Published in Int J Mol Sci on January 08, 2015
Electrosensory Midbrain Neurons Display Feature Invariant Responses to Natural Communication Stimuli. PLoS Comput Biol (2015) 0.85
Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current. Int J Mol Sci (2015) 0.85
Ivabradine in Cardiovascular Disease: Heart Rate Isn't Everything. J Cardiovasc Pharmacol (2015) 0.75
Association between hyperpolarization-activated channel in interstitial cells of Cajal and gastrointestinal dysmotility induced by malignant ascites. Oncol Lett (2017) 0.75
HCN Channels Modulators: The Need for Selectivity. Curr Top Med Chem (2016) 0.75
Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis. Commun Integr Biol (2017) 0.75
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Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev (2007) 3.75
The cell and molecular basis of mechanical, cold, and inflammatory pain. Science (2008) 3.46
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Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature (2001) 3.20
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J (2003) 3.02
Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. J Comp Neurol (2004) 2.85
Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J (2005) 2.78
Inward current activated during hyperpolarization in the rabbit sinoatrial node cell. Pflugers Arch (1980) 2.72
TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat. J Pain (2008) 2.56
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A (2003) 2.53
Two pacemaker channels from human heart with profoundly different activation kinetics. EMBO J (1999) 2.51
Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res (1999) 2.47
Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy. Eur Heart J (2011) 2.44
Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy. Circ Res (2008) 2.29
The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells. Cell (2003) 2.24
Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial. Eur Heart J (2009) 2.21
HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. EMBO J (2007) 2.13
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J Physiol (2004) 2.09
Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc Natl Acad Sci U S A (1999) 2.07
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NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. EMBO J (2003) 1.87
Pacemaking by HCN channels requires interaction with phosphoinositides. Neuron (2006) 1.84
Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2. J Gen Physiol (2006) 1.84
Differential distribution of four hyperpolarization-activated cation channels in mouse brain. Biol Chem (1999) 1.82
Assessing the role of Ih channels in synaptic transmission and mossy fiber LTP. Proc Natl Acad Sci U S A (2002) 1.81
Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4. Proc Natl Acad Sci U S A (2011) 1.71
Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. Neuron (2009) 1.64
Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem (2003) 1.63
Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart. Cardiovasc Res (2008) 1.63
Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetry. Neuron (2003) 1.59
Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure. Circulation (2004) 1.55
Molecular basis of funny current (If) in normal and failing human heart. J Mol Cell Cardiol (2008) 1.53
Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med (2011) 1.50
Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis (2005) 1.49
Modulation of the hyperpolarization-activated current (Ih) by cyclic nucleotides in guinea-pig primary afferent neurons. J Physiol (1996) 1.48
HCN2 channels account for mechanical (but not heat) hyperalgesia during long-standing inflammation. Pain (2014) 1.44
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Tamoxifen-inducible gene deletion in the cardiac conduction system. J Mol Cell Cardiol (2008) 1.32
A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase. J Biol Chem (2005) 1.32
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype. J Clin Invest (2005) 1.30
Role of the hyperpolarization-activated current Ih in somatosensory neurons. J Physiol (2008) 1.24
Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C. Pflugers Arch (2007) 1.21
Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes from human failing heart. Circulation (1997) 1.21
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H-channels in epilepsy: new targets for seizure control? Trends Pharmacol Sci (2002) 1.18
Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice. J Neurosci (2011) 1.16
Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis. Cardiovasc Res (2008) 1.13
Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2. Neurobiol Dis (2008) 1.12
Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart. J Mol Cell Cardiol (2011) 1.12
Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channels. Pflugers Arch (2003) 1.11
HCN3 contributes to the ventricular action potential waveform in the murine heart. Circ Res (2011) 1.11
Serotonergic modulation of hyperpolarization-activated current in acutely isolated rat dorsal root ganglion neurons. J Physiol (1999) 1.10
Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes isolated from hypertensive rats. J Physiol (1994) 1.08
Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure. Am J Physiol Heart Circ Physiol (2008) 1.05
Constitutively active Src tyrosine kinase changes gating of HCN4 channels through direct binding to the channel proteins. J Cardiovasc Pharmacol (2006) 1.05
Hyperpolarization-activated, cyclic nucleotide-gated cation channels: roles in the differential electrophysiological properties of rat primary afferent neurons. J Neurosci Res (2004) 1.04
HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. J Biol Chem (2007) 1.03
Pacemaker activity of the human sinoatrial node: role of the hyperpolarization-activated current, I(f). Int J Cardiol (2009) 1.03
Ivabradine in combination with beta-blocker improves symptoms and quality of life in patients with stable angina pectoris: results from the ADDITIONS study. Clin Res Cardiol (2012) 1.02
Hyperpolarization-activated inward current in ventricular myocytes from normal and failing human hearts. Circulation (1998) 1.01
Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat. Neuroscience (2006) 1.00
Hyperpolarization-activated cyclic nucleotide-gated channel mRNA and protein expression in large versus small diameter dorsal root ganglion neurons: correlation with hyperpolarization-activated current gating. Neuroscience (2008) 1.00
Chronic inflammatory pain is associated with increased excitability and hyperpolarization-activated current (Ih) in C- but not Aδ-nociceptors. Pain (2012) 1.00
Heart rate reduction with ivabradine prevents the global phenotype of left ventricular remodeling. Am J Physiol Heart Circ Physiol (2010) 1.00
Cellular mechanisms underlying the pharmacological induction of phosphenes. Br J Pharmacol (2007) 0.99
Upregulation of the hyperpolarization-activated cation current after chronic compression of the dorsal root ganglion. J Neurosci (2003) 0.98
Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531. Am J Physiol Cell Physiol (2007) 0.95
Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart. Cardiovasc Res (2012) 0.95
Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts. J Am Heart Assoc (2013) 0.95
Ivabradine in heart failure--no paradigm SHIFT…yet. Lancet (2010) 0.94
HCN channels in the heart: lessons from mouse mutants. Br J Pharmacol (2012) 0.93
Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons. Neuroscience (2006) 0.92
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and pain. Curr Pharm Des (2009) 0.90
Sick sinus syndrome in HCN1-deficient mice. Circulation (2013) 0.89
Myocardial remodeling and arrhythmogenesis in moderate cardiac hypertrophy in rats. Am J Physiol Heart Circ Physiol (2001) 0.89
Molecular mechanism underlying phosphatidylinositol 4,5-bisphosphate-induced inhibition of SpIH channels. J Biol Chem (2011) 0.89
Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain. Reg Anesth Pain Med (2005) 0.84
Spinal hyperpolarization-activated cyclic nucleotide-gated cation channels at primary afferent terminals contribute to chronic pain. Pain (2010) 0.84
Expression and properties of hyperpolarization-activated current in rat dorsal root ganglion neurons with known sensory function. J Physiol (2012) 0.84
Substance P regulates Ih via a NK-1 receptor in vagal sensory neurons of the ferret. J Neurophysiol (1998) 0.83
HCN1 and HCN2 in Rat DRG neurons: levels in nociceptors and non-nociceptors, NT3-dependence and influence of CFA-induced skin inflammation on HCN2 and NT3 expression. PLoS One (2012) 0.83
Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation. Nat Commun (2014) 0.83
Heart rate reduction for 12 months with ivabradine reduces left ventricular mass in cardiac allograft recipients. Transplantation (2009) 0.82
PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons. J Neurosci (2011) 0.81
Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels. Pain (2014) 0.80
Electrophysiologic changes in heart failure: focus on pacemaker channels. Can J Physiol Pharmacol (2009) 0.79
Plasticity of hyperpolarization-activated and cyclic nucleotid-gated cation channel subunit 2 expression in the spinal dorsal horn in inflammatory pain. Eur J Neurosci (2010) 0.78