Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes.

Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase. Sci Rep (2016) 0.75

Sea lampreys elicit strong transcriptomic responses in the lake trout liver during parasitism. BMC Genomics (2016) 0.75

Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med (2010) 2.12

Immunopathogenesis of cerebral malaria. Int J Parasitol (2006) 2.08

Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. J Immunol (2008) 1.42

Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. Int J Parasitol (2006) 1.35

Early cytokine production is associated with protection from murine cerebral malaria. Infect Immun (2005) 1.32

Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. FASEB J (2004) 1.06

Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria. Int J Parasitol (2010) 1.03

Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium. Int J Parasitol (2004) 0.98

Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease. Amino Acids (2013) 0.98

Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. J Physiol (2002) 0.96

Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells. Cytokine (2007) 0.96

Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis. J Immunol (2012) 0.93

1-L-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-D-methyltryptophan. Comp Biochem Physiol B Biochem Mol Biol (2010) 0.93

Differential microRNA expression in experimental cerebral and noncerebral malaria. Infect Immun (2011) 0.91

A role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. J Neuroimmunol (2006) 0.91

Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1. Amino Acids (2014) 0.90

Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice. Int J Parasitol (2010) 0.89

Predominance of interferon-related responses in the brain during murine malaria, as identified by microarray analysis. Infect Immun (2008) 0.88

Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS One (2008) 0.88

Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials. Comp Biochem Physiol B Biochem Mol Biol (2009) 0.83

Indoleamine 2,3-dioxygenases with very low catalytic activity are well conserved across kingdoms: IDOs of Basidiomycota. Fungal Genet Biol (2013) 0.83

The kynurenine pathway of tryptophan degradation is activated during osteoblastogenesis. Stem Cells (2015) 0.82

Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. Bioorg Med Chem Lett (2012) 0.81

Molecular evolution and characterization of fungal indoleamine 2,3-dioxygenases. J Mol Evol (2010) 0.81

Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties. Amino Acids (2008) 0.81

The evolution of three types of indoleamine 2,3 dioxygenases in fungi with distinct molecular and biochemical characteristics. Gene (2012) 0.79

Molecular evolution of bacterial indoleamine 2,3-dioxygenase. Gene (2011) 0.79

Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria. Int J Parasitol (2008) 0.79

Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria. PLoS One (2013) 0.78

Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.78

Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials. Comp Biochem Physiol B Biochem Mol Biol (2009) 0.78

Improved spectrophotometric human interferon-gamma bioassay. J Immunol Methods (2013) 0.75