Published in EMBO J on March 10, 2015
Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma. J Hum Genet (2015) 0.82
Lysyl Oxidase-like-2 Cross-links Collagen IV of Glomerular Basement Membrane. J Biol Chem (2016) 0.78
Enzymatic and non-enzymatic functions of the lysyl oxidase family in bone. Matrix Biol (2016) 0.77
Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer. Oncotarget (2017) 0.77
Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and Cancer. Expert Opin Ther Targets (2016) 0.76
Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice. Sci Rep (2016) 0.75
Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis. Sci Rep (2017) 0.75
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell (2009) 6.66
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature (1986) 6.14
The metastatic niche: adapting the foreign soil. Nat Rev Cancer (2009) 5.28
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem (2003) 4.58
Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet (2004) 3.83
Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice. Circulation (2002) 3.57
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med (2010) 3.44
Lysyl oxidase: an oxidative enzyme and effector of cell function. Cell Mol Life Sci (2006) 3.31
Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell (2012) 2.75
A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J (2005) 2.71
Lysyl oxidases: a novel multifunctional amine oxidase family. Prog Nucleic Acid Res Mol Biol (2001) 2.69
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Genes Dev (2007) 2.61
Paradoxical roles for lysyl oxidases in cancer--a prospect. J Cell Biochem (2007) 2.30
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci U S A (2011) 2.17
The rationale for targeting the LOX family in cancer. Nat Rev Cancer (2012) 2.02
Epidermal Notch signalling: differentiation, cancer and adhesion. Curr Opin Cell Biol (2008) 1.99
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
Lysyl oxidase is required for vascular and diaphragmatic development in mice. J Biol Chem (2002) 1.90
EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nat Cell Biol (2008) 1.88
Crosstalk of Notch with p53 and p63 in cancer growth control. Nat Rev Cancer (2009) 1.79
Regulation of Notch1 gene expression by p53 in epithelial cells. Mol Cell Biol (2007) 1.78
The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis--thirty-third G. H. A. Clowes Memorial Award Lecture. Cancer Res (1994) 1.76
Retracted Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. Mol Cell (2012) 1.74
LOXL2-mediated matrix remodeling in metastasis and mammary gland involution. Cancer Res (2011) 1.54
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas. Cancer Res (2008) 1.48
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proc Natl Acad Sci U S A (2008) 1.48
Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Cancer Res (2009) 1.37
Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells. Nucleic Acids Res (2009) 1.35
Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway. Carcinogenesis (2009) 1.35
Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte. Carcinogenesis (2004) 1.31
Nuclear Krüppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis. Cancer Biol Ther (2008) 1.29
Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression. Semin Cancer Biol (2004) 1.29
Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas. EMBO Mol Med (2011) 1.28
Claudin-1 is not restricted to tight junctions in the rat epididymis. Endocrinology (2001) 1.19
Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane. Blood (2011) 1.16
Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells. Int J Cancer (2009) 1.13
The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin. Mol Biol Rep (2010) 1.13
Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma. Hepatology (2014) 1.08
Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains. Matrix Biol (2001) 1.06
Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes. PLoS One (2010) 1.03
Tumor-secreted LOXL2 activates fibroblasts through FAK signaling. Mol Cancer Res (2013) 0.99
Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization. Oncogene (2014) 0.99
Cloning and characterization of a fourth human lysyl oxidase isoenzyme. Biochem J (2001) 0.98
Gene expression profiling and its relevance to the blood-epididymal barrier in the human epididymis. Biol Reprod (2007) 0.98
Emerging role of Notch signaling in epidermal differentiation and skin cancer. Cancer Biol Ther (2009) 0.97
LOXL2 in epithelial cell plasticity and tumor progression. Future Oncol (2012) 0.96
Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17. J Clin Invest (2012) 0.95
Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition. Mol Cell (2013) 0.94
Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer. J Clin Invest (2014) 0.92
Reduction of LOX- and LOXL2-mRNA expression in head and neck squamous cell carcinomas. Anticancer Res (2003) 0.90
Genetic background and development of skin tumors. Carcinog Compr Surv (1989) 0.88
Orchestration of occludins, claudins, catenins and cadherins as players involved in maintenance of the blood-epididymal barrier in animals and humans. Asian J Androl (2007) 0.88
LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition. Biol Open (2014) 0.85
The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation. J Biol Chem (2011) 0.85
Helicase-like transcription factor (Hltf) regulates G2/M transition, Wt1/Gata4/Hif-1a cardiac transcription networks, and collagen biogenesis. PLoS One (2013) 0.84
The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models. J Skin Cancer (2012) 0.80
Reciprocal regulation of LOX and LOXL2 expression during cell adhesion and terminal differentiation in epidermal keratinocytes. J Dermatol Sci (2009) 0.78