Published in J Biol Chem on October 27, 2004
Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy. Hepatology (2014) 1.87
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. J Cell Biol (2009) 1.77
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity. J Cell Biol (2007) 1.75
WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth. Breast Cancer Res (2009) 1.70
Existence of the canonical Wnt signaling pathway in the human trabecular meshwork. Invest Ophthalmol Vis Sci (2012) 1.53
Dishevelled and Wnt signaling: is the nucleus the final frontier? J Biol (2005) 1.28
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol Cell Biol (2008) 1.27
Abundance, complexation, and trafficking of Wnt/beta-catenin signaling elements in response to Wnt3a. J Mol Signal (2007) 1.27
Myocilin is a modulator of Wnt signaling. Mol Cell Biol (2009) 1.14
Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. Br J Cancer (2009) 1.14
Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J (2010) 1.10
Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells. Mol Biol Cell (2009) 1.08
Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility. Oncogene (2012) 1.03
Rho GTPase activity modulates Wnt3a/beta-catenin signaling. Cell Signal (2009) 1.01
The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling. J Biol Chem (2012) 0.98
Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration. Mol Cancer Res (2010) 0.98
Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. J Biol Chem (2013) 0.94
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Proc Natl Acad Sci U S A (2014) 0.93
Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine/threonine kinase signaling pathway. J Cell Physiol (2011) 0.90
Epigenetic regulation of wnt pathway antagonists in human glioblastoma multiforme. Genes Cancer (2010) 0.87
Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling. Dev Biol (2006) 0.87
Mathematically guided approaches to distinguish models of periodic patterning. Development (2015) 0.86
Automated time-lapse microscopy and high-resolution tracking of cell migration. Cytotechnology (2006) 0.85
Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation. Invest Ophthalmol Vis Sci (2013) 0.84
Parathyroid hormone induces epithelial-to-mesenchymal transition via the Wnt/β-catenin signaling pathway in human renal proximal tubular cells. Int J Clin Exp Pathol (2014) 0.84
Myosin phosphatase modulates the cardiac cell fate by regulating the subcellular localization of Nkx2.5 in a Wnt/Rho-associated protein kinase-dependent pathway. Circ Res (2012) 0.82
Overexpression of Dishevelled-2 contributes to proliferation and migration of human esophageal squamous cell carcinoma. J Mol Histol (2016) 0.80
C-Jun N-terminal kinase (JNK) mediates Wnt5a-induced cell motility dependent or independent of RhoA pathway in human dental papilla cells. PLoS One (2013) 0.79
Potential of casein kinase I in digestive cancer screening. World J Gastrointest Oncol (2009) 0.79
Activation and function of small GTPases Rho, Rac, and Cdc42 during gastrulation. Methods Mol Biol (2012) 0.78
Wnt-RhoA signaling is involved in dental enamel development. Eur J Oral Sci (2011) 0.78
Identification of the GTPase-activating protein DEP domain containing 1B (DEPDC1B) as a transcriptional target of Pitx2. Exp Cell Res (2015) 0.76
RhoA GTPase interacts with beta-catenin signaling in clinorotated osteoblasts. J Bone Miner Metab (2013) 0.76
Cardiac progenitor migration and specification: The dual function of Wnts. Cell Adh Migr (2008) 0.76
Custos controls β-catenin to regulate head development during vertebrate embryogenesis. Proc Natl Acad Sci U S A (2014) 0.75
Wnt Signaling in Cell Motility and Invasion: Drawing Parallels between Development and Cancer. Cancers (Basel) (2016) 0.75
Activation of the Wnt Pathway by Mycobacterium tuberculosis: A Wnt-Wnt Situation. Front Immunol (2017) 0.75
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. J Cell Biol (2004) 2.55
A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells. J Biol Chem (2002) 2.40
Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development (2003) 2.18
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med (2009) 2.17
Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy. Hepatology (2014) 1.87
Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Curr Biol (2005) 1.79
Wnt signaling in B-cell neoplasia. Oncogene (2003) 1.73
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. J Clin Invest (2010) 1.73
Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth. J Cell Biol (2011) 1.68
Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin. Blood (2002) 1.65
Wnts induce migration and invasion of myeloma plasma cells. Blood (2005) 1.58
Regulation of thymic epithelium by keratinocyte growth factor. Blood (2002) 1.57
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem (2009) 1.56
Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer. Cancer Res (2005) 1.56
N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Cell Motil Cytoskeleton (2009) 1.54
Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation. J Biol Chem (2003) 1.53
Existence of the canonical Wnt signaling pathway in the human trabecular meshwork. Invest Ophthalmol Vis Sci (2012) 1.53
Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Adv Cancer Res (2004) 1.48
Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. J Bone Miner Res (2004) 1.45
Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure. J Clin Invest (2008) 1.39
Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. Mol Cell Biol (2006) 1.36
Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. Cancer Res (2006) 1.32
Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology (2005) 1.31
Predicting new indications for approved drugs using a proteochemometric method. J Med Chem (2012) 1.29
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol Cell Biol (2008) 1.27
Keratinocyte growth factor expression and activity in cancer: implications for use in patients with solid tumors. J Natl Cancer Inst (2006) 1.27
Contribution of high-resolution correlative imaging techniques in the study of the liver sieve in three-dimensions. Microsc Res Tech (2007) 1.21
Myocilin is a modulator of Wnt signaling. Mol Cell Biol (2009) 1.14
Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells. Circ Res (2006) 1.14
Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules. J Biol Chem (2001) 1.10
Wnt signaling promotes proliferation and stemness regulation of spermatogonial stem/progenitor cells. Reproduction (2009) 1.09
Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. Pediatr Blood Cancer (2008) 1.04
PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis. Oncogene (2005) 1.03
A role for sphingomyelin-rich lipid domains in the accumulation of phosphatidylinositol-4,5-bisphosphate to the cleavage furrow during cytokinesis. Mol Cell Biol (2012) 1.00
Wnt/Frizzled signaling in Ewing sarcoma. Pediatr Blood Cancer (2004) 1.00
Wnt signaling and neurite outgrowth: insights and questions. Cancer Sci (2007) 1.00
Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling. Cell Signal (2013) 0.99
Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Dev Biol (2008) 0.98
MgcRacGAP regulates cortical activity through RhoA during cytokinesis. Exp Cell Res (2004) 0.98
N-terminal extension of N-methylpurine DNA glycosylase is required for turnover in hypoxanthine excision reaction. J Biol Chem (2007) 0.97
Emergence of ETS transcription factors as diagnostic tools and therapeutic targets in prostate cancer. Am J Transl Res (2013) 0.96
Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. Arthritis Rheum (2002) 0.95
VHL loss of function and its impact on oncogenic signaling networks in clear cell renal cell carcinoma. Int J Biochem Cell Biol (2008) 0.95
Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. Mol Biol Cell (2003) 0.95
Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling. Cancer Cell (2012) 0.95
Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. J Biol Chem (2013) 0.94
Development of a novel assay for human tyrosyl DNA phosphodiesterase 2. Anal Biochem (2011) 0.93
Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal (2012) 0.92
Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells. J Cell Physiol (2012) 0.92
A global benchmark study using affinity-based biosensors. Anal Biochem (2008) 0.91
Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function. Cell Signal (2009) 0.90
SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. Stem Cells (2012) 0.90
Excised damaged base determines the turnover of human N-methylpurine-DNA glycosylase. DNA Repair (Amst) (2009) 0.90
Airway smooth muscle remodels pericellular collagen fibrils: implications for proliferation. Am J Physiol Lung Cell Mol Physiol (2010) 0.89
The ezrin metastatic phenotype is associated with the initiation of protein translation. Neoplasia (2012) 0.89
Dormant but migratory tumour cells in desmoplastic stroma of invasive ductal carcinomas. Clin Exp Metastasis (2012) 0.87
The E6 oncoprotein from HPV16 enhances the canonical Wnt/β-catenin pathway in skin epidermis in vivo. Mol Cancer Res (2011) 0.87
Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study. BMC Cancer (2006) 0.87
Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells. PLoS One (2012) 0.86
VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells. Cancer Biol Ther (2011) 0.86
Enhancement of myosin II/actin turnover at the contractile ring induces slower furrowing in dividing HeLa cells. Biochem J (2011) 0.86
1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription. Br J Pharmacol (2014) 0.86
Heparin inhibits Hepatocyte Growth Factor induced motility and invasion of hepatocellular carcinoma cells through early growth response protein 1. PLoS One (2012) 0.86
Expression, purification and characterization of codon-optimized human N-methylpurine-DNA glycosylase from Escherichia coli. Protein Expr Purif (2007) 0.85
Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. Oncotarget (2014) 0.85
Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction. BMC Res Notes (2012) 0.84
sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration. Arch Biochem Biophys (2011) 0.84
A new era for an ancient drug: arsenic trioxide and Hedgehog signaling. Vitam Horm (2012) 0.84
Fibrillar collagen clamps lung mesenchymal cells in a nonproliferative and noncontractile phenotype. Am J Respir Cell Mol Biol (2009) 0.84
Single-chain antibodies to the EWS NH(2) terminus structurally discriminate between intact and chimeric EWS in Ewing's sarcoma and interfere with the transcriptional activity of EWS in vivo. Cancer Res (2006) 0.84
SFRP1 promoter methylation and expression in human trabecular meshwork cells. Exp Eye Res (2012) 0.84
A comparative study of recombinant mouse and human apurinic/apyrimidinic endonuclease. Mol Cell Biochem (2011) 0.83
Binding kinetics and activity of human poly(ADP-ribose) polymerase-1 on oligo-deoxyribonucleotide substrates. J Mol Recognit (2009) 0.83
The visualization of hepatic vasculature by X-ray micro-computed tomography. J Electron Microsc (Tokyo) (2006) 0.82
Dipole-dipole interaction stabilizes the transition state of apurinic/apyrimidinic endonuclease--abasic site interaction. J Biol Chem (2007) 0.82
Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity. Front Oncol (2012) 0.82
Regulation of ROCK1 via Notch1 during breast cancer cell migration into dense matrices. BMC Cell Biol (2012) 0.81
Loss of SS18-SSX1 inhibits viability and induces apoptosis in synovial sarcoma. Clin Orthop Relat Res (2014) 0.81
Identification of a peptide binding motif for secreted frizzled-related protein-1. Peptides (2004) 0.81
Proliferation and pluripotency of human embryonic stem cells maintained on type I collagen. Stem Cells Dev (2010) 0.80
The hepatic sinusoidal endothelial lining and colorectal liver metastases. World J Gastroenterol (2007) 0.80
Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue. Virology (2013) 0.80
Mitogenic synergy through multilevel convergence of hepatocyte growth factor and interleukin-4 signaling pathways. Oncogene (2002) 0.80
Insulin-like growth factor 1 receptor as a therapeutic target in ewing sarcoma: lack of consistent upregulation or recurrent mutation and a review of the clinical trial literature. Sarcoma (2013) 0.80
Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. J Biol Chem (2013) 0.79
Effects of recombinant human thyroid-stimulating hormone superagonists on thyroidal uptake of 18F-fluorodeoxyglucose and radioiodide. Thyroid (2011) 0.78
Purification and Wnt-inhibitory activities of secreted frizzled-related proteins. Methods Mol Biol (2008) 0.78
Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1. Exp Cell Res (2012) 0.77
Nucleotide-induced conformational changes of PMP70, an ATP binding cassette transporter on rat liver peroxisomal membranes. Biochem Biophys Res Commun (2002) 0.76