Published in Nat Methods on March 02, 2015
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat Biotechnol (2015) 3.56
Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display. Nat Methods (2015) 2.42
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. Nat Methods (2015) 1.27
Editing the epigenome: technologies for programmable transcription and epigenetic modulation. Nat Methods (2016) 1.24
Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation. Nat Rev Mol Cell Biol (2015) 1.20
Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR. Mol Cell (2015) 1.09
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell (2016) 1.08
Cas9 gRNA engineering for genome editing, activation and repression. Nat Methods (2015) 1.04
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife (2016) 1.02
Versatile protein tagging in cells with split fluorescent protein. Nat Commun (2016) 1.00
Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice. Nat Commun (2016) 1.00
Potent and Targeted Activation of Latent HIV-1 Using the CRISPR/dCas9 Activator Complex. Mol Ther (2015) 0.98
CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs. Sci Rep (2015) 0.98
Comparison of Cas9 activators in multiple species. Nat Methods (2016) 0.96
Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation. Stem Cell Reports (2015) 0.94
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. Nat Methods (2016) 0.93
A multi-purpose toolkit to enable advanced genome engineering in plants. Plant Cell (2017) 0.92
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators. Genome Res (2015) 0.92
A multifunctional AAV-CRISPR-Cas9 and its host response. Nat Methods (2016) 0.92
EGRINs (Environmental Gene Regulatory Influence Networks) in Rice That Function in the Response to Water Deficit, High Temperature, and Agricultural Environments. Plant Cell (2016) 0.91
Enabling functional genomics with genome engineering. Genome Res (2015) 0.90
In Vivo Transcriptional Activation Using CRISPR/Cas9 in Drosophila. Genetics (2015) 0.90
Cornerstones of CRISPR-Cas in drug discovery and therapy. Nat Rev Drug Discov (2016) 0.88
Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems. PLoS One (2016) 0.87
The New State of the Art: Cas9 for Gene Activation and Repression. Mol Cell Biol (2015) 0.87
Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells. Cell Stem Cell (2016) 0.85
Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells. Nat Biotechnol (2017) 0.85
CRISPR guide RNA design for research applications. FEBS J (2016) 0.83
Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. Nat Rev Genet (2016) 0.82
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening. Nat Protoc (2017) 0.82
Using CRISPR/Cas to study gene function and model disease in vivo. FEBS J (2016) 0.82
Applications of Engineered DNA-Binding Molecules Such as TAL Proteins and the CRISPR/Cas System in Biology Research. Int J Mol Sci (2015) 0.81
Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity. Nat Commun (2016) 0.80
Effective knockdown of Drosophila long non-coding RNAs by CRISPR interference. Nucleic Acids Res (2016) 0.80
Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells. Biol Direct (2016) 0.79
Strategies for precision modulation of gene expression by epigenome editing: an overview. Epigenetics Chromatin (2015) 0.79
Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators. Sci Rep (2016) 0.79
Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons. Sci Rep (2016) 0.78
Applications of CRISPR Genome Engineering in Cell Biology. Trends Cell Biol (2016) 0.78
Complex transcriptional modulation with orthogonal and inducible dCas9 regulators. Nat Methods (2016) 0.78
Advances and perspectives in the application of CRISPR/Cas9 in insects. Dongwuxue Yanjiu (2016) 0.78
A genome editing primer for the hematologist. Blood (2016) 0.77
Concise review: programming human pluripotent stem cells into blood. Br J Haematol (2016) 0.77
iPSC-based drug screening for Huntington׳s disease. Brain Res (2015) 0.77
Transcriptional regulation with CRISPR-Cas9: principles, advances, and applications. Curr Opin Biotechnol (2016) 0.77
Controlling transcription in human pluripotent stem cells using CRISPR-effectors. Methods (2015) 0.77
CRISPR applications in ophthalmologic genome surgery. Curr Opin Ophthalmol (2017) 0.76
Gene Editing: Powerful New Tools for Nephrology Research and Therapy. J Am Soc Nephrol (2016) 0.76
Human Induced Pluripotent Stem Cell NEUROG2 Dual Knockin Reporter Lines Generated by the CRISPR/Cas9 System. Stem Cells Dev (2015) 0.76
Recent Advances in Genome Editing Using CRISPR/Cas9. Front Plant Sci (2016) 0.76
Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system. Oncotarget (2016) 0.75
An Efficient Light-Inducible P53 Expression System for Inhibiting Proliferation of Bladder Cancer Cell. Int J Biol Sci (2016) 0.75
The CRISPR-Cas9 System in Neisseria spp. Pathog Dis (2017) 0.75
To CRISPR and beyond: the evolution of genome editing in stem cells. Regen Med (2016) 0.75
Epigenetic Editing: On the Verge of Reprogramming Gene Expression at Will. Curr Genet Med Rep (2016) 0.75
Reprogramming cell fate with a genome-scale library of artificial transcription factors. Proc Natl Acad Sci U S A (2016) 0.75
DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells. Cell Rep (2016) 0.75
Transcriptional reprogramming in yeast using dCas9 and combinatorial gRNA strategies. Microb Cell Fact (2017) 0.75
An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells. Protein Cell (2017) 0.75
CRISPR/CAS9 Technologies. J Bone Miner Res (2017) 0.75
Development of an AAV9 coding for a 3XFLAG-TALEfrat#8-VP64 able to increase in vivo the human frataxin in YG8R mice. Gene Ther (2016) 0.75
Gene Editing and Genetic Lung Disease: Basic Research Meets Therapeutic Application. Am J Respir Cell Mol Biol (2016) 0.75
Genetic and epigenetic control of gene expression by CRISPR-Cas systems. F1000Res (2017) 0.75
The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice. Genetics (2016) 0.75
Animal Models Are Valid to Uncover Disease Mechanisms. PLoS Genet (2016) 0.75
Treatment with an SLC12A1 antagonist inhibits tumorigenesis in a subset of hepatocellular carcinomas. Oncotarget (2016) 0.75
Editing the Neuronal Genome: a CRISPR View of Chromatin Regulation in Neuronal Development, Function, and Plasticity. Yale J Biol Med (2016) 0.75
Challenges of CRISPR/Cas9 applications for long non-coding RNA genes. Nucleic Acids Res (2017) 0.75
Genome and Epigenome Editing in Mechanistic Studies of Human Aging and Aging-Related Disease. Gerontology (2016) 0.75
Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes. Stem Cell Reports (2017) 0.75
Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries. Sci Rep (2017) 0.75
Mutant Cas9-transcriptional activator activates HIV-1 in U1 cells in the presence and absence of LTR-specific guide RNAs. Matters (Zur) (2017) 0.75
CRISPR-Cas Genome Surgery in Ophthalmology. Transl Vis Sci Technol (2017) 0.75
Optimized strategy for in vivo Cas9-activation in Drosophila. Proc Natl Acad Sci U S A (2017) 0.75
dCas9-mediated transcriptional activation of tissue inhibitor of metalloproteinases. Metalloproteinases Med (2017) 0.75
Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy. Stem Cells Int (2017) 0.75
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
RNA-guided human genome engineering via Cas9. Science (2013) 48.29
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (2012) 48.17
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature (2010) 14.21
Development and applications of CRISPR-Cas9 for genome engineering. Cell (2014) 13.50
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol (2013) 11.35
Short motif sequences determine the targets of the prokaryotic CRISPR defence system. Microbiology (2009) 10.67
The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli. Nucleic Acids Res (2011) 10.43
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell (2013) 9.55
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Res (2013) 7.77
Cas9 as a versatile tool for engineering biology. Nat Methods (2013) 6.87
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature (2014) 5.19
RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat Methods (2013) 4.85
CRISPR RNA-guided activation of endogenous human genes. Nat Methods (2013) 4.69
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods (2013) 4.61
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell (2014) 3.76
A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae. Yeast (2007) 3.30
Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron (2013) 2.51
A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell (2014) 2.27
The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64
Rapid neurogenesis through transcriptional activation in human stem cells. Mol Syst Biol (2014) 1.05
Genome engineering: the next genomic revolution. Nat Methods (2014) 0.94
Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues. Nat Protoc (2015) 1.12
Cas9 gRNA engineering for genome editing, activation and repression. Nat Methods (2015) 1.04
Comparison of Cas9 activators in multiple species. Nat Methods (2016) 0.96