Published in Oncotarget on April 30, 2015
Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer (2003) 13.01
Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol (2006) 8.52
pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci U S A (1992) 8.46
Focal adhesion kinase: the first ten years. J Cell Sci (2003) 6.83
Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell (2005) 6.04
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol (1995) 5.36
Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc Natl Acad Sci U S A (1990) 5.25
Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev (2003) 4.62
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J Cell Sci (1999) 3.93
Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res (1995) 3.38
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell (2008) 3.31
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. J Cell Sci (2010) 3.17
Integrins in cell migration. Cold Spring Harb Perspect Biol (2011) 3.15
Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol (1997) 2.83
Overexpression of focal adhesion kinase in head and neck squamous cell carcinoma is independent of fak gene copy number. Clin Cancer Res (2006) 2.75
Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model. Cancer Res (2008) 2.59
Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol (2002) 2.50
FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer (2014) 2.46
The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol (2010) 2.23
Expression of focal adhesion kinase gene and invasive cancer. Lancet (1993) 1.93
FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol (2012) 1.87
Role of focal adhesion kinase in integrin signaling. Int J Biochem Cell Biol (1998) 1.83
Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma. Int J Cancer (1996) 1.79
Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A (2011) 1.76
Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression. Mol Biol Cell (2001) 1.75
Treatment for advanced tumors: SRC reclaims center stage. Clin Cancer Res (2006) 1.74
The role of Src in prostate cancer. Ann Oncol (2007) 1.71
Src activation regulates anoikis in human colon tumor cell lines. Oncogene (2002) 1.70
TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling. Exp Cell Res (2007) 1.68
Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases. Br J Cancer (2006) 1.67
Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells. Oncogene (2001) 1.67
Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenografts. Cancer Res (2004) 1.60
The focal adhesion kinase--a regulator of cell migration and invasion. IUBMB Life (2002) 1.55
Nonreceptor tyrosine kinases in prostate cancer. Neoplasia (2007) 1.50
SRC family kinase activity is up-regulated in hormone-refractory prostate cancer. Clin Cancer Res (2009) 1.47
Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. Cancer Res (2005) 1.45
FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br J Cancer (2003) 1.32
Up-regulation of focal adhesion kinase in non-small cell lung cancer. Lung Cancer (2006) 1.27
Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II. J Cell Biochem (1994) 1.25
Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts. J Biol Chem (2004) 1.25
The role of HGF/c-Met signaling in prostate cancer progression and c-Met inhibitors in clinical trials. Expert Opin Investig Drugs (2011) 1.24
Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer. Biochem Biophys Res Commun (2006) 1.23
A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer. Oncogene (1997) 1.23
FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion. Mol Biol Cell (2011) 1.22
FYN is overexpressed in human prostate cancer. BJU Int (2008) 1.22
Reduced proliferation and enhanced migration: two sides of the same coin? Molecular mechanisms of metastatic progression by YB-1. Cell Cycle (2009) 1.21
Focal adhesion kinase: exploring Fak structure to gain insight into function. Int Rev Cell Mol Biol (2011) 1.19
The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target. Oncogene (2012) 1.17
Expression of focal adhesion kinase in normal and pathologic human prostate tissues. Prostate (2002) 1.14
c-Src regulates constitutive and EGF-mediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK. Pancreas (2005) 1.14
Pre-clinical mouse models of human prostate cancer and their utility in drug discovery. Curr Protoc Pharmacol (2010) 1.12
Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo. J Biol Chem (2012) 1.10
FAK expression regulation and therapeutic potential. Adv Cancer Res (2008) 1.09
FAK signaling in human cancer as a target for therapeutics. Pharmacol Ther (2014) 1.09
Regulation of angiogenesis and vascular permeability by Src family kinases: opportunities for therapeutic treatment of solid tumors. Expert Opin Ther Targets (2007) 1.03
Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility. BMC Cell Biol (2011) 1.02
Targeting constitutively activated β1 integrins inhibits prostate cancer metastasis. Mol Cancer Res (2013) 1.01
Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis. Oncogene (2014) 1.00
Preferential phosphorylation of focal adhesion kinase tyrosine 861 is critical for mediating an anti-apoptotic response to hyperosmotic stress. J Biol Chem (2007) 0.97
The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells. Int J Cancer (2011) 0.96
Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells. Clin Exp Metastasis (2007) 0.93
Ligand-independent activation of MET through IGF-1/IGF-1R signaling. Int J Cancer (2013) 0.92
Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathways. PLoS One (2012) 0.88
Fyn is downstream of the HGF/MET signaling axis and affects cellular shape and tropism in PC3 cells. Clin Cancer Res (2011) 0.87
Small-molecule protein tyrosine kinase inhibitors for the treatment of metastatic prostate cancer. Future Med Chem (2012) 0.87
Lyn tyrosine kinase regulates androgen receptor expression and activity in castrate-resistant prostate cancer. Oncogenesis (2014) 0.84
Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate cancer cells. Cancer Lett (2011) 0.81
Differential requirement for Src family tyrosine kinases in the initiation, progression, and metastasis of prostate cancer. Mol Cancer Res (2014) 0.80
Focal adhesion kinase overexpression: correlation with lymph node metastasis and shorter survival in oral squamous cell carcinoma. Head Neck (2012) 0.79
High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype. BMC Cancer (2014) 0.78
Sequencing robot-assisted extended pelvic lymph node dissection prior to radical prostatectomy: a step-by-step guide to exposure and efficiency. BJU Int (2015) 0.76
Current technique and results for extended pelvic lymph node dissection during robot-assisted radical prostatectomy. Investig Clin Urol (2016) 0.75
Risk of hospitalisation after primary treatment for prostate cancer. BJU Int (2016) 0.75
Correlation of histomorphologic findings and partial neurovascular bundle preservation during laparoscopic and robotic radical prostatectomy. J Robot Surg (2011) 0.75
Performance of a Prostate Cancer Genomic Classifier in Predicting Metastasis in Men with Prostate-specific Antigen Persistence Postprostatectomy. Eur Urol (2017) 0.75
Baseline and Longitudinal Plasma Caveolin-1 Level as a Biomarker in Active Surveillance for Early Stage Prostate Cancer. BJU Int (2017) 0.75