Published in Curr Opin Cell Biol on May 15, 2015
Mitochondria and Cancer. Mol Cell (2016) 1.11
Autophagy, Metabolism, and Cancer. Clin Cancer Res (2015) 0.95
Protein kinase C controls lysosome biogenesis independently of mTORC1. Nat Cell Biol (2016) 0.93
Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic. EMBO J (2016) 0.87
Recent insights into the function of autophagy in cancer. Genes Dev (2016) 0.86
C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling. Mol Biol Cell (2016) 0.83
Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Immunity (2016) 0.79
Lysosomes relax in the cellular suburbs. J Cell Biol (2016) 0.77
Lysosomal and vacuolar sorting: not so different after all! Biochem Soc Trans (2016) 0.76
Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C. Acta Neuropathol Commun (2016) 0.75
Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification. PLoS One (2016) 0.75
C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease. Traffic (2017) 0.75
mTOR signaling in growth control and disease. Cell (2012) 29.21
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 11.65
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 9.58
Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol (2008) 8.92
TFEB links autophagy to lysosomal biogenesis. Science (2011) 8.87
Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol (2002) 8.04
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (2011) 7.55
A gene network regulating lysosomal biogenesis and function. Science (2009) 7.17
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell (2008) 6.88
Rheb binds and regulates the mTOR kinase. Curr Biol (2005) 6.09
Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome. Cancer Cell (2002) 5.10
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J (2012) 5.03
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol (2003) 4.01
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science (2013) 3.96
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem (2003) 3.83
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell (2012) 3.77
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci U S A (2006) 3.51
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal (2012) 3.40
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity. Proc Natl Acad Sci U S A (2013) 3.33
Tuberous sclerosis: from tubers to mTOR. Ann Hum Genet (2003) 3.15
Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell (2013) 3.15
c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev (2000) 3.13
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol (2013) 3.11
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature (2011) 2.96
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy (2012) 2.87
A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14. Nat Med (2006) 2.85
Regulation of TFEB and V-ATPases by mTORC1. EMBO J (2011) 2.84
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell (2004) 2.80
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science (2015) 2.80
Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. Cancer Discov (2014) 2.79
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell (2013) 2.79
Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Dev Cell (2011) 2.71
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell (2014) 2.68
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol (2013) 2.62
Nutrient-sensing mechanisms and pathways. Nature (2015) 2.46
Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet (2013) 2.43
A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. J Cell Biol (2001) 2.42
The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs. Bioinformatics (2013) 2.31
Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. J Biochem (2005) 2.28
Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Proc Natl Acad Sci U S A (2009) 2.28
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell (2012) 2.22
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. EMBO J (2009) 2.17
Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science (2015) 2.14
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes. Nat Genet (2014) 2.11
Mutations in DEPDC5 cause familial focal epilepsy with variable foci. Nat Genet (2013) 2.10
Response and acquired resistance to everolimus in anaplastic thyroid cancer. N Engl J Med (2014) 2.09
PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function. Sci Transl Med (2012) 2.07
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature (2015) 2.01
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov (2014) 1.99
The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. J Cell Biol (2012) 1.93
TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res (2007) 1.93
Mutations of DEPDC5 cause autosomal dominant focal epilepsies. Nat Genet (2013) 1.91
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol (2015) 1.88
Lymphangioleiomyomatosis - a wolf in sheep's clothing. J Clin Invest (2012) 1.87
Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene (2008) 1.82
Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc Natl Acad Sci U S A (2003) 1.73
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep (2014) 1.72
MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells. Proc Natl Acad Sci U S A (2015) 1.68
Mutations in mammalian target of rapamycin regulator DEPDC5 cause focal epilepsy with brain malformations. Ann Neurol (2014) 1.62
The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci Signal (2014) 1.58
Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin. J Med Genet (2009) 1.57
Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep (2014) 1.51
Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution. Hum Mol Genet (2003) 1.47
Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease. EMBO Mol Med (2013) 1.44
Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases. J Cell Biol (2013) 1.43
Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes. J Cell Biol (2013) 1.35
VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy. Acta Neuropathol (2013) 1.34
mTOR signaling in cellular and organismal energetics. Curr Opin Cell Biol (2014) 1.32
Nutrient-sensing mechanisms across evolution. Cell (2015) 1.30
Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. Open Biol (2012) 1.29
Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy. Nat Med (2015) 1.26
Lysosomal lipid storage diseases. Cold Spring Harb Perspect Biol (2011) 1.26
Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia. Ann Neurol (2015) 1.24
Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization. PLoS One (2010) 1.23
DEPDC5 mutations in genetic focal epilepsies of childhood. Ann Neurol (2014) 1.21
The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells. Cancer Res (2006) 1.19
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med (2014) 1.17
A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts. Genes Dev (2013) 1.15
The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. J Clin Invest (2014) 1.10
Cell biology and function of neuronal ceroid lipofuscinosis-related proteins. Biochim Biophys Acta (2013) 1.09
Targeted treatment trials for tuberous sclerosis and autism: no longer a dream. Curr Opin Neurobiol (2012) 1.05
The roles of microphthalmia-associated transcription factor and pigmentation in melanoma. Arch Biochem Biophys (2014) 1.05
Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers. Nat Rev Urol (2014) 0.97
Rag GTPases are cardioprotective by regulating lysosomal function. Nat Commun (2014) 0.95
mTORC1 status dictates tumor response to targeted therapeutics. Sci Signal (2013) 0.95
Molecular architecture and function of the SEA complex, a modulator of the TORC1 pathway. Mol Cell Proteomics (2014) 0.94
RagA, but not RagB, is essential for embryonic development and adult mice. Dev Cell (2014) 0.93
Renal carcinoma-associated transcription factors TFE3 and TFEB are leukemia inhibitory factor-responsive transcription activators of E-cadherin. J Biol Chem (2005) 0.90
Unique mutation, accelerated mTOR signaling and angiogenesis in the pulmonary cysts of Birt-Hogg-Dubé syndrome. Pathol Int (2013) 0.88
Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly. J Med Genet (2013) 0.87
TBC1D7 mutations are associated with intellectual disability, macrocrania, patellar dislocation, and celiac disease. Hum Mutat (2014) 0.86