Published in Nature on June 09, 2002
A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes. Genome Biol (2004) 4.94
60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm. EMBO J (2002) 3.62
The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes. EMBO J (2003) 3.38
Dead-box proteins: a family affair--active and passive players in RNP-remodeling. Nucleic Acids Res (2006) 3.26
Topological structure analysis of the protein-protein interaction network in budding yeast. Nucleic Acids Res (2003) 2.90
The cell cycle-regulated genes of Schizosaccharomyces pombe. PLoS Biol (2005) 2.86
Ribosome biogenesis in the yeast Saccharomyces cerevisiae. Genetics (2013) 2.70
Identification of cross-linked peptides from complex samples. Nat Methods (2012) 2.70
Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61
The size of the nucleus increases as yeast cells grow. Mol Biol Cell (2007) 2.55
RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components. Genes Dev (2004) 2.48
Sequential protein association with nascent 60S ribosomal particles. Mol Cell Biol (2003) 2.40
Powering through ribosome assembly. RNA (2009) 2.19
Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Mol Biol Cell (2004) 2.02
Predicting co-complexed protein pairs using genomic and proteomic data integration. BMC Bioinformatics (2004) 2.00
The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively. Mol Cell Biol (2003) 1.99
Coevolution of gene expression among interacting proteins. Proc Natl Acad Sci U S A (2004) 1.96
PIN domain of Nob1p is required for D-site cleavage in 20S pre-rRNA. RNA (2004) 1.94
Maturation of eukaryotic ribosomes: acquisition of functionality. Trends Biochem Sci (2010) 1.93
MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem (2008) 1.93
Nucleolus: the fascinating nuclear body. Histochem Cell Biol (2007) 1.87
Holoenzyme proteins required for the physiological assembly and activity of telomerase. Genes Dev (2004) 1.86
The small-subunit processome is a ribosome assembly intermediate. Eukaryot Cell (2004) 1.84
The splicing ATPase prp43p is a component of multiple preribosomal particles. Mol Cell Biol (2005) 1.82
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism. Mol Cell Biol (2007) 1.82
Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol (2009) 1.81
Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell. Nucleic Acids Res (2005) 1.77
The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast. EMBO J (2004) 1.77
A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits. Genes Dev (2004) 1.76
When ribosomes go bad: diseases of ribosome biogenesis. Mol Biosyst (2010) 1.76
The WD-repeat protein superfamily in Arabidopsis: conservation and divergence in structure and function. BMC Genomics (2003) 1.73
Modulation of RNA editing by functional nucleolar sequestration of ADAR2. Proc Natl Acad Sci U S A (2003) 1.73
The breakpoint region of the most common isochromosome, i(17q), in human neoplasia is characterized by a complex genomic architecture with large, palindromic, low-copy repeats. Am J Hum Genet (2003) 1.70
The small subunit processome in ribosome biogenesis—progress and prospects. Wiley Interdiscip Rev RNA (2011) 1.66
Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination. Genes Dev (2008) 1.64
RNomics in Drosophila melanogaster: identification of 66 candidates for novel non-messenger RNAs. Nucleic Acids Res (2003) 1.61
The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Mol Cell Biol (2009) 1.60
A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification. EMBO J (2011) 1.59
Transcription elongation by RNA polymerase I is linked to efficient rRNA processing and ribosome assembly. Mol Cell (2007) 1.59
Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. Genes Dev (2007) 1.57
SLOW WALKER1, essential for gametogenesis in Arabidopsis, encodes a WD40 protein involved in 18S ribosomal RNA biogenesis. Plant Cell (2005) 1.56
Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA (2004) 1.48
The putative NTPase Fap7 mediates cytoplasmic 20S pre-rRNA processing through a direct interaction with Rps14. Mol Cell Biol (2005) 1.46
Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification. Mol Cell Biol (2004) 1.45
Components of an interdependent unit within the SSU processome regulate and mediate its activity. Mol Cell Biol (2002) 1.45
The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries. Mol Cell (2009) 1.45
Ribosome biogenesis is sensed at the Start cell cycle checkpoint. Mol Biol Cell (2006) 1.43
A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Mol Cell Proteomics (2009) 1.42
The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. Nucleic Acids Res (2003) 1.41
A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export. PLoS Biol (2010) 1.39
The nucleolus: a model for the organization of nuclear functions. Histochem Cell Biol (2006) 1.39
Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes. Mol Cell Biol (2005) 1.39
Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae. Genetics (2006) 1.34
The helicase Has1p is required for snoRNA release from pre-rRNA. Mol Cell Biol (2006) 1.34
Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Mol Cell Biol (2007) 1.31
The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Proc Natl Acad Sci U S A (2006) 1.31
Defects in 18 S or 28 S rRNA processing activate the p53 pathway. J Biol Chem (2010) 1.30
An overview of pre-ribosomal RNA processing in eukaryotes. Wiley Interdiscip Rev RNA (2014) 1.30
Potential interface between ribosomal protein production and pre-rRNA processing. Mol Cell Biol (2007) 1.30
Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae. Mol Cell Biol (2006) 1.30
A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Mol Cell Biol (2008) 1.30
The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b. Proc Natl Acad Sci U S A (2004) 1.28
Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media. Mol Cell Biol (2005) 1.28
Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome. PLoS Pathog (2009) 1.28
RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing. Proc Natl Acad Sci U S A (2006) 1.28
Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in Drosophila. Nat Cell Biol (2009) 1.26
The small subunit processome is required for cell cycle progression at G1. Mol Biol Cell (2004) 1.26
The nuclear poly(A) polymerase and Exosome cofactor Trf5 is recruited cotranscriptionally to nucleolar surveillance. RNA (2009) 1.24
The pre-ribosomal network. Nucleic Acids Res (2003) 1.24
The initial U3 snoRNA:pre-rRNA base pairing interaction required for pre-18S rRNA folding revealed by in vivo chemical probing. Nucleic Acids Res (2011) 1.23
Assembly of Saccharomyces cerevisiae 60S ribosomal subunits: role of factors required for 27S pre-rRNA processing. EMBO J (2011) 1.22
Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation. Mol Cell Proteomics (2011) 1.22
5'-end surveillance by Xrn2 acts as a shared mechanism for mammalian pre-rRNA maturation and decay. Nucleic Acids Res (2010) 1.22
Role of pre-rRNA base pairing and 80S complex formation in subnucleolar localization of the U3 snoRNP. Mol Cell Biol (2004) 1.21
Dim2p, a KH-domain protein required for small ribosomal subunit synthesis. RNA (2004) 1.20
A plant snoRNP complex containing snoRNAs, fibrillarin, and nucleolin-like proteins is competent for both rRNA gene binding and pre-rRNA processing in vitro. Mol Cell Biol (2004) 1.20
Tracking the interactions of rRNA processing proteins during nucleolar assembly in living cells. Mol Biol Cell (2005) 1.18
The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway. Hum Mol Genet (2008) 1.18
Imp3p and Imp4p mediate formation of essential U3-precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA. Proc Natl Acad Sci U S A (2004) 1.17
Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation. Mol Cell Biol (2007) 1.16
Comprehensive mutational analysis of yeast DEXD/H box RNA helicases involved in large ribosomal subunit biogenesis. Mol Cell Biol (2006) 1.15
Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis. Dev Biol (2007) 1.14
Two RNA polymerase I subunits control the binding and release of Rrn3 during transcription. Mol Cell Biol (2007) 1.12
Nop9 is an RNA binding protein present in pre-40S ribosomes and required for 18S rRNA synthesis in yeast. RNA (2007) 1.12
Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol (2006) 1.12
Comprehensive mutational analysis of yeast DEXD/H box RNA helicases required for small ribosomal subunit synthesis. Mol Cell Biol (2006) 1.11
The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis. Nucleic Acids Res (2010) 1.10
The 5' external transcribed spacer in mouse ribosomal RNA contains two cleavage sites. RNA (2008) 1.09
Role and dynamics of the ribosomal protein P0 and its related trans-acting factor Mrt4 during ribosome assembly in Saccharomyces cerevisiae. Nucleic Acids Res (2009) 1.09
NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing. PLoS Genet (2012) 1.07
Arabidopsis thaliana XRN2 is required for primary cleavage in the pre-ribosomal RNA. Nucleic Acids Res (2010) 1.07
Elucidation of the assembly events required for the recruitment of Utp20, Imp4 and Bms1 onto nascent pre-ribosomes. Nucleic Acids Res (2011) 1.07
Protein-protein interactions within late pre-40S ribosomes. PLoS One (2011) 1.07
Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation. RNA (2007) 1.06
Interaction of Saccharomyces Cdc13p with Pol1p, Imp4p, Sir4p and Zds2p is involved in telomere replication, telomere maintenance and cell growth control. Nucleic Acids Res (2004) 1.06
Delayed rRNA processing results in significant ribosome biogenesis and functional defects. Mol Cell Biol (2003) 1.05
Why Dom34 stimulates growth of cells with defects of 40S ribosomal subunit biosynthesis. Mol Cell Biol (2010) 1.05
The essential WD-repeat protein Rsa4p is required for rRNA processing and intra-nuclear transport of 60S ribosomal subunits. Nucleic Acids Res (2005) 1.05
The DEAD-box RNA helicase-like Utp25 is an SSU processome component. RNA (2010) 1.04
Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Mol Cell Biol (2005) 1.04
Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry. Proc Natl Acad Sci U S A (2004) 13.14
Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae. Nat Biotechnol (2002) 8.37
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell (2003) 6.44
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature (2005) 6.40
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol (2002) 5.42
Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry. Proc Natl Acad Sci U S A (2007) 5.09
Novel linear quadrupole ion trap/FT mass spectrometer: performance characterization and use in the comparative analysis of histone H3 post-translational modifications. J Proteome Res (2004) 4.32
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol (2004) 4.20
Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem (2006) 3.84
Chemical derivatization of histones for facilitated analysis by mass spectrometry. Nat Protoc (2007) 3.78
Gene silencing: trans-histone regulatory pathway in chromatin. Nature (2002) 3.77
Protein identification using sequential ion/ion reactions and tandem mass spectrometry. Proc Natl Acad Sci U S A (2005) 3.77
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A (2003) 3.75
Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell (2008) 3.09
A neutral loss activation method for improved phosphopeptide sequence analysis by quadrupole ion trap mass spectrometry. Anal Chem (2004) 3.08
Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem (2005) 3.00
Matrix cells from Wharton's jelly form neurons and glia. Stem Cells (2003) 2.95
In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes. Mol Cell Biol (2003) 2.88
The utility of ETD mass spectrometry in proteomic analysis. Biochim Biophys Acta (2006) 2.85
Pre-18S ribosomal RNA is structurally compacted into the SSU processome prior to being cleaved from nascent transcripts in Saccharomyces cerevisiae. Mol Cell (2004) 2.81
Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal (2010) 2.79
Ribosome biogenesis in the yeast Saccharomyces cerevisiae. Genetics (2013) 2.70
Ribosome biogenesis: of knobs and RNA processing. Exp Cell Res (2004) 2.70
MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. J Biol Chem (2003) 2.53
RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components. Genes Dev (2004) 2.48
Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis. Genes Dev (2010) 2.44
Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proc Natl Acad Sci U S A (2007) 2.43
N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. Nat Cell Biol (2007) 2.36
Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. J Biol Chem (2006) 2.32
The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr Biol (2004) 2.31
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28
O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem (2008) 2.27
Electron transfer dissociation of peptide anions. J Am Soc Mass Spectrom (2005) 2.26
RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes Dev (2007) 2.26
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr Biol (2005) 2.20
Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J Biol Chem (2002) 2.01
Genomic and functional evolution of the Drosophila melanogaster sperm proteome. Nat Genet (2006) 1.97
The long unwinding road of RNA helicases. Mol Cell (2007) 1.97
Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. J Biol Chem (2002) 1.96
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. Nature (2010) 1.95
Characterization of histones and their post-translational modifications by mass spectrometry. Curr Opin Chem Biol (2006) 1.92
Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. Proc Natl Acad Sci U S A (2005) 1.91
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc Natl Acad Sci U S A (2012) 1.89
Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes. Mol Biol Cell (2003) 1.89
Methods for analyzing peptides and proteins on a chromatographic timescale by electron-transfer dissociation mass spectrometry. Nat Protoc (2008) 1.87
Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins. Curr Biol (2010) 1.86
Post-acquisition ETD spectral processing for increased peptide identifications. J Am Soc Mass Spectrom (2009) 1.86
The small-subunit processome is a ribosome assembly intermediate. Eukaryot Cell (2004) 1.84
Draft genome sequence and genetic transformation of the oleaginous alga Nannochloropis gaditana. Nat Commun (2012) 1.83
Proteome-wide prediction of acetylation substrates. Proc Natl Acad Sci U S A (2009) 1.81
RPD3 is required for the inactivation of yeast ribosomal DNA genes in stationary phase. EMBO J (2002) 1.79
When ribosomes go bad: diseases of ribosome biogenesis. Mol Biosyst (2010) 1.76
A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. J Biol Chem (2008) 1.76
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A (2012) 1.75