Published in Nat Commun on February 06, 2015
Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα. PLoS Pathog (2017) 1.38
Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol (2016) 1.27
Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol (2015) 1.06
Inflammasomes in the Pathophysiology of Kidney Diseases. Kidney Dis (Basel) (2015) 0.80
New Insights into Orphan Nuclear Receptor SHP in Liver Cancer. Nucl Receptor Res (2015) 0.79
Small Heterodimer Partner and Innate Immune Regulation. Endocrinol Metab (Seoul) (2016) 0.76
MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. Autophagy (2016) 0.75
Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases. Mediators Inflamm (2016) 0.75
Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med (2017) 0.75
Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling. Immunol Cell Biol (2017) 0.75
A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol (2009) 8.40
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ (2007) 7.74
NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nat Rev Immunol (2010) 5.90
Activation and regulation of the inflammasomes. Nat Rev Immunol (2013) 5.71
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity (2012) 5.08
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem (2002) 4.02
Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity (2011) 3.97
Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat Protoc (2009) 3.65
Redundant pathways for negative feedback regulation of bile acid production. Dev Cell (2002) 3.51
Inflammasomes and their roles in health and disease. Annu Rev Cell Dev Biol (2012) 3.18
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol (2013) 3.08
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat Immunol (2011) 2.81
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab (2012) 2.80
Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity (2012) 2.57
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39
Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes (2007) 2.34
The inflammasome in pathogen recognition and inflammation. J Leukoc Biol (2007) 2.28
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature (2014) 2.10
Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action. Cell Host Microbe (2012) 1.99
The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell (2013) 1.93
Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM). Biochim Biophys Acta (2012) 1.75
Role of nuclear receptor SHP in metabolism and cancer. Biochim Biophys Acta (2010) 1.66
Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation. Genes Dev (2009) 1.62
ZTP (5-amino 4-imidazole carboxamide riboside 5'-triphosphate): a proposed alarmone for 10-formyl-tetrahydrofolate deficiency. Cell (1982) 1.61
ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis (2012) 1.60
Isolation of endoplasmic reticulum, mitochondria, and mitochondria-associated membrane fractions from transfected cells and from human cytomegalovirus-infected primary fibroblasts. Curr Protoc Cell Biol (2007) 1.56
Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol (2010) 1.50
Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein. J Biol Chem (2012) 1.20
Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. J Biol Chem (2009) 1.20
The CARD plays a critical role in ASC foci formation and inflammasome signalling. Biochem J (2013) 1.18
Of inflammasomes and pathogens--sensing of microbes by the inflammasome. EMBO Mol Med (2013) 1.12
Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria? Biochim Biophys Acta (2013) 1.03
Measuring the inflammasome. Methods Mol Biol (2012) 1.01
Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis. Proc Natl Acad Sci U S A (2012) 1.01
Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status. Free Radic Biol Med (2013) 0.92
Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout. Arthritis Rheum (2011) 0.90
Negative regulation of NLRP3 inflammasome signaling. Protein Cell (2013) 0.87
A pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways. J Lipids (2012) 0.87
Characterization of the mitochondrial localization of the nuclear receptor SHP and regulation of its subcellular distribution by interaction with Bcl2 and HNF4α. PLoS One (2013) 0.86
The role of fenofibrate in clinical practice. Diab Vasc Dis Res (2007) 0.85
Small heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2. PLoS One (2013) 0.81
Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation. Immunity (2015) 0.89
Mycobacterium abscessus ESX-3 plays an important role in host inflammatory and pathological responses during infection. Microbes Infect (2016) 0.75