Published in Exp Cell Res on February 19, 2015
NIH Image to ImageJ: 25 years of image analysis. Nat Methods (2012) 84.41
GEFs and GAPs: critical elements in the control of small G proteins. Cell (2007) 7.32
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev (2002) 6.54
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell (2001) 4.22
Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nat Genet (1996) 4.21
Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts. Nat Cell Biol (1999) 4.08
Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue. Nature (1997) 3.55
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev (2003) 3.46
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell (2002) 3.37
Rac1 is required for the formation of three germ layers during gastrulation. Oncogene (1998) 2.61
U2AF homology motifs: protein recognition in the RRM world. Genes Dev (2004) 2.34
Microtubule-induced cortical cell polarity. Genes Dev (2007) 2.28
Axenfeld-Rieger syndrome in the age of molecular genetics. Am J Ophthalmol (2000) 1.99
Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature (1997) 1.90
Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol (2008) 1.88
Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway. Proc Natl Acad Sci U S A (2003) 1.68
Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta. Mol Cell (2005) 1.66
Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nat Struct Biol (1998) 1.63
TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG. J Cell Sci (2000) 1.54
Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Development (2003) 1.52
Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes Dev (2005) 1.51
The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia. Mol Cell Biol (1996) 1.51
RanGAP mediates GTP hydrolysis without an arginine finger. Nature (2002) 1.50
Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2. J Biol Chem (2004) 1.43
DEPDC1B coordinates de-adhesion events and cell-cycle progression at mitosis. Dev Cell (2014) 1.43
Differential regulation of gene expression by PITX2 isoforms. J Biol Chem (2002) 1.41
The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo. Oncogene (1998) 1.33
Rap-specific GTPase activating protein follows an alternative mechanism. J Biol Chem (2002) 1.28
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. EMBO J (2008) 1.28
Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. FEBS Lett (2002) 1.27
Novel SACS mutations in autosomal recessive spastic ataxia of Charlevoix-Saguenay type. Neurology (2004) 1.26
Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network. Hum Mol Genet (2003) 1.24
The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. Genes Dev (1999) 1.24
ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP. J Cell Sci (2006) 1.21
A molecular basis for differential developmental anomalies in Axenfeld-Rieger syndrome. Hum Mol Genet (2002) 1.21
Antagonistic regulation of Dlx2 expression by PITX2 and Msx2: implications for tooth development. Gene Expr (2001) 1.18
PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5. J Biol Chem (2003) 1.18
PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene expression: implications for the pathology of Rieger syndrome. J Cell Biol (2001) 1.16
Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol (2014) 1.11
A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality. Dev Biol (2013) 1.10
Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit. Proc Natl Acad Sci U S A (1996) 1.09
DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients. Breast Cancer Res Treat (2007) 1.08
Left-right patterning: conserved and divergent mechanisms. Development (2012) 1.06
Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway. Hum Mol Genet (2010) 1.06
Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle. Mol Biol Cell (2009) 1.04
Reprogrammable recognition codes in bicoid homeodomain-DNA interaction. Mol Cell Biol (2000) 1.03
Wnt3a-mediated chemorepulsion controls movement patterns of cardiac progenitors and requires RhoA function. Development (2008) 1.03
Biochemical studies of the mechanism of action of the Cdc42-GTPase-activating protein. J Biol Chem (1998) 1.02
Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signaling. Mol Biol Cell (2002) 1.01
A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. Hum Mol Genet (2013) 1.00
Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells. Proc Natl Acad Sci U S A (2012) 0.96
Pitx2a binds to human papillomavirus type 18 E6 protein and inhibits E6-mediated P53 degradation in HeLa cells. J Biol Chem (2005) 0.96
Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo. Development (2011) 0.96
Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins. Proc Natl Acad Sci U S A (2012) 0.96
Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21. Dev Biol (2010) 0.94
Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation. Exp Cell Res (2006) 0.94
TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J (2003) 0.93
Rho guanine nucleotide exchange factor xNET1 implicated in gastrulation movements during Xenopus development. Differentiation (2004) 0.92
The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules. Semin Cell Dev Biol (2011) 0.87
Pitx2-dependent occupancy by histone deacetylases is associated with T-box gene regulation in mammalian abdominal tissue. J Biol Chem (2010) 0.87
Association of PITX2 mRNA down-regulation in prostate cancer with promoter hypermethylation and poor prognosis. Urol Oncol (2011) 0.87
Interactome for auxiliary splicing factor U2AF(65) suggests diverse roles. Biochim Biophys Acta (2009) 0.86
Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth. Mol Cell Neurosci (2008) 0.85
Cre fate mapping reveals lineage specific defects in neuronal migration with loss of Pitx2 function in the developing mouse hypothalamus and subthalamic nucleus. Mol Cell Neurosci (2007) 0.84
Expression of BRCC3, a novel cell cycle regulated molecule, is associated with increased phospho-ERK and cell proliferation. Int J Mol Med (2007) 0.82
DEPDC1B enhances migration and invasion of non-small cell lung cancer cells via activating Wnt/β-catenin signaling. Biochem Biophys Res Commun (2014) 0.81
Regulation of motility of myogenic cells in filling limb muscle anlagen by Pitx2. PLoS One (2012) 0.80
Role of a novel coiled-coil domain-containing protein CCDC69 in regulating central spindle assembly. Cell Cycle (2010) 0.80
The enigmatic ERH protein: its role in cell cycle, RNA splicing and cancer. Protein Cell (2013) 0.80
DEP domains: structurally similar but functionally different. Nat Rev Mol Cell Biol (2014) 0.80
A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-independent growth in oral cancer cells that is mediated by Rac1 and ERK. J Biomed Sci (2014) 0.77
Novel head-to-head gene fusion of MLL with ZC3H13 in a JAK2 V617F-positive patient with essential thrombocythemia without blast cells. Leuk Res (2011) 0.76