Published in Oncogene on December 31, 1998
CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis. J Cell Biol (2000) 3.55
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev (2003) 3.46
GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays (2007) 3.26
Regulatory and signaling properties of the Vav family. Mol Cell Biol (2000) 3.14
Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell (2008) 3.02
Principles of planar polarity in animal development. Development (2011) 2.94
Rac and Rho GTPases in cancer cell motility control. Cell Commun Signal (2010) 2.56
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell (2011) 2.32
Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell (2010) 2.19
Requirement of Rac1 in the development of cardiac hypertrophy. Proc Natl Acad Sci U S A (2006) 2.02
Rho GTPases: functions and association with cancer. Clin Exp Metastasis (2007) 1.98
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J (2003) 1.98
Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol (2006) 1.96
The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration. EMBO J (2003) 1.92
Myoblast fusion: when it takes more to make one. Dev Biol (2009) 1.87
Rac signaling in breast cancer: a tale of GEFs and GAPs. Cell Signal (2011) 1.61
Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell (2006) 1.60
PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol (2003) 1.55
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse. Proc Natl Acad Sci U S A (2009) 1.55
Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene (2013) 1.44
Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood (2006) 1.41
Generation and characterization of Rac3 knockout mice. Mol Cell Biol (2005) 1.37
Apical accumulation of Rho in the neural plate is important for neural plate cell shape change and neural tube formation. Mol Biol Cell (2008) 1.24
The small GTPase Rac1 regulates auditory hair cell morphogenesis. J Neurosci (2009) 1.24
Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration. J Cell Sci (2008) 1.22
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Mol Biol Cell (2003) 1.21
Immunological function in mice lacking the Rac-related GTPase RhoG. Mol Cell Biol (2004) 1.19
Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse. PLoS Biol (2010) 1.17
Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function. Proc Natl Acad Sci U S A (2009) 1.14
Rac GTPases play critical roles in early T-cell development. Blood (2008) 1.13
The RhoGAP domain of CYK-4 has an essential role in RhoA activation. Curr Biol (2012) 1.13
Critical roles for Rac GTPases in T-cell migration to and within lymph nodes. Blood (2010) 1.11
Rac deletion in osteoclasts causes severe osteopetrosis. J Cell Sci (2011) 1.10
Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood (2007) 1.10
Rac1 is essential for phospholipase C-gamma2 activation in platelets. Pflugers Arch (2008) 1.08
Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Dev Biol (2008) 1.08
P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proc Natl Acad Sci U S A (2008) 1.07
Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration. Front Cell Neurosci (2014) 1.07
Neural crest cell-specific deletion of Rac1 results in defective cell-matrix interactions and severe craniofacial and cardiovascular malformations. Dev Biol (2010) 1.06
B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin. J Biol Chem (2009) 1.06
Essential role for Abi1 in embryonic survival and WAVE2 complex integrity. Proc Natl Acad Sci U S A (2011) 1.04
Rac1 expression by fibroblasts is required for tissue repair in vivo. Am J Pathol (2009) 1.03
Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease. Nat Rev Nephrol (2013) 1.01
Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia. Mol Cell Biol (2005) 1.01
A dual role of the GTPase Rac in cardiac differentiation of stem cells. Mol Biol Cell (2003) 0.99
Rho GTPase isoforms in cell motility: Don't fret, we have FRET. Cell Adh Migr (2014) 0.98
Embryonic lethality caused by apoptosis during gastrulation in mice lacking the gene of the ADP-ribosylation factor-related protein 1. Mol Cell Biol (2002) 0.98
Impact of Rac1 and Cdc42 signaling during early herpes simplex virus type 1 infection of keratinocytes. J Virol (2009) 0.98
Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis. Gastroenterology (2011) 0.97
Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo. Development (2011) 0.96
The rho GTPase Rac1 is required for proliferation and survival of progenitors in the developing forebrain. Dev Neurobiol (2010) 0.96
A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. PLoS One (2010) 0.95
Oncogenic H-Ras V12 promotes anchorage-independent cytokinesis in human fibroblasts. Proc Natl Acad Sci U S A (2007) 0.94
Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging. Cell Death Dis (2013) 0.92
Rac1 is essential for basement membrane-dependent epiblast survival. Mol Cell Biol (2010) 0.92
Rac1 regulates pancreatic islet morphogenesis. BMC Dev Biol (2009) 0.92
Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development (2009) 0.91
Application of in utero electroporation and live imaging in the analyses of neuronal migration during mouse brain development. Med Mol Morphol (2012) 0.91
A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res Ther (2010) 0.91
K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity. PLoS One (2011) 0.90
Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. J Biol Chem (2009) 0.90
Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Diabetologia (2013) 0.88
Migrating anterior mesoderm cells and intercalating trunk mesoderm cells have distinct responses to Rho and Rac during Xenopus gastrulation. Dev Dyn (2006) 0.88
Cellular and molecular mechanisms underlying blood vessel lumen formation. Bioessays (2013) 0.87
Apoptotic cell recognition receptors and scavenger receptors. Immunol Rev (2016) 0.87
Osteoclasts lacking Rac2 have defective chemotaxis and resorptive activity. Calcif Tissue Int (2010) 0.86
Epithelial fusion during neural tube morphogenesis. Birth Defects Res A Clin Mol Teratol (2012) 0.86
Phosphorylation of Rac1 T108 by extracellular signal-regulated kinase in response to epidermal growth factor: a novel mechanism to regulate Rac1 function. Mol Cell Biol (2013) 0.86
Rac GTPases play multiple roles in erythropoiesis. Haematologica (2010) 0.85
Inhibition of Rac1 promotes BMP-2-induced osteoblastic differentiation. Cell Death Dis (2013) 0.84
Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases. Front Synaptic Neurosci (2013) 0.84
Lymphocyte signaling: beyond knockouts. Nat Immunol (2009) 0.83
Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems. Neural Dev (2015) 0.83
Redox regulation of Rac1 by thiol oxidation. Free Radic Biol Med (2014) 0.83
Crossroads of PI3K and Rac pathways. Small GTPases (2015) 0.83
Rac1 and Rac3 GTPases regulate the development of hilar mossy cells by affecting the migration of their precursors to the hilus. PLoS One (2011) 0.82
Epithelial-specific knockout of the Rac1 gene leads to enamel defects. Eur J Oral Sci (2011) 0.81
Structure and expression of murine mgcRacGAP: its developmental regulation suggests a role for the Rac/MgcRacGAP signalling pathway in neurogenesis. Biochem J (1999) 0.81
Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5. PLoS One (2013) 0.81
Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol (2016) 0.81
Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium. Cardiovasc Res (2014) 0.80
Rac GTPases in erythroid biology. Transfus Clin Biol (2010) 0.80
Rho-GTPases as key regulators of T lymphocyte biology. Small GTPases (2014) 0.80
Mesp1 controls the speed, polarity, and directionality of cardiovascular progenitor migration. J Cell Biol (2016) 0.80
The RHO-1 RhoGTPase modulates fertility and multiple behaviors in adult C. elegans. PLoS One (2011) 0.80
Diffuse angiopathy in Adams-Oliver syndrome associated with truncating DOCK6 mutations. Am J Med Genet A (2014) 0.79
Inhibition of tumor cell migration and invasion through knockdown of Rac1 expression in medulloblastoma cells. Cell Mol Neurobiol (2010) 0.79
Rho GTPases in embryonic development. Small GTPases (2014) 0.79
Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis. Arterioscler Thromb Vasc Biol (2011) 0.79
Inhibition of the Rho/Rho kinase pathway prevents lipopolysaccharide-induced hyperalgesia and the release of TNF-α and IL-1β in the mouse spinal cord. Sci Rep (2015) 0.78
Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases. Open Rheumatol J (2012) 0.78
Regulation of cell protrusions by small GTPases during fusion of the neural folds. Elife (2016) 0.78
The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis. Dev Biol (2014) 0.78
A Rac1-independent role for P-Rex1 in melanoblasts. J Invest Dermatol (2014) 0.78
Rho GTPases: Novel Players in the Regulation of the DNA Damage Response? Biomolecules (2015) 0.77
Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ (2015) 0.77
Identification of the GTPase-activating protein DEP domain containing 1B (DEPDC1B) as a transcriptional target of Pitx2. Exp Cell Res (2015) 0.76
Rac1 Regulates Endometrial Secretory Function to Control Placental Development. PLoS Genet (2015) 0.76
Rac1 signaling is critical to cardiomyocyte polarity and embryonic heart development. J Am Heart Assoc (2014) 0.76
Rho GTPases in erythroid maturation. Curr Opin Hematol (2014) 0.76
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (1995) 11.06
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity (2000) 10.34
Endoscopic mucosal resection for treatment of early gastric cancer. Gut (2001) 8.70
The outer membrane proteins of Gram-negative bacteria: biosynthesis, assembly, and functions. Annu Rev Biochem (1978) 7.96
Urban residential environments and senior citizens' longevity in megacity areas: the importance of walkable green spaces. J Epidemiol Community Health (2002) 7.79
Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature (2000) 7.15
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature (2000) 6.49
Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc Natl Acad Sci U S A (1996) 6.04
Efficient gene transfer into the embryonic mouse brain using in vivo electroporation. Dev Biol (2001) 5.64
Effects of heating in dodecyl sulfate solution on the conformation and electrophoretic mobility of isolated major outer membrane proteins from Escherichia coli K-12. J Biochem (1976) 5.52
Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr Biol (2001) 5.42
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J (1997) 5.03
Intestinal transplantation in composite visceral grafts or alone. Ann Surg (1992) 4.96
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J (1999) 4.55
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc Natl Acad Sci U S A (1995) 4.40
A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell (1994) 4.35
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell (1994) 4.34
DNA sequence of the gene for the outer membrane lipoprotein of E. coli: an extremely AT-rich promoter. Cell (1979) 4.31
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A (1981) 4.12
Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer (1995) 3.83
Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli. J Bacteriol (1990) 3.78
The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem (1994) 3.75
Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest (1991) 3.70
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells (1999) 3.69
Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology (1983) 3.67
Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure. Circulation (1994) 3.63
A new endoscopic mucosal resection procedure using an insulation-tipped electrosurgical knife for rectal flat lesions: report of two cases. Gastrointest Endosc (1999) 3.55
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett (1996) 3.46
Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane. Proc Natl Acad Sci U S A (1982) 3.44
T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation (1999) 3.41
Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat Genet (1998) 3.38
Structure of the AAA ATPase p97. Mol Cell (2000) 3.37
Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med (1997) 3.35
Parallel neural networks for learning sequential procedures. Trends Neurosci (1999) 3.35
Risk factors for lymph node metastasis from intramucosal gastric carcinoma. Cancer (1996) 3.21
Redox regulation of cellular activation. Annu Rev Immunol (1997) 3.17
Calreticulin: one protein, one gene, many functions. Biochem J (1999) 3.16
Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab (2001) 3.16
Natural history of branch duct intraductal papillary-mucinous neoplasms of the pancreas without mural nodules: long-term follow-up results. Gut (2007) 3.11
Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol (1994) 3.05
Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases. Endoscopy (2001) 3.01
Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors. Neuron (2001) 2.94
Different sensitivity to wortmannin of two vacuolar sorting signals indicates the presence of distinct sorting machineries in tobacco cells. J Cell Biol (1995) 2.93
Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage. Kidney Int (2007) 2.93
Calreticulin is essential for cardiac development. J Cell Biol (1999) 2.88
Synergistic release of Ca2+ from IP3-sensitive stores evoked by synaptic activation of mGluRs paired with backpropagating action potentials. Neuron (1999) 2.79
Metastatic patterns of prostatic cancer. Correlation between sites and number of organs involved. Cancer (1984) 2.78
Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75
Cadaveric small bowel and small bowel-liver transplantation in humans. Transplantation (1992) 2.75
Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells (1997) 2.72
Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin Pharmacol Ther (1985) 2.69
Construction of versatile expression cloning vehicles using the lipoprotein gene of Escherichia coli. EMBO J (1982) 2.68
Distribution of the insertion sequence IS1 in gram-negative bacteria. Nature (1981) 2.63
Management of intestinal transplantation in humans. Transplant Proc (1992) 2.62
Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circ Res (2001) 2.62
Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum (2000) 2.61
Uni-directional growth of F-actin. J Biochem (1976) 2.61
Cardiac fibrosis in mice lacking brain natriuretic peptide. Proc Natl Acad Sci U S A (2000) 2.58
K-ras is essential for the development of the mouse embryo. Oncogene (1997) 2.57
Messenger ribonucleic acid of the lipoprotein of the Escherichia coli outer membrane. II. The complete nucleotide sequence. J Biol Chem (1980) 2.57
Expression of the Fas ligand in cells of T cell lineage. J Immunol (1995) 2.54
Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro. Cell (1998) 2.54
Propeptide of a precursor to a plant vacuolar protein required for vacuolar targeting. Proc Natl Acad Sci U S A (1991) 2.48
Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. Gan (1968) 2.44
Regulatory region of the gene for the ompA protein, a major outer membrane protein of Escherichia coli. Proc Natl Acad Sci U S A (1980) 2.44
Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab (2000) 2.43
Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. Development (2001) 2.42
Takayasu's arteritis. Clinical report of eighty-four cases and immunological studies of seven cases. Circulation (1967) 2.42
Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy. Hypertension (1996) 2.37
Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage (2005) 2.36
Fluorescence in situ hybridization using 16S rRNA-targeted oligonucleotides reveals localization of methanogens and selected uncultured bacteria in mesophilic and thermophilic sludge granules. Appl Environ Microbiol (1999) 2.33
The human amygdala plays an important role in gaze monitoring. A PET study. Brain (1999) 2.33
Complications of double balloon enteroscopy: a multicenter survey. Endoscopy (2007) 2.28
Beta-catenin mutation in carcinoma of the uterine endometrium. Cancer Res (1998) 2.27
Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice. Kidney Int (2007) 2.21
Amino acid sequence of the signal peptide of ompA protein, a major outer membrane protein of Escherichia coli. J Biol Chem (1980) 2.20
Sugar-sweetened beverage and diet soda consumption and the 7-year risk for type 2 diabetes mellitus in middle-aged Japanese men. Eur J Nutr (2013) 2.20
Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome. Eur Heart J (2002) 2.17
Use of a lac promoter-operator fragment as a transcriptional control switch for expression of the constitutive lpp gene in Escherichia coli. J Mol Appl Genet (1982) 2.15
Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload. J Clin Invest (1995) 2.15
Phylogenetic diversity of mesophilic and thermophilic granular sludges determined by 16S rRNA gene analysis. Microbiology (1998) 2.14
An analysis of health levels and various indicators of urban environments for Healthy Cities projects. J Epidemiol Community Health (2001) 2.14