Published in EMBO J on January 15, 2003
A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res (2010) 3.99
Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons. Neuron (2004) 2.74
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A (2003) 2.53
Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy. J Neurosci (2007) 2.34
HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. EMBO J (2007) 2.13
Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron (2012) 2.11
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J Physiol (2004) 2.09
Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci (2003) 1.94
Molecular targets for antiepileptic drug development. Neurotherapeutics (2007) 1.78
The pelvis-kidney junction contains HCN3, a hyperpolarization-activated cation channel that triggers ureter peristalsis. Kidney Int (2009) 1.67
The multiple personalities of h-channels. Trends Neurosci (2003) 1.64
Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. J Neurosci (2009) 1.63
Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice. Hum Mol Genet (2009) 1.45
Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol (2011) 1.37
Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4. Hum Mol Genet (2008) 1.36
Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model. J Physiol (2006) 1.34
Exploring HCN channels as novel drug targets. Nat Rev Drug Discov (2011) 1.28
Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy. J Neurosci (2009) 1.27
Dendritic HCN channels shape excitatory postsynaptic potentials at the inner hair cell afferent synapse in the mammalian cochlea. J Neurophysiol (2010) 1.27
Role of the hyperpolarization-activated current Ih in somatosensory neurons. J Physiol (2008) 1.24
Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling. J Neurosci (2010) 1.20
IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase. EMBO J (2004) 1.20
Kinetic relationship between the voltage sensor and the activation gate in spHCN channels. J Gen Physiol (2007) 1.20
Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels. J Gen Physiol (2007) 1.19
Control of heart rate by cAMP sensitivity of HCN channels. Proc Natl Acad Sci U S A (2009) 1.18
Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels. J Physiol (2006) 1.17
Subunit-specific effects of isoflurane on neuronal Ih in HCN1 knockout mice. J Neurophysiol (2008) 1.17
Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels. J Mol Cell Cardiol (2009) 1.17
Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy. J Physiol (2006) 1.15
Pathophysiology of HCN channels. Pflugers Arch (2007) 1.13
The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial node. J Physiol (2003) 1.13
HCN channels in behavior and neurological disease: too hyper or not active enough? Mol Cell Neurosci (2010) 1.13
Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2. Neurobiol Dis (2008) 1.12
HCN-related channelopathies. Pflugers Arch (2010) 1.11
Towards an integrated view of HCN channel role in epilepsy. Curr Opin Neurobiol (2011) 1.08
L-type Ca(2+) channels in heart and brain. Wiley Interdiscip Rev Membr Transp Signal (2014) 1.06
Dual stretch responses of mHCN2 pacemaker channels: accelerated activation, accelerated deactivation. Biophys J (2006) 1.02
Loss of sensory input increases the intrinsic excitability of layer 5 pyramidal neurons in rat barrel cortex. J Physiol (2009) 1.02
The sleep relay--the role of the thalamus in central and decentral sleep regulation. Pflugers Arch (2011) 1.02
Cardiac electrophysiology in mice: a matter of size. Front Physiol (2012) 1.01
HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering. J Membr Biol (2007) 1.00
The fast and slow ups and downs of HCN channel regulation. Channels (Austin) (2011) 1.00
Cortical HCN channels: function, trafficking and plasticity. J Physiol (2014) 0.99
Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels. J Biol Chem (2009) 0.99
Cyclic nucleotide-regulated cation channels. J Biol Chem (2008) 0.99
Augmented currents of an HCN2 variant in patients with febrile seizure syndromes. Ann Neurol (2010) 0.98
Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus. J Neurosci (2010) 0.98
The Yin and Yang of the H-Channel and Its Role in Epilepsy. Epilepsy Curr (2004) 0.96
Disturbed atrio-ventricular conduction and normal contractile function in isolated hearts from Cav1.3-knockout mice. Naunyn Schmiedebergs Arch Pharmacol (2004) 0.96
Processing of retinal signals in normal and HCN deficient mice. PLoS One (2012) 0.96
Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability. PLoS One (2013) 0.95
HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications. Br J Pharmacol (2012) 0.94
Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations. J Neurosci (2009) 0.94
Dorsoventral differences in intrinsic properties in developing CA1 pyramidal cells. J Neurosci (2012) 0.93
HCN channels in the heart: lessons from mouse mutants. Br J Pharmacol (2012) 0.93
Hyperpolarization activated cyclic-nucleotide gated (HCN) channels in developing neuronal networks. Prog Neurobiol (2008) 0.93
Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS One (2012) 0.92
HCN channels expressed in the inner ear are necessary for normal balance function. J Neurosci (2011) 0.92
Sensitivity of HCN channel deactivation to cAMP is amplified by an S4 mutation combined with activation mode shift. Pflugers Arch (2009) 0.91
HCN and KV7 (M-) channels as targets for epilepsy treatment. Neuropharmacology (2012) 0.91
The Role of HCN Channels on Membrane Excitability in the Nervous System. J Signal Transduct (2012) 0.91
Reciprocal modulation of I (h) and I (TASK) in thalamocortical relay neurons by halothane. Pflugers Arch (2008) 0.91
The Contribution of HCN4 to normal sinus node function in humans and animal models. Pacing Clin Electrophysiol (2009) 0.90
Inhibition of cardiac pacemaker channel hHCN2 depends on intercalation of lipopolysaccharide into channel-containing membrane microdomains. J Physiol (2013) 0.90
Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models. Front Physiol (2012) 0.90
Ionic mechanisms of pacemaker activity in spontaneously contracting atrial HL-1 cells. J Cardiovasc Pharmacol (2011) 0.89
LKB1 knockout mouse develops spontaneous atrial fibrillation and provides mechanistic insights into human disease process. J Am Heart Assoc (2015) 0.88
Modern concepts concerning the origin of the heartbeat. Physiology (Bethesda) (2013) 0.88
Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity. Br J Pharmacol (2006) 0.88
Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling. Front Cell Neurosci (2010) 0.88
Genomic biomarkers of SUDEP in brain and heart. Epilepsy Behav (2013) 0.87
Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. Neurobiol Dis (2007) 0.86
The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration. Pflugers Arch (2006) 0.86
Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains. Neurobiol Dis (2011) 0.86
Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear. J Gen Physiol (2013) 0.86
Dysfunctional HCN ion channels in neurological diseases. Front Cell Neurosci (2015) 0.85
Transcription profiling of HCN-channel isotypes throughout mouse cardiac development. Basic Res Cardiol (2009) 0.85
Isoform dependent regulation of human HCN channels by cholesterol. Sci Rep (2015) 0.85
Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current. Int J Mol Sci (2015) 0.85
Decreased hyperpolarization-activated currents in layer 5 pyramidal neurons enhances excitability in focal cortical dysplasia. J Neurophysiol (2011) 0.85
Cell-cell junction remodeling in the heart: possible role in cardiac conduction system function and arrhythmias? Life Sci (2011) 0.85
H-channel dysfunction in generalized epilepsy: it takes two. Epilepsy Curr (2006) 0.84
The distribution of HCN2-positive cells in the gastrointestinal tract of mice. J Anat (2012) 0.84
Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels. Am J Physiol Cell Physiol (2008) 0.84
Regulation of the hyperpolarization-activated cationic current Ih in mouse hippocampal pyramidal neurones by vitronectin, a component of extracellular matrix. J Physiol (2004) 0.84
Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart. Circ Arrhythm Electrophysiol (2015) 0.84
Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons. J Gen Physiol (2014) 0.83
Regulation of firing frequency in nociceptive neurons by pro-inflammatory mediators. Exp Brain Res (2009) 0.83
Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation. Nat Commun (2014) 0.83
A molecular signature of tissues with pacemaker activity in the heart and upper urinary tract involves coexpressed hyperpolarization-activated cation and T-type Ca2+ channels. FASEB J (2013) 0.83
Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy. Neurobiol Dis (2015) 0.82
Genetic loss of HCN1 channels is exciting, but is it epileptic? Epilepsy Curr (2010) 0.82
Functional impact of the hyperpolarization-activated current on the excitability of myelinated A-type vagal afferent neurons in the rat. Clin Exp Pharmacol Physiol (2010) 0.82
Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). J Biol Chem (2013) 0.81
Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice. Cell Tissue Res (2010) 0.81
Enhanced GABAA-Mediated Tonic Inhibition in Auditory Thalamus of Rats with Behavioral Evidence of Tinnitus. J Neurosci (2015) 0.81
The interplay of seven subthreshold conductances controls the resting membrane potential and the oscillatory behavior of thalamocortical neurons. J Neurophysiol (2014) 0.81
Sudden unexpected death in epilepsy genetics: Molecular diagnostics and prevention. Epilepsia (2016) 0.81
Local anesthetic inhibits hyperpolarization-activated cationic currents. Mol Pharmacol (2011) 0.80
HCN channels--modulators of cardiac and neuronal excitability. Int J Mol Sci (2015) 0.80
Thalamocortical oscillations in the sleeping and aroused brain. Science (1993) 10.02
Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annu Rev Physiol (1996) 5.64
A family of hyperpolarization-activated mammalian cation channels. Nature (1998) 4.97
Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J Physiol (1990) 4.87
Sleep and arousal: thalamocortical mechanisms. Annu Rev Neurosci (1997) 4.40
Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol (1993) 4.34
Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS. J Neurosci (2000) 3.96
Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell (1998) 3.90
Cardiac pacemaking in the sinoatrial node. Physiol Rev (1993) 3.86
Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels. Neuron (2001) 3.37
Corticothalamic resonance, states of vigilance and mentation. Neuroscience (2000) 3.07
Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats. J Neurosci (2002) 2.99
Biological pacemaker created by gene transfer. Nature (2002) 2.83
H-current: properties of a neuronal and network pacemaker. Neuron (1998) 2.59
Two pacemaker channels from human heart with profoundly different activation kinetics. EMBO J (1999) 2.51
Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur J Biochem (2001) 2.47
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med (2001) 2.40
Dynamics of spontaneous activity in neocortical slices. Neuron (2001) 2.34
Properties of the hyperpolarization-activated current (I(f)) in isolated mouse sino-atrial cells. Cardiovasc Res (2001) 2.27
Abnormal heart rate regulation in GIRK4 knockout mice. Neuron (1998) 2.27
Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node. J Biol Chem (1999) 2.23
Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects. J Neurosci (1994) 2.07
Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc Natl Acad Sci U S A (1999) 2.07
Regional expression and cellular localization of the alpha1 and beta subunit of high voltage-activated calcium channels in rat brain. J Neurosci (1997) 2.05
Differential distribution of four hyperpolarization-activated cation channels in mouse brain. Biol Chem (1999) 1.82
cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium. Circ Res (2002) 1.71
Not so funny anymore: pacing channels are cloned. Neuron (1998) 1.53
Mibefradil block of cloned T-type calcium channels. J Pharmacol Exp Ther (2000) 1.52
Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels. Science (2002) 1.51
Residues beyond the selectivity filter of the K+ channel kir2.1 regulate permeation and block by external Rb+ and Cs+. J Physiol (2000) 1.22
Ionic mechanisms of the cardiac pacemaker potential. Jpn Heart J (1996) 1.16
A method for the quantification of synchrony and oscillatory properties of neuronal activity. J Neurosci Methods (1994) 1.07
Extracellular free potassium and calcium during synchronous activity induced by 4-aminopyridine in the juvenile rat hippocampus. J Physiol (1996) 1.04
The pacemaker current (I(f)) does not play an important role in regulating SA node pacemaker activity. Cardiovasc Res (1995) 1.04
The sustained inward current and inward rectifier K+ current in pacemaker cells dissociated from rat sinoatrial node. J Physiol (2000) 1.03
Regulation of the calcium channel alpha(1G) subunit by divalent cations and organic blockers. Neuropharmacology (2000) 1.01
Neuronal circuitry of thalamocortical epilepsy and mechanisms of antiabsence drug action. Adv Neurol (1999) 0.98
Contribution of intralaminar thalamic nuclei to spike-and-wave-discharges during spontaneous seizures in a genetic rat model of absence epilepsy. Eur J Neurosci (2001) 0.95
Morphological and membrane characteristics of spider and spindle cells isolated from rabbit sinus node. Am J Physiol Heart Circ Physiol (2001) 0.86
Multiple inhibitory effects of zatebradine (UL-FS 49) on the electrophysiological properties of retinal rod photoreceptors. Pflugers Arch (2001) 0.85
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
In vivo two-photon calcium imaging of neuronal networks. Proc Natl Acad Sci U S A (2003) 9.97
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44
Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med (2010) 9.19
The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Science (2008) 8.45
Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell (2006) 7.21
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature (2008) 7.03
Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS One (2010) 6.38
Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72
Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature (2009) 4.68
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature (2006) 4.35
Dendritic organization of sensory input to cortical neurons in vivo. Nature (2010) 4.31
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol (2003) 4.25
Effect of intensive versus standard lipid-lowering treatment with atorvastatin on the progression of calcified coronary atherosclerosis over 12 months: a multicenter, randomized, double-blind trial. Circulation (2006) 3.99
Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science (2010) 3.92
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell (2007) 3.74
Hyperpolarization-activated cation channels: from genes to function. Physiol Rev (2009) 3.73
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat Biotechnol (2010) 3.70
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med (2004) 3.63
Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature (2002) 3.60
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. Science (2008) 3.59
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell (2007) 3.54
Quantification of the sixth DNA base hydroxymethylcytosine in the brain. Angew Chem Int Ed Engl (2010) 3.50
Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval. Science (2003) 3.50
Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat Genet (2004) 3.47
Differential histone modifications mark mouse imprinting control regions during spermatogenesis. EMBO J (2007) 3.46
Imaging calcium in neurons. Neuron (2012) 3.36
ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med (2002) 3.36
Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat Genet (2004) 3.33
Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A (2005) 3.13
Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci U S A (2002) 3.13
Postsynaptic Induction of BDNF-Mediated Long-Term Potentiation. Science (2002) 3.02
Targeted bulk-loading of fluorescent indicators for two-photon brain imaging in vivo. Nat Protoc (2006) 2.95
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development (2002) 2.71
Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell (2008) 2.68
Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (2009) 2.60
Epigenetic regulation of mammalian genomic imprinting. Curr Opin Genet Dev (2004) 2.58
Origins and fates of cardiovascular progenitor cells. Cell (2008) 2.55
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A (2003) 2.53
Functional mapping of single spines in cortical neurons in vivo. Nature (2011) 2.52
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (2004) 2.50
Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9. Nature (2002) 2.49
Identification of cardiac-specific myosin light chain kinase. Circ Res (2008) 2.45
Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes. EMBO J (2002) 2.40
Islet1 cardiovascular progenitors: a single source for heart lineages? Development (2008) 2.39
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med (2002) 2.37
The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores. Pflugers Arch (2009) 2.35
Global hypomethylation of the genome in XX embryonic stem cells. Nat Genet (2005) 2.35
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A (2002) 2.32
TRPC3 channels are required for synaptic transmission and motor coordination. Neuron (2008) 2.30
Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala. Neuron (2008) 2.29
Running: the risk of coronary events : Prevalence and prognostic relevance of coronary atherosclerosis in marathon runners. Eur Heart J (2008) 2.28
Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. J Neurosci (2005) 2.27
Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature (2003) 2.26
Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo. Neuron (2013) 2.15
HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. EMBO J (2007) 2.13
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol (2004) 2.12
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol (2013) 2.11
Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme. Circ Res (2007) 2.11
Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nat Commun (2013) 2.08
Radiation exposure during cardiac CT: effective doses at multi-detector row CT and electron-beam CT. Radiology (2003) 2.07
GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase. Blood (2003) 2.05
Cortical calcium waves in resting newborn mice. Nat Neurosci (2005) 2.02
Site-specific analysis of histone methylation and acetylation. Methods Mol Biol (2004) 1.97
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol (2004) 1.95
Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation. EMBO J (2003) 1.95
Sparsification of neuronal activity in the visual cortex at eye-opening. Proc Natl Acad Sci U S A (2009) 1.94
Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell (2009) 1.92
Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc Natl Acad Sci U S A (2007) 1.88
Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development. Dev Dyn (2002) 1.87
Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice. Circ Res (2003) 1.82
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med (2011) 1.81
Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice. Circulation (2005) 1.80
Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. PLoS Genet (2007) 1.79
Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol (2004) 1.79
Stem cells: lost in translation. Nature (2004) 1.79
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest (2004) 1.79
Towards regenerative therapy for cardiac disease. Lancet (2012) 1.75
Improved calcium imaging in transgenic mice expressing a troponin C-based biosensor. Nat Methods (2007) 1.75
Epigenetic deregulation of imprinting in congenital diseases of aberrant growth. Bioessays (2006) 1.75
Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology (2008) 1.72
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol (2009) 1.72
Laboratory acquired infection with recombinant vaccinia virus containing an immunomodulating construct. J Invest Dermatol (2003) 1.71
cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium. Circ Res (2002) 1.71