Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.

PubWeight™: 5.08‹?› | Rank: Top 1%

🔗 View Article (PMC 3312986)

Published in Immunity on February 16, 2012

Authors

Kenichi Shimada1, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius, Altan Rentsendorj, Mario Vargas, Candace Guerrero, Yinsheng Wang, Katherine A Fitzgerald, David M Underhill, Terrence Town, Moshe Arditi

Author Affiliations

1: Division of Pediatrics Infectious Disease and Immunology, Cedars-Sinai Medical Center and David Geffen School of Medicine, UCLA, Los Angeles, CA 90048, USA.

Articles citing this

(truncated to the top 100)

Activation and regulation of the inflammasomes. Nat Rev Immunol (2013) 5.71

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity (2013) 3.96

Mitochondrial DNA stress primes the antiviral innate immune response. Nature (2015) 3.82

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation. J Exp Med (2014) 2.60

Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination. Nat Rev Immunol (2012) 2.48

Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity (2013) 2.45

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell (2016) 2.40

Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol (2013) 2.31

Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol (2012) 2.28

Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc Natl Acad Sci U S A (2012) 2.19

Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity (2013) 2.02

The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell (2013) 1.93

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production. Cell (2014) 1.88

The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome. Immunity (2013) 1.78

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. Immunity (2015) 1.74

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. J Clin Invest (2016) 1.62

Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci (2014) 1.54

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons. Immunity (2016) 1.50

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite. J Neuroinflammation (2015) 1.48

Caspase-1: is IL-1 just the tip of the ICEberg? Cell Death Dis (2012) 1.47

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med (2016) 1.45

Inflammasomes in the CNS. Nat Rev Neurosci (2014) 1.44

Mitochondria in the regulation of innate and adaptive immunity. Immunity (2015) 1.40

Innate immune signalling at the intestinal epithelium in homeostasis and disease. EMBO Rep (2012) 1.37

Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis. Nat Immunol (2013) 1.36

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy (2013) 1.34

Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol (2013) 1.34

Lighting the fires within: the cell biology of autoinflammatory diseases. Nat Rev Immunol (2012) 1.34

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO Rep (2014) 1.33

TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun (2013) 1.32

Uric acid as a danger signal in gout and its comorbidities. Nat Rev Rheumatol (2012) 1.31

Toll-like receptor (TLR) and inflammasome actions in the central nervous system. Trends Immunol (2012) 1.30

Regulation of inflammasome activation. Immunol Rev (2015) 1.28

P2X7 receptor regulation of non-classical secretion from immune effector cells. Cell Microbiol (2012) 1.28

Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells. J Immunol (2013) 1.28

Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death Dis (2013) 1.25

Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function. J Immunol (2014) 1.25

Mechanisms of inflammasome activation: recent advances and novel insights. Trends Cell Biol (2015) 1.20

New insights into mechanisms controlling the NLRP3 inflammasome and its role in lung disease. Am J Pathol (2013) 1.19

Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev (2015) 1.18

Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome. Trends Immunol (2014) 1.17

An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology. Front Immunol (2013) 1.17

Heme on innate immunity and inflammation. Front Pharmacol (2014) 1.15

Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion. J Biol Chem (2013) 1.15

Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma. EMBO Mol Med (2012) 1.14

Alarmins, inflammasomes and immunity. Biomed J (2013) 1.13

Of inflammasomes and pathogens--sensing of microbes by the inflammasome. EMBO Mol Med (2013) 1.12

Reactive oxygen species at the crossroads of inflammasome and inflammation. Front Physiol (2014) 1.12

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. Proc Natl Acad Sci U S A (2014) 1.11

TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis. EMBO J (2012) 1.11

Inflammasomes and host defenses against bacterial infections. Curr Opin Microbiol (2013) 1.11

The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity. J Immunol (2013) 1.10

Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat Rev Immunol (2015) 1.10

Regulation where autophagy intersects the inflammasome. Antioxid Redox Signal (2013) 1.09

Mitochondria: diversity in the regulation of the NLRP3 inflammasome. Trends Mol Med (2014) 1.09

NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases. Redox Biol (2015) 1.08

Functions of NOD-Like Receptors in Human Diseases. Front Immunol (2013) 1.08

Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector? Antioxid Redox Signal (2015) 1.07

Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol (2015) 1.06

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells. Front Cell Neurosci (2014) 1.05

Innate immunity in Alzheimer's disease: a complex affair. CNS Neurol Disord Drug Targets (2013) 1.05

NLRP3 inflammasome activation induced by engineered nanomaterials. Small (2012) 1.03

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis. Redox Biol (2015) 1.03

NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10. Antioxid Redox Signal (2013) 1.03

The Mitochondrial Basis of Aging. Mol Cell (2016) 1.02

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines. BMC Med (2013) 1.01

Mevalonate kinase deficiency and neuroinflammation: balance between apoptosis and pyroptosis. Int J Mol Sci (2013) 1.00

DNA recognition in immunity and disease. Curr Opin Immunol (2013) 1.00

The role of pattern recognition receptors in intestinal inflammation. Mucosal Immunol (2013) 1.00

Licensing Adaptive Immunity by NOD-Like Receptors. Front Immunol (2013) 0.99

Vibrio parahaemolyticus effector proteins suppress inflammasome activation by interfering with host autophagy signaling. PLoS Pathog (2013) 0.99

Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection. Proc Natl Acad Sci U S A (2013) 0.99

Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen. Mucosal Immunol (2013) 0.98

Monogenic autoinflammatory diseases: disorders of amplified danger sensing and cytokine dysregulation. Rheum Dis Clin North Am (2013) 0.98

α7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release. Mol Med (2014) 0.97

NOD-Like Receptors: Master Regulators of Inflammation and Cancer. Front Immunol (2014) 0.97

Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. EMBO Rep (2013) 0.96

Inflammasomes. Cold Spring Harb Perspect Biol (2014) 0.95

Energy metabolism and inflammation in brain aging and Alzheimer's disease. Free Radic Biol Med (2016) 0.95

The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. Am J Respir Cell Mol Biol (2014) 0.95

Mechanism and Regulation of NLRP3 Inflammasome Activation. Trends Biochem Sci (2016) 0.95

Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux. J Immunol (2014) 0.94

Beyond pattern recognition: NOD-like receptors in dendritic cells. Trends Immunol (2013) 0.94

Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link. Int J Mol Sci (2015) 0.94

Regulation of mitochondrial biogenesis and its intersection with inflammatory responses. Antioxid Redox Signal (2015) 0.94

This old heart: Cardiac aging and autophagy. J Mol Cell Cardiol (2014) 0.93

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus. J Exp Med (2016) 0.93

Release of interleukin-1α or interleukin-1β depends on mechanism of cell death. J Biol Chem (2014) 0.93

International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol Rev (2015) 0.92

TXNIP shuttling: missing link between oxidative stress and inflammasome activation. Front Physiol (2013) 0.92

Lysosomes integrate metabolic-inflammatory cross-talk in primary macrophage inflammasome activation. J Biol Chem (2014) 0.92

NOD-Like Receptors in Lung Diseases. Front Immunol (2013) 0.92

Immune aging, dysmetabolism, and inflammation in neurological diseases. Front Neurosci (2015) 0.92

Role of inflammasome activation in the pathophysiology of vascular diseases of the neurovascular unit. Antioxid Redox Signal (2014) 0.92

The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation. J Immunol (2014) 0.91

P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. PLoS One (2013) 0.91

Getting away with murder: how does the BCL-2 family of proteins kill with immunity? Ann N Y Acad Sci (2013) 0.91

Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer. Autophagy (2014) 0.91

Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation. PLoS Pathog (2014) 0.90

NLRP3 inflammasome: activation and regulation in age-related macular degeneration. Mediators Inflamm (2015) 0.90

Articles cited by this

The inflammasomes. Cell (2010) 19.37

Cryopyrin activates the inflammasome in response to toxins and ATP. Nature (2006) 18.74

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol (2008) 16.65

Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol (2009) 14.33

A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21

The inflammasomes: guardians of the body. Annu Rev Immunol (2009) 12.89

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science (1995) 11.38

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ (2007) 8.85

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol (2009) 7.80

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature (1996) 7.27

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell (1998) 6.79

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol (2010) 6.64

Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun (2005) 6.31

NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nat Rev Immunol (2010) 5.90

The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proc Natl Acad Sci U S A (1999) 5.17

Organelle-specific initiation of cell death pathways. Nat Cell Biol (2001) 5.03

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J Exp Med (2010) 4.52

Mitochondria, oxidative stress and cell death. Apoptosis (2007) 4.29

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J Cell Biol (2009) 3.85

The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis (2003) 3.75

The inflammasome: an integrated view. Immunol Rev (2011) 3.52

The inflammasomes: mechanisms of activation and function. Curr Opin Immunol (2010) 3.41

Interleukin 1 is processed and released during apoptosis. Proc Natl Acad Sci U S A (1991) 3.09

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell (2007) 2.79

Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol (2010) 2.61

Inflammasomes: too big to miss. J Clin Invest (2009) 2.51

Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion. Cell Host Microbe (2010) 2.49

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proc Natl Acad Sci U S A (2007) 2.48

Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine. Oncogene (2003) 2.09

Regulation of apoptosis-associated lysosomal membrane permeabilization. Apoptosis (2010) 1.92

Critical functions of priming and lysosomal damage for NLRP3 activation. Eur J Immunol (2010) 1.87

Mitochondrial potassium transport: the K(+) cycle. Biochim Biophys Acta (2003) 1.77

Adult Apaf-1-deficient mice exhibit male infertility. Dev Biol (2000) 1.70

Mitochondria: Sovereign of inflammation? Eur J Immunol (2011) 1.64

The role of mitochondria in cellular defense against microbial infection. Semin Immunol (2009) 1.52

Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection. PLoS One (2011) 1.25

Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase. Diabetes (2008) 1.24

Coordinated regulation of expression of Salmonella pathogenicity island 1 and flagellar type III secretion systems by ATP-dependent ClpXP protease. J Bacteriol (2008) 1.18

Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics do. Antimicrob Agents Chemother (1990) 1.16

Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studies in vivo and in vitro. FASEB J (1999) 1.13

Oxidative DNA damage in diabetes mellitus: its association with diabetic complications. Diabetologia (1999) 1.10

Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization. Proc Natl Acad Sci U S A (2009) 1.05

The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects. Br J Cancer (1996) 1.05

Release of mitochondrial DNA fragments from brain mitochondria of irradiated mice. Mitochondrion (2006) 0.87

Prevention of neutrophil apoptosis by monosodium urate crystals. Rheumatol Int (1997) 0.86

Potassium efflux during apoptosis. J Biochem Mol Biol (2002) 0.85

Acidification induces Bax translocation to the mitochondria and promotes ultraviolet light-induced apoptosis. Cell Mol Biol Lett (2007) 0.85

Cyclosporin A inhibits Al-induced cytochrome c release from mitochondria in aged rabbits. J Alzheimers Dis (2001) 0.85

Articles by these authors

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol (2008) 16.65

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature (2009) 13.23

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature (2010) 10.60

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol (2008) 10.39

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02

IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol (2010) 8.97

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol (2009) 8.40

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol (2007) 8.33

TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol (2004) 8.06

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med (2004) 7.49

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol (2010) 7.47

Interchromosomal associations between alternatively expressed loci. Nature (2005) 7.45

Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol (2009) 6.97

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity (2009) 5.70

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A (2004) 5.58

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science (2012) 5.34

A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol (2009) 5.26

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol (2005) 4.83

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol (2012) 4.72

TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell (2012) 4.44

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem (2006) 4.33

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc Natl Acad Sci U S A (2003) 4.33

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol (2008) 4.31

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol (2005) 4.28

Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J (2005) 4.18

Regulation of inflammasome signaling. Nat Immunol (2012) 4.10

Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity (2007) 4.07

Control of TH17 cells occurs in the small intestine. Nature (2011) 4.03

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovasc Res (2013) 3.92

Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity (2011) 3.74

Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary research agenda. Environ Health Perspect (2011) 3.69

An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe (2009) 3.52

TLR signaling in the gut in health and disease. J Immunol (2005) 3.51

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature (2011) 3.32

Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut. J Immunol (2003) 2.96

Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J Exp Med (2009) 2.92

A long noncoding RNA mediates both activation and repression of immune response genes. Science (2013) 2.85

The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol (2006) 2.83

Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology (2007) 2.82

Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem (2011) 2.81

Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology (2006) 2.78

Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells. J Immunol (2007) 2.73

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J Exp Med (2005) 2.66

Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity (2012) 2.58

Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med (2003) 2.56

HMGB1 mediates endogenous TLR2 activation and brain tumor regression. PLoS Med (2009) 2.56

Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion. Cell Host Microbe (2010) 2.49

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. J Biol Chem (2005) 2.47

Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. J Immunol (2003) 2.44

Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J Immunol (2006) 2.43

FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell (2012) 2.43

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut (2010) 2.42

Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol (2009) 2.42

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation. J Biol Chem (2005) 2.41

Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. J Biol Chem (2006) 2.40

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol (2013) 2.38

TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J Biol Chem (2002) 2.37

5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res (2011) 2.36

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J (2011) 2.36

Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem (2004) 2.36

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature (2012) 2.35

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β. Nat Immunol (2012) 2.34

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog (2010) 2.33

NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. PLoS Pathog (2009) 2.31

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome. Eur J Immunol (2010) 2.30

Molecular mechanisms involved in inflammasome activation. Trends Cell Biol (2009) 2.29

The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol (2003) 2.26

Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci U S A (2004) 2.23

Differential use of CARD9 by dectin-1 in macrophages and dendritic cells. J Immunol (2009) 2.23

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis. J Exp Med (2007) 2.23

Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors. J Biol Chem (2004) 2.21

The oral microbiota: living with a permanent guest. DNA Cell Biol (2009) 2.19

Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc Natl Acad Sci U S A (2008) 2.17

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A (2006) 2.13

Metabolic state of glioma stem cells and nontumorigenic cells. Proc Natl Acad Sci U S A (2011) 2.13

Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid. J Clin Invest (2005) 2.07

The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. J Immunol (2008) 2.07

TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol Interv (2003) 2.06

Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J Immunol (2004) 2.05

The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiol Genomics (2004) 2.03

Beta-glucan recognition by the innate immune system. Immunol Rev (2009) 2.03

Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci (2005) 1.99

TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA. Cell Host Microbe (2008) 1.98

Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nat Neurosci (2002) 1.97

Recognition of herpesviruses by the innate immune system. Nat Rev Immunol (2011) 1.96

Characterization and comparative profiling of the small RNA transcriptomes in two phases of locust. Genome Biol (2009) 1.96

NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest (2012) 1.91

The PYHIN protein family as mediators of host defenses. Immunol Rev (2011) 1.90

Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. J Immunol (2006) 1.88

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell (2011) 1.86

Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis (2011) 1.86

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. J Immunol (2013) 1.85

Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase. PLoS One (2010) 1.85

Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections. J Exp Med (2003) 1.83