Published in Genes Dev on March 01, 2007
Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer (2014) 3.37
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A (2011) 3.10
Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol (2012) 3.07
Impact of normalization on miRNA microarray expression profiling. RNA (2009) 2.63
p53 and its mutants in tumor cell migration and invasion. J Cell Biol (2011) 2.49
Temporal dissection of tumorigenesis in primary cancers. Cancer Discov (2011) 2.40
Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. Cancer Discov (2012) 2.39
Notch tumor suppressor function. Oncogene (2008) 2.26
From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest (2012) 2.01
Epidermal Notch signalling: differentiation, cancer and adhesion. Curr Opin Cell Biol (2008) 1.99
gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res (2009) 1.98
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nat Cell Biol (2008) 1.88
Crosstalk of Notch with p53 and p63 in cancer growth control. Nat Rev Cancer (2009) 1.79
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes Dev (2009) 1.76
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation. Nat Cell Biol (2015) 1.61
Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature (2010) 1.57
The double-edged sword of Notch signaling in cancer. Semin Cell Dev Biol (2012) 1.53
NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. J Invest Dermatol (2014) 1.40
Redefining the p53 response element. Proc Natl Acad Sci U S A (2009) 1.36
A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors. Cancer Res (2011) 1.33
IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes. EMBO J (2011) 1.33
Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling. Oncogene (2012) 1.27
Suppressor role of activating transcription factor 2 (ATF2) in skin cancer. Proc Natl Acad Sci U S A (2008) 1.26
Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis. Genes Dev (2010) 1.25
The transcription factor p53: not a repressor, solely an activator. Cell Cycle (2014) 1.23
The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response. EMBO J (2008) 1.20
Down-regulation of Notch signaling during corneal epithelial proliferation. Mol Vis (2008) 1.20
Concern DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation. J Biol Chem (2011) 1.18
A miR-34a-SIRT6 axis in the squamous cell differentiation network. EMBO J (2013) 1.18
microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation. Proc Natl Acad Sci U S A (2012) 1.11
Restoration of p53 expression in human cancer cell lines upregulates the expression of Notch1: implications for cancer cell fate determination after genotoxic stress. Neoplasia (2007) 1.11
Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling. Proc Natl Acad Sci U S A (2012) 1.09
A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. J Clin Invest (2009) 1.09
Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Dev Biol (2008) 1.04
Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes. PLoS One (2010) 1.03
Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene (2014) 0.99
Notch inhibition during corneal epithelial wound healing promotes migration. Invest Ophthalmol Vis Sci (2012) 0.98
Mapping the p53 transcriptome universe using p53 natural polymorphs. Cell Death Differ (2013) 0.95
Wild-type tumor repressor protein 53 (Trp53) promotes ovarian cancer cell survival. Endocrinology (2012) 0.95
Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17. J Clin Invest (2012) 0.95
Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion. PLoS One (2011) 0.95
ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63. Proc Natl Acad Sci U S A (2013) 0.94
Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1. Development (2010) 0.93
p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish. PLoS Genet (2014) 0.93
The p53 control of apoptosis and proliferation: lessons from Drosophila. Apoptosis (2014) 0.93
Ras and Raf pathways in epidermis development and carcinogenesis. Br J Cancer (2010) 0.93
Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer. J Clin Invest (2014) 0.92
ΔNp63α promotes cellular quiescence via induction and activation of Notch3. Cell Cycle (2011) 0.92
Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma. Head Neck Pathol (2012) 0.91
Inflammation-mediated skin tumorigenesis induced by epidermal c-Fos. Genes Dev (2013) 0.91
Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Cancer Res (2011) 0.90
Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice. Gastroenterology (2011) 0.90
Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. BMC Biol (2011) 0.89
Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma. Am J Cancer Res (2012) 0.89
Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies. J Cell Mol Med (2009) 0.88
Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation. Mol Cell Biol (2013) 0.88
Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice. Am J Pathol (2010) 0.87
Notch signaling: its roles and therapeutic potential in hematological malignancies. Oncotarget (2016) 0.87
Tumor cell vascular mimicry: Novel targeting opportunity in melanoma. Pharmacol Ther (2016) 0.86
Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo. Mol Cancer Res (2011) 0.86
Notch1 is a 5-fluorouracil resistant and poor survival marker in human esophagus squamous cell carcinomas. PLoS One (2013) 0.85
Small GTPase RhoE/Rnd3 is a critical regulator of Notch1 signaling. Cancer Res (2014) 0.85
In the absence of Sonic hedgehog, p53 induces apoptosis and inhibits retinal cell proliferation, cell-cycle exit and differentiation in zebrafish. PLoS One (2010) 0.85
Arsenite suppresses Notch1 signaling in human keratinocytes. J Invest Dermatol (2008) 0.85
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression. EMBO J (2015) 0.84
A novel anticancer therapy that simultaneously targets aberrant p53 and Notch activities in tumors. PLoS One (2012) 0.84
Epiprofin orchestrates epidermal keratinocyte proliferation and differentiation. J Cell Sci (2014) 0.83
Role of human papillomavirus in oral squamous cell carcinoma and oral potentially malignant disorders: A review of the literature. Indian J Dent (2015) 0.83
The p63 protein isoform ΔNp63α modulates Y-box binding protein 1 in its subcellular distribution and regulation of cell survival and motility genes. J Biol Chem (2012) 0.82
p53 in cell invasion, podosomes, and invadopodia. Cell Adh Migr (2014) 0.82
Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ (2012) 0.81
Regulation of ROCK1 via Notch1 during breast cancer cell migration into dense matrices. BMC Cell Biol (2012) 0.81
Squamous Cell Cancers: A Unified Perspective on Biology and Genetics. Cancer Cell (2016) 0.81
Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression. Oncotarget (2016) 0.81
Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features. Cancer Prev Res (Phila) (2015) 0.81
Transcriptional regulation of Rho GTPase signaling. Transcription (2012) 0.81
An aquaporin 3-notch1 axis in keratinocyte differentiation and inflammation. PLoS One (2013) 0.80
Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer. Oncotarget (2016) 0.80
The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer. J Mol Med (Berl) (2014) 0.80
p53 protects against LPS-induced lung endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol (2015) 0.79
Therapeutic efficacy by targeting correction of Notch1-induced aberrants in uveal tumors. PLoS One (2012) 0.79
Human papilloma virus-dependent HMGA1 expression is a relevant step in cervical carcinogenesis. Neoplasia (2008) 0.79
Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells. Korean J Physiol Pharmacol (2013) 0.79
p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1. J Cell Physiol (2015) 0.79
Negative control of CSL gene transcription by stress/DNA damage response and p53. Cell Cycle (2016) 0.79
Distinctive pharmacological differences between liver cancer cell lines HepG2 and Hep3B. Cytotechnology (2014) 0.78
A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Commun Signal (2014) 0.78
Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis. Cell Cycle (2014) 0.78
Cutaneous Notch signaling in health and disease. Cold Spring Harb Perspect Med (2013) 0.78
c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression. Oncotarget (2015) 0.77
Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? Cancer Med (2016) 0.77
Notch and TGF-β pathways cooperatively regulate receptor protein tyrosine phosphatase-κ (PTPRK) gene expression in human primary keratinocytes. Mol Biol Cell (2015) 0.75
Targeting the Notch signaling pathway in cancer therapeutics. Thorac Cancer (2014) 0.75
Shoc2/Sur8 protein regulates neurite outgrowth. PLoS One (2014) 0.75
Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling. Biomed Res Int (2016) 0.75
Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest. Virology (2015) 0.75
Dual tumor suppressing and promoting function of Notch1 signaling in human prostate cancer. Oncotarget (2016) 0.75
Interaction of Wnt5a with Notch1 is Critical for the Pathogenesis of Psoriasis. Ann Dermatol (2016) 0.75
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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
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The IARC TP53 database: new online mutation analysis and recommendations to users. Hum Mutat (2002) 12.39
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
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HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol (2003) 7.32
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Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev (2001) 6.36
Notch signals control the fate of immature progenitor cells in the intestine. Nature (2005) 6.13
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Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol (2003) 4.43
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell (2006) 4.28
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med (2002) 4.04
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol (2004) 3.87
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet (2000) 3.82
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev (2006) 3.72
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell (2006) 3.42
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Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A (2006) 2.49
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest (2005) 2.38
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Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev (2002) 1.97
Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res (2003) 1.92
Dynamics of notch expression during murine prostate development and tumorigenesis. Cancer Res (2001) 1.92
CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis. Nat Med (2002) 1.86
NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK. Genes Dev (2004) 1.85
Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression. Cancer Res (2005) 1.85
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Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature (2008) 4.60
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev (2006) 3.72
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51
Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Sorèze 2009. J Am Acad Dermatol (2010) 2.87
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The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol (2007) 2.57
Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A (2006) 2.49
Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev Cell (2005) 2.21
A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol (2009) 2.21
Association between miR-200c and the survival of patients with stage I epithelial ovarian cancer: a retrospective study of two independent tumour tissue collections. Lancet Oncol (2011) 2.21
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17
Progesterone/RANKL is a major regulatory axis in the human breast. Sci Transl Med (2013) 2.09
Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev (2002) 1.97
Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. Hum Mol Genet (2003) 1.96
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nat Cell Biol (2008) 1.88
IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell (2002) 1.79
High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism. Dev Cell (2004) 1.78
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J (2004) 1.78
p53 rescue through HDM2 antagonism suppresses melanoma growth and potentiates MEK inhibition. J Invest Dermatol (2011) 1.77
c-Myc phosphorylation is required for cellular response to oxidative stress. Mol Cell (2006) 1.64
High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. Ann Intern Med (2002) 1.58
The non-classical export routes: FGF1 and IL-1alpha point the way. J Cell Sci (2003) 1.57
Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature (2010) 1.57
Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda. J Invest Dermatol (2003) 1.53
Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion. J Cell Biol (2002) 1.48
Molecular genetics of pseudoxanthoma elasticum: type and frequency of mutations in ABCC6. Hum Mutat (2005) 1.47
Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing. Mol Cell Biol (2006) 1.45
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Split-thickness skin graft harvested with saline moistening. J Burn Care Res (2011) 1.39
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CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential. Blood (2007) 1.35
ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One (2010) 1.35
Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes. Proc Natl Acad Sci U S A (2006) 1.35
Nrf2 links epidermal barrier function with antioxidant defense. EMBO Mol Med (2012) 1.35
IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes. EMBO J (2011) 1.33
Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat Genet (2009) 1.31
Resistance to platinum-based chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer. Eur J Cancer (2012) 1.30
Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma. J Biomed Opt (2004) 1.30
The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' family. Exp Dermatol (2012) 1.29
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Trace element supplementation after major burns modulates antioxidant status and clinical course by way of increased tissue trace element concentrations. Am J Clin Nutr (2007) 1.28
Real-time full field laser Doppler imaging. Biomed Opt Express (2011) 1.26
Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis. Genes Dev (2010) 1.25
CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. EMBO J (2007) 1.25
SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda. J Invest Dermatol (2006) 1.23
'Srcasm: a novel Src activating and signaling molecule. J Biol Chem (2001) 1.21
The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response. EMBO J (2008) 1.20
Concern DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation. J Biol Chem (2011) 1.18
A miR-34a-SIRT6 axis in the squamous cell differentiation network. EMBO J (2013) 1.18
Isolation and characterization of human repetin, a member of the fused gene family of the epidermal differentiation complex. J Invest Dermatol (2005) 1.17
Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. EMBO J (2004) 1.15
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Copper chelation represses the vascular response to injury. Proc Natl Acad Sci U S A (2003) 1.13
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J (2011) 1.12
Notch activation suppresses fibroblast growth factor-dependent cellular transformation. J Biol Chem (2003) 1.12
Cornulin, a new member of the "fused gene" family, is expressed during epidermal differentiation. J Invest Dermatol (2005) 1.11
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A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. J Clin Invest (2009) 1.09
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Basal cell carcinoma - molecular biology and potential new therapies. J Clin Invest (2012) 1.06
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