Published in N Engl J Med on February 26, 2015
Trial of Respiratory Infections in Children for Enhanced Diagnostics (TREND) | NCT03233516
Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults. N Engl J Med (2015) 6.04
Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia. Clin Infect Dis (2016) 3.58
Taxonomer: an interactive metagenomics analysis portal for universal pathogen detection and host mRNA expression profiling. Genome Biol (2016) 1.99
Effects of Chronologic Age and Young Child Exposure on Respiratory Syncytial Virus Disease among US Preterm Infants Born at 32 to 35 Weeks Gestation. PLoS One (2016) 1.39
Respiratory Viral Detection in Children and Adults: Comparing Asymptomatic Controls and Patients With Community-Acquired Pneumonia. J Infect Dis (2015) 1.17
Aetiology of childhood pneumonia in a well vaccinated South African birth cohort: a nested case-control study of the Drakenstein Child Health Study. Lancet Respir Med (2016) 1.07
Unbiased Detection of Respiratory Viruses by Use of RNA Sequencing-Based Metagenomics: a Systematic Comparison to a Commercial PCR Panel. J Clin Microbiol (2016) 1.05
Community-acquired pneumonia among U.S. children. N Engl J Med (2015) 0.96
Community-acquired pneumonia among U.S. children. N Engl J Med (2015) 0.96
Molecular Identification and Epidemiological Features of Human Adenoviruses Associated with Acute Respiratory Infections in Hospitalized Children in Southern China, 2012-2013. PLoS One (2016) 0.86
Hospital admissions for lower respiratory tract infections among infants in the Canadian Arctic: a cohort study. CMAJ Open (2016) 0.86
Association Between Hospitalization With Community-Acquired Laboratory-Confirmed Influenza Pneumonia and Prior Receipt of Influenza Vaccination. JAMA (2015) 0.85
Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012. BMC Infect Dis (2015) 0.83
Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment. Clin Microbiol Rev (2017) 0.83
In Vitro Activity of Lefamulin Tested against Streptococcus pneumoniae with Defined Serotypes, Including Multidrug-Resistant Isolates Causing Lower Respiratory Tract Infections in the United States. Antimicrob Agents Chemother (2016) 0.83
Airway microbiota and acute respiratory infection in children. Expert Rev Clin Immunol (2015) 0.82
Antibiotic Choice for Children Hospitalized With Pneumonia and Adherence to National Guidelines. Pediatrics (2015) 0.82
Pneumococcal Disease in the Era of Pneumococcal Conjugate Vaccine. Infect Dis Clin North Am (2015) 0.82
The role of respiratory viruses in the etiology of bacterial pneumonia: An ecological perspective. Evol Med Public Health (2016) 0.82
Molecular Detection and Characterization of Mycoplasma pneumoniae Among Patients Hospitalized With Community-Acquired Pneumonia in the United States. Open Forum Infect Dis (2015) 0.81
Composition and dynamics of the respiratory tract microbiome in intubated patients. Microbiome (2016) 0.81
Identification of Human Adenovirus in Respiratory Samples with Luminex Respiratory Virus Panel Fast V2 Assay and Real-Time Polymerase Chain Reaction. Int J Mol Sci (2016) 0.80
Etiology and Factors Associated with Pneumonia in Children under 5 Years of Age in Mali: A Prospective Case-Control Study. PLoS One (2015) 0.80
Recognizing and managing sepsis: what needs to be done? BMC Med (2015) 0.79
Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate. Sci Rep (2016) 0.79
Recurrent rhinovirus infections in a child with inherited MDA5 deficiency. J Exp Med (2017) 0.78
Streptococcus pyogenes Pneumonia in Adults: Clinical Presentation and Molecular Characterization of Isolates 2006-2015. PLoS One (2016) 0.78
Infection with and Carriage of Mycoplasma pneumoniae in Children. Front Microbiol (2016) 0.78
Aggregate and hospital-level impact of national guidelines on diagnostic resource utilization for children with pneumonia at children's hospitals. J Hosp Med (2016) 0.78
Association of sputum microbiota profiles with severity of community-acquired pneumonia in children. BMC Infect Dis (2016) 0.78
Pneumovirus-Induced Lung Disease in Mice Is Independent of Neutrophil-Driven Inflammation. PLoS One (2016) 0.77
Incidence of childhood pneumonia: facility-based surveillance estimate compared to measured incidence in a South African birth cohort study. BMJ Open (2015) 0.77
Prevention and Control of Childhood Pneumonia and Diarrhea. Pediatr Clin North Am (2016) 0.77
Epidemiological and clinical profiles of respiratory syncytial virus infection in hospitalized neonates in Suzhou, China. BMC Infect Dis (2015) 0.77
Should Controls With Respiratory Symptoms Be Excluded From Case-Control Studies of Pneumonia Etiology? Reflections From the PERCH Study. Clin Infect Dis (2017) 0.77
Community-acquired pneumonia among U.S. children. N Engl J Med (2015) 0.77
Severe viral respiratory infections in children with IFIH1 loss-of-function mutations. Proc Natl Acad Sci U S A (2017) 0.76
Interleukin-27: a novel biomarker in predicting bacterial infection among the critically ill. Crit Care (2015) 0.76
Secondhand Smoke Exposure and Illness Severity among Children Hospitalized with Pneumonia. J Pediatr (2015) 0.76
Predicting Severe Pneumonia Outcomes in Children. Pediatrics (2016) 0.76
A Critical, Nonlinear Threshold Dictates Bacterial Invasion and Initial Kinetics During Influenza. Sci Rep (2016) 0.76
The Saudi Thoracic Society pneumococcal vaccination guidelines-2016. Ann Thorac Med (2016) 0.76
Clinical features and inflammatory markers in pediatric pneumonia: a prospective study. Eur J Pediatr (2017) 0.76
Viral Pathogen Detection by Metagenomics and Pan Viral Group PCR in Children with Pneumonia Lacking Identifiable Etiology. J Infect Dis (2017) 0.76
Viral Pneumonia in Patients with Hematologic Malignancy or Hematopoietic Stem Cell Transplantation. Clin Chest Med (2016) 0.75
Human metapneumovirus in the preterm neonate: current perspectives. Res Rep Neonatol (2016) 0.75
Genome-Wide Analysis of Human Metapneumovirus Evolution. PLoS One (2016) 0.75
Time to reconsider routine high-dose amoxicillin for community-acquired pneumonia in all Canadian children. Paediatr Child Health (2016) 0.75
Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study. PLoS One (2016) 0.75
Establishing Equipoise: National Survey of the Treatment of Pediatric Para-Pneumonic Effusion and Empyema. Surg Infect (Larchmt) (2016) 0.75
Type-specific clinical characteristics of adenovirus-associated influenza-like illness at five US military medical centers, 2009-2014. Influenza Other Respir Viruses (2016) 0.75
Bending the Twig Does the Tree Incline: Lung Function after Lower Respiratory Tract Illness in Infancy. Am J Respir Crit Care Med (2017) 0.75
Mycoplasma pneumoniae: Current Knowledge on Nucleic Acid Amplification Techniques and Serological Diagnostics. Front Microbiol (2016) 0.75
Identification of Bacterial and Viral Codetections With Mycoplasma pneumoniae Using the TaqMan Array Card in Patients Hospitalized With Community-Acquired Pneumonia. Open Forum Infect Dis (2016) 0.75
Comparison of severe acute respiratory illness (sari) and clinical pneumonia case definitions for the detection of influenza virus infections among hospitalized patients, western Kenya, 2009-2013. Influenza Other Respir Viruses (2016) 0.75
Rates of pneumonia among children and adults with chronic medical conditions in Germany. BMC Infect Dis (2015) 0.75
Immunological Features of Respiratory Syncytial Virus-Caused Pneumonia-Implications for Vaccine Design. Int J Mol Sci (2017) 0.75
Community-Acquired Pneumonia Hospitalization among Children with Neurologic Disorders. J Pediatr (2016) 0.75
An Expression of Clinical Significance: Exploring the Human Genome to Understand the Variable Response to Rhinovirus. Am J Respir Crit Care Med (2016) 0.75
Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis. Ann Fam Med (2016) 0.75
Transcriptome assists prognosis of disease severity in respiratory syncytial virus infected infants. Sci Rep (2016) 0.75
The Evolution of Advanced Molecular Diagnostics for the Detection and Characterization of Mycoplasma pneumoniae. Front Microbiol (2016) 0.75
Time to clinical stability among children hospitalized with pneumonia. J Hosp Med (2015) 0.75
Burden of human metapneumovirus infections in patients with cancer: Risk factors and outcomes. Cancer (2017) 0.75
Comparison of the frequency of bacterial and viral infections among children with community-acquired pneumonia hospitalized across distinct severity categories: a prospective cross-sectional study. BMC Pediatr (2016) 0.75
Viral Respiratory Infections in Preterm Infants during and after Hospitalization. J Pediatr (2016) 0.75
Viruses as Sole Causative Agents of Severe Acute Respiratory Tract Infections in Children. PLoS One (2016) 0.75
A GeXP-Based Assay for Simultaneous Detection of Multiple Viruses in Hospitalized Children with Community Acquired Pneumonia. PLoS One (2016) 0.75
Improved Detection of Respiratory Pathogens Using High-Quality Sputum with TaqMan Array Card Technology. J Clin Microbiol (2016) 0.75
Modulation of Host Immunity by the Human Metapneumovirus. Clin Microbiol Rev (2016) 0.75
Clinical Evaluation of a Single-Tube Multiple RT-PCR Assay for the Detection of 13 Common Virus Types/Subtypes Associated with Acute Respiratory Infection. PLoS One (2016) 0.75
A nationwide study of children and adolescents with pneumonia who visited Emergency Department in South Korea in 2012. Korean J Pediatr (2016) 0.75
Burden of Severe Respiratory Syncytial Virus Disease Among 33-35 Week Gestational Age Infants Born During Multiple Respiratory Syncytial Virus Seasons. Pediatr Infect Dis J (2016) 0.75
Insurance Status and the Risk of Severe Respiratory Syncytial Virus Disease in United States Preterm Infants Born at 32-35 Weeks Gestational Age. Open Forum Infect Dis (2016) 0.75
Serology Enhances Molecular Diagnosis of Respiratory Virus Infections Other than Influenza in Children and Adults Hospitalized with Community-Acquired Pneumonia. J Clin Microbiol (2016) 0.75
Respiratory viruses in patients with influenza-like illness in Senegal: Focus on human respiratory adenoviruses. PLoS One (2017) 0.75
Antibody Response to Mycoplasma pneumoniae: Protection of Host and Influence on Outbreaks? Front Microbiol (2016) 0.75
The potential impact of pneumococcal conjugate vaccine in Africa: Considerations and early lessons learned from the South African experience. Hum Vaccin Immunother (2016) 0.75
Acute Hemorrhagic Edema of Infancy after Coronavirus Infection with Recurrent Rash. Case Rep Pediatr (2017) 0.75
A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques. Nat Commun (2016) 0.75
Network of Surface-Displayed Glycolytic Enzymes in Mycoplasma pneumoniae and Their Interactions with Human Plasminogen. Infect Immun (2015) 0.75
Nasopharyngeal microbiome in premature infants and stability during rhinovirus infection. J Investig Med (2017) 0.75
Is the role of rhinoviruses as causative agents of pediatric community-acquired pneumonia over-estimated? Eur J Pediatr (2016) 0.75
Effects of different anaesthetics on cytokine levels in children with community-acquired pneumonia undergoing flexible fibreoptic bronchoscopy. J Int Med Res (2016) 0.75
Chest radiographic features of human metapneumovirus infection in pediatric patients. Pediatr Radiol (2017) 0.75
Comparison between diagnosis and treatment of community-acquired pneumonia in children in various medical centres across Europe with the United States, United Kingdom and the World Health Organization guidelines. Pneumonia (Nathan) (2016) 0.75
Bayesian latent class estimation of the incidence of chest radiograph-confirmed pneumonia in rural Thailand. Epidemiol Infect (2016) 0.75
Reliability of Examination Findings in Suspected Community-Acquired Pneumonia. Pediatrics (2017) 0.75
Influence of Antibiotics on the Detection of Bacteria by Culture-Based and Culture-Independent Diagnostic Tests in Patients Hospitalized With Community-Acquired Pneumonia. Open Forum Infect Dis (2017) 0.75
Clinical Characteristics of Macrolide-Resistant Mycoplasma pneumoniae from Children in Jeju. J Korean Med Sci (2017) 0.75
Febrile Rhinovirus Illness During Pregnancy Is Associated With Low Birth Weight in Nepal. Open Forum Infect Dis (2017) 0.75
The Use of Statins and Risk of Community-Acquired Pneumonia. Curr Infect Dis Rep (2017) 0.75
Community-acquired pneumonia in children - a changing spectrum of disease. Pediatr Radiol (2017) 0.75
Utility of Blood Culture Among Children Hospitalized With Community-Acquired Pneumonia. Pediatrics (2017) 0.75
Challenges of Empirical Antibiotic Therapy for Community-Acquired Pneumonia in Children. Curr Ther Res Clin Exp (2017) 0.75
Elucidation of Bacterial Pneumonia-Causing Pathogens in Patients with Respiratory Viral Infection. Tuberc Respir Dis (Seoul) (2017) 0.75
Broadly Reactive Anti-Respiratory Syncytial Virus G Antibodies from Exposed Individuals Effectively Inhibit Infection of Primary Airway Epithelial Cells. J Virol (2017) 0.75
Oseltamivir Use Among Children and Adults Hospitalized With Community-Acquired Pneumonia. Open Forum Infect Dis (2016) 0.75
Pediatric clinical features of Mycoplasma pneumoniae infection are associated with bacterial P1 genotype. Exp Ther Med (2017) 0.75
Mycoplasma pneumoniae and its role as a human pathogen. Clin Microbiol Rev (2004) 7.51
U.S. hospitalizations for pneumonia after a decade of pneumococcal vaccination. N Engl J Med (2013) 6.60
Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis. Lancet (2007) 5.50
Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children. Pediatrics (2004) 4.74
Evaluation and improvement of real-time PCR assays targeting lytA, ply, and psaA genes for detection of pneumococcal DNA. J Clin Microbiol (2007) 4.44
Better tests, better care: improved diagnostics for infectious diseases. Clin Infect Dis (2013) 4.27
Real-time reverse transcription-PCR assay for comprehensive detection of human rhinoviruses. J Clin Microbiol (2007) 3.95
Standardized interpretation of paediatric chest radiographs for the diagnosis of pneumonia in epidemiological studies. Bull World Health Organ (2005) 3.36
Superiority of reverse-transcription polymerase chain reaction to conventional viral culture in the diagnosis of acute respiratory tract infections in children. J Infect Dis (2004) 3.25
Executive summary: the management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infect Dis (2011) 3.16
The impact of a 9-valent pneumococcal conjugate vaccine on the public health burden of pneumonia in HIV-infected and -uninfected children. Clin Infect Dis (2005) 2.81
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Human metapneumovirus infection among children hospitalized with acute respiratory illness. Emerg Infect Dis (2004) 2.35
Rhinovirus and the lower respiratory tract. Rev Med Virol (2004) 2.26
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Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children. J Infect Dis (2011) 1.93
National hospitalization trends for pediatric pneumonia and associated complications. Pediatrics (2010) 1.86
Molecular analysis improves pathogen identification and epidemiologic study of pediatric parapneumonic empyema. Pediatr Infect Dis J (2011) 1.86
Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. PLoS One (2011) 1.85
Multiplex PCR and emerging technologies for the detection of respiratory pathogens. Clin Infect Dis (2011) 1.82
Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clin Infect Dis (2011) 1.78
The definition of pneumonia, the assessment of severity, and clinical standardization in the Pneumonia Etiology Research for Child Health study. Clin Infect Dis (2012) 1.78
Impact of the introduction of pneumococcal conjugate vaccine on rates of community acquired pneumonia in children and adults. Vaccine (2008) 1.74
Medical microbiology: laboratory diagnosis of invasive pneumococcal disease. Clin Infect Dis (2008) 1.59
Detection of Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella spp. in clinical specimens using a single-tube multiplex real-time PCR assay. Diagn Microbiol Infect Dis (2011) 1.58
Increased sensitivity and reduced specificity of hemagglutination inhibition tests with ether-treated influenza B/Singapore/222/79. J Clin Microbiol (1983) 1.39
Spectrum of respiratory viruses in children with community-acquired pneumonia. Pediatr Infect Dis J (2012) 1.34
Current epidemiology and trends in invasive Haemophilus influenzae disease--United States, 1989-2008. Clin Infect Dis (2011) 1.30
Performance of different mono- and multiplex nucleic acid amplification tests on a multipathogen external quality assessment panel. J Clin Microbiol (2011) 1.27
Interpreting assays for the detection of Streptococcus pneumoniae. Clin Infect Dis (2011) 1.19
The burden of childhood pneumonia in the developed world: a review of the literature. Pediatr Infect Dis J (2013) 1.15
Serology as an adjunct to polymerase chain reaction assays for surveillance of acute respiratory virus infections. Clin Infect Dis (2011) 1.01
Additional diagnostic yield of adding serology to PCR in diagnosing viral acute respiratory infections in Kenyan patients 5 years of age and older. Clin Vaccine Immunol (2012) 1.00
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