Published in J Biol Chem on April 30, 2015
Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling. BMC Cancer (2015) 0.79
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases. Redox Biol (2017) 0.76
Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles. PLoS One (2016) 0.75
Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells. J Cell Sci (2015) 0.75
Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem (1996) 45.70
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol (2005) 18.23
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev (1999) 13.43
Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol (2009) 9.32
Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol (2009) 7.96
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell (2009) 6.88
Selective autophagy mediated by autophagic adapter proteins. Autophagy (2011) 6.88
Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med (2004) 5.88
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem (2009) 5.80
Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem (2000) 5.75
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem (2003) 5.67
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell (2008) 5.60
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci (2009) 4.50
An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell (2009) 4.07
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev (2003) 3.92
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem (2010) 3.84
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution. Genes Cells (2011) 3.76
Transcription factor and polymerase recruitment, modification, and movement on dhsp70 in vivo in the minutes following heat shock. Mol Cell Biol (2003) 3.65
Signal integration and diversification through the p62 scaffold protein. Trends Biochem Sci (2006) 3.50
The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev (2013) 3.40
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene (2002) 3.33
Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells (2008) 3.23
Stress-activated cap'n'collar transcription factors in aging and human disease. Sci Signal (2010) 3.19
Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. J Biol Chem (2003) 3.02
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol (2010) 2.93
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol (2008) 2.90
Autophagy in malignant transformation and cancer progression. EMBO J (2015) 2.67
Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Dev Cell (2008) 2.66
KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 2.55
Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells (2002) 2.43
Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Oncogene (2001) 2.21
The LIR motif - crucial for selective autophagy. J Cell Sci (2013) 2.02
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell (2013) 1.95
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy (2010) 1.93
Uba1 functions in Atg7- and Atg3-independent autophagy. Nat Cell Biol (2013) 1.91
Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis. Mech Dev (1991) 1.82
Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions. J Mol Biol (2002) 1.79
PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. Mol Cell (2003) 1.78
The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes. J Cell Sci (2008) 1.67
An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance. J Biol Chem (2007) 1.63
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster. Cell Death Differ (2012) 1.60
Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy (2010) 1.58
The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway. Mol Cell Biol (2002) 1.57
Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci U S A (2012) 1.53
Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages. Biochem Biophys Res Commun (1997) 1.41
p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy (2011) 1.39
Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1. Autophagy (2011) 1.39
Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila. PLoS One (2012) 1.37
Genetic resistance to viral infection: the molecular cloning of a Drosophila gene that restricts infection by the rhabdovirus sigma. Genetics (1989) 1.31
Antioxidant and cytoprotective responses to redox stress. Biochem Soc Symp (2004) 1.29
Transcriptional regulation of xenobiotic detoxification in Drosophila. Genes Dev (2011) 1.25
Molecular analysis of ref(2)P, a Drosophila gene implicated in sigma rhabdovirus multiplication and necessary for male fertility. EMBO J (1989) 1.24
Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila. Development (2013) 1.20
Control of Drosophila head segment identity by the bZIP homeotic gene cnc. Development (1995) 1.19
JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech Dev (2009) 1.18
The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription. J Biol Chem (2007) 1.17
A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture. PLoS One (2012) 1.11
A cap 'n' collar protein isoform contains a selective Hox repressor function. Development (1998) 1.06
Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster. PLoS Genet (2013) 1.04
Control of sigma virus multiplication by the ref(2)P gene of Drosophila melanogaster: an in vivo study of the PB1 domain of Ref(2)P. Genetics (2007) 1.03
iLIR: A web resource for prediction of Atg8-family interacting proteins. Autophagy (2014) 1.02
Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death Differ (2012) 1.01
Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome. Mol Cell Biol (2010) 0.99
Identification of NRF2, a member of the NF-E2 family of transcription factors, as a substrate for caspase-3(-like) proteases. Cell Death Differ (1999) 0.99
The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development. Genetics (2004) 0.98
The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription. Nucleic Acids Res (2007) 0.96
Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis. Cell Death Differ (2014) 0.94
Regulation of antioxidant response element-dependent induction of detoxifying enzyme synthesis. Methods Enzymol (2004) 0.93
Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy. FEBS Lett (2014) 0.93
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling. Mol Cell (2015) 0.92
Atg9 interacts with dTRAF2/TRAF6 to regulate oxidative stress-induced JNK activation and autophagy induction. Dev Cell (2013) 0.90
Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila. FEBS Lett (2013) 0.88
The putative HORMA domain protein Atg101 dimerizes and is required for starvation-induced and selective autophagy in Drosophila. Biomed Res Int (2014) 0.85
Autophagy in Drosophila: from historical studies to current knowledge. Biomed Res Int (2014) 0.85
Constitutive activation of the Nrf2/Keap1 pathway in insecticide-resistant strains of Drosophila. Insect Biochem Mol Biol (2013) 0.81
Selective autophagy in Drosophila. Int J Cell Biol (2012) 0.77