Published in Chromosoma on February 12, 2015
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A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell (2014) 1.35
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Ribosomal genes in focus: new transcripts label the dense fibrillar components and form clusters indicative of "Christmas trees" in situ. J Cell Biol (2002) 1.10
NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing. PLoS Genet (2012) 1.07
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Nucleolar size and activity are related to pRb and p53 status in human breast cancer. J Histochem Cytochem (2004) 1.04
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Nucleologenesis: use of non-isotopic in situ hybridization and immunocytochemistry to compare the localization of rDNA and nucleolar proteins during mitosis. Biol Cell (1989) 1.02
Prognostic relevance of AgNORs in tumor pathology. Micron (2000) 1.00
Three-dimensional organization of active rRNA genes within the nucleolus. J Cell Sci (2002) 0.98
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Conserved regulators of nucleolar size revealed by global phenotypic analyses. Sci Signal (2013) 0.95
Number of nucleoli in various cell types of the mouse. J Morphol (1966) 0.91
Repositioning of human interphase chromosomes by nucleolar dynamics in the reverse transformation of HT1080 fibrosarcoma cells. Exp Cell Res (1998) 0.88
Two orthogonal cleavages separate subunit RNAs in mouse ribosome biogenesis. Nucleic Acids Res (2014) 0.87
The traffic of proteins between nucleolar organizer regions and prenucleolar bodies governs the assembly of the nucleolus at exit of mitosis. Nucleus (2010) 0.85
Targeting RNA polymerase I transcription and the nucleolus for cancer therapy. Expert Opin Ther Targets (2013) 0.85
Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body. PLoS Genet (2014) 0.85
Bystin-like protein is upregulated in hepatocellular carcinoma and required for nucleologenesis in cancer cell proliferation. Cell Res (2009) 0.84
Expression of rRNA genes and nucleolus formation at ectopic chromosomal sites in the yeast Saccharomyces cerevisiae. Mol Cell Biol (2006) 0.82
Construction of synthetic nucleoli and what it tells us about propagation of sub-nuclear domains through cell division. Cell Cycle (2014) 0.76
A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature (2002) 6.19
Pre-18S ribosomal RNA is structurally compacted into the SSU processome prior to being cleaved from nascent transcripts in Saccharomyces cerevisiae. Mol Cell (2004) 2.81
Ribosome biogenesis in the yeast Saccharomyces cerevisiae. Genetics (2013) 2.70
Ribosome biogenesis: of knobs and RNA processing. Exp Cell Res (2004) 2.70
RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components. Genes Dev (2004) 2.48
The long unwinding road of RNA helicases. Mol Cell (2007) 1.97
The small-subunit processome is a ribosome assembly intermediate. Eukaryot Cell (2004) 1.84
When ribosomes go bad: diseases of ribosome biogenesis. Mol Biosyst (2010) 1.76
The small subunit processome in ribosome biogenesis—progress and prospects. Wiley Interdiscip Rev RNA (2011) 1.66
The sigma(70)-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis. Mol Cell (2002) 1.53
The putative NTPase Fap7 mediates cytoplasmic 20S pre-rRNA processing through a direct interaction with Rps14. Mol Cell Biol (2005) 1.46
Components of an interdependent unit within the SSU processome regulate and mediate its activity. Mol Cell Biol (2002) 1.45
Genetics. Mysterious ribosomopathies. Science (2013) 1.44
Ribosome biogenesis is sensed at the Start cell cycle checkpoint. Mol Biol Cell (2006) 1.43
The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. Nucleic Acids Res (2003) 1.41
Crosstalk in gene expression: coupling and co-regulation of rDNA transcription, pre-ribosome assembly and pre-rRNA processing. Curr Opin Cell Biol (2005) 1.35
The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Proc Natl Acad Sci U S A (2006) 1.31
A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Mol Cell Biol (2008) 1.30
The small subunit processome is required for cell cycle progression at G1. Mol Biol Cell (2004) 1.26
The initial U3 snoRNA:pre-rRNA base pairing interaction required for pre-18S rRNA folding revealed by in vivo chemical probing. Nucleic Acids Res (2011) 1.23
Comprehensive mutational analysis of yeast DEXD/H box RNA helicases involved in large ribosomal subunit biogenesis. Mol Cell Biol (2006) 1.15
A dimeric structure for archaeal box C/D small ribonucleoproteins. Science (2009) 1.14
The nucleolar protein Esf2 interacts directly with the DExD/H box RNA helicase, Dbp8, to stimulate ATP hydrolysis. Nucleic Acids Res (2006) 1.13
Comprehensive mutational analysis of yeast DEXD/H box RNA helicases required for small ribosomal subunit synthesis. Mol Cell Biol (2006) 1.11
The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis. Nucleic Acids Res (2010) 1.10
NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing. PLoS Genet (2012) 1.07
Delayed rRNA processing results in significant ribosome biogenesis and functional defects. Mol Cell Biol (2003) 1.05
Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs. Bioorg Med Chem Lett (2008) 1.05
The DEAD-box RNA helicase-like Utp25 is an SSU processome component. RNA (2010) 1.04
Biomarker discovery using protein microarray technology platforms: antibody-antigen complex profiling. Expert Rev Proteomics (2005) 0.98
A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability. Cell Rep (2012) 0.92
Assembling a protein-protein interaction map of the SSU processome from existing datasets. PLoS One (2011) 0.90
The box C/D sRNP dimeric architecture is conserved across domain Archaea. RNA (2012) 0.89
Two-hybrid Mpp10p interaction-defective Imp4 proteins are not interaction defective in vivo but do confer specific pre-rRNA processing defects in Saccharomyces cerevisiae. Nucleic Acids Res (2004) 0.86
A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics. Protein Eng Des Sel (2009) 0.84
Dissecting the role of conserved box C/D sRNA sequences in di-sRNP assembly and function. Nucleic Acids Res (2010) 0.82
Survival motor neuron protein in the nucleolus of mammalian neurons. Brain Res (2002) 0.81
Probing the yeast proteome for RNA-processing factors. Genome Biol (2003) 0.81
Ribonucleoproteins in archaeal pre-rRNA processing and modification. Archaea (2013) 0.79
Ribonucleoprotein multimers and their functions. Crit Rev Biochem Mol Biol (2010) 0.78
Driving nucleolar assembly. Genes Dev (2014) 0.76
Long noncoding RNAs as sinks in Prader-Willi syndrome. Mol Cell (2012) 0.75
Applications of protein arrays for small molecule drug discovery and characterization. Biotechnol Genet Eng Rev (2006) 0.75
In vivo approaches to dissecting the function of RNA helicases in eukaryotic ribosome assembly. Methods Enzymol (2012) 0.75
Dr. Janie Merkel is interviewed by Ryan Blum and Janice Friend. Yale J Biol Med (2007) 0.75