2010) 1.65
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem (2004) 1.64
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol (2012) 1.64
SOSS complexes participate in the maintenance of genomic stability. Mol Cell (2009) 1.63
Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival. Mol Pharmacol (2005) 1.61
BRCA1 participates in DNA decatenation. Nat Struct Mol Biol (2005) 1.59
Focus on histone variant H2AX: to be or not to be. FEBS Lett (2010) 1.56
53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol (2005) 1.56
Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol (2010) 1.55
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem (2007) 1.55
Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. J Biol Chem (2008) 1.52
MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev (2011) 1.52
PALB2 regulates recombinational repair through chromatin association and oligomerization. J Biol Chem (2009) 1.50
Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol Cell Biol (2008) 1.50
Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci (2009) 1.49
The mitotic checkpoint in cancer and aging: what have mice taught us? Curr Opin Cell Biol (2005) 1.47
The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem (2006) 1.45
Sumoylation of MDC1 is important for proper DNA damage response. EMBO J (2012) 1.44
Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell (2010) 1.40
MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol (2011) 1.40
Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem (2009) 1.39
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem (2009) 1.39
Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol (2008) 1.38
Improved molecular imaging contrast agent for detection of human thrombus. Magn Reson Med (2003) 1.37
The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol Cell (2012) 1.37
Harmonic phase MR tagging for direct quantification of Lagrangian strain in rat hearts after myocardial infarction. Magn Reson Med (2004) 1.35
Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo. J Virol (2005) 1.34
DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res (2013) 1.33
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. J Exp Med (2010) 1.33
Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol (2008) 1.32
MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem (2004) 1.32
BRCA1 is a negative modulator of the PRC2 complex. EMBO J (2013) 1.31
Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem (2005) 1.31
Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol (2005) 1.31
Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. Circulation (2009) 1.30
SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem (2010) 1.30
Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol (2008) 1.29