Published in Comput Struct Biotechnol J on March 24, 2015
SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer. Trends Biochem Sci (2015) 0.95
How SUMOylation Fine-Tunes the Fanconi Anemia DNA Repair Pathway. Front Genet (2016) 0.78
CYLD and SUMO in neuroblastoma therapy. Oncoscience (2016) 0.75
Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer. Pathol Oncol Res (2016) 0.75
SUMO and the robustness of cancer. Nat Rev Cancer (2017) 0.75
Zinc finger-containing cellular transcription corepressor ZBTB25 promotes influenza virus RNA transcription and is a target for zinc-ejector drugs. J Virol (2017) 0.75
Viral manipulation of the cellular sumoylation machinery. Cell Commun Signal (2017) 0.75
Concepts in sumoylation: a decade on. Nat Rev Mol Cell Biol (2007) 11.48
SUMO--nonclassical ubiquitin. Annu Rev Cell Dev Biol (2000) 5.37
A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet (2004) 4.95
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. Nat Rev Mol Cell Biol (2010) 4.72
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell (2007) 4.46
Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. Cell (2002) 4.09
Modification in reverse: the SUMO proteases. Trends Biochem Sci (2007) 3.84
SUMOylation and De-SUMOylation: wrestling with life's processes. J Biol Chem (2008) 3.22
Mechanisms, regulation and consequences of protein SUMOylation. Biochem J (2010) 3.22
Function and regulation of SUMO proteases. Nat Rev Mol Cell Biol (2012) 2.55
Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. EMBO J (2005) 2.54
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell (2010) 2.52
SUMO-specific proteases: a twist in the tail. Trends Cell Biol (2007) 2.50
Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature (2010) 2.41
SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol (2008) 2.35
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell (2007) 2.34
A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. Structure (2004) 2.15
A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. J Biol Chem (2004) 2.13
Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates. Nat Struct Mol Biol (2006) 2.07
Sumoylation regulates diverse biological processes. Cell Mol Life Sci (2007) 2.03
Role of desumoylation in the development of prostate cancer. Neoplasia (2006) 1.90
SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Mol Cell Biol (2004) 1.89
SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol (2006) 1.89
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86
Angiogenesis in ischemic and neoplastic disorders. Annu Rev Med (2001) 1.82
Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways. Curr Opin Struct Biol (2007) 1.76
Sumoylation increases HIF-1alpha stability and its transcriptional activity. Biochem Biophys Res Commun (2004) 1.70
A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation. Biochem Biophys Res Commun (2005) 1.68
Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development. Mol Cell Biol (2005) 1.52
The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem J (2006) 1.49
Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. J Biol Chem (2008) 1.47
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J (2009) 1.41
DeSUMOylating enzymes--SENPs. IUBMB Life (2008) 1.37
Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors. J Clin Endocrinol Metab (2004) 1.35
SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells. Mol Endocrinol (2008) 1.32
Sumoylation and human disease pathogenesis. Trends Biochem Sci (2009) 1.29
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. J Biol Chem (2010) 1.29
Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases. J Biol Chem (2005) 1.28
SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem (2010) 1.16
SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene (2012) 1.16
Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies. Future Oncol (2007) 1.15
Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease. Biochem J (2006) 1.12
SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors. Cancer Lett (2011) 1.10
Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases. Chembiochem (2005) 1.07
The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases. J Biol Chem (2011) 1.06
SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity. Biochem Biophys Res Commun (2007) 1.05
SUMO-specific protease 2 in Mdm2-mediated regulation of p53. Cell Death Differ (2010) 1.04
Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity. Cancer Cell (2014) 1.03
Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression. PLoS One (2012) 1.02
Important role of SUMOylation of Spliceosome factors in prostate cancer cells. J Proteome Res (2014) 0.99
De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis. Circ Res (2013) 0.99
Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors. Chem Biol (2011) 0.99
Protein interactions in the sumoylation cascade: lessons from X-ray structures. FEBS J (2008) 0.96
Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes. J Am Chem Soc (2010) 0.95
The holistic integration of virtual screening in drug discovery. Drug Discov Today (2013) 0.90
Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation. Oncol Rep (2008) 0.88
Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors. Bioorg Med Chem Lett (2011) 0.87
Development of small molecule inhibitors and probes of human SUMO deconjugating proteases. Chem Biol (2011) 0.87
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9. Tumour Biol (2014) 0.87
Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction. J Mol Cell Cardiol (2011) 0.87
Identification and characterization of a new chemotype of noncovalent SENP inhibitors. ACS Chem Biol (2013) 0.87
Hierarchical virtual screening approaches in small molecule drug discovery. Methods (2014) 0.85
SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of β-catenin. Asian Pac J Cancer Prev (2012) 0.84
Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors. Bioorg Med Chem Lett (2012) 0.83
A mechanistic view of the role of E3 in sumoylation. PLoS Comput Biol (2010) 0.83
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation. Bioorg Med Chem Lett (2012) 0.83
SENP2 regulated the stability of β-catenin through WWOX in hepatocellular carcinoma cell. Tumour Biol (2014) 0.82
Identification of 1,2,5-oxadiazoles as a new class of SENP2 inhibitors using structure based virtual screening. J Chem Inf Model (2014) 0.81
Detection and characterization of SUMO protease activity using a sensitive enzyme-based reporter assay. Methods Mol Biol (2009) 0.81
Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation. Oncol Rep (2013) 0.79
Exploring the desumoylation process of SENP1: a study combined MD simulations with QM/MM calculations on SENP1-SUMO1-RanGAP1. J Chem Inf Model (2013) 0.79
Inhibition of SENP5 suppresses cell growth and promotes apoptosis in osteosarcoma cells. Exp Ther Med (2014) 0.78
Engineering pre-SUMO4 as efficient substrate of SENP2. Protein Eng Des Sel (2014) 0.78
SENP5 mediates breast cancer invasion via a TGFβRI SUMOylation cascade. Oncotarget (2014) 0.78
Glycine fluoromethylketones as SENP-specific activity based probes. Chembiochem (2011) 0.77
Small ubiquitin-like modifier protein-specific protease 1 and prostate cancer. Asian J Androl (2008) 0.76
The crystal and solution structure of YdiE from Escherichia coli. Acta Crystallogr F Struct Biol Commun (2015) 0.76
Identification of new SUMO activating enzyme 1 inhibitors using virtual screening and scaffold hopping. Bioorg Med Chem Lett (2016) 0.75
Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives. Bioorg Chem (2015) 0.75