Published in EMBO J on May 04, 1999
Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. J Gen Physiol (2001) 3.04
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J (2003) 3.02
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A (2003) 2.53
Amino acid runs in eukaryotic proteomes and disease associations. Proc Natl Acad Sci U S A (2002) 2.17
Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest (2003) 2.14
Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc Natl Acad Sci U S A (1999) 2.07
Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate. J Gen Physiol (2001) 1.82
Integrated allosteric model of voltage gating of HCN channels. J Gen Physiol (2001) 1.72
The pelvis-kidney junction contains HCN3, a hyperpolarization-activated cation channel that triggers ureter peristalsis. Kidney Int (2009) 1.67
A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews. J Cardiovasc Electrophysiol (2010) 1.60
Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions. J Gen Physiol (2001) 1.55
Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node. J Physiol (2003) 1.54
Electrophysiological properties of human mesenchymal stem cells. J Physiol (2003) 1.53
Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine. J Gen Physiol (2002) 1.52
Hyperpolarization-activated currents in presynaptic terminals of mouse cerebellar basket cells. J Physiol (2000) 1.45
Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggests evolving roles in the developing rat hippocampus. Neuroscience (2001) 1.44
Exploring HCN channels as novel drug targets. Nat Rev Drug Discov (2011) 1.28
Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels. J Physiol (2006) 1.28
Structural basis for the cAMP-dependent gating in the human HCN4 channel. J Biol Chem (2010) 1.22
Calcium influx through hyperpolarization-activated cation channels (I(h) channels) contributes to activity-evoked neuronal secretion. Proc Natl Acad Sci U S A (2004) 1.21
TRIP8b regulates HCN1 channel trafficking and gating through two distinct C-terminal interaction sites. J Neurosci (2011) 1.17
Modulation of a presynaptic hyperpolarization-activated cationic current (I(h)) at an excitatory synaptic terminal in the rat auditory brainstem. J Physiol (2001) 1.14
Functional expression of the hyperpolarization-activated, non-selective cation current I(f) in immortalized HL-1 cardiomyocytes. J Physiol (2002) 1.13
How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels. Nat Chem Biol (2011) 1.12
Whole genome expression differences in human left and right atria ascertained by RNA sequencing. Circ Cardiovasc Genet (2012) 1.12
HCN-related channelopathies. Pflugers Arch (2010) 1.11
Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels. J Physiol (2003) 1.10
KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents. Pflugers Arch (2003) 1.08
GLI3 repressor controls functional development of the mouse ureter. J Clin Invest (2011) 1.05
Constitutively active Src tyrosine kinase changes gating of HCN4 channels through direct binding to the channel proteins. J Cardiovasc Pharmacol (2006) 1.05
A homology model of the pore region of HCN channels. Biophys J (2005) 1.02
In the ventral cochlear nucleus Kv1.1 and subunits of HCN1 are colocalized at surfaces of neurons that have low-voltage-activated and hyperpolarization-activated conductances. Neuroscience (2008) 1.02
Countervailing modulation of Ih by neuropeptide Y and corticotrophin-releasing factor in basolateral amygdala as a possible mechanism for their effects on stress-related behaviors. J Neurosci (2010) 1.02
Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes. Biochim Biophys Acta (2009) 1.01
HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering. J Membr Biol (2007) 1.00
Caveolin-3 associates with and affects the function of hyperpolarization-activated cyclic nucleotide-gated channel 4. Biochemistry (2008) 0.99
Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels. J Biol Chem (2009) 0.99
Functional expression and regulation of the hyperpolarization activated non-selective cation current in embryonic stem cell-derived cardiomyocytes. J Physiol (2000) 0.96
Determinants of activation kinetics in mammalian hyperpolarization-activated cation channels. J Physiol (2001) 0.96
Calcium influx through If channels in rat ventricular myocytes. Am J Physiol Cell Physiol (2006) 0.93
Functional characterisation and subcellular localisation of HCN1 channels in rabbit retinal rod photoreceptors. J Physiol (2002) 0.93
HCN channels in the heart: lessons from mouse mutants. Br J Pharmacol (2012) 0.93
Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy. Mol Brain (2011) 0.93
Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS One (2012) 0.92
Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells. J Mol Cell Cardiol (2015) 0.91
Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP. J Biol Chem (2012) 0.91
Sensitivity of HCN channel deactivation to cAMP is amplified by an S4 mutation combined with activation mode shift. Pflugers Arch (2009) 0.91
The Contribution of HCN4 to normal sinus node function in humans and animal models. Pacing Clin Electrophysiol (2009) 0.90
Action of internal pronase on the f-channel kinetics in the rabbit SA node. J Physiol (1999) 0.90
Pore topology of the hyperpolarization-activated cyclic nucleotide-gated channel from sea urchin sperm. Biophys J (2002) 0.89
Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity. Br J Pharmacol (2006) 0.88
Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: ligand-independent relief of autoinhibition in HCN4. J Gen Physiol (2012) 0.86
Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. Neurobiol Dis (2007) 0.86
The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration. Pflugers Arch (2006) 0.86
Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear. J Gen Physiol (2013) 0.86
Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells. J Membr Biol (2006) 0.85
Isoform dependent regulation of human HCN channels by cholesterol. Sci Rep (2015) 0.85
Hyperpolarization-activated current (I(h)) in ganglion-cell photoreceptors. PLoS One (2010) 0.85
Generation of Shox2-Cre allele for tissue specific manipulation of genes in the developing heart, palate, and limb. Genesis (2013) 0.84
Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells. J Endocrinol (2009) 0.84
Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons. J Gen Physiol (2014) 0.83
A molecular signature of tissues with pacemaker activity in the heart and upper urinary tract involves coexpressed hyperpolarization-activated cation and T-type Ca2+ channels. FASEB J (2013) 0.83
Thermodynamic properties of hyperpolarization-activated current (Ih) in a subgroup of primary sensory neurons. Exp Brain Res (2006) 0.83
Pertussis toxin sensitive and insensitive effects of adenosine and carbachol in murine atria overexpressing A(1)-adenosine receptors. Br J Pharmacol (2003) 0.82
Remodeling of ion channel expression in patients with chronic atrial fibrillation and mitral valvular heart disease. Korean J Intern Med (2010) 0.81
Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation. J Physiol (2006) 0.80
HCN channels--modulators of cardiac and neuronal excitability. Int J Mol Sci (2015) 0.80
Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels. Biophys J (2005) 0.79
Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides. Biophys J (2015) 0.77
Tissue-specific N terminus of the HCN4 channel affects channel activation. J Biol Chem (2011) 0.77
P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels. PLoS One (2009) 0.77
Histidine 518 in the S6-CNBD linker controls pH dependence and gating of HCN channel from sea-urchin sperm. Pflugers Arch (2004) 0.77
The expression of hyperpolarization activated cyclic nucleotide gated (HCN) channels in the rat ovary are dependent on the type of cell and the reproductive age of the animal: a laboratory investigation. Reprod Biol Endocrinol (2008) 0.76
Architecture of the HCN selectivity filter and control of cation permeation. Sci Rep (2012) 0.76
cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore. PLoS One (2014) 0.75
Ischemia-induced cell depolarization: does the hyperpolarization-activated cation channel HCN2 affect the outcome after stroke in mice? Exp Transl Stroke Med (2013) 0.75
Gene Therapy for Cardiac Arrhythmias. Zhonghua Minguo Xin Zang Xue Hui Za Zhi (2013) 0.75
Genetics and Sinus Node Dysfunction. J Atr Fibrillation (2009) 0.75
Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening. Int J Oncol (2016) 0.75
Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse. Mol Brain (2015) 0.75
Sympathetic innervation alters activation of pacemaker current (If) in rat ventricle. J Physiol (2000) 0.75
The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (1998) 39.86
Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annu Rev Physiol (1996) 5.64
A family of hyperpolarization-activated mammalian cation channels. Nature (1998) 4.97
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature (1995) 4.96
Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol (1993) 4.34
Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature (1991) 4.31
Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell (1998) 3.90
Cardiac pacemaking in the sinoatrial node. Physiol Rev (1993) 3.86
Properties of the hyperpolarizing-activated current (if) in cells isolated from the rabbit sino-atrial node. J Physiol (1986) 3.79
Structure and function of cyclic nucleotide-gated channels. Annu Rev Neurosci (1996) 3.69
How does adrenaline accelerate the heart? Nature (1979) 3.54
A new interpretation of the pace-maker current in calf Purkinje fibres. J Physiol (1981) 3.05
Inward current activated during hyperpolarization in the rabbit sinoatrial node cell. Pflugers Arch (1980) 2.72
H-current: properties of a neuronal and network pacemaker. Neuron (1998) 2.59
Abnormal heart rate regulation in GIRK4 knockout mice. Neuron (1998) 2.27
Block and activation of the pace-maker channel in calf purkinje fibres: effects of potassium, caesium and rubidium. J Physiol (1982) 1.98
Modulation of single hyperpolarization-activated channels (i(f)) by cAMP in the rabbit sino-atrial node. J Physiol (1994) 1.87
Pacemaking in rabbit isolated sino-atrial node cells during Cs+ block of the hyperpolarization-activated current if. J Physiol (1990) 1.76
Membrane currents underlying activity in frog sinus venosus. J Physiol (1977) 1.62
Structure and function of cyclic nucleotide-gated channels. Rev Physiol Biochem Pharmacol (1999) 1.59
An integrated metric physical map of human chromosome 19. Nat Genet (1995) 1.54
Not so funny anymore: pacing channels are cloned. Neuron (1998) 1.53
Familial heart block and sinus bradycardia. Classification and natural history. Am J Cardiol (1972) 1.53
Retracted Cloning and functional expression of a rat heart KATP channel. Nature (1994) 1.42
Defective "pacemaker" current (Ih) in a zebrafish mutant with a slow heart rate. Proc Natl Acad Sci U S A (1997) 1.30
Pacemaker current i(f) in adult canine cardiac ventricular myocytes. J Physiol (1995) 1.27
Molecular cloning and expression of the Modulatory subunit of the cyclic nucleotide-gated cation channel. J Biol Chem (1996) 1.21
Hyperpolarization-activated cation channels: a multi-gene family. Rev Physiol Biochem Pharmacol (1999) 1.03
Cation-dependent gating of the hyperpolarization-activated cation current in the rabbit sino-atrial node cells. J Physiol (1994) 1.01
The pacemaker current I(f) in single human atrial myocytes and the effect of beta-adrenoceptor and A1-adenosine receptor stimulation. Br J Pharmacol (1997) 0.95
A hyperpolarization-activated inward current in human myocardial cells. J Mol Cell Cardiol (1992) 0.92
Familial sinus node dysfunction with autosomal dominant inheritance. Br Heart J (1978) 0.92
Two kinetically distinct components of hyperpolarization-activated current in rat superior colliculus-projecting neurons. J Physiol (1993) 0.89
Characterization of a hyperpolarization-activated inward current in cultured pacemaker cells from the sinoatrial node. J Mol Cell Cardiol (1996) 0.88
Sinus node disease affecting both parents and both children. Eur J Cardiol (1979) 0.87
Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature (2003) 5.84
A family of hyperpolarization-activated mammalian cation channels. Nature (1998) 4.97
The naming of voltage-gated calcium channels. Neuron (1994) 4.31
Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature (1991) 3.77
Nomenclature of voltage-gated sodium channels. Neuron (2000) 3.10
Nomenclature of voltage-gated calcium channels. Neuron (2000) 3.09
Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science (1996) 3.01
The roles of the subunits in the function of the calcium channel. Science (1991) 2.97
Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proc Natl Acad Sci U S A (2004) 2.97
Defective smooth muscle regulation in cGMP kinase I-deficient mice. EMBO J (1998) 2.96
Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol (2001) 2.94
On the mechanism of beta-adrenergic regulation of the Ca channel in the guinea-pig heart. Pflugers Arch (1985) 2.93
Serum antibodies to L-type calcium channels in patients with amyotrophic lateral sclerosis. N Engl J Med (1992) 2.86
Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O. Proc Natl Acad Sci U S A (2001) 2.67
Molecular basis for Ca2+ channel diversity. Annu Rev Neurosci (1994) 2.65
Effects of air pollution on blood pressure: a population-based approach. Am J Public Health (2001) 2.64
MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling. Nat Cell Biol (2008) 2.55
Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur J Biochem (2001) 2.47
Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci U S A (1999) 2.46
New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis. Nat Genet (2001) 2.44
Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel. Nature (1986) 2.41
Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am J Pathol (2000) 2.41
Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle. Science (1989) 2.40
Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current. Nature (1982) 2.33
Modulation of Ca current during the phosphorylation cycle in the guinea pig heart. Pflugers Arch (1986) 2.26
Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Nature (2000) 2.17
HCN channels: structure, cellular regulation and physiological function. Cell Mol Life Sci (2009) 2.15
Increases in heart rate during an air pollution episode. Am J Epidemiol (1999) 2.13
Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse. J Biol Chem (2000) 2.09
Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel. Nature (1991) 2.09
Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung. FEBS Lett (1990) 2.08
A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins. J Biol Chem (1998) 2.08
Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. EMBO J (1995) 2.06
Regional expression and cellular localization of the alpha1 and beta subunit of high voltage-activated calcium channels in rat brain. J Neurosci (1997) 2.05
Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle. J Biol Chem (1975) 2.03
Temporally controlled somatic mutagenesis in smooth muscle. Genesis (2000) 2.01
Calcium channel beta subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain. EMBO J (1992) 1.92
The relation of alcohol intake to coronary heart disease and all-cause mortality in a beer-drinking population. Epidemiology (1997) 1.91
Differential distribution of four hyperpolarization-activated cation channels in mouse brain. Biol Chem (1999) 1.82
Increased availability and open probability of single L-type calcium channels from failing compared with nonfailing human ventricle. Circulation (1998) 1.77
Transmission of hepatitis C virus from a patient to an anesthesiology assistant to five patients. N Engl J Med (2000) 1.67
Concentrations of cyclic AMP-dependent protein kinase subunits in various tissues. J Biol Chem (1977) 1.67
Assessing hypertension management in the community: trends of prevalence, detection, treatment, and control of hypertension in the MONICA Project, Augsburg 1984-1995. J Hum Hypertens (2001) 1.65
Molecular diversity of the calcium channel alpha2delta subunit. J Neurosci (1999) 1.63
Structure and function of cyclic nucleotide-gated channels. Rev Physiol Biochem Pharmacol (1999) 1.59
An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons. Proc Natl Acad Sci U S A (1998) 1.57
Soluble guanylate cyclase purified from bovine lung contains heme and copper. FEBS Lett (1981) 1.55
Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile. Infect Immun (2001) 1.54
Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5. Eur J Biochem (1982) 1.50
Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation. J Biol Chem (1996) 1.50
Amyotrophic lateral sclerosis patient antibodies label Ca2+ channel alpha 1 subunit. Ann Neurol (1994) 1.50
Cyclic GMP-dependent protein kinase stimulates the plasmalemmal Ca2+ pump of smooth muscle via phosphorylation of phosphatidylinositol. Biochem J (1988) 1.50
Low pH-induced formation of ion channels by clostridium difficile toxin B in target cells. J Biol Chem (2001) 1.49
Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggests evolving roles in the developing rat hippocampus. Neuroscience (2001) 1.44
Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart. Proc Natl Acad Sci U S A (1994) 1.44
Alternatively spliced IS6 segments of the alpha 1C gene determine the tissue-specific dihydropyridine sensitivity of cardiac and vascular smooth muscle L-type Ca2+ channels. Circ Res (1997) 1.41
[Use of vitamins and minerals all food supplements from the MONICA cross-sectional study of 1994/95 from the Augsburg study region]. Z Ernahrungswiss (1998) 1.41
A family of gamma-like calcium channel subunits. FEBS Lett (2000) 1.39
The cDNA of the two isoforms of bovine cGMP-dependent protein kinase. FEBS Lett (1989) 1.39
Transduction in taste receptor cells requires cAMP-dependent protein kinase. Nature (1988) 1.39
Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle. Biochem J (1988) 1.38
Mechanisms of NO/cGMP-dependent vasorelaxation. Circ Res (2000) 1.36
Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. Proc Natl Acad Sci U S A (2000) 1.36
Absence of the gamma subunit of the skeletal muscle dihydropyridine receptor increases L-type Ca2+ currents and alters channel inactivation properties. J Biol Chem (2000) 1.35
Three amino acids in the C-linker are major determinants of gating in cyclic nucleotide-gated channels. EMBO J (1998) 1.35
Structure and function of cGMP-dependent protein kinases. Rev Physiol Biochem Pharmacol (1999) 1.34
Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor. Am J Pathol (1999) 1.34
Calcium channel alpha(2)delta subunits-structure and Gabapentin binding. Mol Pharmacol (2001) 1.33
Demonstration of cGMP-dependent protein kinase and cGMP-dependent phosphorylation in cell-free extracts of platelets. Eur J Biochem (1986) 1.31
Calmodulin is essential for smooth muscle contraction. FEBS Lett (1981) 1.31
The cardiovascular risk factor profile in the study area Augsburg. Results from the first MONICA survey 1984/85. Acta Med Scand Suppl (1988) 1.31
Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci (2000) 1.29
Purification of a soluble, sodium-nitroprusside-stimulated guanylate cyclase from bovine lung. Eur J Biochem (1981) 1.28
cGMP and cAMP inhibit tension development in skinned coronary arteries. Pflugers Arch (1984) 1.28
Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases. J Biol Chem (2000) 1.27