Published in Naunyn Schmiedebergs Arch Pharmacol on February 27, 2011
The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia. Curr Pharm Des (2016) 0.75
Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency. Mol Genet Metab (2017) 0.75
Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke (1986) 8.23
Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Res (2007) 3.44
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res (2007) 2.78
Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci (1997) 2.62
Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol (2003) 2.54
Neuropharmacology of quinolinic and kynurenic acids. Pharmacol Rev (1993) 2.45
Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene (2007) 2.24
Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med (2010) 2.12
Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. Eur J Pharmacol (1981) 2.02
Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons. Glia (2005) 1.93
Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor. Hypertension (2006) 1.80
Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection. J Neurochem (2001) 1.79
Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate. J Biol Chem (1975) 1.72
Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice. Neurosci Lett (2000) 1.51
Characterization of the kynurenine pathway in human neurons. J Neurosci (2007) 1.44
Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res (2006) 1.39
Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2-deficient mice. Br J Pharmacol (2009) 1.36
Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide. J Cereb Blood Flow Metab (2010) 1.36
Synergistic transcriptional activation of indoleamine dioxygenase by IFN-gamma and tumor necrosis factor-alpha. J Interferon Cytokine Res (2003) 1.29
Effect of suture size and carotid clip application upon blood flow and infarct volume after permanent and temporary middle cerebral artery occlusion in mice. Brain Res (2003) 1.24
The role of IFN-gamma and TNF-alpha-responsive regulatory elements in the synergistic induction of indoleamine dioxygenase. J Interferon Cytokine Res (2005) 1.12
Indoleamine 2,3-dioxygenase. Potassium superoxide as substrate. J Biol Chem (1977) 1.10
Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration. J Neuroimmunol (2008) 1.09
Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells. J Biol Chem (2008) 1.08
Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia. J Neurochem (1993) 1.07
Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation. J Neurochem (1993) 1.05
Altered kynurenine metabolism correlates with infarct volume in stroke. Eur J Neurosci (2007) 1.05
Differential vulnerability of central neurons of the rat to quinolinic acid. Neurosci Lett (1983) 1.00
NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke. Brain Res (2006) 0.98
Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium. Int J Parasitol (2004) 0.98
Identification of tryptophan 2,3-dioxygenase RNA in rodent brain. J Neurochem (1993) 0.95
Indoleamine 2,3-dioxygenase. Kinetic studies on the binding of superoxide anion and molecular oxygen to enzyme. J Biol Chem (1979) 0.94
Identification and characterization of novel variants of the tryptophan 2,3-dioxygenase gene: differential regulation in the mouse nervous system during development. Neurosci Res (2009) 0.93
Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line. Brain Res (1989) 0.92
Effects of aminoguanidine on cerebral ischemia in mice: comparison between mice with and without inducible nitric oxide synthase gene. Neurosci Lett (2002) 0.92
Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2. Amino Acids (2010) 0.90
Tissue distribution of indoleamine 2,3-dioxygenase in normal and malaria-infected tissue. Redox Rep (2000) 0.89
Neuronal localization of indoleamine 2,3-dioxygenase in mice. Neurosci Lett (2005) 0.89
Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. Behav Brain Res (2003) 0.87
Temporal characteristics of the protective effect of aminoguanidine on cerebral ischemic damage. Brain Res (1998) 0.86
Kynurenine diminishes the ischemia-induced histological and electrophysiological deficits in the rat hippocampus. Neurobiol Dis (2008) 0.85
Tryptophan pyrrole ring cleavage enzymes in placenta. Adv Exp Med Biol (2003) 0.85
Increased anxiety and impaired pain response in puromycin-sensitive aminopeptidase gene-deficient mice obtained by a mouse gene-trap method. J Neurosci (1999) 0.85
Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in gerbils. Eur J Pharmacol (2007) 0.84
L-Arginine increases ischemic injury in wild-type mice but not in iNOS-deficient mice. Brain Res (2003) 0.83
Neuroprotection achieved in the ischaemic rat cortex with L-kynurenine sulphate. Life Sci (2008) 0.79
Marked increases in hippocampal neuron indoleamine 2, 3-dioxygenase via IFN-gamma-independent pathway following transient global ischemia in mouse. Neurosci Res (2008) 0.77
Effect of systemic administration of L-kynurenine on corticocerebral blood flow under normal and ischemic conditions of the brain in conscious rabbits. J Cardiovasc Pharmacol (2003) 0.77
Localization and spatiotemporal expression of IDO following transient forebrain ischemia in gerbils. Brain Res (2008) 0.75
Apoptotic mechanisms after cerebral ischemia. Stroke (2009) 3.92
DNAzyme targeting c-jun suppresses skin cancer growth. Sci Transl Med (2012) 3.09
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov (2011) 3.08
Insulin resistance is a cellular antioxidant defense mechanism. Proc Natl Acad Sci U S A (2009) 2.60
Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. Crit Care Med (2011) 2.27
The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents. J Biol Chem (2007) 2.25
Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene (2007) 2.24
Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med (2010) 2.12
Immunopathogenesis of cerebral malaria. Int J Parasitol (2006) 2.08
Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice. Am J Physiol Heart Circ Physiol (2009) 2.00
NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Circ Res (2005) 1.65
Angiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats. Hypertension (2012) 1.61
Targeting Rho and Rho-kinase in the treatment of cardiovascular disease. Trends Pharmacol Sci (2005) 1.60
Association between both lipid and protein oxidation and the risk of fatal or non-fatal coronary heart disease in a human population. Clin Sci (Lond) (2009) 1.59
NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition. Pharmacol Ther (2008) 1.58
Prevalence, incidence, and lifetime risk of atrial fibrillation in China: new insights into the global burden of atrial fibrillation. Chest (2015) 1.54
Relation of renal dysfunction to the increased risk of stroke and death in female patients with atrial fibrillation. Int J Cardiol (2013) 1.50
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Mol Neurodegener (2011) 1.48
Evidence for a detrimental role of TLR8 in ischemic stroke. Exp Neurol (2013) 1.46
Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. J Immunol (2008) 1.42
Ruminative Responses to Negative and Positive Affect Among Students Diagnosed with Bipolar Disorder and Major Depressive Disorder. Cognit Ther Res (2008) 1.39
Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide. J Cereb Blood Flow Metab (2010) 1.36
Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. Int J Parasitol (2006) 1.35
Oxidative stress and endothelial dysfunction in cerebrovascular disease. Front Biosci (Landmark Ed) (2011) 1.34
Early cytokine production is associated with protection from murine cerebral malaria. Infect Immun (2005) 1.32
Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. Am J Physiol Heart Circ Physiol (2010) 1.29
Adiponectin receptor signalling in the brain. Br J Pharmacol (2012) 1.28
Serum amyloid A in uremic HDL promotes inflammation. J Am Soc Nephrol (2012) 1.27
Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. Arterioscler Thromb Vasc Biol (2010) 1.27
Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus. Nat Med (2012) 1.23
Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia. J Cereb Blood Flow Metab (2012) 1.22
Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis. Am J Pathol (2002) 1.18
Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide. J Biol Chem (2007) 1.16
Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. J Exp Med (2006) 1.16
NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival. Naunyn Schmiedebergs Arch Pharmacol (2009) 1.15
The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions. J Biol Chem (2002) 1.14
Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: role of estrogen. Stroke (2007) 1.13
Nongastric Helicobacter species detected in the intestinal tract of children. J Clin Microbiol (2006) 1.13
Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo. Stroke (2004) 1.11
NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2. Am J Physiol Heart Circ Physiol (2008) 1.10
Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase. J Biol Chem (2009) 1.08
Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein. J Lipid Res (2002) 1.08
Recent evidence for an involvement of rho-kinase in cerebral vascular disease. Stroke (2006) 1.08
Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells. J Biol Chem (2008) 1.08
Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration. Biochem Pharmacol (2006) 1.07
More research is needed to investigate the effect of denervation on blood pressure. Hypertension (2014) 1.07
Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. FASEB J (2004) 1.06
The lipocalin alpha1-microglobulin has radical scavenging activity. J Biol Chem (2007) 1.06
Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1. Circulation (2004) 1.05
Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke. Mol Pharmacol (2011) 1.04
Pharmacologic induction of heme oxygenase-1. Antioxid Redox Signal (2007) 1.04
Actions of "antioxidants" in the protection against atherosclerosis. Free Radic Biol Med (2012) 1.03
Acute hypertriglyceridaemia in humans increases the triglyceride content and decreases the anti-inflammatory capacity of high density lipoproteins. Atherosclerosis (2008) 1.03
Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria. Int J Parasitol (2010) 1.03
The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria. J Infect Dis (2002) 1.03
Effect of gender and sex hormones on vascular oxidative stress. Clin Exp Pharmacol Physiol (2007) 1.02
Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cell Physiol Biochem (2007) 1.02
NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts. Antioxid Redox Signal (2012) 1.02
Flow-induced cerebral vasodilatation in vivo involves activation of phosphatidylinositol-3 kinase, NADPH-oxidase, and nitric oxide synthase. J Cereb Blood Flow Metab (2006) 1.02
Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria. J Infect Dis (2003) 1.01
Heme moves to center stage in cerebral malaria. Nat Med (2007) 1.01
Evidence that nitric oxide inhibits vascular inflammation and superoxide production via a p47phox-dependent mechanism in mice. Clin Exp Pharmacol Physiol (2009) 1.01
Chemokine-related gene expression in the brain following ischemic stroke: no role for CXCR2 in outcome. Brain Res (2010) 1.00
Inwardly rectifying potassium channels in the regulation of vascular tone. Curr Drug Targets (2003) 1.00
The role of vitamin E in atherosclerosis. Prog Lipid Res (2003) 1.00
Novel isoforms of NADPH-oxidase in cerebral vascular control. Pharmacol Ther (2006) 0.99
Reactive oxygen species in the cerebral circulation: are they all bad? Antioxid Redox Signal (2006) 0.99
NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke. Brain Res (2006) 0.98
Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium. Int J Parasitol (2004) 0.98
Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease. Amino Acids (2013) 0.98
Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure. Hypertension (2014) 0.97
Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain. J Appl Physiol (1985) (2012) 0.97
New insights into intracellular locations and functions of heme oxygenase-1. Antioxid Redox Signal (2014) 0.97
Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. Psychiatry Res (2006) 0.97
Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke. Brain Res (2009) 0.97
Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models. Redox Rep (2010) 0.97
Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species. Stroke (2009) 0.97
Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. J Physiol (2002) 0.96
Probucol promotes functional reendothelialization in balloon-injured rabbit aortas. Circulation (2003) 0.96
Detection of reactive oxygen species derived from the family of NOX NADPH oxidases. Free Radic Biol Med (2012) 0.96
Evidence that estrogen suppresses rho-kinase function in the cerebral circulation in vivo. Stroke (2004) 0.96
Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells. Cytokine (2007) 0.96
Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet. J Lipid Res (2006) 0.95
Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1. Free Radic Biol Med (2013) 0.95
The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues. Biochemistry (2010) 0.95
Segmental differences in the roles of rho-kinase and protein kinase C in mediating vasoconstriction. J Pharmacol Exp Ther (2006) 0.95
Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries. Brain Res (2007) 0.95
Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice. J Lipid Res (2002) 0.95
Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. Stroke (2010) 0.94