Published in Biochem Biophys Res Commun on November 05, 2004
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer (2011) 6.32
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell (2007) 4.46
In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy. Mol Cell Proteomics (2007) 2.30
An additional role for SUMO in ubiquitin-mediated proteolysis. Nat Rev Mol Cell Biol (2009) 2.27
Hypoxia-induced angiogenesis: good and evil. Genes Cancer (2011) 1.52
Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development. Mol Cell Biol (2005) 1.52
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J (2009) 1.41
The ubiquitin ligase Siah2 and the hypoxia response. Mol Cancer Res (2009) 1.29
A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1 alpha. J Cell Sci (2006) 1.20
Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification. PLoS One (2010) 1.12
RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. Nucleic Acids Res (2009) 1.12
Ubiquitin-proteasome system as a modulator of cell fate. Curr Opin Pharmacol (2007) 1.09
Inflammation and Its Correlates in Regenerative Wound Healing: An Alternate Perspective. Adv Wound Care (New Rochelle) (2014) 1.07
HIF-1alpha: a valid therapeutic target for tumor therapy. Cancer Res Treat (2004) 1.06
Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis. J Biol Chem (2010) 1.06
The role of hypoxia inducible factor-1 in hepatocellular carcinoma. Biomed Res Int (2014) 1.03
Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease. Nitric Oxide (2011) 0.99
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia. J Cell Biochem (2011) 0.98
Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response. Cell Signal (2013) 0.97
Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia. J Biol Chem (2010) 0.95
SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells. Am J Pathol (2006) 0.95
Hypoxia-inducible factor-1 facilitates cervical cancer progression in human papillomavirus type 16 transgenic mice. Am J Pathol (2007) 0.94
Transcriptional regulation by hypoxia inducible factors. Crit Rev Biochem Mol Biol (2013) 0.94
RSUME inhibits VHL and regulates its tumor suppressor function. Oncogene (2014) 0.94
Hypoxia inducible factor-1 as a target for neurodegenerative diseases. Curr Med Chem (2011) 0.91
Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation. J Biol Chem (2009) 0.91
SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion. Am J Physiol Endocrinol Metab (2012) 0.90
SUMO1 promotes Aβ production via the modulation of autophagy. Autophagy (2015) 0.89
Advances in the development of SUMO specific protease (SENP) inhibitors. Comput Struct Biotechnol J (2015) 0.88
Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers. Biol Cell (2011) 0.87
Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke. Free Radic Biol Med (2013) 0.87
Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity. Oncogene (2009) 0.86
The role of the ubiquitin proteasome system in ischemia and ischemic tolerance. Neuroscientist (2009) 0.86
Cardiac function and disease: emerging role of small ubiquitin-related modifier. Wiley Interdiscip Rev Syst Biol Med (2010) 0.85
Host cell sumoylation level influences papillomavirus E2 protein stability. Virology (2009) 0.85
Emerging roles of SUMO modification in arthritis. Gene (2010) 0.84
The effect of HIF-1alpha siRNA on growth and chemosensitivity of MIA-paca cell line. Yonsei Med J (2008) 0.84
Sumoylation of hypoxia-inducible factor-1α ameliorates failure of brain stem cardiovascular regulation in experimental brain death. PLoS One (2011) 0.84
PKC-delta inhibitors sustain self-renewal of mouse embryonic stem cells under hypoxia in vitro. Exp Mol Med (2010) 0.83
Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla. J Biomed Sci (2010) 0.83
Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation. J Biol Chem (2012) 0.79
Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation. Nucleic Acids Res (2015) 0.79
Clinical significance of hypoxia-inducible factor 1 and VEGF-A in osteosarcoma. Int J Clin Oncol (2015) 0.79
Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose. J Neurochem (2016) 0.79
Meta-analysis of SUMO1. BMC Res Notes (2008) 0.78
SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α. Sci Rep (2015) 0.78
Suppression of HIF-1α by Valproic Acid Sustains Self-Renewal of Mouse Embryonic Stem Cells under Hypoxia In Vitro. Biomol Ther (Seoul) (2012) 0.78
SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α. Mol Med Rep (2016) 0.77
ING1b negatively regulates HIF1α protein levels in adipose-derived stromal cells by a SUMOylation-dependent mechanism. Cell Death Dis (2015) 0.77
HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells. Graefes Arch Clin Exp Ophthalmol (2015) 0.77
SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein. J Biol Chem (2011) 0.77
T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions. PLoS One (2016) 0.76
A monoclonal antibody against the human SUMO-1 protein obtained by immunization with recombinant protein and CpG-DNA-liposome complex. Monoclon Antib Immunodiagn Immunother (2013) 0.75
The expression of hypoxia-inducible factor-1α gene is not affected by low-oxygen conditions in yellow perch (Perca flavescens) juveniles. Fish Physiol Biochem (2017) 0.75
Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming. Sci Rep (2017) 0.75
Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1α Upstream of Notch and SUMO Pathways. Stem Cells Dev (2017) 0.75
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Analyses of pig genomes provide insight into porcine demography and evolution. Nature (2012) 5.58
Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo): genome assembly and analysis. PLoS Biol (2010) 5.39
Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. Exp Mol Med (2004) 3.04
SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Nat Med (2003) 2.78
Blood-neural barrier: intercellular communication at glio-vascular interface. J Biochem Mol Biol (2006) 1.59
Functional and developmental analysis of the blood-brain barrier in zebrafish. Brain Res Bull (2007) 1.51
Jab1 interacts directly with HIF-1alpha and regulates its stability. J Biol Chem (2001) 1.41
Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells. Biochim Biophys Acta (2008) 1.41
Hypoxia-induced angiogenesis during carcinogenesis. J Biochem Mol Biol (2003) 1.32
Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formation. Dev Biol (2006) 1.32
Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity. Biochem Biophys Res Commun (2003) 1.31
Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines. Oncogene (2002) 1.31
Structural basis for depletion of heat shock protein 90 client proteins by deguelin. J Natl Cancer Inst (2007) 1.27
Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1. Oncol Rep (2006) 1.26
Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1alpha. FASEB J (2003) 1.25
ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nat Med (2011) 1.21
Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells. Inflamm Res (2013) 1.20
Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2. Biochem Biophys Res Commun (2007) 1.17
Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res (2004) 1.16
Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis. J Biol Chem (2002) 1.14
Regulation of the HIF-1alpha stability by histone deacetylases. Oncol Rep (2007) 1.13
Hypoxia-induced angiogenesis in human hepatocellular carcinoma. J Mol Med (Berl) (2002) 1.13
Blood-neural barrier: its diversity and coordinated cell-to-cell communication. BMB Rep (2008) 1.12
Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis. Int J Cancer (2002) 1.11
Melatonin suppresses tumor angiogenesis by inhibiting HIF-1alpha stabilization under hypoxia. J Pineal Res (2010) 1.11
Pro-MMP-2 activation by the PPARgamma agonist, ciglitazone, induces cell invasion through the generation of ROS and the activation of ERK. FEBS Lett (2007) 1.10
Angiopoietin-1 reduces vascular endothelial growth factor-induced brain endothelial permeability via upregulation of ZO-2. Int J Mol Med (2009) 1.09
TNF-related activation-induced cytokine (TRANCE) induces angiogenesis through the activation of Src and phospholipase C (PLC) in human endothelial cells. J Biol Chem (2001) 1.08
Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1. FEBS Lett (2006) 1.08
Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway. J Biol Chem (2007) 1.08
Carbon monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms, translational activation and stabilization of HIF-1alpha protein. J Biol Chem (2010) 1.07
Metastatic tumor antigen 1 is closely associated with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma. Hepatology (2008) 1.07
Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia (2012) 1.07
Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke (2013) 1.07
HIF-1alpha: a valid therapeutic target for tumor therapy. Cancer Res Treat (2004) 1.06
Protective effect of clusterin from oxidative stress-induced apoptosis in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2009) 1.06
Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. Neurotoxicology (2008) 1.06
Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases. Nucleic Acids Res (2009) 1.05
Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface. FEBS J (2009) 1.05
Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation. Biochem Biophys Res Commun (2012) 1.04
Coordinated interaction of the vascular and nervous systems: from molecule- to cell-based approaches. Biochem Biophys Res Commun (2003) 1.04
Recruitment of pericytes and astrocytes is closely related to the formation of tight junction in developing retinal vessels. J Neurosci Res (2009) 1.04
Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest (2013) 1.02
Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha. Int J Cancer (2008) 1.02
Neuronal genes for subcutaneous fat thickness in human and pig are identified by local genomic sequencing and combined SNP association study. PLoS One (2011) 1.02
Metastasis-associated protein 1 enhances angiogenesis by stabilization of HIF-1alpha. Oncol Rep (2006) 1.01
Intravenously administered gold nanoparticles pass through the blood-retinal barrier depending on the particle size, and induce no retinal toxicity. Nanotechnology (2009) 1.01
Characterization of ARD1 variants in mammalian cells. Biochem Biophys Res Commun (2005) 1.01
Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke (2013) 1.01
Nerve injury-induced protein 1 (Ninjurin-1) is a novel therapeutic target for cavernous nerve injury-induced erectile dysfunction in mice. J Sex Med (2013) 1.00
Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesis. Biochem Biophys Res Commun (2004) 0.99
Ninjurin1 is expressed in myeloid cells and mediates endothelium adhesion in the brains of EAE rats. Biochem Biophys Res Commun (2009) 0.99
Osteopontin splice variants differentially modulate the migratory activity of hepatocellular carcinoma cell lines. Int J Oncol (2009) 0.98
The role of clusterin in in vitro ischemia of human retinal endothelial cells. Curr Eye Res (2007) 0.98
Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation. Cancer Res (2010) 0.97
Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy. Am J Pathol (2010) 0.97
AKAP12 regulates human blood-retinal barrier formation by downregulation of hypoxia-inducible factor-1alpha. J Neurosci (2007) 0.97
Homoisoflavanone inhibits retinal neovascularization through cell cycle arrest with decrease of cdc2 expression. Biochem Biophys Res Commun (2007) 0.96
Meteorin promotes the formation of GFAP-positive glia via activation of the Jak-STAT3 pathway. J Cell Sci (2010) 0.96
Neurovascular matrix metalloproteinases and the blood-brain barrier. Curr Pharm Des (2012) 0.96
Establishment and characterization of a novel, spontaneously immortalized retinoblastoma cell line with adherent growth. Int J Oncol (2007) 0.95
The anti-angiogenic activities of glycyrrhizic acid in tumor progression. Phytother Res (2012) 0.95
Protein kinase C-delta regulates the stability of hypoxia-inducible factor-1 alpha under hypoxia. Cancer Sci (2007) 0.94
Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF. EMBO Mol Med (2012) 0.94
Blockade of angiotensin II attenuates VEGF-mediated blood-retinal barrier breakdown in diabetic retinopathy. J Cereb Blood Flow Metab (2008) 0.94
Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3. Biochem Biophys Res Commun (2007) 0.94
Tid-1 interacts with the von Hippel-Lindau protein and modulates angiogenesis by destabilization of HIF-1alpha. Cancer Res (2005) 0.94