Properties of the DNA-binding domain of the simian virus 40 large T antigen.

PubWeight™: 1.08‹?› | Rank: Top 10%

🔗 View Article (PMC 363723)

Published in Mol Cell Biol on December 01, 1989

Authors

D McVey1, M Strauss, Y Gluzman

Author Affiliations

1: Cold Spring Harbor Laboratory, New York 11724.

Articles citing this

The 68-kilodalton E1 protein of bovine papillomavirus is a DNA binding phosphoprotein which associates with the E2 transcriptional activator in vitro. J Virol (1991) 2.65

DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects. J Virol (1993) 1.73

Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication. Mol Cell Biol (1994) 1.40

Purification of the simian virus 40 (SV40) T antigen DNA-binding domain and characterization of its interactions with the SV40 origin. J Virol (1997) 1.15

cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen. J Virol (1993) 1.15

Role of single-stranded DNA binding activity of T antigen in simian virus 40 DNA replication. J Virol (2001) 1.13

T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123. J Virol (1994) 1.12

Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124. J Virol (1996) 1.08

Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication. Virology (2010) 1.03

The human DNA-activated protein kinase phosphorylates simian virus 40 T antigen at amino- and carboxy-terminal sites. J Virol (1991) 1.02

Quantitative analysis of the binding of simian virus 40 large T antigen to DNA. J Virol (2007) 0.99

Nonspecific double-stranded DNA binding activity of simian virus 40 large T antigen is involved in melting and unwinding of the origin. J Virol (2003) 0.96

The finger domain of simian virus 40 large T antigen controls DNA-binding specificity. J Virol (1990) 0.86

The origin DNA-binding and single-stranded DNA-binding domains of simian virus 40 large T antigen are distinct. J Virol (1998) 0.84

Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites. J Virol (1996) 0.76

Simian virus 40 large T antigen can specifically unwind the central palindrome at the origin of DNA replication. J Virol (2009) 0.75

Articles cited by this

Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J Mol Biol (1986) 55.34

Simian virus 40 deoxyribonucleic acid synthesis: the viral replicon. J Virol (1972) 16.59

Monoclonal antibodies specific for simian virus 40 tumor antigens. J Virol (1981) 15.59

Potential metal-binding domains in nucleic acid binding proteins. Science (1986) 13.00

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell (1987) 12.30

Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen. Proc Natl Acad Sci U S A (1980) 10.22

Regulation of tumor antigen synthesis by simain virus 40 gene A. J Virol (1975) 9.93

Zinc fingers: gilt by association. Cell (1988) 9.21

Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins. Nature (1984) 6.79

DNA helicase activity of SV40 large tumor antigen. EMBO J (1986) 6.08

Homology among DNA-binding proteins suggests use of a conserved super-secondary structure. Nature (1982) 5.21

Topography of simian virus 40 A protein-DNA complexes: arrangement of pentanucleotide interaction sites at the origin of replication. J Virol (1983) 5.00

T antigen repression of SV40 early transcription from two promoters. Cell (1981) 4.83

An immunoaffinity purification procedure for SV40 large T antigen. Virology (1985) 4.81

Binding of a simian virus 40 T antigen-related protein to DNA. J Mol Biol (1981) 4.76

Origin-defective mutants of SV40. Cold Spring Harb Symp Quant Biol (1980) 4.64

Initiation of simian virus 40 DNA replication in vitro: large-tumor-antigen- and origin-dependent unwinding of the template. Proc Natl Acad Sci U S A (1987) 4.23

Mutational analysis of the simian virus 40 replicon: pseudorevertants of mutants with a defective replication origin. Proc Natl Acad Sci U S A (1979) 4.15

Localized melting and structural changes in the SV40 origin of replication induced by T-antigen. EMBO J (1988) 3.96

T antigen and template requirements for SV40 DNA replication in vitro. EMBO J (1985) 3.59

Xenopus transcription factor A requires zinc for binding to the 5 S RNA gene. J Biol Chem (1983) 3.54

In vitro mutagenesis of a putative DNA binding domain of SV40 large-T. Virology (1984) 3.50

Functional organization of the simian virus 40 origin of DNA replication. Mol Cell Biol (1986) 3.40

recA protein-catalyzed strand assimilation: stimulation by Escherichia coli single-stranded DNA-binding protein. Proc Natl Acad Sci U S A (1980) 3.38

Distinct regions of Sp1 modulate DNA binding and transcriptional activation. Science (1988) 3.23

Simian virus 40 large T antigen is phosphorylated at multiple sites clustered in two separate regions. J Virol (1982) 3.18

Biochemical activities of T-antigen proteins encoded by simian virus 40 A gene deletion mutants. Mol Cell Biol (1983) 3.06

An altered DNA conformation in origin region I is a determinant for the binding of SV40 large T antigen. Cell (1986) 2.88

Structural similarity in the DNA-binding domains of catabolite gene activator and cro repressor proteins. Proc Natl Acad Sci U S A (1982) 2.84

Domain structure of the simian virus 40 core origin of replication. Mol Cell Biol (1986) 2.72

Essential contact residues within SV40 large T antigen binding sites I and II identified by alkylation-interference. Cell (1984) 2.59

ATP stimulates the binding of simian virus 40 (SV40) large tumor antigen to the SV40 origin of replication. Proc Natl Acad Sci U S A (1988) 2.51

ATP-dependent formation of a specialized nucleoprotein structure by simian virus 40 (SV40) large tumor antigen at the SV40 replication origin. Proc Natl Acad Sci U S A (1987) 2.49

ATP enhances the binding of simian virus 40 large T antigen to the origin of replication. J Virol (1987) 2.43

SV40 T antigen binding site mutations that affect autoregulation. Cell (1983) 2.43

Structure and function of SV40 large-T antigen. Philos Trans R Soc Lond B Biol Sci (1987) 2.37

The adenine-thymine domain of the simian virus 40 core origin directs DNA bending and coordinately regulates DNA replication. Mol Cell Biol (1986) 2.31

DNA binding properties of simian virus 40 temperature-sensitive A proteins. J Virol (1982) 2.31

Regulation of SV40 DNA replication by phosphorylation of T antigen. EMBO J (1987) 2.17

Consensus topography in the ATP binding site of the simian virus 40 and polyomavirus large tumor antigens. Proc Natl Acad Sci U S A (1987) 2.15

Purification of simian virus 40 large T antigen by immunoaffinity chromatography. J Virol (1985) 2.01

DNA-binding activity of simian virus 40 large T antigen correlates with a distinct phosphorylation state. J Virol (1984) 2.01

Secondary structure determination for the Antennapedia homeodomain by nuclear magnetic resonance and evidence for a helix-turn-helix motif. EMBO J (1988) 1.89

Expression of simian virus 40 T antigen in Escherichia coli: localization of T-antigen origin DNA-binding domain to within 129 amino acids. J Virol (1988) 1.77

DNA-binding properties of simian virus 40 T-antigen mutants defective in viral DNA replication. Mol Cell Biol (1983) 1.76

Different forms of simian virus 40 large tumor antigen varying in their affinities for DNA. J Virol (1982) 1.72

Modification of SV40 T antigen by poly ADP-ribosylation. Cell (1981) 1.70

Simian virus 40 mutant T antigens with relaxed specificity for the nucleotide sequence at the viral DNA origin of replication. J Virol (1984) 1.65

Seventeen base pairs of region I encode a novel tripartite binding signal for SV40 T antigen. Cell (1985) 1.64

DNA-binding region of the simian virus 40 tumor antigen. J Virol (1986) 1.62

Single strand DNA binding of simian virus 40 tumor antigen. J Biol Chem (1979) 1.60

Studies on the origin-specific DNA-binding domain of simian virus 40 large T antigen. J Virol (1987) 1.56

Removal of serine phosphates from simian virus 40 large T antigen increases its ability to stimulate DNA replication in vitro but has no effect on ATPase and DNA binding. J Virol (1987) 1.56

Acylated simian virus 40 large T-antigen: a new subclass associated with a detergent-resistant lamina of the plasma membrane. EMBO J (1983) 1.55

Phosphorylation downregulates the DNA-binding activity of simian virus 40 T antigen. J Virol (1986) 1.50

The zinc finger region of simian virus 40 large T antigen. J Virol (1989) 1.47

Subclasses of simian virus 40 large T antigen: differential binding of two subclasses of T antigen from productively infected cells to viral and cellular DNA. EMBO J (1982) 1.46

DNA-binding activities of the Drosophila melanogaster even-skipped protein are mediated by its homeo domain and influenced by protein context. Mol Cell Biol (1988) 1.45

Specific in vitro adenylylation of the simian virus 40 large tumor antigen. Proc Natl Acad Sci U S A (1984) 1.38

Effects of in vitro dephosphorylation on DNA-binding and DNA helicase activities of simian virus 40 large tumor antigen. J Virol (1988) 1.31

Binding of dephosphorylated A protein to SV40 DNA. Virology (1981) 1.30

Specific DNA binding activity of T antigen subclasses varies among different SV40-transformed cell lines. Virology (1983) 1.23

Production of simian virus 40 large tumor antigen in bacteria: altered DNA-binding specificity and dna-replication activity of underphosphorylated large tumor antigen. Proc Natl Acad Sci U S A (1989) 1.20

Modification of simian virus 40 large tumor antigen by glycosylation. Virology (1985) 1.18

Interactions of bacteriophage T4-coded gene 32 protein with nucleic acids. II. Specificity of binding to DNA and RNA. J Mol Biol (1981) 1.10

Helicase, DNA-binding, and immunological properties of replication-defective simian virus 40 mutant T antigens. J Virol (1989) 1.07

Geometry of the simian virus 40 large tumor antigen-DNA complex as probed by protease digestion. Proc Natl Acad Sci U S A (1988) 1.06

Simian virus 40 (SV40) T antigen binds specifically to double-stranded DNA but not to single-stranded DNA or DNA/RNA hybrids containing the SV40 regulatory sequences. J Virol (1988) 1.02

Large T-antigen mutants define multiple steps in the initiation of simian virus 40 DNA replication. J Virol (1989) 0.95

Simian virus 40-transformed human cells that express large T antigens defective for viral DNA replication. J Virol (1987) 0.94

DNA binding properties and replication activity of the T antigen related D2 phosphoprotein. Biochemistry (1989) 0.90

Articles by these authors

SV40-transformed simian cells support the replication of early SV40 mutants. Cell (1981) 34.67

Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system. Cell (1981) 9.81

Identification of a promoter component involved in positioning the 5' termini of simian virus 40 early mRNAs. Proc Natl Acad Sci U S A (1981) 5.89

Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells. Mol Cell Biol (1985) 5.83

Expression of early genes of origin-defective mutants of simian virus 40. Proc Natl Acad Sci U S A (1980) 5.33

Cloning and sequencing of the class B beta-lactamase gene (ccrA) from Bacteroides fragilis TAL3636. Antimicrob Agents Chemother (1990) 5.24

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature (1995) 4.78

Origin-defective mutants of SV40. Cold Spring Harb Symp Quant Biol (1980) 4.64

Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res (1997) 3.70

T antigen and template requirements for SV40 DNA replication in vitro. EMBO J (1985) 3.59

NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol (1999) 3.42

Identification of differentially expressed mRNA species by an improved display technique (DDRT-PCR). Nucleic Acids Res (1993) 3.26

Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol Cell Biol (1995) 3.16

Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83

New host cell system for regulated simian virus 40 DNA replication. Mol Cell Biol (1985) 2.82

Cyclin D1 protein expression and function in human breast cancer. Int J Cancer (1994) 2.81

Duplications of a mutated simian virus 40 enhancer restore its activity. Nature (1985) 2.75

Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication. Nature (1989) 2.67

Efficient gene transfer into human hepatocytes by baculovirus vectors. Proc Natl Acad Sci U S A (1995) 2.60

Infection of eucaryotic cells by helper-independent recombinant adenoviruses: early region 1 is not obligatory for integration of viral DNA. J Virol (1984) 2.28

Reactivation of the previously silenced cytomegalovirus major immediate-early promoter in the mouse liver: involvement of NFkappaB. J Virol (1998) 2.23

Regulation of SV40 DNA replication by phosphorylation of T antigen. EMBO J (1987) 2.17

Rescue of functional replication origins from embedded configurations in a plasmid carrying the adenovirus genome. Mol Cell Biol (1984) 2.14

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. J Cell Biol (1994) 2.11

A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function. EMBO J (1996) 2.11

Cyclin D1 expression is regulated by the retinoblastoma protein. Proc Natl Acad Sci U S A (1994) 2.09

Properties of permissive monkey cells transformed by UV-irradiated simian virus 40. J Virol (1977) 2.03

Purification and properties of poliovirus RNA polymerase expressed in Escherichia coli. J Virol (1989) 2.00

Replacement mutagenesis of the human cytomegalovirus genome: US10 and US11 gene products are nonessential. J Virol (1991) 1.96

Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines. J Med Chem (1994) 1.93

Genetic and biochemical analysis of transformation-competent, replication-defective simian virus 40 large T antigen mutants. J Virol (1985) 1.92

Suppression of the phenotype of gamma(1)34.5- herpes simplex virus 1: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the alpha47 gene. J Virol (1997) 1.88

A precision measurement of the mass of the top quark. Nature (2004) 1.87

Enhanced transformation of human fibroblasts by origin-defective simian virus 40. Nature (1982) 1.84

SV40 early mutants that are defective for viral DNA synthesis but competent for transformation of cultured rat and simian cells. Virology (1982) 1.77

DNA-binding properties of simian virus 40 T-antigen mutants defective in viral DNA replication. Mol Cell Biol (1983) 1.76

The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas. Int J Cancer (1994) 1.71

Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome. Antimicrob Agents Chemother (1991) 1.69

Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer. Cancer Res (1995) 1.68

Hyperbaric oxygen and thrombolysis in myocardial infarction: the "HOT MI" pilot study. Am Heart J (1997) 1.67

Cellular and cell-free synthesis of simian virus 40 T-antigens in permissive and transformed cells. J Virol (1978) 1.66

STUDIES ON THE SUPRARENAL CORTEX : IV. THE EFFECT OF SODIUM SALTS IN SUSTAINING THE SUPRARENALECTOMIZED DOG. J Exp Med (1935) 1.61

Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60

Escherichia coli chromosomal mutations that permit direct cloning of the Bacteroides fragilis metallo-beta-lactamase gene, ccrA. Mol Microbiol (1991) 1.59

Studies on the origin-specific DNA-binding domain of simian virus 40 large T antigen. J Virol (1987) 1.56

Measurement of the forward-backward charge asymmetry in top-quark pair production. Phys Rev Lett (2008) 1.53

Cyclin D3: requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation. Oncogene (1998) 1.52

A 29 residue region of the sarcomeric myosin rod is necessary for filament formation. J Mol Biol (1997) 1.52

Simian virus 40 large T-antigen point mutants that are defective in viral DNA replication but competent in oncogenic transformation. Mol Cell Biol (1984) 1.51

Allergic fungal sinusitis: problems in diagnosis and treatment. Laryngoscope (1991) 1.49

Expression and analysis of the human cytomegalovirus UL80-encoded protease: identification of autoproteolytic sites. J Virol (1993) 1.47

Measurement of the W boson mass with the D0 detector. Phys Rev Lett (2012) 1.46

Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain. J Immunol (1995) 1.42

Observation of a centrality-dependent dijet asymmetry in lead-lead collisions at sqrt[S(NN)] =2.76 TeV with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.41

Surgical treatment of obstructive sleep apnea. Technical variations. Arch Otolaryngol Head Neck Surg (1993) 1.41

The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis. Eur J Biochem (1997) 1.41

Ovine adenovirus vectors overcome preexisting humoral immunity against human adenoviruses in vivo. J Virol (1999) 1.40

[Evaluation of a training system for middle ear surgery with optoelectric detection]. HNO (2009) 1.40

GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Trends Biochem Sci (2000) 1.40

Measurement of dijet azimuthal decorrelations in pp collisions at sqrt(s)=7  TeV. Phys Rev Lett (2011) 1.39

Elongated styloid process syndrome: intraoral versus external approach for styloid surgery. Laryngoscope (1985) 1.39

Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene (1995) 1.39

Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types. Oncogene (1995) 1.37

A herpes simplex virus type 1 gamma34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals. J Virol (2001) 1.37

Inhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines. Antimicrob Agents Chemother (1994) 1.36

STUDIES ON THE SUPRARENAL CORTEX : V. THE INFLUENCE OF THE CORTICAL HORMONE UPON THE EXCRETION OF WATER AND ELECTROLYTES IN THE SUPRARENALECTOMIZED DOG. J Exp Med (1936) 1.35

Selection of efficient cleavage sites in target RNAs by using a ribozyme expression library. Mol Cell Biol (1995) 1.35

Efficient transformation of human fibroblasts by adenovirus-simian virus 40 recombinants. Mol Cell Biol (1984) 1.35

Determination of the strange-quark density of the proton from ATLAS measurements of the W→ℓν and Z→ℓℓ cross sections. Phys Rev Lett (2012) 1.34

Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.32

Relation of measures of sleep-disordered breathing to neuropsychological functioning. Am J Respir Crit Care Med (2001) 1.31

Fetal respiratory distress causing CNS and inner ear hemorrhage. Laryngoscope (1978) 1.31

Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins. Eur J Biochem (1989) 1.31

Analysis of altered gene expression by differential display. Methods Enzymol (1995) 1.29

Observation of associated near-side and away-side long-range correlations in sqrt[s(NN)]=5.02 TeV proton-lead collisions with the ATLAS detector. Phys Rev Lett (2013) 1.27

Epistaxis: medical versus surgical therapy: a comparison of efficacy, complications, and economic considerations. Laryngoscope (1987) 1.27

Relationship between sleepiness and general health status. Sleep (1996) 1.26

Baculovirus-mediated gene transfer in the presence of human serum or blood facilitated by inhibition of the complement system. Gene Ther (1998) 1.24

Gene transfer into hepatocytes and human liver tissue by baculovirus vectors. Hum Gene Ther (1996) 1.23

Recombination between endogenous and exogenous simian virus 40 genes. II. Biochemical evidence for genetic exchange. J Virol (1977) 1.23

Adult-onset otitis media with effusion. Arch Otolaryngol Head Neck Surg (1994) 1.22

Production of simian virus 40 large tumor antigen in bacteria: altered DNA-binding specificity and dna-replication activity of underphosphorylated large tumor antigen. Proc Natl Acad Sci U S A (1989) 1.20

SV40-induced somatic mutations: possible relevance to viral transformation. Cold Spring Harb Symp Quant Biol (1980) 1.20

Search for dark matter candidates and large extra dimensions in events with a photon and missing transverse momentum in pp collision data at sqrt[s]=7 TeV with the ATLAS detector. Phys Rev Lett (2013) 1.19

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Nat Med (1997) 1.19

Airway and other complications of percutaneous endoscopic gastrostomy in head and neck cancer patients. Ann Otol Rhinol Laryngol (1992) 1.18

Recombination between endogenous and exogenous simian virus 40 genes. I. Rescue of a simian virus 40 temperature-sensitive mutant by passage in permissive transformed monkey lines. J Virol (1977) 1.16

Palindromic adenovirus type 5-simian virus 40 hybrid. J Virol (1983) 1.15

cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen. J Virol (1993) 1.15

Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines. Int J Cancer (1995) 1.15

Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain. J Immunol (1993) 1.14

Search for a supersymmetric partner to the top quark in final states with jets and missing transverse momentum at sqrt[s] = 7 TeV with the ATLAS detector. Phys Rev Lett (2012) 1.13

Stable gene transfer and tissue-specific expression of a human globin gene using adenoviral vectors. EMBO J (1986) 1.13

Transfer of genes into hematopoietic cells using recombinant DNA viruses. Proc Natl Acad Sci U S A (1985) 1.12

Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis. Am J Hum Genet (1998) 1.09

Measurement of the electron charge asymmetry in pp[over ]-->W+X-->enu+X events at sqrt[s]=1.96 TeV. Phys Rev Lett (2008) 1.09

Evidence for a particle produced in association with weak bosons and decaying to a bottom-antibottom quark pair in higgs boson searches at the tevatron. Phys Rev Lett (2012) 1.08